Gene: ANKRD44

91526
PP6-ARS-B
ankyrin repeat domain 44
protein-coding
2q33.1
Ensembl:ENSG00000065413 Vega:OTTHUMG00000154411 UniprotKB:Q8N8A2
NC_000002.12
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.415e-1 (AD)  3.065e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs1896857chr2:197299806 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg26132737chr2:198029141ANKRD443.800e-8Smoking27651444
cg07683388chr2:198029332ANKRD444.900e-8Smoking27651444
cg26132737chr2:198029141ANKRD441.540e-8Smoking28686328

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TET20.811
NHLRC20.786
ZNF810.785
STAG10.785
TCP11L20.782
SERINC50.778
SMC40.775
KAT6A0.773
PHC30.771
RECQL0.761

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MUC12-0.388
NANOS3-0.35
ASPDH-0.317
RBM34-0.313
SPEF1-0.31
CRYBA2-0.295
GSG1-0.292
FBLL1-0.289
CHST8-0.286
PARD6A-0.282

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of ANKRD44 mRNA19933214
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ANKRD44 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ANKRD44 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ANKRD44 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ANKRD44 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of ANKRD44 mRNA29067470
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of ANKRD44 gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of ANKRD44 mRNA19770486
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of ANKRD44 mRNA24449571
C015001arsenitearsenite results in increased methylation of ANKRD44 promoter23974009
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in decreased expression of ANKRD44 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ANKRD44 mRNA20064835
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ANKRD44 mRNA19770486|2071347
C006780bisphenol Abisphenol A affects the expression of ANKRD44 mRNA21786754
C006780bisphenol Abisphenol A results in increased methylation of ANKRD44 gene28505145
D003300Copper[ATP7A gene mutant form results in increased abundance of Copper] which results in increased expression of ANKRD44 mRNA15467011
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of ANKRD44 mRNA27392435
D002945CisplatinCisplatin results in decreased expression of ANKRD44 mRNA27392435
D004041Dietary FatsDietary Fats results in decreased expression of ANKRD44 mRNA18042831
C118739entinostatentinostat results in decreased expression of ANKRD44 mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ANKRD44 mRNA"27188386
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of ANKRD44 mRNA22079256
D006534Heptachlor EpoxideHeptachlor Epoxide results in increased expression of ANKRD44 mRNA25270620
D006830Hydralazine[Hydralazine co-treated with Valproic Acid] results in increased expression of ANKRD44 mRNA17183730
D006861Hydrogen PeroxideHydrogen Peroxide results in increased expression of ANKRD44 mRNA18951874
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of ANKRD44 mRNA25613284
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of ANKRD44 mRNA27392435
D058185Magnetite Nanoparticles[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of ANKRD44 mRNA21641980
D008694Methamphetamine[Methamphetamine co-treated with SCH 23390] results in decreased expression of ANKRD44 mRNA19564919
D008694MethamphetamineMethamphetamine results in decreased expression of ANKRD44 mRNA19564919
D008727MethotrexateMethotrexate results in decreased expression of ANKRD44 mRNA24449571
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of ANKRD44 mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of ANKRD44 mRNA26011545
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of ANKRD44 mRNA23649840
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of ANKRD44 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of ANKRD44 mRNA"25554681
D009532NickelNickel results in increased expression of ANKRD44 mRNA24768652|2558310
D000073878Palm OilPalm Oil results in decreased expression of ANKRD44 mRNA18042831
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in decreased expression of ANKRD44 mRNA]19482888
D010634PhenobarbitalPhenobarbital results in decreased expression of ANKRD44 mRNA19482888
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of ANKRD44 mRNA19710929
C006253pirinixic acidpirinixic acid results in decreased expression of ANKRD44 mRNA17426115
D010936Plant ExtractsPlant Extracts results in increased expression of ANKRD44 mRNA23557933
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of ANKRD44 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of ANKRD44 mRNA22079256
C534628SCH 23390[Methamphetamine co-treated with SCH 23390] results in decreased expression of ANKRD44 mRNA19564919
C534628SCH 23390SCH 23390 results in decreased expression of ANKRD44 mRNA19564919
C009277sodium arsenatesodium arsenate results in decreased expression of ANKRD44 mRNA21795629
D004113Succimer[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of ANKRD44 mRNA21641980
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of ANKRD44 mRNA19770486|1993321
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of ANKRD44 mRNA25613284
D013806TheophyllineTheophylline results in increased expression of ANKRD44 mRNA18951874
D013849ThimerosalThimerosal results in increased expression of ANKRD44 mRNA27188386
D013849ThimerosalThimerosal results in increased expression of ANKRD44 mRNA24675092
C009495titanium dioxidetitanium dioxide results in increased expression of ANKRD44 mRNA23557971
D014212TretinoinTretinoin results in increased expression of ANKRD44 mRNA21934132
D014635Valproic Acid[Hydralazine co-treated with Valproic Acid] results in increased expression of ANKRD44 mRNA17183730
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ANKRD44 mRNA"27188386
D014635Valproic AcidValproic Acid results in increased expression of ANKRD44 mRNA23179753|2438349

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI16555005  18186651  24255178  25416956  
GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal