Gene: PDCD5

9141
TFAR19
programmed cell death 5
protein-coding
19q13.11
Ensembl:ENSG00000105185 MIM:604583 Vega:OTTHUMG00000180224 UniprotKB:O14737
NC_000019.10
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  1.674e-1 (ND)   (Frontal_Cortex)
2.062e-1 (AD)  2.789e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PSMB40.909
CWC150.904
TBCA0.902
DGUOK0.9
ERH0.898
MRPL200.894
PSMB30.89
TSG1010.889
TXN0.888
CSNK2B0.888

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.792
OR4F29-0.745
MTRNR2L6-0.157
OR2A14-0.157
TDGF1-0.155
MTRNR2L9-0.155
PRDM14-0.146
OR6C74-0.146
PRAMEF17-0.141
MROH9-0.14

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C47167410'(Z),13'(E),15'(E)-heptadecatrienylhydroquinone"10'(Z),13'(E),15'(E)-heptadecatrienylhydroquinone results in increased expression of PDCD5 mRNA"23088786
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether analog results in increased expression of PDCD5 mRNA"19095052
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of PDCD5 mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of PDCD5 mRNA"21346803
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of PDCD5 mRNA"18648102
D000082AcetaminophenAcetaminophen affects the expression of PDCD5 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of PDCD5 mRNA27153756
C006632arsenic trioxidearsenic trioxide results in increased expression of PDCD5 mRNA20458559
C015001arsenitearsenite results in increased methylation of PDCD5 promoter23974009
D001280AtrazineAtrazine results in increased expression of PDCD5 mRNA22378314
C004456beauvericinbeauvericin results in increased expression of PDCD5 mRNA29203277
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of PDCD5 mRNA20504355
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of PDCD5 mRNA22228805
C006780bisphenol Abisphenol A affects the expression of PDCD5 mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of PDCD5 mRNA22576693|2927551
C006780bisphenol Abisphenol A results in increased expression of PDCD5 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of PDCD5 gene28505145
C005961bis(tri-n-butyltin)oxidebis(tri-n-butyltin)oxide results in increased phosphorylation of PDCD5 protein22174045
C013418bromfenacoumbromfenacoum results in decreased expression of PDCD5 protein28903499
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of PDCD5 mRNA14729362
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of PDCD5 gene20938992
C018021cobaltous chloridecobaltous chloride results in decreased expression of PDCD5 mRNA19376846
D003042CocaineCocaine affects the expression of PDCD5 mRNA15681117
D003703DemecolcineDemecolcine results in decreased expression of PDCD5 mRNA23649840
D003907Dexamethasone[PDCD5 protein co-treated with Dexamethasone] results in decreased expression of BIRC520693715
D003907Dexamethasone[PDCD5 protein co-treated with Dexamethasone] results in increased expression of CASP320693715
D003907DexamethasonePDCD5 protein results in increased susceptibility to Dexamethasone20693715
D003976DiazinonDiazinon results in increased methylation of PDCD5 gene22964155
D002945CisplatinPDCD5 protein results in increased susceptibility to Cisplatin20869960
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in decreased expression of PDCD5 mRNA19850644
D004051Diethylhexyl PhthalatePPARA protein inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of PDCD5 mRNA]19850644
D002117CalcitriolCalcitriol results in decreased expression of PDCD5 mRNA12875902
C024629dimethyl phthalatedimethyl phthalate affects the expression of PDCD5 mRNA26924002
D004317Doxorubicin[Doxorubicin co-treated with pluronic block copolymer p85] results in increased expression of PDCD5 mRNA16579640
D052244Endocrine DisruptorsEndocrine Disruptors results in decreased expression of PDCD5 mRNA25198161
C045651epigallocatechin gallateepigallocatechin gallate results in decreased expression of PDCD5 mRNA22079256
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of PDCD5 mRNA22079256
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of PDCD5 mRNA24096037
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of PDCD5 mRNA17108234|2409603
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of PDCD5 gene20938992
D005839GentamicinsGentamicins results in increased expression of PDCD5 mRNA22061828
D006861Hydrogen PeroxideHydrogen Peroxide results in increased expression of PDCD5 mRNA14729362
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of PDCD5 mRNA25613284
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of PDCD5 gene20938992
D009020MorphineMorphine results in increased expression of PDCD5 protein23056601
C437683motexafin gadoliniummotexafin gadolinium results in decreased expression of PDCD5 mRNA16357179
C437683motexafin gadolinium[Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of PDCD5 mRNA16357179
C022838nickel chloridenickel chloride affects the expression of PDCD5 mRNA22546817
C016340o,p'-DDT"o,p'-DDT results in increased expression of PDCD5 mRNA"24096037
C016340o,p'-DDT"o,p'-DDT results in increased expression of PDCD5 mRNA"24096037
D052638Particulate MatterParticulate Matter results in increased expression of PDCD5 mRNA21703343
C086401pentabromodiphenyl etherpentabromodiphenyl ether analog results in increased expression of PDCD5 mRNA19095052
D010634PhenobarbitalPhenobarbital affects the expression of PDCD5 mRNA19159669
C006253pirinixic acidpirinixic acid results in increased expression of PDCD5 mRNA18301758|2081375
D010936Plant ExtractsPlant Extracts results in increased expression of PDCD5 mRNA23557933
C422648pluronic block copolymer p85[Doxorubicin co-treated with pluronic block copolymer p85] results in increased expression of PDCD5 mRNA16579640
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of PDCD5 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of PDCD5 mRNA22079256
C502851quinocetonequinocetone results in decreased expression of PDCD5 protein27046791
C502851quinocetonequinocetone results in increased expression of PDCD5 protein27046791
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride results in increased expression of PDCD5 mRNA16202921
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of PDCD5 mRNA25895662
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PDCD5 mRNA21570461
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of PDCD5 mRNA25613284
D014212TretinoinTretinoin results in decreased expression of PDCD5 mRNA12875902
D014635Valproic AcidValproic Acid results in decreased expression of PDCD5 mRNA23179753|2438349
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of PDCD5 gene25560391
C025643vinclozolinvinclozolin results in decreased expression of PDCD5 mRNA23555832
D014750VincristineVincristine results in decreased expression of PDCD5 mRNA23649840
C111237vorinostatvorinostat results in increased expression of PDCD5 protein20543569
D014874Water Pollutants, Chemical"Water Pollutants, Chemical results in decreased expression of PDCD5 mRNA"25198161
D019345Zinc Acetate[Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of PDCD5 mRNA16357179
D019345Zinc AcetateZinc Acetate results in decreased expression of PDCD5 mRNA16357179

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003677DNA binding-IEA-  
GO:0005515protein binding-IPI24012345  24375412  
GO:0008201heparin binding-IDA17165023  
GO:0010698acetyltransferase activator activity-IDA24012345  
GO:0048487beta-tubulin binding-IPI24375412  
GO ID GO Term Qualifier Evidence PubMed
GO:0006915apoptotic process-IEA-  
GO:0008285negative regulation of cell proliferation-IMP16374546  
GO:0010628positive regulation of gene expression-IDA24012345  
GO:0043065positive regulation of apoptotic process-IMP9920759  
GO:0043280positive regulation of cysteine-type endopeptidase activity involved in apoptotic process-IMP16374546  
GO:0071560cellular response to transforming growth factor beta stimulus-IDA24012345  
GO:0090200positive regulation of release of cytochrome c from mitochondria-IMP16374546  
GO:1903638positive regulation of protein import into mitochondrial outer membrane-IMP16374546  
GO:1903645negative regulation of chaperone-mediated protein folding-IMP24375412  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-IDA24012345  
GO:0005737cytoplasm-HDA16791210  
GO:0005829cytosol-IBA21873635  
GO:0070062extracellular exosome-HDA20458337  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
21479467The allelic distribution of a single nucleotide polymorphism in the PDCD5 gene locus of Japanese non-small cell lung cancer patients. (2008 Sep-Oct)Nanba KMol Med Rep
16549820Association of the PDCD5 locus with lung cancer risk and prognosis in smokers. (2006 Apr 10)Spinola MJ Clin Oncol