Gene info: ID 9145

Gene: SYNGR1

GENE ID: 9145

Synonyms: -

Description: synaptogyrin 1

Gene type: protein-coding

Location: 22q13.1

dbXrefs: Ensembl:ENSG00000100321 MIM:603925 Vega:OTTHUMG00000030978 UniprotKB:O43759

RefSeq: NG_047102.1

Retrived from: SNP Mapped

SNPs: 3 ANCO-SNPs

Phenotype: AD

# Publications: 0

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : NA (AD) NA (ND)

ANCO-SNPs

SNP ID	Position	Alleles	Trait	Variation Type
rs4821888	chr22:39374592 (GRCh38.p7)	A>G / A>T	alcohol dependence	SNV(Single Nucleotide Variation)
rs1569499	chr22:39373813 (GRCh38.p7)	T>C	alcohol dependence	SNV(Single Nucleotide Variation)
rs5757642	chr22:39368819 (GRCh38.p7)	T>C	alcohol dependence	SNV(Single Nucleotide Variation)

DNA Methylation

Probe	Locus(GRCh37)	Gene	Region	p-val	Trait	PubMed ID
cg03442977	chr22:39772154	SYNGR1	Gene body	1.313e-4	Alcohol use disorders	26763658
cg06397161	chr22:39760059	SYNGR1		5.040e-10	Maternal smoking in pregnancy	27040690
cg20496314	chr22:39759864	SYNGR1		1.040e-8	Maternal smoking in pregnancy	27040690
cg20496314	chr22:39759864	SYNGR1		1.700e-13	Smoking	27651444
cg06397161	chr22:39760059	SYNGR1		8.300e-8	Smoking	27651444
cg22650271	chr22:39760165	SYNGR1		2.630e-8	Smoking	28686328

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
TOLLIP	0.982
ATCAY	0.981
SCAMP5	0.98
PGBD5	0.977
MADD	0.973
RAB3A	0.973
CLSTN1	0.972
STXBP1	0.972
PI4KA	0.971
MAPT	0.97

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F5	-0.564
TFPI2	-0.552
REST	-0.538
WWTR1	-0.532
RAI14	-0.528
YES1	-0.515
OR4F29	-0.512
HEY2	-0.501
CNN2	-0.501
CLEC2B	-0.5

