Gene: EXO1

9156
HEX1|hExoI
exonuclease 1
protein-coding
1q43
Ensembl:ENSG00000174371 MIM:606063 Vega:OTTHUMG00000039965 UniprotKB:Q9UQ84
NG_029100.1
PubMed
0   ANCO-SNPs
ND
8   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.348e-2 (AD)  5.282e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RASGRF20.692
CNR10.686
HDAC90.68
VSTM2A0.678
SLC10A40.678
PIP5K1B0.678
CHRNA70.672
ZNF804A0.672
CNTN50.671
LRRTM40.668

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MYL3-0.381
HEY2-0.37
CPM-0.369
SNHG18-0.367
ROM1-0.367
KIF19-0.363
TGFB3-0.363
GNG8-0.349
FXYD3-0.347
PSTPIP1-0.342

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of EXO1 mRNA"22698814|2890350
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of EXO1 mRNA"25510870
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of EXO1 mRNA"19167446
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of EXO1 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of EXO1 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of EXO1 mRNA"25510870
C0109142,4-diaminotoluene"2,4-diaminotoluene results in increased expression of EXO1 mRNA"20713471
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of EXO1 mRNA"25510870
C0369902-amino-3,8-dimethylimidazo(4,5-f)quinoxaline"[flumequine co-treated with 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline] results in increased expression of EXO1 mRNA"23681119
C0067574-biphenylamine4-biphenylamine results in decreased expression of EXO1 mRNA24857880
D000082AcetaminophenAcetaminophen results in increased expression of EXO1 mRNA22230336
D016604Aflatoxin B1Aflatoxin B1 affects the expression of EXO1 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of EXO1 mRNA22100608
D000638AmiodaroneAmiodarone results in increased expression of EXO1 mRNA19774075
C059765amphotericin B, deoxycholate drug combination"amphotericin B, deoxycholate drug combination results in increased expression of EXO1 mRNA"22863853
D001280AtrazineAtrazine results in decreased expression of EXO1 mRNA22378314
D001379AzathioprineAzathioprine results in decreased expression of EXO1 mRNA22623647
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in increased expression of EXO1 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of EXO1 mRNA20064835|2180250
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of EXO1 mRNA22316170
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of EXO1 mRNA20713471
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of EXO1 mRNA"20382639
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of EXO1 mRNA"26238291
D004958EstradiolEstradiol results in increased expression of EXO1 mRNA19167446
C044887beta-methylcholinebeta-methylcholine affects the expression of EXO1 mRNA21179406
C006780bisphenol Abisphenol A results in decreased expression of EXO1 mRNA25181051
D002104CadmiumCadmium results in decreased expression of EXO1 mRNA23256528
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of EXO1 mRNA17484886
D002509CephaloridineCephaloridine results in increased expression of EXO1 mRNA18500788
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of EXO1 mRNA20938992
D003033Coal TarCoal Tar results in increased expression of EXO1 mRNA27858113
C018021cobaltous chloridecobaltous chloride results in decreased expression of EXO1 mRNA19320972
C018021cobaltous chloridecobaltous chloride results in increased expression of EXO1 mRNA24386269
D003300Copper[NSC 689534 binds to Copper] which results in decreased expression of EXO1 mRNA20971185
D019327Copper SulfateCopper Sulfate results in decreased expression of EXO1 mRNA19549813
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of EXO1 mRNA"19167446
D003375Coumestrol[Coumestrol co-treated with resveratrol] results in increased expression of EXO1 mRNA19167446
D003375CoumestrolCoumestrol results in increased expression of EXO1 mRNA19167446
C408982CPG-oligonucleotideCPG-oligonucleotide results in decreased expression of EXO1 mRNA21878529
C408982CPG-oligonucleotideCPG-oligonucleotide results in decreased expression of EXO1 mRNA21878529
D016572CyclosporineCyclosporine results in decreased expression of EXO1 mRNA19159671|2010694
D000069439DasatinibDasatinib results in decreased expression of EXO1 mRNA20579391
