Gene: CD5

921
LEU1|T1
CD5 molecule
protein-coding
11q12.2
Ensembl:ENSG00000110448 MIM:153340 Vega:OTTHUMG00000167825 UniprotKB:P06127
NC_000011.10
PubMed
0   ANCO-SNPs
ND|AD
11   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.992e-1 (AD)  3.141e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
GALNT140.629
GRIK30.613
HS3ST40.606
DRD50.601
KCNK20.597
PDZRN40.592
RAB3B0.59
NXPH40.582
FOXP20.579
TRABD2A0.573

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ACSS3-0.354
PARD3-0.353
IMPA2-0.352
TMPRSS3-0.349
TPD52L1-0.346
YAP1-0.34
CDC14A-0.329
DDIT4L-0.328
GRAMD1C-0.323
EYA1-0.323

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C430898AGN 194204AGN 194204 results in decreased expression of CD5 mRNA16339527
D000535Aluminum[APP protein modified form binds to Aluminum] which results in decreased expression of CD5 mRNA21298039
D000643Ammonium ChlorideAmmonium Chloride affects the expression of CD5 mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of CD5 mRNA24449571
D001554BenzeneBenzene results in increased expression of CD5 mRNA19162166
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of CD5 mRNA21569818
D004958EstradiolEstradiol results in decreased expression of CD5 mRNA23373633
C002791bismuth tripotassium dicitratebismuth tripotassium dicitrate results in decreased expression of CD5 mRNA15912405
C006780bisphenol Abisphenol A results in decreased expression of CD5 mRNA25181051
C006780bisphenol Abisphenol A results in increased expression of CD5 mRNA18180321
C005961bis(tri-n-butyltin)oxidebis(tri-n-butyltin)oxide results in increased phosphorylation of CD5 protein22174045
D000069286BortezomibBortezomib results in decreased expression of CD5 mRNA20977926
C073316carvacrolcarvacrol results in increased expression of CD5 mRNA20008804
D002737ChloropreneChloroprene results in decreased expression of CD5 mRNA23125180
D003520CyclophosphamideCyclophosphamide results in decreased expression of CD5 mRNA21041162
D016572CyclosporineCyclosporine results in decreased methylation of CD5 promoter27989131
D003907DexamethasoneDexamethasone results in decreased expression of CD5 mRNA21041162
D003976DiazinonDiazinon results in increased methylation of CD5 gene22964155
D019422Dietary SucroseDietary Sucrose results in increased expression of CD5 mRNA26033743
D004054DiethylstilbestrolDiethylstilbestrol results in decreased expression of CD5 mRNA21041162
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in increased expression of CD5 mRNA"19480007
D005839GentamicinsGentamicins results in increased expression of CD5 mRNA22061828
D006581HexachlorobenzeneHexachlorobenzene affects the expression of CD5 mRNA15159207
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of CD5 mRNA25613284
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of CD5 mRNA26752646
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of CD5 mRNA21540303
D008748MethylcholanthreneMethylcholanthrene results in increased expression of CD5 mRNA25926378
D037742Nanotubes, Carbon"Nanotubes, Carbon affects the expression of CD5 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of CD5 mRNA"25554681
D009532NickelNickel results in increased expression of CD5 mRNA25583101
D005996NitroglycerinNitroglycerin results in decreased expression of CD5 mRNA12102619
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of CD5 mRNA25729387
D010126OzoneOzone results in increased expression of CD5 mRNA16330353
D059808PolyphenolsPolyphenols results in decreased expression of CD5 mRNA16293270
D018038Sodium SeleniteSodium Selenite results in decreased expression of CD5 mRNA23274088
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of CD5 protein18684927
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of CD5 mRNA25613284
C009495titanium dioxidetitanium dioxide results in increased expression of CD5 mRNA23557971
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of CD5 mRNA20133372
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of CD5 mRNA25729387
D014118Toxins, Biological"Toxins, Biological affects the expression of CD5 mRNA"19682533
D014635Valproic AcidValproic Acid results in increased methylation of CD5 gene29154799

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004888transmembrane signaling receptor activity-NAS3093892  
GO:0005044scavenger receptor activity-IEA-  
GO:0005515protein binding-IPI1711157  
GO:0038023signaling receptor activity-NAS1711157  
GO ID GO Term Qualifier Evidence PubMed
GO:0006898receptor-mediated endocytosis-IEA-  
GO:0008037cell recognition-NAS1711157  
GO:0008283cell proliferation-NAS3093892  
GO:0031295T cell costimulation-IBA21873635  
GO:0031295T cell costimulation-IEA-  
GO:0097190apoptotic signaling pathway-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-IBA21873635  
GO:0005886plasma membrane-IDA11390434  
GO:0005887integral component of plasma membrane-NAS1711157  
GO:0009897external side of plasma membrane-IEA-  
KEGG ID KEGG Term
hsa04640Hematopoietic cell lineage
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
10342588CD5+ persistent polyclonal B-cell lymphocytosis in a male. (1999 May)Reeder CBLeuk Lymphoma
15644129Immunohistochemistry of the B-cell component in lower lip salivary glands of Sjogren's syndrome and healthy subjects. (2005 Jan)Larsson AScand J Immunol
8986204Distribution of peripheral blood lymphoid subsets in alcoholic liver cirrhosis: influence of ethanol intake. (1996 Dec)Laso FJAlcohol Clin Exp Res
24952144Assessment of selected B cells populations in the workers of X-ray departments. (2014 Jun)Klucinski PInt J Occup Med Environ Health
8979026Long lasting immunological effects of ethanol after withdrawal. (1996 Dec 15)Laso FJCytometry
18587574Combined automated cell and flow cytometric analysis enables recognition of persistent polyclonal B-cell lymphocytosis (PPBL), a study of 25 patients. (2008 Oct)Schmidt-Hieber MAnn Hematol
1683282Immunologic biomarkers associated with an acute exposure to exothermic byproducts of a ureaformaldehyde spill. (1991 Aug)Madison REEnviron Health Perspect
9377748[Trace elements in biological samples and immunologic parameters in environmentally exposed populations (preliminary study)]. (1997 Jan-Mar)Boscolo PG Ital Med Lav Ergon
9438530II: the effects of recombinant human insulin-like growth factor-1 on immunological recovery in the malnourished alcoholic rat. (1997 Dec)Mendenhall CLAlcohol Clin Exp Res
21291536The impact of maternal HIV infection on cord blood lymphocyte subsets and cytokine profile in exposed non-infected newborns. (2011 Feb 3)Borges-Almeida EBMC Infect Dis
23319214Thymic carcinomas: clinicopathologic study of 37 cases from a single institution. (2013 Mar)Thomas de Montpreville VVirchows Arch