Gene: NLRP12

91662
CLR19.3|FCAS2|NALP12|PAN6|PYPAF7|RNO|RNO2
NLR family pyrin domain containing 12
protein-coding
19q13.42
Ensembl:ENSG00000142405 MIM:609648 Vega:OTTHUMG00000060776 UniprotKB:P59046
NG_008651.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.977e-1 (AD)  5.135e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CEACAM30.764
KCNJ150.762
CEACAM40.748
LILRB20.744
TRIM100.734
VNN20.731
LILRA50.724
IL18RAP0.721
FOLR30.72
PROK20.719

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ASPDH-0.539
FAM43B-0.475
CYP46A1-0.462
MAGIX-0.462
C15orf59-0.453
PARD6A-0.452
THY1-0.447
KCNIP3-0.447
YJEFN3-0.445
HAGHL-0.444

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0142112,3,7,8-tetrachlorodibenzofuran"2,3,7,8-tetrachlorodibenzofuran affects the expression of NLRP12 mRNA"20702594
C5240423,5-bis(2-fluorobenzylidene)piperidin-4-one"3,5-bis(2-fluorobenzylidene)piperidin-4-one inhibits the reaction [Oxygen deficiency results in increased expression of NLRP12 mRNA]"23452621
C0297284-phenylenediamine4-phenylenediamine results in decreased expression of NLRP12 protein27585668
C0297284-phenylenediamine4-phenylenediamine results in increased expression of NLRP12 mRNA27585668
D000395Air Pollutants, Occupational"Air Pollutants, Occupational results in decreased expression of NLRP12 mRNA"23195993
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of NLRP12 mRNA24449571
D001151ArsenicArsenic affects the methylation of NLRP12 gene25304211
C006632arsenic trioxidearsenic trioxide results in increased expression of NLRP12 mRNA20471514
C006632arsenic trioxideBortezomib promotes the reaction [arsenic trioxide results in increased expression of NLRP12 mRNA]20471514
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of NLRP12 mRNA20064835
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of NLRP12 mRNA19770486
C006780bisphenol Abisphenol A results in decreased expression of NLRP12 mRNA21932408
C006780bisphenol Abisphenol A results in decreased expression of NLRP12 mRNA25181051
D000069286BortezomibBortezomib promotes the reaction [arsenic trioxide results in increased expression of NLRP12 mRNA]20471514
D000069286BortezomibBortezomib results in increased expression of NLRP12 mRNA20471514
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of NLRP12 mRNA27339419
D003474CurcuminCurcumin inhibits the reaction [Oxygen deficiency results in increased expression of NLRP12 mRNA]23452621
D004041Dietary FatsDietary Fats results in increased expression of NLRP12 mRNA25016146
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in decreased expression of NLRP12 mRNA28085963
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of NLRP12 mRNA24535843
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Thioacetamide] results in decreased expression of NLRP12 mRNA28943392
D004137DinitrochlorobenzeneDinitrochlorobenzene results in decreased expression of NLRP12 protein27585668
D004365Drugs, Chinese Herbal"Drugs, Chinese Herbal results in increased expression of NLRP12 mRNA"23811387
D019833GenisteinGenistein inhibits the reaction [Oxygen deficiency results in increased expression of NLRP12 mRNA]23452621
C433788lipopolysaccharide, E. coli O26-B6"lipopolysaccharide, E. coli O26-B6 results in decreased expression of NLRP12 mRNA"23090859
C433788lipopolysaccharide, E. coli O26-B6"nickel chloride inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in decreased expression of NLRP12 mRNA]"23090859
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of NLRP12 mRNA27339419
D009285NaphthoquinonesNaphthoquinones results in increased expression of NLRP12 mRNA23811387
D009532NickelNickel results in decreased expression of NLRP12 mRNA23195993
C022838nickel chloride"nickel chloride inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in decreased expression of NLRP12 mRNA]"23090859
C572573N-nitroso-tris-chloroethylurea[N-nitroso-tris-chloroethylurea co-treated with XL147] results in increased expression of NLRP12 mRNA27935865
D010100Oxygen"3,5-bis(2-fluorobenzylidene)piperidin-4-one inhibits the reaction [Oxygen deficiency results in increased expression of NLRP12 mRNA]"23452621
D010100OxygenCurcumin inhibits the reaction [Oxygen deficiency results in increased expression of NLRP12 mRNA]23452621
D010100OxygenGenistein inhibits the reaction [Oxygen deficiency results in increased expression of NLRP12 mRNA]23452621
D010100OxygenOxygen deficiency results in increased expression of NLRP12 mRNA23452621|2651600
D010100OxygenPlant Extracts inhibits the reaction [Oxygen deficiency results in increased expression of NLRP12 mRNA]23452621
D010100Oxygenresveratrol inhibits the reaction [Oxygen deficiency results in increased expression of NLRP12 mRNA]23452621
D052638Particulate MatterParticulate Matter results in decreased expression of NLRP12 mRNA27158778|2737705
D010578PetroleumPetroleum results in decreased expression of NLRP12 mRNA25208076
D010634PhenobarbitalPhenobarbital affects the expression of NLRP12 mRNA23091169
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of NLRP12 mRNA19710929
C006253pirinixic acidpirinixic acid results in increased expression of NLRP12 mRNA23811191
D010936Plant ExtractsPlant Extracts inhibits the reaction [Oxygen deficiency results in increased expression of NLRP12 mRNA]23452621
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of NLRP12 mRNA28903501
C043680ptaquilosideptaquiloside results in decreased expression of NLRP12 mRNA23274088
C059514resveratrolresveratrol inhibits the reaction [Oxygen deficiency results in increased expression of NLRP12 mRNA]23452621
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of NLRP12 mRNA23806026
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of NLRP12 mRNA20702594|2637764
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of NLRP12 mRNA19770486
D013750TetrachloroethyleneTetrachloroethylene results in increased expression of NLRP12 mRNA28973375
D013853Thioacetamide[Diethylnitrosamine co-treated with Thioacetamide] results in decreased expression of NLRP12 mRNA28943392
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of NLRP12 mRNA22363418
D014241TrichloroethyleneTrichloroethylene results in increased expression of NLRP12 mRNA28973375
C013320tris(2-butoxyethyl) phosphatetris(2-butoxyethyl) phosphate affects the expression of NLRP12 mRNA29024780
D014635Valproic AcidValproic Acid results in increased methylation of NLRP12 gene29154799
D014635Valproic AcidValproic Acid affects the expression of NLRP12 mRNA17963808
D014874Water Pollutants, Chemical"Water Pollutants, Chemical results in decreased expression of NLRP12 mRNA"25208076
C581157XL147[N-nitroso-tris-chloroethylurea co-treated with XL147] results in increased expression of NLRP12 mRNA27935865

