Gene: SLC16A7

9194
MCT2
solute carrier family 16 member 7
protein-coding
12q14.1
Ensembl:ENSG00000118596 MIM:603654 Vega:OTTHUMG00000169923 UniprotKB:O60669
NC_000012.12
PubMed
0   ANCO-SNPs
AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.112e-1 (AD)  3.205e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
KITLG0.735
KCNH50.727
KCNA30.717
SYT160.707
STXBP50.707
CNTNAP50.698
HDAC90.696
GULP10.695
ANKRD500.688
CNTN50.688

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
FXYD3-0.439
STON2-0.434
ROM1-0.432
KIF19-0.426
S100A1-0.425
CYP2J2-0.424
ZHX2-0.418
IMPA2-0.417
DLL1-0.412
TMEM176A-0.412

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00119Pyruvic acidSmall Molecule127-17-3Approved|Investigational|NutraceuticalTransporter
DB01032ProbenecidSmall Molecule57-66-9Approved|InvestigationalTransporter
DB01440Gamma Hydroxybutyric AcidSmall Molecule591-81-1Approved|Illicit|InvestigationalTransporter
DB01762Acetoacetic AcidSmall Molecule541-50-4ExperimentalTransporter
DB03066D-Lactic acidSmall Molecule10326-41-7ExperimentalTransporter
DB03773alpha-D-quinovopyranoseSmall Molecule7658-08-4ExperimentalTransporter
DB04074Alpha-ketoisovalerateSmall Molecule759-05-7ExperimentalTransporter
DB04216QuercetinSmall Molecule117-39-5Experimental|InvestigationalTransporter
DB04398Lactic AcidSmall Molecule50-21-5ApprovedTransporter
DB04552Niflumic AcidSmall Molecule4394-00-7ApprovedTransporter
DB00119Pyruvic acidSmall Molecule127-17-3Approved|Investigational|NutraceuticalTarget
ID Drug Name Action PubMed
C0264861,2,5,6-dibenzanthracene"1,2,5,6-dibenzanthracene results in increased expression of SLC16A7 mRNA"26377693
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of SLC16A7 mRNA"25510870
C0142112,3,7,8-tetrachlorodibenzofuran"2,3,7,8-tetrachlorodibenzofuran affects the expression of SLC16A7 mRNA"20702594
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of SLC16A7 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of SLC16A7 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of SLC16A7 mRNA"25510870
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of SLC16A7 mRNA"21346803
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of SLC16A7 mRNA"25510870
C4879483-iodothyronamineSLC16A7 mRNA affects the uptake of 3-iodothyronamine19074582
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SLC16A7 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLC16A7 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLC16A7 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLC16A7 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SLC16A7 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLC16A7 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLC16A7 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLC16A7 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of SLC16A7 mRNA21420995|2906747
D000082AcetaminophenAcetaminophen results in increased expression of SLC16A7 mRNA26690555
D000082AcetaminophenAcetaminophen affects the expression of SLC16A7 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of SLC16A7 mRNA19770486
D000393Air PollutantsAir Pollutants analog results in decreased expression of SLC16A7 mRNA21757418
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in decreased expression of SLC16A7 mRNA28522335
D000638AmiodaroneAmiodarone results in increased expression of SLC16A7 mRNA24535564
D000643Ammonium ChlorideAmmonium Chloride affects the expression of SLC16A7 mRNA16483693
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of SLC16A7 mRNA"20018196
D004958Estradiol[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of SLC16A7 mRNA19619570
D004958EstradiolEstradiol results in increased expression of SLC16A7 mRNA19619570
D004958Estradiol[bisphenol A co-treated with Estradiol] results in decreased expression of SLC16A7 mRNA26496021
C006780bisphenol Abisphenol A affects the expression of SLC16A7 mRNA21786754
C006780bisphenol Abisphenol A results in decreased methylation of SLC16A7 promoter27312807
C006780bisphenol A[bisphenol A co-treated with Estradiol] results in decreased expression of SLC16A7 mRNA26496021
C006780bisphenol Abisphenol A results in decreased expression of SLC16A7 mRNA25181051
