Gene: MYOM2

9172
TTNAP
myomesin 2
protein-coding
8p23.3
Ensembl:ENSG00000036448 MIM:603509 Vega:OTTHUMG00000129175 UniprotKB:P54296
NC_000008.11
SNP Mapped
1   ANCO-SNPs
ND
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.262e-1 (AD)  5.853e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs13269383chr8:2088699 (GRCh38.p7)T>Cnicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg11955491chr8:2092909MYOM23'UTR5.320e-4Alcohol use disorders26763658
cg10700718chr8:1992719MYOM23.400e-8Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
URGCP0.828
AP3B20.826
CAMKK10.824
ZFYVE270.823
UBE2O0.821
SIN3B0.817
NGEF0.815
PPP1R13B0.815
KIAA1211L0.815
KIAA05130.814

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SH2D1A-0.436
TFPI2-0.434
RAI14-0.433
OR4F5-0.429
REST-0.407
KLF17-0.405
CD48-0.403
DISC1-0.402
YES1-0.402
C9orf135-0.399

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000082Acetaminophen[Clofibrate co-treated with Acetaminophen] affects the expression of MYOM2 mRNA17585979
D000082AcetaminophenPPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of MYOM2 mRNA]17585979
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of MYOM2 mRNA22100608
D001151ArsenicArsenic results in decreased expression of MYOM2 mRNA19654921
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased mutagenesis of MYOM2 gene25435355
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of MYOM2 mRNA22610609
D004958EstradiolEstradiol results in decreased expression of MYOM2 mRNA19484750
C006780bisphenol Abisphenol A results in increased expression of MYOM2 mRNA25594700
C006780bisphenol Abisphenol A results in decreased expression of MYOM2 mRNA25181051
C006780bisphenol Abisphenol A results in increased expression of MYOM2 mRNA18180321
C037123cadmium sulfatecadmium sulfate affects the reaction [MTF1 affects the expression of MYOM2 mRNA]16221973
D002738ChloroquineChloroquine results in increased expression of MYOM2 mRNA19393257
D002794CholineCholine affects the expression of MYOM2 mRNA17616785
D002994Clofibrate[Clofibrate co-treated with Acetaminophen] affects the expression of MYOM2 mRNA17585979
D002994ClofibratePPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of MYOM2 mRNA]17585979
D003630DaunorubicinDaunorubicin results in decreased expression of MYOM2 mRNA26537877|2894005
C010902decabromobiphenyl etherdecabromobiphenyl ether results in decreased expression of MYOM2 mRNA23640034
C014347decitabinedecitabine results in decreased methylation of MYOM2 gene27923600
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of MYOM2 mRNA21266533
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in increased expression of MYOM2 mRNA28085963
D004317DoxorubicinDoxorubicin results in decreased expression of MYOM2 mRNA26537877|2894005
D004317DoxorubicinDoxorubicin results in increased expression of MYOM2 mRNA16243910
C069837fullerene C60fullerene C60 affects the expression of MYOM2 mRNA19167457
C544151jinfukangjinfukang results in increased expression of MYOM2 mRNA27392435
D008044LinuronLinuron results in increased expression of MYOM2 mRNA16498641
D008748MethylcholanthreneMethylcholanthrene promotes the reaction [AHR protein binds to MYOM2 promoter]20348232
D008942MitoxantroneMitoxantrone results in decreased expression of MYOM2 mRNA26537877|2894005
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of MYOM2 mRNA"25620056
C572573N-nitroso-tris-chloroethylurea[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of MYOM2 mRNA27935865
D010795Phthalic AcidsPhthalic Acids results in increased expression of MYOM2 mRNA15728792
C060836pioglitazone[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of MYOM2 mRNA27935865
C006253pirinixic acidpirinixic acid results in increased expression of MYOM2 mRNA18301758
D011441PropylthiouracilPropylthiouracil results in decreased expression of MYOM2 mRNA24780913
C012526quercitrinquercitrin results in increased expression of MYOM2 mRNA25193878
C017947sodium arsenitesodium arsenite affects the methylation of MYOM2 gene28589171
D012999SomanSoman results in decreased expression of MYOM2 mRNA19281266
D013096SpermineSpermine results in increased expression of MYOM2 mRNA18673383
D013629TamoxifenTamoxifen results in increased expression of MYOM2 mRNA25123088
C009495titanium dioxidetitanium dioxide results in decreased expression of MYOM2 mRNA23557971
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of MYOM2 mRNA20133372
D014635Valproic AcidValproic Acid results in increased methylation of MYOM2 gene29154799
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of MYOM2 gene25560391
C029297vinylidene chloridevinylidene chloride results in decreased expression of MYOM2 mRNA26682919

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI23414517  
GO:0008307structural constituent of muscle-IBA21873635  
GO:0008307structural constituent of muscle-TAS7505783  
GO:0019900kinase binding-IPI12972258  
GO:0051015actin filament binding-IBA21873635  
GO:0051371muscle alpha-actinin binding-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0002074extraocular skeletal muscle development-IEA-  
GO:0006936muscle contraction-TAS7505783  
GO:0006941striated muscle contraction-IBA21873635  
GO:0007015actin filament organization-IBA21873635  
GO:0030240skeletal muscle thin filament assembly-IBA21873635  
GO:0030241skeletal muscle myosin thick filament assembly-IBA21873635  
GO:0045214sarcomere organization-IBA21873635  
GO:0048739cardiac muscle fiber development-IBA21873635  
GO:0055003cardiac myofibril assembly-IBA21873635  
GO:0055008cardiac muscle tissue morphogenesis-IBA21873635  
GO:0071688striated muscle myosin thick filament assembly-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005739mitochondrion-HDA20833797  
GO:0005859muscle myosin complex-IBA21873635  
GO:0005865striated muscle thin filament-IBA21873635  
GO:0030018Z disc-IBA21873635  
GO:0031430M band-IBA21873635  
GO:0032982myosin filament-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal