Gene: CD4

920
CD4mut
CD4 molecule
protein-coding
12p13.31
Ensembl:ENSG00000010610 MIM:186940 Vega:OTTHUMG00000168514 UniprotKB:P01730
NG_027688.1
PubMed
CD|OD|ND|AD
737   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.241e-1 (AD)  2.330e-3 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CXCL160.817
ADAP20.806
MYO1F0.805
TMEM1190.803
TBXAS10.802
C3AR10.801
LAPTM50.797
CD370.797
SYK0.796
ITGAM0.794

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
KCNB2-0.493
CALHM1-0.482
HAS1-0.468
DLK2-0.466
TMEFF2-0.466
ATOH7-0.462
TENM3-0.46
DRD5-0.459
B3GALT2-0.455
BCL11A-0.453

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00098Antithymocyte immunoglobulin (rabbit)BiotechDrugApprovedTarget
DB06241ClenoliximabBiotechDrugInvestigationalTarget
DB12698IbalizumabBiotechDrug680188-33-4Approved|InvestigationalTarget
ID Drug Name Action PubMed
D000082Acetaminophen[Clofibrate co-treated with Acetaminophen] affects the expression of CD4 mRNA17585979
D000082AcetaminophenPPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of CD4 mRNA]17585979
D000276Adjuvants, Immunologic"CD4 protein affects the susceptibility to Adjuvants, Immunologic"11160013
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of CD4 gene27153756
D000536Aluminum HydroxideCD4 protein affects the susceptibility to Aluminum Hydroxide11160013
D0150812-Naphthylamine2-Naphthylamine results in increased expression of CD4 mRNA18247414
D000643Ammonium ChlorideAmmonium Chloride affects the expression of CD4 mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of CD4 mRNA24449571
D001194AsbestosAsbestos results in decreased expression of CD4 mRNA22398240
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of CD4 mRNA18247414
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of CD4 mRNA21569818
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of CD4 mRNA20504355
C033363beta-1,3-glucan"beta-1,3-glucan results in increased expression of CD4 protein"17690738
C033363beta-1,3-glucan"[resveratrol co-treated with beta-1,3-glucan] results in increased expression of CD4 protein"17690738
C006780bisphenol Abisphenol A affects the expression of CD4 mRNA21786754
C006780bisphenol Abisphenol A affects the expression of CD4 mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of CD4 mRNA25181051
D019256Cadmium ChlorideCadmium Chloride results in increased expression of CD4 mRNA12160620
C040048caffeic acid[resveratrol co-treated with Catechin co-treated with caffeic acid] results in decreased expression of CD4 mRNA16806235
D002392Catechin[resveratrol co-treated with Catechin co-treated with caffeic acid] results in decreased expression of CD4 mRNA16806235
D002713ChlorineChlorine results in decreased expression of CD4 mRNA18636392
D002713Chlorine[Ozone co-treated with Chlorine] affects the expression of CD4 mRNA18636392
D002994Clofibrate[Clofibrate co-treated with Acetaminophen] affects the expression of CD4 mRNA17585979
D002994ClofibratePPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of CD4 mRNA]17585979
D003042Cocaine[Cocaine co-treated with FOS protein mutant form] results in decreased expression of CD4 mRNA18355967
D003471CuprizoneCuprizone results in increased expression of CD4 mRNA27523638
D003520CyclophosphamideCyclophosphamide results in decreased expression of CD4 mRNA21041162
D016572CyclosporineCyclosporine results in increased methylation of CD4 promoter27989131
C014347decitabinedecitabine results in increased expression of CD4 mRNA19194470
D003907DexamethasoneDexamethasone results in decreased expression of CD4 protein11408767|2036325
D003907DexamethasoneMifepristone inhibits the reaction [Dexamethasone results in decreased expression of CD4 protein]20363256
D003907DexamethasoneDexamethasone results in decreased expression of CD4 mRNA21041162
D003999Dichloroacetic AcidDichloroacetic Acid results in decreased expression of CD4 mRNA28962523
D002945CisplatinCD4 mutant form inhibits the reaction [[Cisplatin co-treated with IL33] results in increased expression of CXCL1]21949094
C023635dienogest[Ethinyl Estradiol co-treated with dienogest] results in decreased expression of CD4 protein10813102
D004041Dietary FatsDietary Fats results in increased expression of CD4 mRNA25016146
D004041Dietary FatsDietary Fats results in increased expression of CD4 mRNA22010203
D004041Dietary FatsTestosterone inhibits the reaction [Dietary Fats results in increased expression of CD4 mRNA]22010203
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Thioacetamide] results in increased expression of CD4 mRNA23830814
D004054DiethylstilbestrolDiethylstilbestrol results in decreased expression of CD4 mRNA21041162
D004997Ethinyl Estradiol[Ethinyl Estradiol co-treated with dienogest] results in decreased expression of CD4 protein10813102
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CD4 mRNA17942748
C442659ethinyl estradiol-desogestrel combinationethinyl estradiol-desogestrel combination results in increased expression of CD4 protein10813102
C004912ethylbenzeneethylbenzene results in increased expression of CD4 mRNA20955722
D005038EthylnitrosoureaEthylnitrosourea results in increased mutagenesis of CD4 intron27776689
D005839GentamicinsGentamicins results in increased expression of CD4 mRNA22061828
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of CD4 mRNA23086925|2675264
D008727MethotrexateMethotrexate results in decreased expression of CD4 protein15476228
D008752Methylene ChlorideMethylene Chloride results in increased expression of CD4 mRNA20955722
D015735MifepristoneMifepristone inhibits the reaction [Dexamethasone results in decreased expression of CD4 protein]20363256
D015735MifepristoneMifepristone inhibits the reaction [rimexolone results in decreased expression of CD4 protein]20363256
D015735MifepristoneMifepristone results in decreased expression of CD4 protein20363256
D009151Mustard GasMustard Gas results in increased expression of CD4 mRNA15674843
C517552N-(6-methylamino-3-nitrophenyl)-3-(3-indolyl)acrylamideN-(6-methylamino-3-nitrophenyl)-3-(3-indolyl)acrylamide binds to CD4 protein16787663
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of CD4 mRNA"25620056
D009532NickelNickel results in increased expression of CD4 mRNA24768652|2558310
D009538NicotineNicotine results in decreased expression of CD4 mRNA18247414
D010126Ozone[Ozone co-treated with Chlorine] affects the expression of CD4 mRNA18636392
D052638Particulate MatterParticulate Matter results in decreased expression of CD4 mRNA27832168
D052638Particulate MatterParticulate Matter results in increased expression of CD4 mRNA23638009
C043680ptaquilosideptaquiloside results in decreased expression of CD4 mRNA23274088
C059514resveratrol"[resveratrol co-treated with beta-1,3-glucan] results in increased expression of CD4 protein"17690738
C059514resveratrol[resveratrol co-treated with Catechin co-treated with caffeic acid] results in decreased expression of CD4 mRNA16806235
C059514resveratrolresveratrol inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of CD4 protein]20715097
C059514resveratrolresveratrol results in increased expression of CD4 protein17690738
C013769rimexoloneMifepristone inhibits the reaction [rimexolone results in decreased expression of CD4 protein]20363256
C013769rimexolonerimexolone results in decreased expression of CD4 protein20363256
C017947sodium arsenitesodium arsenite results in decreased expression of CD4 mRNA17879257
C017947sodium arsenitesodium arsenite results in decreased expression of CD4 protein16275621
C025462sulindac sulfidesulindac sulfide results in increased expression of CD4 mRNA12734198
D013739TestosteroneTestosterone inhibits the reaction [Dietary Fats results in increased expression of CD4 mRNA]22010203
D013749Tetrachlorodibenzodioxinresveratrol inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of CD4 protein]20715097
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CD4 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CD4 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of CD4 mRNA28922406
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of CD4 protein14718643|1597263
D013750TetrachloroethyleneTetrachloroethylene results in decreased expression of CD4 mRNA28973375
D013755Tetradecanoylphorbol Acetate[Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of CD4 mRNA16979875
D013806TheophyllineTheophylline results in decreased expression of CD4 protein11408767
D013853Thioacetamide[Diethylnitrosamine co-treated with Thioacetamide] results in increased expression of CD4 mRNA23830814
D014051Toluene 2,4-Diisocyanate"CD4 protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of IFNG mRNA]"15590890
D014051Toluene 2,4-Diisocyanate"CD4 protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL13 mRNA]"15590890
D014051Toluene 2,4-Diisocyanate"CD4 protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL4 mRNA]"15590890
D014051Toluene 2,4-Diisocyanate"CD4 protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL5 mRNA]"15590890
D014212TretinoinTretinoin results in increased expression of CD4 protein17361223
D014241TrichloroethyleneTrichloroethylene results in increased expression of CD4 mRNA20955722
D014241TrichloroethyleneTrichloroethylene results in increased methylation of CD4 gene27618143
D001335Vehicle EmissionsVehicle Emissions results in decreased expression of CD4 mRNA27832168
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of CD4 gene25560391
C025643vinclozolinvinclozolin results in increased expression of CD4 mRNA23034163
D015032Zinc[Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of CD4 mRNA16979875
D015032ZincZinc deficiency results in increased expression of CD4 mRNA11717422

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0001618virus receptor activity-IEA-  
GO:0004888transmembrane signaling receptor activity-TAS10358157  
GO:0005201extracellular matrix structural constituent-NAS12444132  
GO:0005515protein binding-IPI7831289  8246987  9168119  10816381  10922058  11113139  
11264384  15660419  16888650  17005671  17301785  19333378  
20080564  20357769  23890821  26098315  
GO:0008270zinc ion binding-IDA9668045  
GO:0015026coreceptor activity-NAS8512039  
GO:0019865immunoglobulin binding-IEA-  
GO:0019899enzyme binding-IPI19333378  
GO:0019901protein kinase binding-IPI7486703  
GO:0038023signaling receptor activity-TAS10413516  
GO:0042011interleukin-16 binding-IPI24942581  
GO:0042012interleukin-16 receptor activity-IDA24942581  
GO:0042289MHC class II protein binding-IDA2823150  11535811  
GO:0042289MHC class II protein binding-IPI24942581  
GO:0042289MHC class II protein binding-NAS8512039  
GO:0042802identical protein binding-IPI9168119  
GO:0042803protein homodimerization activity-IDA9168119  12444132  
GO:1990782protein tyrosine kinase binding-IPI3262426  
GO ID GO Term Qualifier Evidence PubMed
GO:0001816cytokine production-IEA-  
GO:0001934positive regulation of protein phosphorylation-IDA24942581  
GO:0002250adaptive immune response-IEA-  
GO:0006948induction by virus of host cell-cell fusion-IDA9166430  
GO:0006955immune response-NAS8512039  
GO:0007155cell adhesion-IEA-  
GO:0007165signal transduction-TAS9558100  10358157  
GO:0007166cell surface receptor signaling pathway-TAS9780207  
GO:0007167enzyme linked receptor protein signaling pathway-TAS10358157  
GO:0007169transmembrane receptor protein tyrosine kinase signaling pathway-NAS8512039  
GO:0010524positive regulation of calcium ion transport into cytosol-IEA-  
GO:0019064fusion of virus membrane with host plasma membrane-TAS-  
GO:0019221cytokine-mediated signaling pathway-TAS-  
GO:0030217T cell differentiation-IDA1533274  
GO:0030260entry into host cell-TAS-  
GO:0032355response to estradiol-IEA-  
GO:0032507maintenance of protein location in cell-IDA15128768  
GO:0033280response to vitamin D-IEA-  
GO:0033674positive regulation of kinase activity-IDA24942581  
GO:0035397helper T cell enhancement of adaptive immune response-IEA-  
GO:0035723interleukin-15-mediated signaling pathway-IDA24942581  
GO:0042102positive regulation of T cell proliferation-IEA-  
GO:0043123positive regulation of I-kappaB kinase/NF-kappaB signaling-IDA24942581  
GO:0043410positive regulation of MAPK cascade-IDA24942581  
GO:0045058T cell selection-IDA9551897  
GO:0045086positive regulation of interleukin-2 biosynthetic process-NAS1901411  
GO:0045657positive regulation of monocyte differentiation-IDA24942581  
GO:0045860positive regulation of protein kinase activity-IDA2118992  
GO:0045893positive regulation of transcription, DNA-templated-IDA24942581  
GO:0046598positive regulation of viral entry into host cell-IDA24942581  