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI12019269  16203735  19337385  
GO:0005524ATP binding-IEA-  
GO:0008656cysteine-type endopeptidase activator activity involved in apoptotic process-NAS12019269  
GO ID GO Term Qualifier Evidence PubMed
GO:0006919activation of cysteine-type endopeptidase activity involved in apoptotic process-NAS12019269  
GO:0007165signal transduction-NAS12019269  
GO:0009968negative regulation of signal transduction-IDA16203735  
GO:0031953negative regulation of protein autophosphorylation-IDA16203735  
GO:0032088negative regulation of NF-kappaB transcription factor activity-IDA18230725  
GO:0036336dendritic cell migration-IEA-  
GO:0043122regulation of I-kappaB kinase/NF-kappaB signaling-IDA12019269  
GO:0043124negative regulation of I-kappaB kinase/NF-kappaB signaling-IBA21873635  
GO:0043124negative regulation of I-kappaB kinase/NF-kappaB signaling-IDA16203735  
GO:0043281regulation of cysteine-type endopeptidase activity involved in apoptotic process-IBA21873635  
GO:0043281regulation of cysteine-type endopeptidase activity involved in apoptotic process-IDA12019269  
GO:0045345positive regulation of MHC class I biosynthetic process-IBA21873635  
GO:0045345positive regulation of MHC class I biosynthetic process-IDA12759408  
GO:0045381regulation of interleukin-18 biosynthetic process-NAS12019269  
GO:0045409negative regulation of interleukin-6 biosynthetic process-IBA21873635  
GO:0045409negative regulation of interleukin-6 biosynthetic process-IDA16203735  
GO:0045751negative regulation of Toll signaling pathway-IDA16203735  
GO:0050710negative regulation of cytokine secretion-IDA16203735  
GO:0050711negative regulation of interleukin-1 secretion-IDA16203735  
GO:0050718positive regulation of interleukin-1 beta secretion-NAS12019269  
GO:0050728negative regulation of inflammatory response-IMP18230725  
GO:0050729positive regulation of inflammatory response-NAS12019269  
GO:0070373negative regulation of ERK1 and ERK2 cascade-IEA-  
GO:0071345cellular response to cytokine stimulus-IBA21873635  
GO:0071345cellular response to cytokine stimulus-IEA-  
GO:1901223negative regulation of NIK/NF-kappaB signaling-IEA-  
GO:1901224positive regulation of NIK/NF-kappaB signaling-IDA12019269  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleusNOTIDA12019269  
GO:0005737cytoplasm-IDA12019269  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
29623357Membrane microdomains regulate NLRP10- and NLRP12-dependent signalling in A549 cells challenged with cigarette smoke extract. (2018 May)Singh DPArch Toxicol