Gene: ATG12

9140
APG12|APG12L|FBR93|HAPG12
autophagy related 12
protein-coding
5q22.3
Ensembl:ENSG00000145782 MIM:609608 Vega:OTTHUMG00000128889 UniprotKB:O94817
NC_000005.10
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.869e-1 (AD)  2.005e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
COPS20.945
API50.942
PGRMC20.931
RPE0.931
PSMC60.93
CGGBP10.929
MAP3K70.928
RUFY30.927
ETNK10.923
UBE2G10.922

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.623
OR4F29-0.601
MTRNR2L10-0.32
MTRNR2L6-0.295
MTRNR2L9-0.286
KCNK5-0.284
PLA2G5-0.281
TTLL10-0.276
MTRNR2L2-0.273
PTGDR2-0.268

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0415944-nonylphenol4-nonylphenol results in increased expression of ATG12 mRNA28041982
D000082AcetaminophenAcetaminophen results in increased expression of ATG12 mRNA21420995
D000082AcetaminophenAcetaminophen affects the expression of ATG12 mRNA17562736
D000111AcetylcysteineAcetylcysteine inhibits the reaction [vorinostat promotes the reaction [ATG5 protein binds to ATG12 protein]]20543569
D000111AcetylcysteineAcetylcysteine inhibits the reaction [Zinc Oxide analog results in increased expression of ATG12 mRNA]24614525
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of ATG12 gene27153756
D001280AtrazineAtrazine results in decreased expression of ATG12 mRNA22378314
C426023austenitic steel[Nickel co-treated with austenitic steel analog] results in increased expression of ATG12 mRNA23638002
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of ATG12 mRNA22228805
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of ATG12 mRNA"20018196
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehyde[MYBPC3 protein affects the susceptibility to benzyloxycarbonylleucyl-leucyl-leucine aldehyde] which results in increased expression of ATG12 mRNA25566086
C006780bisphenol Abisphenol A results in decreased expression of ATG12 mRNA29027980
C006780bisphenol Abisphenol A results in increased expression of ATG12 mRNA26746108
C006780bisphenol Abisphenol A results in increased expression of ATG12 mRNA26139607|2753935
C018475butyraldehydebutyraldehyde results in decreased expression of ATG12 mRNA26079696
D002104CadmiumCadmium results in increased expression of ATG12 mRNA27492225
D002220CarbamazepineCarbamazepine affects the expression of ATG12 mRNA25979313
D002701ChloramphenicolChloramphenicol results in increased expression of ATG12 mRNA17457038
C018021cobaltous chloride[cobaltous chloride co-treated with TP53 gene mutant form] results in increased expression of ATG12 protein23380477
C018021cobaltous chloridecobaltous chloride results in increased expression of ATG12 mRNA19376846
D019327Copper SulfateCopper Sulfate results in increased expression of ATG12 mRNA19549813
C017160cypermethrincypermethrin results in increased expression of ATG12 mRNA27704156
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of ATG12 mRNA]27941970
D002945CisplatinCisplatin results in decreased expression of ATG12 mRNA21151649
C000944dicrotophosdicrotophos results in decreased expression of ATG12 mRNA28302478
D004041Dietary FatsDietary Fats results in decreased expression of ATG12 mRNA25016146
D004178Diquat[Diquat co-treated with procyanidin B2] results in increased expression of ATG12 mRNA27057282
C100264enniatinsenniatins results in decreased expression of ATG12 mRNA27163883
D000431EthanolEthanol results in increased expression of ATG12 mRNA24492484
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ATG12 mRNA17942748
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of ATG12 mRNA23649840
D011345FenofibrateFenofibrate results in increased expression of ATG12 mRNA21318169
D011345FenofibratePPARA protein affects the reaction [Fenofibrate results in increased expression of ATG12 mRNA]21318169
D000068876Fingolimod HydrochlorideFingolimod Hydrochloride results in increased expression of ATG12 protein25939952
D005472FluorouracilFluorouracil results in decreased expression of ATG12 mRNA16510598
D005557FormaldehydeFormaldehyde results in increased expression of ATG12 mRNA23649840
C037032galangin[ATG12 mutant form co-treated with galangin] results in decreased activity of CASP3 protein25268046
C037032galangingalangin results in increased expression of ATG12 mRNA25268046
C037032galangingalangin results in increased expression of ATG12 protein25268046
C037032galanginLY2109761 inhibits the reaction [galangin results in increased expression of ATG12 protein]25268046
C037032galanginSMAD4 mutant form inhibits the reaction [galangin results in increased expression of ATG12 protein]25268046
C059922gossypetin"gossypetin promotes the reaction [malondialdehyde-low density lipoprotein, human promotes the reaction [ATG5 protein binds to ATG12 protein]]"25622137
D006861Hydrogen PeroxideHydrogen Peroxide results in increased expression of ATG12 protein23726866
D006861Hydrogen Peroxide[Hydrogen Peroxide co-treated with procyanidin B2] results in increased expression of ATG12 mRNA27057282
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of ATG12 mRNA25613284
C410337K 7174K 7174 results in increased expression of ATG12 mRNA24086573
D007649KetamineKetamine results in increased expression of ATG12 mRNA20080153
D007657Ketone BodiesKetone Bodies results in increased expression of ATG12 mRNA16807920
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of ATG12 mRNA"24972896
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of ATG12 mRNA25613284
C530108LY2109761LY2109761 inhibits the reaction [galangin results in increased expression of ATG12 protein]25268046
C569869malondialdehyde-low density lipoprotein, human"gossypetin promotes the reaction [malondialdehyde-low density lipoprotein, human promotes the reaction [ATG5 protein binds to ATG12 protein]]"25622137
C569869malondialdehyde-low density lipoprotein, human"malondialdehyde-low density lipoprotein, human promotes the reaction [ATG5 protein binds to ATG12 protein]"25622137
D008344ManebManeb promotes the reaction [Paraquat results in increased expression of ATG12 protein]22292029
D008727MethotrexateMethotrexate results in increased expression of ATG12 mRNA21678067
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of ATG12 mRNA23649840
D009532Nickel[Nickel co-treated with austenitic steel analog] results in increased expression of ATG12 mRNA23638002
C010615Nonidet P-40Nonidet P-40 results in increased expression of ATG12 mRNA26552463
D009842OligopeptidesOligopeptides analog results in decreased expression of ATG12 protein24875536
D010269ParaquatATG5 protein affects the reaction [Paraquat results in increased expression of [ATG5 protein binds to ATG12 protein]]22982048
D010269ParaquatParaquat results in increased expression of ATG12 mRNA27220436
D010269ParaquatParaquat results in increased expression of [ATG5 protein binds to ATG12 protein]22982048
D010269ParaquatManeb promotes the reaction [Paraquat results in increased expression of ATG12 protein]22292029
D010269ParaquatParaquat results in increased expression of ATG12 protein22292029
D010269ParaquatParaquat results in increased expression of [ATG5 protein binds to ATG12 protein]22982048
D052638Particulate Matter[Vehicle Emissions results in increased abundance of Particulate Matter] which results in increased expression of ATG12 protein28013216
C568608PCI 5002[PCI 5002 co-treated with Zinc] results in increased expression of ATG12 mRNA18593933
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in increased expression of ATG12 mRNA27825932
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of ATG12 mRNA26879310
D010634PhenobarbitalPhenobarbital affects the expression of ATG12 mRNA19159669
C006253pirinixic acidpirinixic acid results in increased expression of ATG12 mRNA18301758|2081375
C006253pirinixic acidPPARA protein affects the reaction [pirinixic acid results in increased expression of ATG12 mRNA]21318169
D010936Plant ExtractsPlant Extracts results in increased expression of ATG12 mRNA23557933
C479580procyanidin B2[Diquat co-treated with procyanidin B2] results in increased expression of ATG12 mRNA27057282
C479580procyanidin B2[Hydrogen Peroxide co-treated with procyanidin B2] results in increased expression of ATG12 mRNA27057282