GO:0050690regulation of defense response to virus by virus-TAS-  
GO:0050731positive regulation of peptidyl-tyrosine phosphorylation-IEA-  
GO:0050829defense response to Gram-negative bacterium-IEA-  
GO:0050850positive regulation of calcium-mediated signaling-IEA-  
GO:0050852T cell receptor signaling pathway-TAS-  
GO:0050863regulation of T cell activation-IDA1533274  
GO:0051924regulation of calcium ion transport-IDA24942581  
GO:0061024membrane organization-TAS-  
GO:0070374positive regulation of ERK1 and ERK2 cascade-IDA24942581  
GO:0097011cellular response to granulocyte macrophage colony-stimulating factor stimulus-IDA24942581  
GO ID GO Term Qualifier Evidence PubMed
GO:0005769early endosome-TAS-  
GO:0005788endoplasmic reticulum lumen-IEA-  
GO:0005789endoplasmic reticulum membrane-TAS-  
GO:0005886plasma membrane-IDA2823150  8124721  11390434  19333378  
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-IDA24942581  
GO:0009897external side of plasma membrane-IDA17213291  
GO:0030665clathrin-coated vesicle membrane-TAS-  
GO:0042101T cell receptor complex-NAS8512039  
GO:0045121membrane raft-IDA9168119  
KEGG ID KEGG Term
hsa04514Cell adhesion molecules (CAMs)
hsa04612Antigen processing and presentation
hsa04640Hematopoietic cell lineage
hsa04660T cell receptor signaling pathway
hsa05340Primary immunodeficiency
Reactome ID Reactome Term Evidence
R-HSA-1280215Cytokine Signaling in Immune systemTAS
R-HSA-1280218Adaptive Immune SystemTAS
R-HSA-1461973DefensinsTAS
R-HSA-1462054Alpha-defensinsTAS
R-HSA-162587HIV Life CycleTAS
R-HSA-162594Early Phase of HIV Life CycleTAS
R-HSA-162906HIV InfectionTAS
R-HSA-162909Host Interactions of HIV factorsTAS
R-HSA-1643685DiseaseTAS
R-HSA-164938Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adaptersTAS
R-HSA-164952The role of Nef in HIV-1 replication and disease pathogenesisTAS
R-HSA-167590Nef Mediated CD4 Down-regulationTAS
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-173107Binding and entry of HIV virionTAS
R-HSA-180534Vpu mediated degradation of CD4TAS
R-HSA-199991Membrane TraffickingTAS
R-HSA-202403TCR signalingTAS
R-HSA-202424Downstream TCR signalingTAS
R-HSA-202427Phosphorylation of CD3 and TCR zeta chainsTAS
R-HSA-202430Translocation of ZAP-70 to Immunological synapseTAS
R-HSA-202433Generation of second messenger moleculesTAS
R-HSA-388841Costimulation by the CD28 familyTAS
R-HSA-389948PD-1 signalingTAS
R-HSA-449147Signaling by InterleukinsTAS
R-HSA-449836Other interleukin signalingTAS
R-HSA-5653656Vesicle-mediated transportTAS
R-HSA-5663205Infectious diseaseTAS
R-HSA-6803157Antimicrobial peptidesTAS
R-HSA-8856825Cargo recognition for clathrin-mediated endocytosisTAS
R-HSA-8856828Clathrin-mediated endocytosisTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
7709007Alveolar lavage fluid (ALF) of normal volunteer subjects: cytologic, immunocytochemical, and biochemical reference values. (1995 Feb)Sutinen SRespir Med
26409740Comparison between potential risk factors for cardiovascular disease in people living with HIV/AIDS in areas of Brazil. (2015 Sep 27)Ximenes RAJ Infect Dev Ctries
17941917Effects of 4 months of smoking in mice with ovalbumin-induced airway inflammation. (2007 Dec)Melgert BNClin Exp Allergy
15599347Incidence of oral candidiasis and oral hairy leukoplakia in HIV-infected adults in North Carolina. (2005 Jan)Chattopadhyay AOral Surg Oral Med Oral Pathol Oral Radiol Endod
23286246Perturbation of cellular immune functions in cigarette smokers and protection by palm oil vitamin E supplementation. (2013 Jan 3)Jubri ZNutr J
17707063Telomere dysfunction in peripheral lymphocytes as a potential predisposition factor for renal cancer. (2007 Oct)Shao LJ Urol
25092442Is serum Interleukin-17 associated with early atherosclerosis in obese patients? (2014 Aug 6)Tarantino GJ Transl Med
11200748[Cytokines TNF-alpha and GM-CSF in BAL from two different segments of lungs defined by high resolution computerized tomography (HRCT) in patients with sarcoidosis]. (2000)Ziora DPneumonol Alergol Pol
22059107Fasting Triglyceride Concentrations are Associated with Early Mortality Following Antiretroviral Therapy in Zambia. (2010)Ngu JNN Am J Med Sci (Boston)