C006780bisphenol Abisphenol A results in increased expression of SLC16A7 mRNA29097150
C006780bisphenol Abisphenol A results in increased methylation of SLC16A7 gene28505145
D020245p-Chloromercuribenzoic Acid"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SLC16A7 mRNA"27188386
D020245p-Chloromercuribenzoic Acidp-Chloromercuribenzoic Acid results in decreased expression of SLC16A7 mRNA26272509
D002922CiguatoxinsCiguatoxins affects the expression of SLC16A7 mRNA18353800
D019327Copper SulfateCopper Sulfate results in decreased expression of SLC16A7 mRNA19549813
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of SLC16A7 mRNA27392435
D002945CisplatinCisplatin results in decreased expression of SLC16A7 mRNA27392435
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of SLC16A7 mRNA26924002
D004026DieldrinDieldrin results in decreased expression of SLC16A7 mRNA23153324
D004041Dietary FatsDietary Fats results in decreased expression of SLC16A7 mRNA25016146
C024629dimethyl phthalatedimethyl phthalate results in increased expression of SLC16A7 mRNA26924002
C074283estradiol 3-benzoateestradiol 3-benzoate results in increased methylation of SLC16A7 promoter27415467
D000431EthanolEthanol results in increased expression of SLC16A7 mRNA19167417
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of SLC16A7 mRNA29097150
D018120FinasterideFinasteride results in increased expression of SLC16A7 mRNA24136188
D005419FlavonoidsFlavonoids results in decreased expression of SLC16A7 mRNA18035473
D005485FlutamideFlutamide results in decreased expression of SLC16A7 mRNA24793618
D005485FlutamideFlutamide results in increased expression of SLC16A7 mRNA24136188
D005557FormaldehydeFormaldehyde results in decreased expression of SLC16A7 mRNA27664576
C001277geldanamycingeldanamycin results in increased expression of SLC16A7 mRNA26705709
D005897GlafenineGlafenine results in decreased expression of SLC16A7 mRNA24136188
D006533HeptachlorHeptachlor results in decreased expression of SLC16A7 mRNA23153324
D017313FenretinideFenretinide results in decreased expression of SLC16A7 mRNA28973697
D006861Hydrogen PeroxideSLC16A7 protein results in decreased susceptibility to Hydrogen Peroxide16766717
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of SLC16A7 mRNA27392435
C544151jinfukangjinfukang results in decreased expression of SLC16A7 mRNA27392435
C098607JP8 aviation fuelJP8 aviation fuel results in increased expression of SLC16A7 protein17337753
C028521lanthanum chloridelanthanum chloride results in decreased expression of SLC16A7 mRNA29264619
C028521lanthanum chloridelanthanum chloride results in decreased expression of SLC16A7 protein29264619
C045463leflunomideleflunomide results in increased expression of SLC16A7 mRNA24136188
C008493methylselenic acidmethylselenic acid results in increased expression of SLC16A7 mRNA18548127
D008917MirexMirex results in decreased expression of SLC16A7 mRNA23153324
C517284monomethyl phthalatemonomethyl phthalate affects the expression of SLC16A7 mRNA26924002
D009151Mustard GasMustard Gas affects the expression of SLC16A7 mRNA15651846
C051752nefazodonenefazodone results in increased expression of SLC16A7 mRNA24136188
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of SLC16A7 mRNA"25510870
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in increased expression of SLC16A7 mRNA26705709
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in increased expression of SLC16A7 mRNA]19482888
D010634PhenobarbitalPhenobarbital results in increased expression of SLC16A7 mRNA19270015|1948288
D010656PhenylephrinePhenylephrine results in decreased expression of SLC16A7 mRNA18158353
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLC16A7 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of SLC16A7 mRNA26272509
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of SLC16A7 mRNA19710929
C006253pirinixic acidpirinixic acid results in increased expression of SLC16A7 mRNA18301758|2005976
C006253pirinixic acidPPARA protein promotes the reaction [pirinixic acid results in increased expression of SLC16A7 mRNA]20059764
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of SLC16A7 mRNA19162173