D011794QuercetinQuercetin results in increased expression of [ATG12 protein binds to ATG5 protein]25293876
C059514resveratrolresveratrol results in increased expression of ATG12 mRNA25866375
D012643SeleniumSelenium results in decreased expression of ATG12 mRNA19244175
C017947sodium arsenitesodium arsenite results in decreased expression of ATG12 mRNA28595984
D019311StaurosporineATG12 protein affects the susceptibility to Staurosporine16497721
D013311StreptozocinStreptozocin results in increased expression of ATG12 mRNA24889822
D013605T-2 ToxinT-2 Toxin results in increased expression of ATG12 protein26138683
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ATG12 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ATG12 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of ATG12 mRNA19770486
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of ATG12 mRNA15328365
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of ATG12 mRNA25613284
C009438tetrandrinetetrandrine results in increased expression of ATG12 protein26822499
C483909torcetrapibtorcetrapib results in increased expression of ATG12 mRNA23228038
C001899triptolidetriptolide results in increased expression of ATG12 protein26990902
D014635Valproic AcidValproic Acid results in increased expression of ATG12 mRNA20546886
D001335Vehicle Emissions[Vehicle Emissions results in increased abundance of Particulate Matter] which results in increased expression of ATG12 protein28013216
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of ATG12 gene25560391
C025643vinclozolinvinclozolin affects the expression of ATG12 mRNA19015723
D014810Vitamin EVitamin E results in decreased expression of ATG12 mRNA19244175
C111237vorinostatAcetylcysteine inhibits the reaction [vorinostat promotes the reaction [ATG5 protein binds to ATG12 protein]]20543569
C111237vorinostatvorinostat promotes the reaction [ATG5 protein binds to ATG12 protein]20543569
D015032Zinc[PCI 5002 co-treated with Zinc] results in increased expression of ATG12 mRNA18593933
D015034Zinc OxideAcetylcysteine inhibits the reaction [Zinc Oxide analog results in increased expression of ATG12 mRNA]24614525
D015034Zinc OxideZinc Oxide analog results in increased expression of ATG12 mRNA24614525

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI9852036  11096062  11825910  17353931  20562859  23202584  
25416956  26812546  
GO:0019776Atg8 ligase activity-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0000045autophagosome assembly-IBA21873635  
GO:0000045autophagosome assembly-ISS-  
GO:0000422autophagy of mitochondrion-IBA21873635  
GO:0006501C-terminal protein lipidation-IBA21873635  
GO:0016236macroautophagy-TAS-  
GO:0044804autophagy of nucleus-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005776autophagosome-IDA24954904  
GO:0005829cytosol-TAS-  
GO:0030670phagocytic vesicle membrane-TAS-  
GO:0034045phagophore assembly site membrane-IBA21873635  
GO:0034045phagophore assembly site membrane-ISS-  
GO:0034274Atg12-Atg5-Atg16 complex-IBA21873635  
KEGG ID KEGG Term
hsa04140Regulation of autophagy
hsa04622RIG-I-like receptor signaling pathway
Reactome ID Reactome Term Evidence
R-HSA-1632852MacroautophagyTAS
R-HSA-1632852MacroautophagyIEA
R-HSA-168249Innate Immune SystemIEA
R-HSA-168256Immune SystemIEA
R-HSA-168928DDX58/IFIH1-mediated induction of interferon-alpha/betaIEA
R-HSA-5205647MitophagyTAS
R-HSA-5205685Pink/Parkin Mediated MitophagyTAS
R-HSA-8934903Receptor Mediated MitophagyTAS
R-HSA-8953897Cellular responses to external stimuliTAS
R-HSA-8953897Cellular responses to external stimuliIEA
R-HSA-936440Negative regulators of DDX58/IFIH1 signalingIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
21676957Cigarette smoke extract induces prolonged endoplasmic reticulum stress and autophagic cell death in human umbilical vein endothelial cells. (2011 Oct 1)Csordas ACardiovasc Res
24727585Interaction of caveolin-1 with ATG12-ATG5 system suppresses autophagy in lung epithelial cells. (2014 Jun 1)Chen ZHAm J Physiol Lung Cell Mol Physiol