Gene: REPS2

9185
POB1
RALBP1 associated Eps domain containing 2
protein-coding
Xp22.2
Ensembl:ENSG00000169891 MIM:300317 Vega:OTTHUMG00000021199 UniprotKB:Q8NFH8
NG_012557.1
SNP Mapped
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
NA (AD)  NA (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs7058279chrX:17062593 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
DYNC1I10.974
PPM1H0.971
FAXC0.971
HSPA12A0.969
PPP3CB0.968
MAPK90.967
KRT2220.966
CREG20.966
CLCN40.966
NMNAT20.966

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RNF135-0.587
CSAG1-0.57
RAB13-0.562
TGIF1-0.552
CHST14-0.552
FLT3LG-0.54
SYDE1-0.539
EMP3-0.536
MYL3-0.535
SLC43A3-0.533

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of REPS2 mRNA"28903501
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of REPS2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of REPS2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of REPS2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of REPS2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of REPS2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of REPS2 mRNA"27188386
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of REPS2 mRNA22100608|2715375
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of REPS2 gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of REPS2 mRNA19770486
C068073Am 580Am 580 results in decreased expression of REPS2 mRNA16982809
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of REPS2 mRNA24449571
C547126AZM551248AZM551248 results in increased expression of REPS2 mRNA22323515
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of REPS2 mRNA20064835|2180250
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of REPS2 mRNA19770486
C006780bisphenol Abisphenol A results in increased expression of REPS2 mRNA27685785
C006780bisphenol Abisphenol A results in decreased methylation of REPS2 promoter27312807
C006780bisphenol Abisphenol A results in decreased expression of REPS2 mRNA25181051
D0151248-Bromo Cyclic Adenosine Monophosphate8-Bromo Cyclic Adenosine Monophosphate results in increased expression of REPS2 mRNA22079614
D020245p-Chloromercuribenzoic Acid"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of REPS2 mRNA"27188386
D020245p-Chloromercuribenzoic Acidp-Chloromercuribenzoic Acid results in decreased expression of REPS2 mRNA26272509
C015835dimethyl-4-toluidinedimethyl-4-toluidine results in increased expression of REPS2 mRNA27638505
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of REPS2 mRNA26865667
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of REPS2 mRNA23649840
D005557FormaldehydeFormaldehyde results in decreased expression of REPS2 mRNA23649840
D019833GenisteinGenistein affects the expression of REPS2 mRNA26865667
D017313FenretinideFenretinide results in decreased expression of REPS2 mRNA28973697
D017313FenretinideFenretinide results in increased expression of REPS2 mRNA28973697
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of REPS2 mRNA"27188386
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of REPS2 mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of REPS2 mRNA23649840
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of REPS2 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of REPS2 mRNA"25554681
D009532NickelNickel results in decreased expression of REPS2 mRNA24768652|2558310
C029938nickel sulfatenickel sulfate results in increased expression of REPS2 mRNA22714537
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of REPS2 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of REPS2 mRNA26272509
D011374ProgesteroneProgesterone results in increased expression of REPS2 mRNA23012394
C089730rosiglitazonerosiglitazone results in decreased expression of REPS2 mRNA16982809
D012822Silicon DioxideSilicon Dioxide analog affects the expression of REPS2 mRNA25895662
C017947sodium arsenitesodium arsenite results in increased expression of REPS2 mRNA22714537
C020806tetrabromobisphenol Atetrabromobisphenol A results in increased expression of REPS2 mRNA25172293
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of REPS2 mRNA21802500
D014520UrethaneUrethane results in increased expression of REPS2 mRNA28818685
D014635Valproic AcidValproic Acid results in increased expression of REPS2 mRNA28001369
D014635Valproic AcidValproic Acid results in increased methylation of REPS2 gene29154799
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of REPS2 gene25560391
C029297vinylidene chloridevinylidene chloride results in decreased expression of REPS2 mRNA26682919
C088658zoledronic acidzoledronic acid results in increased expression of REPS2 mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005509calcium ion binding-IEA-  
GO:0005515protein binding-IPI9422736  10557078  18154663  
GO ID GO Term Qualifier Evidence PubMed
GO:0007173epidermal growth factor receptor signaling pathway-TAS9422736  
GO:0061024membrane organization-TAS-  
GO:0065003protein-containing complex assembly-TAS9422736  
GO ID GO Term Qualifier Evidence PubMed
GO:0005829cytosol-TAS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-199991Membrane TraffickingTAS
R-HSA-5653656Vesicle-mediated transportTAS
R-HSA-8856825Cargo recognition for clathrin-mediated endocytosisTAS
R-HSA-8856828Clathrin-mediated endocytosisTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal