Gene: HTR3B

9177
5-HT3B
5-hydroxytryptamine receptor 3B
protein-coding
11q23.2
Ensembl:ENSG00000149305 MIM:604654 Vega:OTTHUMG00000168210 UniprotKB:O95264
NG_011483.1
PubMed
CD|ND|AD
11   
NA (AD)  1.579e-1 (ND)   (Frontal_Cortex)
4.098e-1 (AD)  7.607e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
C1QL30.902
SCN8A0.901
PCDHAC20.898
KCNH10.891
MCHR20.886
TMEM178B0.88
MTUS20.877
CDH180.872
SOWAHB0.871
OPN30.87

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ROM1-0.605
RAB13-0.597
HEY2-0.595
MYL3-0.57
COPZ2-0.556
RNF135-0.555
HEBP2-0.55
PXDC1-0.544
CSAG1-0.54
SNHG18-0.539

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB01049Ergoloid mesylateSmall Molecule8067-24-1ApprovedTarget
DB09304SetiptilineSmall Molecule57262-94-9ApprovedTarget
DB13025TiaprideSmall Molecule51012-32-9Approved|InvestigationalTarget
DB00898EthanolSmall Molecule64-17-5ApprovedTarget
DB00988DopamineSmall Molecule51-61-6ApprovedTarget
DB08839SerotoninSmall Molecule50-67-9Investigational|NutraceuticalTarget
ID Drug Name Action PubMed
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of HTR3B gene27153756
D000643Ammonium ChlorideAmmonium Chloride affects the expression of HTR3B mRNA16483693
D001151ArsenicArsenic affects the methylation of HTR3B gene25304211
D0200011-Butanol1-Butanol promotes the reaction [Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3B protein]]17360702
D002211CapsaicinCapsaicin results in decreased expression of HTR3B mRNA16278290
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of HTR3B mRNA12734012
D004390ChlorpyrifosChlorpyrifos results in decreased expression of HTR3B mRNA18835401
D004390ChlorpyrifosChlorpyrifos results in increased expression of HTR3B mRNA17452286
D003471CuprizoneCuprizone results in decreased expression of HTR3B mRNA27523638
D003976DiazinonDiazinon affects the expression of HTR3B mRNA17452286
D004026DieldrinDieldrin results in decreased expression of HTR3B mRNA18835401
D004298DopamineDopamine binds to and results in increased activity of [HTR3A protein binds to HTR3B protein]17360702
D000431EthanolEthanol promotes the reaction [Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3B protein]]17360702
D000441HexanolsHexanols inhibits the reaction [Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3B protein]]17360702
D012701Serotonin1-Butanol promotes the reaction [Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3B protein]]17360702
D012701Serotonin1-Propanol promotes the reaction [Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3B protein]]17360702
D012701SerotoninEthanol promotes the reaction [Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3B protein]]17360702
D012701SerotoninHexanols inhibits the reaction [Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3B protein]]17360702
D012701SerotoninOctanols inhibits the reaction [Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3B protein]]17360702
D012701SerotoninPentanols promotes the reaction [Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3B protein]]17360702
D012701SerotoninSerotonin binds to and results in increased activity of [HTR3A protein binds to HTR3B protein]17360702
D019161Hydroxymethylglutaryl-CoA Reductase InhibitorsHTR3B gene SNP results in increased susceptibility to Hydroxymethylglutaryl-CoA Reductase Inhibitors17600820
D009532NickelNickel results in decreased expression of HTR3B mRNA18835401
C028007nickel monoxidenickel monoxide results in decreased expression of HTR3B mRNA19167457
C014707nitrosobenzylmethylaminenitrosobenzylmethylamine results in decreased expression of HTR3B mRNA17616710
D000442OctanolsOctanols inhibits the reaction [Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3B protein]]17360702
D000439PentanolsPentanols promotes the reaction [Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3B protein]]17360702
D0004331-Propanol1-Propanol promotes the reaction [Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3B protein]]17360702
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of HTR3B mRNA21570461
D014635Valproic AcidValproic Acid affects the expression of HTR3B mRNA17292431

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004888transmembrane signaling receptor activity-IEA-  
GO:0005230extracellular ligand-gated ion channel activityCONTRIBUTES_TOIBA21873635  
GO:0022850serotonin-gated cation-selective channel activity-IGI9950429  
GO ID GO Term Qualifier Evidence PubMed
GO:0007165signal transduction-IBA21873635  
GO:0007210serotonin receptor signaling pathway-IEA-  
GO:0007268chemical synaptic transmission-IBA21873635  
GO:0034220ion transmembrane transport-IBA21873635  
GO:0034220ion transmembrane transport-IEA-  
GO:0042391regulation of membrane potential-IBA21873635  
GO:0050877nervous system process-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-IBA21873635  
GO:0005887integral component of plasma membrane-IEA-  
GO:0009986cell surface-IDA16571125  
GO:0043005neuron projection-IBA21873635  
GO:0045202synapse-IBA21873635  
GO:0045211postsynaptic membrane-IEA-  
GO:1904602serotonin-activated cation-selective channel complex-IGI9950429  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-112314Neurotransmitter receptors and postsynaptic signal transmissionTAS
R-HSA-112315Transmission across Chemical SynapsesTAS
R-HSA-112316Neuronal SystemTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
20838391Functional genetic variants that increase synaptic serotonin and 5-HT3 receptor sensitivity predict alcohol and drug dependence. (2011 Nov)Enoch MAMol Psychiatry
19185213HTR3B is associated with alcoholism with antisocial behavior and alpha EEG power--an intermediate phenotype for alcoholism and co-morbid behaviors. (2009 Feb)Ducci FAlcohol
20021265Two naturally occurring variants of the serotonin receptor gene HTR3C are associated with nausea in pregnancy. (2010)Goecke TWActa Obstet Gynecol Scand
22933845Polymorphisms of the serotonin transporter and receptor genes: susceptibility to substance abuse. (2012 Jun)Herman AISubst Abuse Rehabil
26227246Susceptibility loci for heroin and cocaine addiction in the serotonergic and adrenergic pathways in populations of different ancestry. (2015)Levran OPharmacogenomics
22048466Smoking cessation pharmacogenetics: analysis of varenicline and bupropion in placebo-controlled clinical trials. (2012 Feb)King DPNeuropsychopharmacology
25655461Clinically relevant genetic biomarkers from the brain in alcoholism with representation on high resolution chromosome ideograms. (2015 Apr 15)Manzardo AMGene
23290502Serotonin transporter and receptor genes significantly impact nicotine dependence through genetic interactions in both European American and African American smokers. (2013 May 1)Yang ZDrug Alcohol Depend
23897038Determination of genotype combinations that can predict the outcome of the treatment of alcohol dependence using the 5-HT(3) antagonist ondansetron. (2013 Sep)Johnson BAAm J Psychiatry
23757001Association, interaction, and replication analysis of genes encoding serotonin transporter and 5-HT3 receptor subunits A and B in alcohol dependence. (2013 Oct)Seneviratne CHum Genet
25161819Genetic, psychosocial, and demographic factors associated with social disinhibition in Mexican-origin youth. (2014 Jul)Archer NPBrain Behav