Gene: CD3E

916
IMD18|T3E|TCRE
CD3e molecule
protein-coding
11q23.3
Ensembl:ENSG00000198851 MIM:186830 Vega:OTTHUMG00000166968 UniprotKB:P07766
NG_007383.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.090e-1 (AD)  7.510e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CTSW0.792
LCK0.775
GZMH0.767
CD20.766
GZMA0.749
NKG70.743
CD960.727
SLAMF70.722
IL7R0.716
IL2RB0.702

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CYP46A1-0.429
WIPF3-0.416
GDF10-0.41
ADPRHL1-0.408
EFNA5-0.407
CA7-0.406
HIPK4-0.4
DAPK1-0.398
ST6GALNAC5-0.394
FAM171A2-0.391

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00075MuromonabBiotechDrug140608-64-6Approved|InvestigationalTarget
DB06607CatumaxomabBiotechDrug509077-98-9Approved|Investigational|WithdrawnTarget
ID Drug Name Action PubMed
D000082AcetaminophenMAP3K5 protein affects the reaction [Acetaminophen results in increased expression of CD3E mRNA]18700144
D020106AcrylamideAcrylamide results in increased expression of CD3E mRNA28959563
D000242Cyclic AMPCyclic AMP results in decreased phosphorylation of CD3E protein2824607
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of CD3E gene27153756
C430898AGN 194204AGN 194204 results in increased expression of CD3E mRNA16339527
D000535Aluminum[APP protein modified form binds to Aluminum] which results in decreased expression of CD3E mRNA21298039
C010845aluminum chloridealuminum chloride promotes the reaction [Sodium Fluoride results in increased phosphorylation of CD3E protein]2824607
C032311aluminum fluoridealuminum fluoride results in increased phosphorylation of CD3E protein2824607
C032311aluminum fluorideTetradecanoylphorbol Acetate inhibits the reaction [aluminum fluoride results in increased phosphorylation of CD3E protein]2824607
D001151ArsenicArsenic affects the methylation of CD3E gene25304211
D001554BenzeneBenzene results in decreased expression of CD3E mRNA22214187
D001554BenzeneBenzene results in increased expression of CD3E mRNA22214187
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of CD3E mRNA21569818
D004958Estradiol[Estradiol co-treated with Progesterone] results in decreased expression of CD3E mRNA21277368
D004958Estradiol[Estradiol co-treated with Progesterone] results in decreased expression of CD3E protein21277368
C006780bisphenol Abisphenol A results in decreased expression of CD3E mRNA25181051|2717856
D003513CycloheximideCycloheximide inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of CD3E mRNA]11007951
D003520CyclophosphamideCyclophosphamide results in decreased expression of CD3E mRNA21041162
D003907DexamethasoneDexamethasone results in decreased expression of CD3E mRNA21041162
D004041Dietary FatsDietary Fats results in increased expression of CD3E mRNA25016146
D004054DiethylstilbestrolDiethylstilbestrol results in decreased expression of CD3E mRNA21041162
D002117CalcitriolCalcitriol promotes the reaction [[[CD3G protein binds to CD3D protein binds to CD3E protein binds to CD247 protein] which co-treated with CD28 protein] results in increased expression of VDR protein]24792400
D002117Calcitriol[[CD3G protein binds to CD3D protein binds to CD3E protein binds to CD247 protein] which co-treated with CD28 protein] results in increased abundance of Calcitriol24792400
D002117CalcitriolKetoconazole inhibits the reaction [[[CD3G protein binds to CD3D protein binds to CD3E protein binds to CD247 protein] which co-treated with CD28 protein] results in increased abundance of Calcitriol]24792400
C039281furanfuran results in increased expression of CD3E mRNA27387713
D005839GentamicinsGentamicins results in increased expression of CD3E mRNA22061828
D002112CalcifediolCalcifediol promotes the reaction [[[CD3G protein binds to CD3D protein binds to CD3E protein binds to CD247 protein] which co-treated with CD28 protein] results in increased expression of VDR protein]24792400
D002112CalcifediolKetoconazole inhibits the reaction [Calcifediol promotes the reaction [[[CD3G protein binds to CD3D protein binds to CD3E protein binds to CD247 protein] which co-treated with CD28 protein] results in increased expression of VDR protein]]24792400
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of CD3E mRNA22802445|2308692
D007654KetoconazoleKetoconazole inhibits the reaction [Calcifediol promotes the reaction [[[CD3G protein binds to CD3D protein binds to CD3E protein binds to CD247 protein] which co-treated with CD28 protein] results in increased expression of VDR protein]]24792400
D007654KetoconazoleKetoconazole inhibits the reaction [[[CD3G protein binds to CD3D protein binds to CD3E protein binds to CD247 protein] which co-treated with CD28 protein] results in increased abundance of Calcitriol]24792400
C008261lead acetatelead acetate results in increased expression of CD3E mRNA22641619
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in decreased expression of CD3E mRNA"24972896
D009532NickelNickel results in increased expression of CD3E mRNA25583101
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of CD3E mRNA25729387
C030110oxaliplatinoxaliplatin results in increased expression of CD3E mRNA25729387
D052638Particulate MatterParticulate Matter results in decreased expression of CD3E mRNA23638009
D010936Plant ExtractsPlant Extracts results in decreased expression of CD3E mRNA23557933
D011374Progesterone[Estradiol co-treated with Progesterone] results in decreased expression of CD3E mRNA21277368
D011374Progesterone[Estradiol co-treated with Progesterone] results in decreased expression of CD3E protein21277368
D011441PropylthiouracilPropylthiouracil results in decreased expression of CD3E mRNA24780913
C059514resveratrolresveratrol inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CD3E protein]20715097
D012601Scopolamine HydrobromideScopolamine Hydrobromide results in decreased expression of CD3E mRNA17540011
D012834SilverSilver results in decreased expression of CD3E mRNA27131904
D012969Sodium Fluoridealuminum chloride promotes the reaction [Sodium Fluoride results in increased phosphorylation of CD3E protein]2824607
D012969Sodium FluorideSodium Fluoride results in increased phosphorylation of CD3E protein2824607
D013749TetrachlorodibenzodioxinCycloheximide inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of CD3E mRNA]11007951
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of CD3E mRNA11007951
D013749Tetrachlorodibenzodioxinresveratrol inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CD3E protein]20715097
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of CD3E protein14718643|2071509
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate inhibits the reaction [aluminum fluoride results in increased phosphorylation of CD3E protein]2824607
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of CD3E mRNA25729387
D019772TopotecanTopotecan results in increased expression of CD3E mRNA25729387
D014241TrichloroethyleneTrichloroethylene results in decreased expression of CD3E mRNA15363585
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of CD3E gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004888transmembrane signaling receptor activity-IBA21873635  
GO:0004888transmembrane signaling receptor activity-NAS9485181  
GO:0005515protein binding-IPI7761456  9698567  11855827  17617578  18424730  18644376  
18955169  
GO:0017124SH3 domain binding-IPI12110186  
GO:0019901protein kinase binding-NAS12110186  
GO:0030159receptor signaling complex scaffold activity-NAS9886373  
GO:0042608T cell receptor binding-NAS11186279  
GO:0042803protein homodimerization activity-IMP14967045  
GO:0046982protein heterodimerization activity-IPI9485181  
GO ID GO Term Qualifier Evidence PubMed
GO:0002250adaptive immune response-IEA-  
GO:0002669positive regulation of T cell anergy-IEA-  
GO:0007166cell surface receptor signaling pathway-IBA21873635  
GO:0007166cell surface receptor signaling pathway-NAS12110186  
GO:0007169transmembrane receptor protein tyrosine kinase signaling pathway-TAS8530500  
GO:0007172signal complex assembly-TAS8490660  
GO:0007186G-protein coupled receptor signaling pathway-TAS8530500  
GO:0007584response to nutrient-IEA-  
GO:0010628positive regulation of gene expression-IMP23817958  
GO:0010629negative regulation of gene expression-IMP23817958  
GO:0016358dendrite development-IEA-  
GO:0021549cerebellum development-IEA-  
GO:0030217T cell differentiation-IBA21873635  
GO:0031295T cell costimulation-IEA-  
GO:0032729positive regulation of interferon-gamma production-IEA-  
GO:0032753positive regulation of interleukin-4 production-IEA-  
GO:0042102positive regulation of T cell proliferation-IMP12110186  
GO:0042110T cell activation-NAS12110186  
GO:0042981regulation of apoptotic process-NAS12567487  
GO:0045059positive thymic T cell selection-IBA21873635  
GO:0045060negative thymic T cell selection-IEA-  
GO:0045086positive regulation of interleukin-2 biosynthetic process-IEA-  
GO:0045879negative regulation of smoothened signaling pathway-IEA-  
GO:0046641positive regulation of alpha-beta T cell proliferation-IEA-  
GO:0050731positive regulation of peptidyl-tyrosine phosphorylation-IEA-  
GO:0050776regulation of immune response-TAS-  
GO:0050850positive regulation of calcium-mediated signaling-IEA-  
GO:0050852T cell receptor signaling pathway-TAS-  
GO:0051260protein homooligomerization-IMP14967045  
GO:0065003protein-containing complex assembly-NAS9886373  
GO:0097190apoptotic signaling pathway-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001772immunological synapse-IEA-  
GO:0005886plasma membrane-IDA11390434  
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-NAS9485181  
GO:0005911cell-cell junction-IEA-  
GO:0009897external side of plasma membrane-IBA21873635  
GO:0009897external side of plasma membrane-IDA11390434  17213291  
GO:0042101T cell receptor complex-IDA8176201  
GO:0042101T cell receptor complex-NAS9485181  
GO:0042105alpha-beta T cell receptor complex-IBA21873635  
GO:0042105alpha-beta T cell receptor complex-IEA-  
GO:0043197dendritic spine-IEA-  
GO:0044297cell body-IEA-  
KEGG ID KEGG Term
hsa04640Hematopoietic cell lineage
hsa04660T cell receptor signaling pathway
hsa05142Chagas disease (American trypanosomiasis)
hsa05340Primary immunodeficiency
Reactome ID Reactome Term Evidence
R-HSA-1280218Adaptive Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-198933Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cellTAS
R-HSA-202403TCR signalingTAS
R-HSA-202424Downstream TCR signalingTAS
R-HSA-202427Phosphorylation of CD3 and TCR zeta chainsTAS
R-HSA-202430Translocation of ZAP-70 to Immunological synapseTAS
R-HSA-202433Generation of second messenger moleculesTAS
R-HSA-388841Costimulation by the CD28 familyTAS
R-HSA-389948PD-1 signalingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26681190Genetic Polymorphisms in XRCC1, CD3EAP, PPP1R13L, XPB, XPC, and XPF and the Risk of Chronic Benzene Poisoning in a Chinese Occupational Population. (2015)Xue PPLoS One