| Gene Symbol | Pearson Correlation Coefficient |
|---|---|
| C1QL3 | 0.902 |
| SCN8A | 0.901 |
| PCDHAC2 | 0.898 |
| KCNH1 | 0.891 |
| MCHR2 | 0.886 |
| TMEM178B | 0.88 |
| MTUS2 | 0.877 |
| CDH18 | 0.872 |
| SOWAHB | 0.871 |
| OPN3 | 0.87 |
| Gene Symbol | Pearson Correlation Coefficient |
|---|---|
| ROM1 | -0.605 |
| RAB13 | -0.597 |
| HEY2 | -0.595 |
| MYL3 | -0.57 |
| COPZ2 | -0.556 |
| RNF135 | -0.555 |
| HEBP2 | -0.55 |
| PXDC1 | -0.544 |
| CSAG1 | -0.54 |
| SNHG18 | -0.539 |
| ID | Drug Name | Drug Type | CAS Num | Status | Role |
|---|---|---|---|---|---|
| DB01049 | Ergoloid mesylate | Small Molecule | 8067-24-1 | Approved | Target |
| DB09304 | Setiptiline | Small Molecule | 57262-94-9 | Approved | Target |
| DB13025 | Tiapride | Small Molecule | 51012-32-9 | Approved|Investigational | Target |
| DB00898 | Ethanol | Small Molecule | 64-17-5 | Approved | Target |
| DB00988 | Dopamine | Small Molecule | 51-61-6 | Approved | Target |
| DB08839 | Serotonin | Small Molecule | 50-67-9 | Investigational|Nutraceutical | Target |
| ID | Drug Name | Action | PubMed |
|---|---|---|---|
| D016604 | Aflatoxin B1 | Aflatoxin B1 results in increased methylation of HTR3B gene | 27153756 |
| D000643 | Ammonium Chloride | Ammonium Chloride affects the expression of HTR3B mRNA | 16483693 |
| D001151 | Arsenic | Arsenic affects the methylation of HTR3B gene | 25304211 |
| D020001 | 1-Butanol | 1-Butanol promotes the reaction [Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3B protein]] | 17360702 |
| D002211 | Capsaicin | Capsaicin results in decreased expression of HTR3B mRNA | 16278290 |
| D002251 | Carbon Tetrachloride | Carbon Tetrachloride affects the expression of HTR3B mRNA | 12734012 |
| D004390 | Chlorpyrifos | Chlorpyrifos results in decreased expression of HTR3B mRNA | 18835401 |
| D004390 | Chlorpyrifos | Chlorpyrifos results in increased expression of HTR3B mRNA | 17452286 |
| D003471 | Cuprizone | Cuprizone results in decreased expression of HTR3B mRNA | 27523638 |
| D003976 | Diazinon | Diazinon affects the expression of HTR3B mRNA | 17452286 |
| D004026 | Dieldrin | Dieldrin results in decreased expression of HTR3B mRNA | 18835401 |
| D004298 | Dopamine | Dopamine binds to and results in increased activity of [HTR3A protein binds to HTR3B protein] | 17360702 |
| D000431 | Ethanol | Ethanol promotes the reaction [Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3B protein]] | 17360702 |
| D000441 | Hexanols | Hexanols inhibits the reaction [Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3B protein]] | 17360702 |
| D012701 | Serotonin | 1-Butanol promotes the reaction [Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3B protein]] | 17360702 |
| D012701 | Serotonin | 1-Propanol promotes the reaction [Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3B protein]] | 17360702 |
| D012701 | Serotonin | Ethanol promotes the reaction [Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3B protein]] | 17360702 |
| D012701 | Serotonin | Hexanols inhibits the reaction [Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3B protein]] | 17360702 |
| D012701 | Serotonin | Octanols inhibits the reaction [Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3B protein]] | 17360702 |
| D012701 | Serotonin | Pentanols promotes the reaction [Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3B protein]] | 17360702 |
| D012701 | Serotonin | Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3B protein] | 17360702 |
| D019161 | Hydroxymethylglutaryl-CoA Reductase Inhibitors | HTR3B gene SNP results in increased susceptibility to Hydroxymethylglutaryl-CoA Reductase Inhibitors | 17600820 |
| D009532 | Nickel | Nickel results in decreased expression of HTR3B mRNA | 18835401 |
| C028007 | nickel monoxide | nickel monoxide results in decreased expression of HTR3B mRNA | 19167457 |
| C014707 | nitrosobenzylmethylamine | nitrosobenzylmethylamine results in decreased expression of HTR3B mRNA | 17616710 |
| D000442 | Octanols | Octanols inhibits the reaction [Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3B protein]] | 17360702 |
| D000439 | Pentanols | Pentanols promotes the reaction [Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3B protein]] | 17360702 |
| D000433 | 1-Propanol | 1-Propanol promotes the reaction [Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3B protein]] | 17360702 |
| D013749 | Tetrachlorodibenzodioxin | Tetrachlorodibenzodioxin affects the expression of HTR3B mRNA | 21570461 |
| D014635 | Valproic Acid | Valproic Acid affects the expression of HTR3B mRNA | 17292431 |
| GO ID | GO Term | Qualifier | Evidence | PubMed |
|---|---|---|---|---|
| GO:0004888 | transmembrane signaling receptor activity | - | IEA | - |
| GO:0005230 | extracellular ligand-gated ion channel activity | CONTRIBUTES_TO | IBA | 21873635 |
| GO:0022850 | serotonin-gated cation-selective channel activity | - | IGI | 9950429 |
| GO ID | GO Term | Qualifier | Evidence | PubMed |
|---|---|---|---|---|
| GO:0007165 | signal transduction | - | IBA | 21873635 |
| GO:0007210 | serotonin receptor signaling pathway | - | IEA | - |
| GO:0007268 | chemical synaptic transmission | - | IBA | 21873635 |
| GO:0034220 | ion transmembrane transport | - | IBA | 21873635 |
| GO:0034220 | ion transmembrane transport | - | IEA | - |
| GO:0042391 | regulation of membrane potential | - | IBA | 21873635 |
| GO:0050877 | nervous system process | - | IBA | 21873635 |
| GO ID | GO Term | Qualifier | Evidence | PubMed |
|---|---|---|---|---|
| GO:0005886 | plasma membrane | - | TAS | - |
| GO:0005887 | integral component of plasma membrane | - | IBA | 21873635 |
| GO:0005887 | integral component of plasma membrane | - | IEA | - |
| GO:0009986 | cell surface | - | IDA | 16571125 |
| GO:0043005 | neuron projection | - | IBA | 21873635 |
| GO:0045202 | synapse | - | IBA | 21873635 |
| GO:0045211 | postsynaptic membrane | - | IEA | - |
| GO:1904602 | serotonin-activated cation-selective channel complex | - | IGI | 9950429 |
| KEGG ID | KEGG Term |
|---|
| Reactome ID | Reactome Term | Evidence |
|---|---|---|
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | TAS |
| R-HSA-112315 | Transmission across Chemical Synapses | TAS |
| R-HSA-112316 | Neuronal System | TAS |
| PMID | Title (Year) | Author | Journal |
|---|---|---|---|
| 20838391 | Functional genetic variants that increase synaptic serotonin and 5-HT3 receptor sensitivity predict alcohol and drug dependence. (2011 Nov) | Enoch MA | Mol Psychiatry |
| 19185213 | HTR3B is associated with alcoholism with antisocial behavior and alpha EEG power--an intermediate phenotype for alcoholism and co-morbid behaviors. (2009 Feb) | Ducci F | Alcohol |
| 20021265 | Two naturally occurring variants of the serotonin receptor gene HTR3C are associated with nausea in pregnancy. (2010) | Goecke TW | Acta Obstet Gynecol Scand |
| 22933845 | Polymorphisms of the serotonin transporter and receptor genes: susceptibility to substance abuse. (2012 Jun) | Herman AI | Subst Abuse Rehabil |
| 26227246 | Susceptibility loci for heroin and cocaine addiction in the serotonergic and adrenergic pathways in populations of different ancestry. (2015) | Levran O | Pharmacogenomics |
| 22048466 | Smoking cessation pharmacogenetics: analysis of varenicline and bupropion in placebo-controlled clinical trials. (2012 Feb) | King DP | Neuropsychopharmacology |
| 25655461 | Clinically relevant genetic biomarkers from the brain in alcoholism with representation on high resolution chromosome ideograms. (2015 Apr 15) | Manzardo AM | Gene |
| 23290502 | Serotonin transporter and receptor genes significantly impact nicotine dependence through genetic interactions in both European American and African American smokers. (2013 May 1) | Yang Z | Drug Alcohol Depend |
| 23897038 | Determination of genotype combinations that can predict the outcome of the treatment of alcohol dependence using the 5-HT(3) antagonist ondansetron. (2013 Sep) | Johnson BA | Am J Psychiatry |
| 23757001 | Association, interaction, and replication analysis of genes encoding serotonin transporter and 5-HT3 receptor subunits A and B in alcohol dependence. (2013 Oct) | Seneviratne C | Hum Genet |
| 25161819 | Genetic, psychosocial, and demographic factors associated with social disinhibition in Mexican-origin youth. (2014 Jul) | Archer NP | Brain Behav |