D003703DemecolcineDemecolcine results in decreased expression of EXO1 mRNA23649840
D015255IdarubicinDexrazoxane inhibits the reaction [Idarubicin results in decreased expression of EXO1 mRNA]28973540
D015255IdarubicinDexrazoxane inhibits the reaction [Idarubicin results in decreased expression of EXO1 protein]28973540
D015255IdarubicinIdarubicin results in decreased expression of EXO1 mRNA28973540
D015255IdarubicinIdarubicin results in decreased expression of EXO1 protein28973540
D064730DexrazoxaneDexrazoxane inhibits the reaction [Idarubicin results in decreased expression of EXO1 mRNA]28973540
D064730DexrazoxaneDexrazoxane inhibits the reaction [Idarubicin results in decreased expression of EXO1 protein]28973540
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of EXO1 mRNA17361019|2126653
D002945CisplatinCisplatin results in increased expression of EXO1 mRNA27594783
D002945CisplatinCisplatin results in decreased expression of EXO1 mRNA22023808
C014476diethyl maleatediethyl maleate results in increased expression of EXO1 mRNA21161181
D002117CalcitriolCalcitriol results in decreased expression of EXO1 mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in decreased expression of EXO1 mRNA21592394
D004317DoxorubicinDoxorubicin results in decreased expression of EXO1 mRNA27181935
D004317DoxorubicinFungal Polysaccharides inhibits the reaction [Doxorubicin results in decreased expression of EXO1 mRNA]27181935
D004726Endosulfan[Endosulfan co-treated with Tetrachlorodibenzodioxin] results in increased expression of EXO1 mRNA26159488
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of EXO1 mRNA20227414
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of EXO1 mRNA23649840
C024352fludarabine[LAQ824 co-treated with fludarabine] results in decreased expression of EXO1 mRNA18852132
C012976flumequine"[flumequine co-treated with 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline] results in increased expression of EXO1 mRNA"23681119
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of EXO1 mRNA20938992
D062610Fungal PolysaccharidesFungal Polysaccharides inhibits the reaction [Doxorubicin results in decreased expression of EXO1 mRNA]27181935
C039281furanfuran results in increased expression of EXO1 mRNA22079235|2250786
D005947Glucose[INS protein co-treated with Glucose] results in increased expression of EXO1 mRNA22634610
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of EXO1 mRNA25613284
C544151jinfukangjinfukang results in increased expression of EXO1 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of EXO1 mRNA24796395
C119620kenpaullonekenpaullone results in decreased expression of EXO1 mRNA17993264
C477361LAQ824[LAQ824 co-treated with fludarabine] results in decreased expression of EXO1 mRNA18852132
D007840LatexLatex analog results in increased expression of EXO1 mRNA24768652
D007854LeadLead affects the expression of EXO1 mRNA28903495
D008154LucanthoneLucanthone results in decreased expression of EXO1 mRNA21148553
D058185Magnetite Nanoparticles[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of EXO1 mRNA21641980
D058185Magnetite Nanoparticles[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of EXO1 mRNA26378955
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of EXO1 mRNA20938992
D008748MethylcholanthreneMethylcholanthrene results in increased expression of EXO1 mRNA20713471
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of EXO1 mRNA26011545
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of EXO1 mRNA23649840
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of EXO1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of EXO1 mRNA"25554681
C558013NSC 689534[NSC 689534 binds to Copper] which results in decreased expression of EXO1 mRNA20971185
C025589ochratoxin Aochratoxin A results in increased expression of EXO1 mRNA23358140
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of EXO1 mRNA25729387
C030110oxaliplatinoxaliplatin results in decreased expression of EXO1 mRNA25729387
D010100OxygenOxygen deficiency results in decreased expression of EXO1 mRNA26516004
C500026palbociclibpalbociclib results in decreased expression of EXO1 mRNA22869556
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of EXO1 mRNA"25510870
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in increased expression of EXO1 mRNA27153767
C031181phenanthrenephenanthrene results in decreased expression of EXO1 mRNA19457238
D010634PhenobarbitalPhenobarbital affects the expression of EXO1 mRNA19159669
D010634PhenobarbitalPhenobarbital results in increased expression of EXO1 mRNA23091169
C030090phosphoramide mustardphosphoramide mustard results in increased expression of EXO1 mRNA26708502
C006253pirinixic acidpirinixic acid results in increased expression of EXO1 mRNA18301758
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of EXO1 mRNA22698814
D011374ProgesteroneProgesterone results in decreased expression of EXO1 mRNA22238285
D011441PropylthiouracilPropylthiouracil results in increased expression of EXO1 mRNA24780913
C059514resveratrol[Coumestrol co-treated with resveratrol] results in increased expression of EXO1 mRNA19167446
C547185riccardin Driccardin D results in decreased expression of EXO1 mRNA24069304
D012402RotenoneRotenone results in increased expression of EXO1 mRNA18191903
C513635S-2-pentyl-4-pentynoic hydroxamic acidS-2-pentyl-4-pentynoic hydroxamic acid results in decreased expression of EXO1 mRNA21427059
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of EXO1 mRNA23806026
C016104sodium bichromatesodium bichromate results in increased expression of EXO1 mRNA22155349
C016104sodium bichromatesodium bichromate affects the expression of EXO1 mRNA22110744
C016104sodium bichromatesodium bichromate results in increased expression of EXO1 mRNA22561333
D053260SootSoot results in increased expression of EXO1 mRNA26551751
D004113Succimer[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of EXO1 mRNA21641980
D004113Succimer[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of EXO1 mRNA26378955
D000952Antigens, Polyomavirus Transforming"Antigens, Polyomavirus Transforming results in increased expression of EXO1 mRNA"26680231
D013739Testosterone[Testosterone co-treated with Calcitriol] results in decreased expression of EXO1 mRNA21592394
D013739TestosteroneTestosterone results in decreased expression of EXO1 mRNA21592394
D013749Tetrachlorodibenzodioxin[Endosulfan co-treated with Tetrachlorodibenzodioxin] results in increased expression of EXO1 mRNA26159488
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of EXO1 mRNA21802500
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of EXO1 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with AHR gene mutant form] results in decreased expression of EXO1 mRNA19465110
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of EXO1 mRNA25613284
D019284ThapsigarginThapsigargin results in decreased expression of EXO1 mRNA22378314
C009495titanium dioxidetitanium dioxide results in increased expression of EXO1 mRNA23557971
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of EXO1 mRNA25729387
D019772TopotecanTopotecan results in decreased expression of EXO1 mRNA25729387
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of EXO1 mRNA19042947
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of EXO1 mRNA"26179874
C057693troglitazonetroglitazone results in decreased expression of EXO1 mRNA19140230
D014635Valproic AcidValproic Acid affects the expression of EXO1 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of EXO1 mRNA21427059
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of EXO1 gene25560391
D014750VincristineVincristine results in decreased expression of EXO1 mRNA23649840

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003677DNA binding-IBA21873635  
GO:0003677DNA binding-IDA11842105  
GO:0003682chromatin binding-IBA21873635  
GO:0003682chromatin binding-IEA-  
GO:0003690double-stranded DNA binding-IBA21873635  
GO:0004523RNA-DNA hybrid ribonuclease activity-TAS10364235  
GO:0004527exonuclease activity-TAS9788596  
GO:0005515protein binding-IPI2414623  9788596  10856833  11427529  11429708  12414623  
14676842  15225546  15886194  21052091  26807646  
GO:00084095'-3' exonuclease activity-ISS9685493  
GO:00084095'-3' exonuclease activity-TAS-  
GO:00171085'-flap endonuclease activity-IBA21873635  
GO:00353125'-3' exodeoxyribonuclease activity-IDA10608837  
GO:0045145single-stranded DNA 5'-3' exodeoxyribonuclease activity-IBA21873635  
GO:0045145single-stranded DNA 5'-3' exodeoxyribonuclease activity-IDA10608837  
GO:0046872metal ion binding-IEA-  
GO:0048256flap endonuclease activity-IBA21873635  
GO:0048256flap endonuclease activity-IDA10608837  11842105  
GO:0051908double-stranded DNA 5'-3' exodeoxyribonuclease activity-IBA21873635  
GO:0051908double-stranded DNA 5'-3' exodeoxyribonuclease activity-IDA10608837  11842105  
GO ID GO Term Qualifier Evidence PubMed
GO:0000706meiotic DNA double-strand break processing-IBA21873635  
GO:0002455humoral immune response mediated by circulating immunoglobulin-IBA21873635  
GO:0002455humoral immune response mediated by circulating immunoglobulin-IEA-  
GO:0006260DNA replication-TAS-  
GO:0006281DNA repair-TAS10364235  
GO:0006298mismatch repair-IBA21873635  
GO:0006298mismatch repair-IDA14636568  
GO:0006298mismatch repair-IMP11809771  
GO:0006298mismatch repair-IPI9788596  
GO:0006298mismatch repair-ISS9685493  
GO:0006298mismatch repair-TAS-  
GO:0006310DNA recombination-IBA21873635  
GO:0006310DNA recombination-IGI10364235  
GO:0016446somatic hypermutation of immunoglobulin genes-IBA21873635  
GO:0016446somatic hypermutation of immunoglobulin genes-IEA-  
GO:0045190isotype switching-IBA21873635  
GO:0045190isotype switching-IEA-  
GO:0051321meiotic cell cycle-IEA-  
GO:0090502RNA phosphodiester bond hydrolysis, endonucleolytic-IEA-  
GO:0090656t-circle formation-TAS27918544  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA11429708  14676842  
GO:0005654nucleoplasm-IDA-  
GO:0005654nucleoplasm-TAS-  
GO:0005886plasma membrane-IDA-  
GO:0016604nuclear body-IDA-  
KEGG ID KEGG Term
hsa03430Mismatch repair
Reactome ID Reactome Term Evidence
R-HSA-1640170Cell CycleTAS
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-3700989Transcriptional Regulation by TP53TAS
R-HSA-5358508Mismatch RepairTAS
R-HSA-5358508Mismatch RepairIEA
R-HSA-5358565Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)TAS
R-HSA-5358606Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)IEA
R-HSA-5633007Regulation of TP53 ActivityTAS
R-HSA-5685938HDR through Single Strand Annealing (SSA)TAS
R-HSA-5685942HDR through Homologous Recombination (HRR)TAS
R-HSA-5693532DNA Double-Strand Break RepairTAS
R-HSA-5693537Resolution of D-Loop StructuresTAS
R-HSA-5693538Homology Directed RepairTAS
R-HSA-5693554Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)TAS
R-HSA-5693567HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA)TAS
R-HSA-5693568Resolution of D-loop Structures through Holliday Junction IntermediatesTAS
R-HSA-5693579Homologous DNA Pairing and Strand ExchangeTAS
R-HSA-5693607Processing of DNA double-strand break endsTAS
R-HSA-5693616Presynaptic phase of homologous DNA pairing and strand exchangeTAS
R-HSA-6804756Regulation of TP53 Activity through PhosphorylationTAS
R-HSA-69473G2/M DNA damage checkpointTAS
R-HSA-69481G2/M CheckpointsTAS
R-HSA-69620Cell Cycle CheckpointsTAS
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-73894DNA RepairTAS
R-HSA-73894DNA RepairIEA
R-HSA-74160Gene expression (Transcription)TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
22573488EGFR exon 19 in-frame deletion and polymorphisms of DNA repair genes in never-smoking female lung adenocarcinoma patients. (2013 Jan 15)Yang SYInt J Cancer
26966378Association between three exonuclease 1 polymorphisms and cancer risks: a meta-analysis. (2016)Chen ZYOnco Targets Ther
24810280The significance of Exo1 K589E polymorphism on cancer susceptibility: evidence based on a meta-analysis. (2014)Duan FPLoS One
24419231Axonal guidance signaling pathway interacting with smoking in modifying the risk of pancreatic cancer: a gene- and pathway-based interaction analysis of GWAS data. (2014 May)Tang HCarcinogenesis
15550454Single nucleotide polymorphisms in the EXO1 gene and risk of colorectal cancer in a Japanese population. (2005 Feb)Yamamoto HCarcinogenesis
19331228Lung cancer susceptibility and genetic polymorphisms of Exo1 gene in Taiwan. (2009 Feb)Hsu NYAnticancer Res
20337148Single-nucleotide polymorphism of the Exo1 gene: association with gastric cancer susceptibility and interaction with smoking in Taiwan. (2009 Dec 31)Bau DTChin J Physiol
19515603Interaction of Exo1 genotypes and smoking habit in oral cancer in Taiwan. (2009 Sep)Tsai MHOral Oncol