Gene: HGS

9146
HRS
hepatocyte growth factor-regulated tyrosine kinase substrate
protein-coding
17q25.3
Ensembl:ENSG00000185359 MIM:604375 Vega:OTTHUMG00000178109 UniprotKB:O14964
NC_000017.11
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.862e-1 (AD)  5.872e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MED150.953
AP3D10.952
CSNK1D0.946
GAK0.944
MAPK8IP30.939
MED240.939
CSNK1E0.938
SCYL10.938
EDC40.937
KHSRP0.935

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.749
OR4F29-0.706
MTRNR2L6-0.316
MTRNR2L9-0.314
MTRNR2L10-0.302
KLRB1-0.266
KCNJ15-0.256
TRDN-0.248
TTLL10-AS1-0.243
CPA3-0.24

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB04272Citric AcidSmall Molecule77-92-9Approved|NutraceuticalTarget
ID Drug Name Action PubMed
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of HGS mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of HGS mRNA"21346803
D000082AcetaminophenAcetaminophen affects the expression of HGS mRNA17562736
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of HGS mRNA21632981
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of HGS mRNA21715664
C006780bisphenol Abisphenol A affects the expression of HGS mRNA21786754
C006780bisphenol Abisphenol A results in increased methylation of HGS promoter27312807
C006780bisphenol Abisphenol A affects the expression of HGS mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of HGS mRNA25181051
C013418bromfenacoumbromfenacoum results in increased expression of HGS protein28903499
C584509C646 compoundC646 compound results in increased expression of HGS mRNA26191083
C010063carbonyl sulfidecarbonyl sulfide results in increased expression of HGS mRNA19395590
C018021cobaltous chloridecobaltous chloride results in increased expression of HGS mRNA19376846
C018021cobaltous chloridecobaltous chloride results in increased expression of HGS mRNA24386269
D019327Copper SulfateCopper Sulfate results in increased expression of HGS mRNA19549813
D016572CyclosporineCyclosporine results in increased expression of HGS mRNA20106945|2556210
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of HGS mRNA]27941970
D000431EthanolEthanol results in decreased expression of HGS mRNA17920746
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of HGS mRNA23550701
D005419FlavonoidsFlavonoids results in decreased expression of HGS mRNA18035473
D005485FlutamideFlutamide results in increased expression of HGS mRNA24136188
D005839GentamicinsGentamicins results in decreased expression of HGS mRNA22061828
C492448ICG 001ICG 001 affects the expression of HGS mRNA26191083
C410337K 7174K 7174 results in increased expression of HGS mRNA24086573
C002385linsidominelinsidomine results in increased oxidation of HGS protein28086193
D008070Lipopolysaccharides[Tetrachlorodibenzodioxin co-treated with Lipopolysaccharides] results in increased methylation of HGS gene21212295
D008727MethotrexateHGS protein affects the susceptibility to Methotrexate16217747
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of HGS mRNA26011545
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of HGS mRNA"20188158
C051752nefazodonenefazodone results in increased expression of HGS mRNA24136188
D010416PentachlorophenolPentachlorophenol results in increased expression of HGS mRNA23892564
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of HGS mRNA19162173
D011794QuercetinQuercetin results in increased expression of HGS mRNA21632981
D012643SeleniumSelenium results in increased expression of HGS mRNA19244175
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of HGS mRNA24680724
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Lipopolysaccharides] results in increased methylation of HGS gene21212295
D014635Valproic AcidValproic Acid results in increased methylation of HGS gene29154799

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI10861283  11916981  12207904  12230472  12750381  12802020  
15611048  16084064  16189514  17853893  18675823  19278655  
20150893  21070952  22458338  24790097  25416956  25588945  
25910212  26871637  27107014  
GO:0019904protein domain specific binding-IPI11984006  
GO:0044389ubiquitin-like protein ligase binding-IPI24790097  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006622protein targeting to lysosome-IMP18767904  
GO:0007165signal transduction-TAS9407053  
GO:0008285negative regulation of cell proliferation-TAS9407053  
GO:0010324membrane invagination-IMP18767904  
GO:0010628positive regulation of gene expression-IMP18767904  
GO:0010642negative regulation of platelet-derived growth factor receptor signaling pathway-IMP18977327  
GO:0016197endosomal transport-NAS10861283  
GO:0016197endosomal transport-TAS-  
GO:0016236macroautophagy-TAS20588296  
GO:0016525negative regulation of angiogenesis-IMP18977327  
GO:0030948negative regulation of vascular endothelial growth factor receptor signaling pathway-IMP18977327  
GO:0036258multivesicular body assembly-TAS20588296  
GO:0042059negative regulation of epidermal growth factor receptor signaling pathway-TAS-  
GO:0042176regulation of protein catabolic process-TAS15611048  
GO:0043405regulation of MAP kinase activity-IMP17714434  
GO:0046426negative regulation of JAK-STAT cascade-IDA12444102  
GO:0061024membrane organization-TAS-  
GO:0072657protein localization to membrane-IMP18767904  
GO:1903543positive regulation of exosomal secretion-IMP24105262  
GO ID GO Term Qualifier Evidence PubMed
GO:0005764lysosome-IDA-  
GO:0005768endosome-IDA15611048  
GO:0005769early endosome-IDA10861283  
GO:0005829cytosol-IDA-  
GO:0005829cytosol-TAS-  
GO:0031901early endosome membrane-IEA-  
GO:0032585multivesicular body membrane-IEA-  
GO:0033565ESCRT-0 complex-IDA24790097  
GO:0033565ESCRT-0 complex-TAS20588296  
GO:0043231intracellular membrane-bounded organelle-IDA-  
GO:0070062extracellular exosome-HDA19056867  
KEGG ID KEGG Term
hsa04144Endocytosis
hsa04145Phagosome
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-1643685DiseaseIEA
R-HSA-177929Signaling by EGFRTAS
R-HSA-182971EGFR downregulationTAS
R-HSA-199991Membrane TraffickingTAS
R-HSA-199992trans-Golgi Network Vesicle BuddingTAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-421837Clathrin derived vesicle buddingTAS
R-HSA-432720Lysosome Vesicle BiogenesisTAS
R-HSA-5653656Vesicle-mediated transportTAS
R-HSA-5663205Infectious diseaseIEA
R-HSA-5688426DeubiquitinationTAS
R-HSA-5689880Ub-specific processing proteasesTAS
R-HSA-597592Post-translational protein modificationTAS
R-HSA-6806834Signaling by METTAS
R-HSA-6807004Negative regulation of MET activityTAS
R-HSA-8856825Cargo recognition for clathrin-mediated endocytosisTAS
R-HSA-8856828Clathrin-mediated endocytosisTAS
R-HSA-8875360InlB-mediated entry of Listeria monocytogenes into host cellIEA
R-HSA-8876384Listeria monocytogenes entry into host cellsIEA
R-HSA-9006934Signaling by Receptor Tyrosine KinasesTAS
R-HSA-917729Endosomal Sorting Complex Required For Transport (ESCRT)TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27222416Age-related decline in skeletal muscle mass and function among elderly men and women in Shanghai, China: a cross sectional study. (2016)Bai HJAsia Pac J Clin Nutr
20541383Global muscle dysfunction as a risk factor of readmission to hospital due to COPD exacerbations. (2010 Dec)Vilaro JRespir Med