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C111118	2',3,3',4',5-pentachloro-4-hydroxybiphenyl	"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of SYNGR1 mRNA"	19114083
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SYNGR1 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SYNGR1 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SYNGR1 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SYNGR1 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SYNGR1 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SYNGR1 mRNA"	27188386
D000082	Acetaminophen	Acetaminophen results in decreased expression of SYNGR1 mRNA	26690555\|2906747
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of SYNGR1 mRNA	16483693
D018501	Antirheumatic Agents	Antirheumatic Agents results in increased expression of SYNGR1 mRNA	24449571
D001151	Arsenic	Arsenic affects the methylation of SYNGR1 gene	25304211
C006632	arsenic trioxide	arsenic trioxide results in decreased expression of SYNGR1 mRNA	19128835\|2252195
D001280	Atrazine	Atrazine results in increased expression of SYNGR1 mRNA	22378314
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of SYNGR1 mRNA	22228805
C006780	bisphenol A	bisphenol A affects the expression of SYNGR1 mRNA	25181051
D002220	Carbamazepine	Carbamazepine affects the expression of SYNGR1 mRNA	25979313
D002794	Choline	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of and results in increased expression of SYNGR1	20938992
D002794	Choline	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of SYNGR1 gene	20938992
D002794	Choline	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of SYNGR1 mRNA	20938992
D003300	Copper	[NSC 689534 binds to Copper] which results in decreased expression of SYNGR1 mRNA	20971185
D016572	Cyclosporine	Cyclosporine results in decreased expression of SYNGR1 mRNA	27989131
C010902	decabromobiphenyl ether	decabromobiphenyl ether results in increased expression of SYNGR1 mRNA	23914054
C014347	decitabine	decitabine affects the expression of SYNGR1 mRNA	23300844
C014347	decitabine	[decitabine co-treated with vorinostat] affects the expression of SYNGR1 mRNA	17330099
D002945	Cisplatin	Cisplatin affects the expression of SYNGR1 mRNA	23300844
D002117	Calcitriol	Calcitriol results in decreased expression of SYNGR1 mRNA	16002434
D004237	Diuron	Diuron results in increased expression of SYNGR1 mRNA	21551480\|2515243
C118739	entinostat	entinostat results in increased expression of SYNGR1 mRNA	26272509\|2718838
C118739	entinostat	"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SYNGR1 mRNA"	27188386
D000431	Ethanol	Ethanol results in increased expression of SYNGR1 mRNA	19167417
D000431	Ethanol	Ethanol results in decreased expression of SYNGR1 mRNA	15353170
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of SYNGR1 mRNA	17555576
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of SYNGR1 mRNA	29097150
D005419	Flavonoids	Flavonoids results in decreased expression of SYNGR1 mRNA	18035473
D005492	Folic Acid	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of and results in increased expression of SYNGR1	20938992
D005492	Folic Acid	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of SYNGR1 gene	20938992
D005492	Folic Acid	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of SYNGR1 mRNA	20938992
D017313	Fenretinide	Fenretinide results in increased expression of SYNGR1 mRNA	28973697
C016517	indole-3-carbinol	indole-3-carbinol affects the expression of SYNGR1 mRNA	21396975
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of SYNGR1 mRNA	25613284
C544151	jinfukang	jinfukang results in increased expression of SYNGR1 mRNA	27392435
D007854	Lead	Lead affects the expression of SYNGR1 mRNA	28903495
D008715	Methionine	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of and results in increased expression of SYNGR1	20938992
D008715	Methionine	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of SYNGR1 gene	20938992
D008715	Methionine	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of SYNGR1 mRNA	20938992
D015632	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	"1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of SYNGR1 mRNA"	15329391
D015735	Mifepristone	Mifepristone results in decreased expression of SYNGR1 mRNA	17584828
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in increased expression of SYNGR1 mRNA"	25554681
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased expression of SYNGR1 mRNA"	25554681
C017096	n-butoxyethanol	n-butoxyethanol results in increased expression of SYNGR1 mRNA	19812364
D009532	Nickel	Nickel results in decreased expression of SYNGR1 mRNA	24768652\|2558310
C558013	NSC 689534	[NSC 689534 binds to Copper] which results in decreased expression of SYNGR1 mRNA	20971185
C496932	panobinostat	"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SYNGR1 mRNA"	27188386
C496932	panobinostat	panobinostat results in increased expression of SYNGR1 mRNA	26272509
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid affects the expression of SYNGR1 mRNA	19429403
C023036	perfluorooctanoic acid	perfluorooctanoic acid affects the expression of SYNGR1 mRNA	19429403
D010662	Phenylmercuric Acetate	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SYNGR1 mRNA"	27188386
D010662	Phenylmercuric Acetate	Phenylmercuric Acetate results in increased expression of SYNGR1 mRNA	26272509
D010795	Phthalic Acids	Phthalic Acids results in decreased expression of SYNGR1 mRNA	15728792
D011285	Pregnenolone Carbonitrile	Pregnenolone Carbonitrile results in decreased expression of SYNGR1 mRNA	22698814
D015474	Isotretinoin	Isotretinoin results in decreased expression of SYNGR1 mRNA	20436886
D012822	Silicon Dioxide	Silicon Dioxide analog results in decreased expression of SYNGR1 mRNA	25895662
D012999	Soman	Soman results in increased expression of SYNGR1 mRNA	19281266
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of SYNGR1 mRNA	22298810
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of SYNGR1 mRNA	25613284
C009495	titanium dioxide	titanium dioxide results in increased expression of SYNGR1 mRNA	23557971\|2776080
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution affects the expression of SYNGR1 mRNA	20133372
D024505	Tocopherols	Tocopherols results in increased expression of SYNGR1 mRNA	17654050
C012589	trichostatin A	trichostatin A results in increased expression of SYNGR1 mRNA	24935251
C015559	trimellitic anhydride	trimellitic anhydride results in decreased expression of SYNGR1 mRNA	19042947
D014303	Trinitrotoluene	Trinitrotoluene affects the expression of SYNGR1 mRNA	21346803
D014635	Valproic Acid	Valproic Acid affects the expression of SYNGR1 mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in increased expression of SYNGR1 mRNA	23179753\|2493525
D001335	Vehicle Emissions	Vehicle Emissions results in decreased methylation of SYNGR1 gene	25560391
C025643	vinclozolin	vinclozolin results in increased expression of SYNGR1 mRNA	22570695
D014810	Vitamin E	Vitamin E results in increased expression of SYNGR1 mRNA	19244175
C111237	vorinostat	[decitabine co-treated with vorinostat] affects the expression of SYNGR1 mRNA	17330099

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005515	protein binding	-	IPI	25416956

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0006605	protein targeting	-	IEA	-
GO:0043312	neutrophil degranulation	-	TAS	-
GO:0045055	regulated exocytosis	-	ISS	-
GO:0048169	regulation of long-term neuronal synaptic plasticity	-	ISS	-
GO:0048172	regulation of short-term neuronal synaptic plasticity	-	ISS	-
GO:0048499	synaptic vesicle membrane organization	-	ISS	-
GO:1990830	cellular response to leukemia inhibitory factor	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005886	plasma membrane	-	TAS	-
GO:0016021	integral component of membrane	-	IEA	-
GO:0030054	cell junction	-	IEA	-
GO:0030672	synaptic vesicle membrane	-	IBA	21873635
GO:0031594	neuromuscular junction	-	IBA	21873635
GO:0035577	azurophil granule membrane	-	TAS	-
GO:0042470	melanosome	-	IEA	-

KEGG ID	KEGG Term

Reactome ID	Reactome Term	Evidence
R-HSA-168249	Innate Immune System	TAS
R-HSA-168256	Immune System	TAS
R-HSA-6798695	Neutrophil degranulation	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal