Gene: SLC6A5

9152
GLYT-2|GLYT2|HKPX3|NET1
solute carrier family 6 member 5
protein-coding
11p15.1
Ensembl:ENSG00000165970 MIM:604159 Vega:OTTHUMG00000166024 UniprotKB:Q9Y345
NG_013086.2
PubMed
0   ANCO-SNPs
AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.062e-1 (AD)  8.746e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
STAMBPL10.767
SEC16B0.754
ZNF385B0.751
NELL10.749
STXBP5L0.748
OSBPL100.745
FLRT30.744
HECW10.743
PTPN30.743
LSM110.742

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RAB13-0.499
MDFI-0.492
ROM1-0.492
NUPR1-0.485
TMEM176A-0.477
RHOD-0.467
HEY2-0.465
PXDC1-0.459
P2RY2-0.456
COPZ2-0.454

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00145GlycineSmall Molecule56-40-6Approved|NutraceuticalTarget
ID Drug Name Action PubMed
C5328494-benzyloxy-3,5-dimethoxy-N-(1-(dimethylaminocyclopently)methyl)benzamide"4-benzyloxy-3,5-dimethoxy-N-(1-(dimethylaminocyclopently)methyl)benzamide results in decreased activity of SLC6A5 protein"21141920
D000643Ammonium ChlorideAmmonium Chloride affects the expression of SLC6A5 mRNA16483693
D000657AmoxapineAmoxapine results in decreased activity of SLC6A5 protein14992291
C006632arsenic trioxidearsenic trioxide results in increased expression of SLC6A5 mRNA15761015
C015001arsenitearsenite results in increased methylation of SLC6A5 promoter23974009
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of SLC6A5 mRNA26001963
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of SLC6A5 mRNA21839799
C006780bisphenol Abisphenol A affects the expression of SLC6A5 mRNA21786754|2355768
C006780bisphenol Abisphenol A affects the expression of SLC6A5 mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of SLC6A5 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of SLC6A5 gene28505145
C013418bromfenacoumbromfenacoum results in decreased expression of SLC6A5 protein28903499
D003300Copper[Copper co-treated with Dietary Sucrose] results in increased expression of SLC6A5 mRNA26033743
D003300CopperCopper deficiency results in increased expression of SLC6A5 mRNA26033743
D019422Dietary Sucrose[Copper co-treated with Dietary Sucrose] results in increased expression of SLC6A5 mRNA26033743
D019422Dietary SucroseDietary Sucrose results in increased expression of SLC6A5 mRNA26033743
D000431EthanolEthanol results in increased expression of SLC6A5 mRNA20655511
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of SLC6A5 mRNA29097150
C039281furanfuran results in decreased expression of SLC6A5 mRNA25539665
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of SLC6A5 mRNA25613284
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of SLC6A5 mRNA26011545
D011441PropylthiouracilPropylthiouracil results in increased expression of SLC6A5 mRNA24780913
D018038Sodium SeleniteSodium Selenite results in decreased expression of SLC6A5 mRNA18175754
C010792testosterone undecanoatetestosterone undecanoate results in increased expression of SLC6A5 mRNA19074003
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of SLC6A5 mRNA25613284

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005215transporter activity-IBA21873635  
GO:0015375glycine:sodium symporter activity-IBA21873635  
GO:0015375glycine:sodium symporter activity-IDA16751771  
GO:0015375glycine:sodium symporter activity-TAS-  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0007268chemical synaptic transmission-TAS9845349  
GO:0035725sodium ion transmembrane transport-IBA21873635  
GO:0060012synaptic transmission, glycinergic-IBA21873635  
GO:0060012synaptic transmission, glycinergic-IMP16751771  
GO:1903804glycine import across plasma membrane-IDA16751771  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-IBA21873635  
GO:0005886plasma membrane-IDA16751771  
GO:0005886plasma membrane-TAS-  
GO:0016021integral component of membrane-TAS9845349  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1643685DiseaseTAS
R-HSA-382551Transport of small moleculesTAS
R-HSA-425366Transport of bile salts and organic acids, metal ions and amine compoundsTAS
R-HSA-425407SLC-mediated transmembrane transportTAS
R-HSA-442660Na+/Cl- dependent neurotransmitter transportersTAS
R-HSA-5619089Defective SLC6A5 causes hyperekplexia 3 (HKPX3)TAS
R-HSA-5619102SLC transporter disordersTAS
R-HSA-5619115Disorders of transmembrane transportersTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
19650813No association of alcohol dependence with SLC6A5 and SLC6A9 glycine transporter polymorphisms. (2009 Sep)Koller GAddict Biol