Gene: LGI1

9211
ADLTE|ADPAEF|ADPEAF|EPITEMPIN|EPT|ETL1|IB1099
leucine rich glioma inactivated 1
protein-coding
10q23.33
Ensembl:ENSG00000108231 MIM:604619 Vega:OTTHUMG00000018777 UniprotKB:O95970
NG_011832.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.988e-1 (AD)  3.920e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CDH20.882
NFS10.871
TMEM2540.871
CDO10.87
FAM171A10.866
DKK30.864
SIRPA0.863
CMTM40.859
VPS450.859
C11orf490.857

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.638
OR4F29-0.575
TFPI2-0.528
TBX21-0.507
KLRB1-0.497
CD2-0.482
IL2RB-0.472
GADL1-0.469
GZMA-0.468
SLAMF7-0.467

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0131862,3-pentanedione"2,3-pentanedione results in decreased expression of LGI1 mRNA"25710175
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of LGI1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of LGI1 mRNA"27188386
D020106AcrylamideAcrylamide results in decreased expression of LGI1 mRNA28959563
D000643Ammonium ChlorideAmmonium Chloride affects the expression of LGI1 mRNA16483693
C006632arsenic trioxidearsenic trioxide results in decreased expression of LGI1 mRNA26705709
C015001arsenitearsenite results in increased methylation of LGI1 promoter23974009
C547126AZM551248AZM551248 results in decreased expression of LGI1 mRNA22323515
C487081belinostatbelinostat results in increased expression of LGI1 mRNA26272509
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of LGI1 mRNA22300585
D004958EstradiolEstradiol results in decreased expression of LGI1 mRNA19484750
C006780bisphenol Abisphenol A results in increased expression of LGI1 mRNA25594700
C006780bisphenol Abisphenol A results in decreased expression of LGI1 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of LGI1 gene28505145
C013418bromfenacoumbromfenacoum results in decreased expression of LGI1 protein28903499
C055494caffeic acid phenethyl ester[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of LGI1 mRNA20360939
D002220CarbamazepineCarbamazepine affects the expression of LGI1 mRNA25979313
D003471CuprizoneCuprizone results in decreased expression of LGI1 mRNA26577399
C014347decitabinedecitabine affects the expression of LGI1 mRNA23300844
D013759DronabinolDronabinol results in decreased expression of LGI1 mRNA12237329
D003976DiazinonDiazinon affects the expression of LGI1 mRNA22546817
D002945CisplatinCisplatin affects the expression of LGI1 mRNA23300844
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of LGI1 mRNA26924002
D004026DieldrinDieldrin affects the expression of LGI1 mRNA22546817
D004041Dietary FatsDietary Fats results in increased expression of LGI1 mRNA18042831
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of LGI1 mRNA20360939
C540355fenamidonefenamidone results in decreased expression of LGI1 mRNA27029645
D007545IsoproterenolIsoproterenol results in decreased expression of LGI1 mRNA20003209
D007854LeadLead affects the expression of LGI1 mRNA28903495
D008748MethylcholanthreneMethylcholanthrene promotes the reaction [AHR protein binds to LGI1 promoter]20348232
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of LGI1 protein25809596
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of LGI1 mRNA23179753|2627250
C016599mono-(2-ethylhexyl)phthalatemono-(2-ethylhexyl)phthalate results in increased expression of LGI1 mRNA22401849
C572573N-nitroso-tris-chloroethylurea[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of LGI1 mRNA27935865
D000073878Palm OilPalm Oil results in increased expression of LGI1 mRNA18042831
C010272palytoxinpalytoxin results in increased expression of LGI1 mRNA26436198
C101814perfluoro-n-undecanoic acidperfluoro-n-undecanoic acid results in decreased expression of LGI1 mRNA23602845
C060836pioglitazone[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of LGI1 mRNA27935865
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of LGI1 mRNA19710929
C006253pirinixic acidpirinixic acid results in increased expression of LGI1 mRNA20813756
D011374ProgesteroneProgesterone results in decreased expression of LGI1 mRNA22238285
D011441PropylthiouracilPropylthiouracil results in decreased expression of LGI1 mRNA24780913
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of LGI1 mRNA21354282
D014212TretinoinTretinoin results in decreased expression of LGI1 mRNA21934132
D014212TretinoinTretinoin results in increased expression of LGI1 mRNA23724009
D014212TretinoinTretinoin results in decreased expression of LGI1 mRNA20488242
D014227TriazinesTriazines inhibits the reaction [IDH2 protein mutant form results in decreased expression of LGI1 mRNA]27469509
C012589trichostatin Atrichostatin A results in increased expression of LGI1 mRNA24935251
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of LGI1 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of LGI1 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of LGI1 mRNA23179753|2438349
D014635Valproic AcidValproic Acid results in increased expression of LGI1 mRNA28001369
D014635Valproic AcidValproic Acid results in decreased expression of LGI1 mRNA24896083

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005102signaling receptor binding-IPI20463223  
GO:0005102signaling receptor bindingNOTIPI20463223  
GO:0005515protein binding-IPI20463223  
GO ID GO Term Qualifier Evidence PubMed
GO:0007399nervous system development-TAS9879993  
GO:0007411axon guidance-IMP20463223  
GO:0008283cell proliferation-TAS9879993  
GO:0030307positive regulation of cell growth-IMP20463223  
GO:0031175neuron projection development-IMP20463223  
GO:0050806positive regulation of synaptic transmission-ISS-  
GO:0051260protein homooligomerization-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005615extracellular space-IEA-  
GO:0030054cell junction-IEA-  
GO:0045202synapse-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1266738Developmental BiologyTAS
R-HSA-5682910LGI-ADAM interactionsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27965002Prevalence and clinical characteristics of serum neuronal cell surface antibodies in first-episode psychosis: a case-control study. (2017 Jan)Lennox BRLancet Psychiatry