D011374ProgesteroneProgesterone results in decreased expression of SLC16A7 mRNA21795739
D015474IsotretinoinIsotretinoin results in decreased expression of SLC16A7 mRNA20436886
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of SLC16A7 mRNA25895662
D012822Silicon DioxideSilicon Dioxide results in decreased expression of SLC16A7 mRNA22300531|2535159
D012822Silicon DioxideSilicon Dioxide results in decreased expression of SLC16A7 mRNA19073995
D012906SmokeSmoke results in decreased expression of SLC16A7 mRNA21095227
C061133tamibarotenetamibarotene affects the expression of SLC16A7 mRNA15498508
C004648testosterone enanthatetestosterone enanthate affects the expression of SLC16A7 mRNA17440010
D013749Tetrachlorodibenzodioxin[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of SLC16A7 mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SLC16A7 mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of SLC16A7 mRNA19619570|2010694
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SLC16A7 mRNA20702594|2821309
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to SLC16A7 gene]28213091
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of SLC16A7 mRNA28922406
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of SLC16A7 mRNA21215274
D013750TetrachloroethyleneTetrachloroethylene results in increased expression of SLC16A7 mRNA28973375
D013752TetracyclineTetracycline results in decreased expression of SLC16A7 mRNA24489787
C009495titanium dioxidetitanium dioxide results in decreased expression of SLC16A7 mRNA23557971
D014212TretinoinTretinoin affects the expression of SLC16A7 mRNA15498508
D014212TretinoinTretinoin results in increased expression of SLC16A7 mRNA21934132
D014241TrichloroethyleneTrichloroethylene results in increased expression of SLC16A7 mRNA19448997
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLC16A7 mRNA"27188386
C012589trichostatin Atrichostatin A results in increased expression of SLC16A7 mRNA24935251|2627250
C406224valdecoxibvaldecoxib results in increased expression of SLC16A7 mRNA24136188
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLC16A7 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of SLC16A7 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased methylation of SLC16A7 gene29154799
D014635Valproic AcidValproic Acid results in increased expression of SLC16A7 mRNA23179753|2438349
D014635Valproic AcidValproic Acid results in increased expression of SLC16A7 mRNA24535564
D014640VancomycinVancomycin results in increased expression of SLC16A7 mRNA18930951
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of SLC16A7 gene25560391
C025643vinclozolinvinclozolin results in increased expression of SLC16A7 mRNA23034163
C029297vinylidene chloridevinylidene chloride results in decreased expression of SLC16A7 mRNA26682919

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005215transporter activity-IBA21873635  
GO:0005477pyruvate secondary active transmembrane transporter activity-TAS9786900  
GO:0008028monocarboxylic acid transmembrane transporter activity-IBA21873635  
GO:0008028monocarboxylic acid transmembrane transporter activity-TAS-  
GO:0015129lactate transmembrane transporter activity-IDA9786900  
GO:0015293symporter activity-IEA-  
GO:0050833pyruvate transmembrane transporter activity-IDA9786900  
GO ID GO Term Qualifier Evidence PubMed
GO:0015718monocarboxylic acid transport-IBA21873635  
GO:0035873lactate transmembrane transport-IMP9786900  
GO:1901475pyruvate transmembrane transport-IDA9786900  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-IBA21873635  
GO:0005887integral component of plasma membrane-IDA15505343  
GO:0016021integral component of membrane-IBA21873635  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-382551Transport of small moleculesTAS
R-HSA-425366Transport of bile salts and organic acids, metal ions and amine compoundsTAS
R-HSA-425407SLC-mediated transmembrane transportTAS
R-HSA-433692Proton-coupled monocarboxylate transportTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
20589092Ethanol and phencyclidine interact with respect to nucleus accumbens dopamine release: differential effects of administration order and pretreatment protocol. (2010)Pickering CFront Behav Neurosci