Gene: MARVELD3

91862
MARVD3|MRVLDC3
MARVEL domain containing 3
protein-coding
16q22.2
Ensembl:ENSG00000140832 MIM:614094 Vega:OTTHUMG00000137591 UniprotKB:Q96A59
NC_000016.10
PubMed
0   ANCO-SNPs
ND
1   
5.826e-1 (AD)  1.780e-1 (ND)   (Frontal_Cortex)
6.097e-1 (AD)  8.297e-2 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HIST2H2AB0.66
HIST1H2AH0.659
SSUH20.612
TFAP2B0.598
MRGPRF0.591
ROR10.58
MYOCD0.577
ART40.572
NR2F2-AS10.57
ALX40.568

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TEX38-0.277
CRYBA2-0.261
EFHB-0.257
PAH-0.255
PRSS27-0.204
PLA2G5-0.202
ENDOU-0.2
CLDND2-0.198
C9orf24-0.196
DYNLRB2-0.193

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MARVELD3 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MARVELD3 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MARVELD3 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MARVELD3 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MARVELD3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MARVELD3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MARVELD3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MARVELD3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MARVELD3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MARVELD3 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of MARVELD3 mRNA29067470
D000082AcetaminophenAcetaminophen affects the expression of MARVELD3 mRNA17562736
D020106AcrylamideAcrylamide results in decreased expression of MARVELD3 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of MARVELD3 gene27153756
D001151ArsenicArsenic affects the methylation of MARVELD3 gene25304211
C030935benz(a)anthracene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of MARVELD3 mRNA27858113
C006703benzo(b)fluoranthene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of MARVELD3 mRNA27858113
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of MARVELD3 mRNA26238291
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of MARVELD3 mRNA27858113
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of MARVELD3 mRNA19770486
C006780bisphenol Abisphenol A results in decreased expression of MARVELD3 mRNA26063408
C006780bisphenol Abisphenol A results in decreased expression of MARVELD3 mRNA25181051
D019256Cadmium ChlorideCadmium Chloride results in increased expression of MARVELD3 mRNA26472689
D002220CarbamazepineCarbamazepine affects the expression of MARVELD3 mRNA25979313
D020245p-Chloromercuribenzoic Acid"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MARVELD3 mRNA"27188386
D020245p-Chloromercuribenzoic Acidp-Chloromercuribenzoic Acid results in increased expression of MARVELD3 mRNA26272509
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of MARVELD3 mRNA20938992
C031180chrysene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of MARVELD3 mRNA27858113
D019327Copper SulfateCopper Sulfate results in decreased expression of MARVELD3 mRNA19549813
D003999Dichloroacetic AcidDichloroacetic Acid results in increased expression of MARVELD3 mRNA28962523
D002945CisplatinCisplatin results in increased expression of MARVELD3 mRNA27392435
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Phenobarbital] results in decreased expression of MARVELD3 mRNA24535843
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of MARVELD3 mRNA24535843
C118739entinostatentinostat results in increased expression of MARVELD3 mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MARVELD3 mRNA"27188386
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of MARVELD3 mRNA20938992
D017313FenretinideFenretinide results in increased expression of MARVELD3 mRNA28973697
C045463leflunomideleflunomide results in decreased expression of MARVELD3 mRNA28988120
C042720mercuric bromidemercuric bromide results in increased expression of MARVELD3 mRNA26272509
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MARVELD3 mRNA"27188386
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of MARVELD3 mRNA20938992
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of MARVELD3 mRNA"25554681
D010634Phenobarbital[Diethylnitrosamine co-treated with Phenobarbital] results in decreased expression of MARVELD3 mRNA24535843
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MARVELD3 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of MARVELD3 mRNA26272509
C006253pirinixic acidpirinixic acid results in increased expression of MARVELD3 mRNA18301758|2081375
D010936Plant ExtractsPlant Extracts results in decreased expression of MARVELD3 mRNA23557933
D011192Potassium DichromatePotassium Dichromate results in decreased expression of MARVELD3 mRNA23608068
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of MARVELD3 mRNA25895662
D013629TamoxifenTamoxifen results in increased expression of MARVELD3 mRNA25123088
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of MARVELD3 mRNA26377647
D014212TretinoinTretinoin results in increased expression of MARVELD3 mRNA21934132
D014241TrichloroethyleneTrichloroethylene results in increased expression of MARVELD3 mRNA25549359
C012589trichostatin Atrichostatin A results in increased expression of MARVELD3 mRNA24935251
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of MARVELD3 mRNA"26179874
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MARVELD3 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of MARVELD3 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of MARVELD3 mRNA29154799
D014635Valproic AcidValproic Acid results in increased expression of MARVELD3 mRNA23179753|2627250
D014635Valproic AcidValproic Acid results in increased methylation of MARVELD3 gene29154799
D001335Vehicle EmissionsVehicle Emissions affects the methylation of MARVELD3 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI20164257  
GO:0031435mitogen-activated protein kinase kinase kinase binding-IDA24567356  
GO ID GO Term Qualifier Evidence PubMed
GO:0006970response to osmotic stress-IMP24567356  
GO:0010633negative regulation of epithelial cell migration-IMP24567356  
GO:0045216cell-cell junction organization-IMP20164257  
GO:0046329negative regulation of JNK cascade-IMP24567356  
GO:0050680negative regulation of epithelial cell proliferation-IMP24567356  
GO:0070830bicellular tight junction assembly-IMP20164257  
GO:1902414protein localization to cell junction-IMP24567356  
GO ID GO Term Qualifier Evidence PubMed
GO:0005923bicellular tight junction-IDA20028514  20164257  
GO:0016021integral component of membrane-IEA-  
GO:0031410cytoplasmic vesicle-IDA20164257  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24398667Genome-wide unmasking of epigenetically silenced genes in lung adenocarcinoma from smokers and never smokers. (2014 Jun)Tessema MCarcinogenesis