29649953Prevalence and variables associated with an abnormal ankle-brachial index among patients with human immunodeficiency virus/acquired immunodeficiency syndrome. (2018 Jan 1)Hinojosa CAVascular
19378224Influence of smoking cessation on airway T lymphocyte subsets in COPD. (2009 Apr)Roos-Engstrand ECOPD
18642789[Correlation between FoxP3(+) regulatory T cells and chronic obstructive pulmonary disease]. (2008 Feb 19)Xiong XZZhonghua Yi Xue Za Zhi
26495852T-Cell Responses Are Associated with Survival in Acute Melioidosis Patients. (2015 Oct)Jenjaroen KPLoS Negl Trop Dis
10366792An Italian national multicenter study for the definition of reference ranges for normal values of peripheral blood lymphocyte subsets in healthy adults. (1999 Jun)Santagostino AHaematologica
8586328[Characterization of bronchoalveolar space cells in pulmonary sarcoidosis]. (1994)Czarnobilska EFolia Med Cracov
25874992Cardiovascular risk factors and lifetime risk estimation in HIV-infected patients under antiretroviral treatment in Spain. (2015 Mar-Apr)Estrada VHIV Clin Trials
26200661Is Impact of Statin Therapy on All-Cause Mortality Different in HIV-Infected Individuals Compared to General Population? Results from the FHDH-ANRS CO4 Cohort. (2015)Lang SPLoS One
17641157Early interstitial lung disease in familial pulmonary fibrosis. (2007 Oct 1)Rosas IOAm J Respir Crit Care Med
18418794Cigarette smoking is an independent predictor of nonadherence in HIV-infected individuals receiving highly active antiretroviral therapy. (2008 Apr)Shuter JNicotine Tob Res
12759590[Bacterial pneumonia in HIV-infected patients] (1999)De Gaetano Donati KInfez Med
9330248Lymphocyte subsets in peripheral blood and smoking habits. (1997)Schaberg TLung
20303362Predictors of reported influenza vaccination in HIV-infected women in the United States, 2006-2007 and 2007-2008 seasons. (2010 May-Jun)Althoff KNPrev Med
28348007Genome-Wide Analysis of DNA Methylation and Acute Coronary Syndrome. (2017 May 26)Li JCirc Res
23994583Cell surface markers for T and B lymphocytes activation and adhesion as putative prognostic biomarkers for head and neck squamous cell carcinoma. (2013 Dec)Andrade MCHum Immunol
22459686Outcomes in HIV-infected patients admitted due to pandemic influenza. (2012 Dec)Lopez-Aldeguer JEnferm Infecc Microbiol Clin
21934446Genital warts and vulvar intraepithelial neoplasia: natural history and effects of treatment and human immunodeficiency virus infection. (2011 Oct)Massad LSObstet Gynecol
9583357Recent advances in clinical/molecular andrology. (1998 May-Jun)Hafez BArch Androl
28252529Immunodeficiency, AIDS-related pneumonia, and risk of lung cancer among HIV-infected individuals. (2017 Apr 24)Marcus JLAIDS
27902485Impacts of cigarette smoking on immune responsiveness: Up and down or upside down? (2017 Jan 3)Qiu FOncotarget
21910726Role of increased CD8/CD28(null) T cells and alternative co-stimulatory molecules in chronic obstructive pulmonary disease. (2011 Oct)Hodge GClin Exp Immunol
17305517Inflammatory cells and chronic obstructive pulmonary disease. (2005 Dec)Tetley TDCurr Drug Targets Inflamm Allergy
23056584Smoking, BCG and employment and the risk of tuberculosis infection in HIV-infected persons in South Africa. (2012)Oni TPLoS One
25879767Khat use in people living with HIV: a facility-based cross-sectional survey from South West Ethiopia. (2015 Apr 3)Soboka MBMC Psychiatry
11860554Th1/Th2 cytokine profiles in saliva of HIV-positive smokers with oropharyngeal candidiasis. (2002 Feb)Slavinsky J 3rdOral Microbiol Immunol
14563253[Basal immunological parameters in a group of retirees]. (2003 Sep)Lazaro del Nogal MRev Clin Esp
20646637[Interleukin-17 expression and significance in normal lung function smokers and chronic obstructive pulmonary disease patients]. (2010 May 25)Zhang JQZhonghua Yi Xue Za Zhi
24489575Persistence of Th17/Tc17 cell expression upon smoking cessation in mice with cigarette smoke-induced emphysema. (2013)Duan MCClin Dev Immunol
21879146[Infection due to Strongyloides stercoralis: epidemiological, clinical, diagnosis findings and outcome in 30 patients]. (2011 Jun)Corti MRev Chilena Infectol
25990808Cell mediated immunity against HPV16 E2, E6 and E7 peptides in women with incident CIN and in constantly HPV-negative women followed-up for 10-years. (2015 May 20)Paaso AJ Transl Med
18180115Recreational drug use and T lymphocyte subpopulations in HIV-uninfected and HIV-infected men. (2008 Apr 1)Chao CDrug Alcohol Depend
22739395Disulfiram reactivates latent HIV-1 expression through depletion of the phosphatase and tensin homolog. (2013 Jan 14)Doyon GAIDS
24783937Effect of cold-dryness on pulmonary and immunologic function in chronic obstructive pulmonary disease model rats. (2014 Apr)Gao ZJ Tradit Chin Med
25447721Spontaneous adult Gram-negative bacillary meningitis in Soweto, South Africa. (2015 Jan)Teckie GInt J Infect Dis
23702171HIV-associated bacterial pneumonia. (2013 Jun)Feldman CClin Chest Med
28812128Protective effect of cigarette smoke on the course of dextran sulfate sodium-induced colitis is accompanied by lymphocyte subpopulation changes in the blood and colon. (2017 Nov)Daniluk JInt J Colorectal Dis
24518040Association between systemic inflammation and obstructive sleep apnea in men with or at risk for HIV infection. (2014)Brigham EPAntivir Ther
21780902Surgical crown lengthening in a population with human immunodeficiency virus: a retrospective analysis). (2012 Mar)Kolhatkar SJ Periodontol
22996096Negative predictive value of pap testing: implications for screening intervals for women with human immunodeficiency virus. (2012 Oct)Massad LSObstet Gynecol
17209335Orofacial lesions in 126 newly diagnosed HIV/AIDS patients seen at the University College Hospital, Ibadan. (2006 Mar)Okoje VNAfr J Med Med Sci
22261033Cigarette smoke induction of osteopontin (SPP1) mediates T(H)17 inflammation in human and experimental emphysema. (2012 Jan 18)Shan MSci Transl Med
23251607Inflammation in HIV-infected patients: impact of HIV, lifestyle, body composition, and demography - a cross sectional cohort study. (2012)Langkilde APLoS One
22820807Frequency and predictors for late start of antiretroviral therapy in primary care clinics, Kampala, Uganda. (2012 Nov 1)Sendagire IJ Acquir Immune Defic Syndr
18668269Oral manifestations as predictors of immune suppression in a HIV-/AIDS-infected population in south India. (2009 Jun)Sharma GClin Oral Investig
17133212Frequency of gynecologic follow-up and cervical cancer screening in the Swiss HIV cohort study. (2006 Dec 15)Keiser OJ Acquir Immune Defic Syndr
11852118Lymphocyte phenotype analysis and chromosome aberration frequency of workers occupationally exposed to styrene, benzene, polycyclic aromatic hydrocarbons or mixed solvents. (2002 Apr 22)Biro AImmunol Lett
28981535Predictors of transitions in frailty severity and mortality among people aging with HIV. (2017)Brothers TDPLoS One
29287311Hypomethylation of CYP2E1 and DUSP22 Promoters Associated With Disease Activity and Erosive Disease Among Rheumatoid Arthritis Patients. (2018 Apr)Mok AArthritis Rheumatol
23900553Risk factors for anal cancer in persons infected with HIV: a nested case-control study in the Swiss HIV Cohort Study. (2013 Sep 15)Bertisch BAm J Epidemiol
27175676Superior Glucose Tolerance and Metabolomic Profiles, Independent of Adiposity, in HIV-Infected Women Compared With Men on Antiretroviral Therapy. (2016 May)Koethe JRMedicine (Baltimore)
22031204Body mass index in individuals with HIV infection and factors associated with thinness and overweight/obesity. (2011 Oct)Mariz Cde ACad Saude Publica
8404164Bronchogenic carcinoma in patients seropositive for human immunodeficiency virus. (1993 Oct)Tenholder MFChest
8533997Increased allergen-specific, steroid-sensitive gamma delta T cells in bronchoalveolar lavage fluid from patients with asthma. (1996 Jan 15)Spinozzi FAnn Intern Med
15563631An animal model of autoimmune emphysema. (2005 Apr 1)Taraseviciene-Stewart LAm J Respir Crit Care Med
23319833Th17 cell enhances CD8 T-cell cytotoxicity via IL-21 production in emphysema mice. (2012)Duan MCMediators Inflamm
25375131Cigarette smoking promotes inflammation in patients with COPD by affecting the polarization and survival of Th/Tregs through up-regulation of muscarinic receptor 3 and 5 expression. (2014)Zhang MQPLoS One
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