Gene: RIPPLY1

92129
-
ripply transcriptional repressor 1
protein-coding
Xq22.3
Ensembl:ENSG00000147223 MIM:300575 Vega:OTTHUMG00000022153 UniprotKB:Q0D2K3
NG_022934.1
PubMed
0   ANCO-SNPs
AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
NA (AD)  NA (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CRYBA40.571
CALCA0.56
ITK0.559
DEC10.553
LRRC150.552
MMP100.549
TEX190.529
KRT33A0.52
TCF70.514
CHRNB40.504

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NXPH1-0.268
C2orf27A-0.251
SLC8A1-0.247
KIT-0.247
PLCXD3-0.247
FSTL5-0.245
TENM1-0.239
LHX6-0.239
FAM133A-0.236
GAD2-0.235

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of RIPPLY1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of RIPPLY1 mRNA"27188386
C006780bisphenol Abisphenol A results in increased expression of RIPPLY1 mRNA26364221
D006830Hydralazine[Hydralazine co-treated with Valproic Acid] results in increased expression of RIPPLY1 mRNA17183730
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of RIPPLY1 mRNA25613284
C572573N-nitroso-tris-chloroethylurea[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of RIPPLY1 mRNA27935865
D010936Plant ExtractsPlant Extracts results in decreased expression of RIPPLY1 mRNA23557933
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of RIPPLY1 mRNA26377647
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of RIPPLY1 mRNA26290441
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of RIPPLY1 mRNA25613284
C012589trichostatin Atrichostatin A results in decreased expression of RIPPLY1 mRNA24935251
D014520UrethaneUrethane results in decreased expression of RIPPLY1 mRNA28818685
D014635Valproic Acid[Hydralazine co-treated with Valproic Acid] results in increased expression of RIPPLY1 mRNA17183730
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of RIPPLY1 mRNA"27188386
D014635Valproic AcidValproic Acid results in decreased expression of RIPPLY1 mRNA23179753|2627250
C581157XL147[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of RIPPLY1 mRNA27935865

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI25416956  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-IBA21873635  
GO:0001757somite specification-ISS-  
GO:0006351transcription, DNA-templated-IEA-  
GO:0009880embryonic pattern specification-IBA21873635  
GO:0009880embryonic pattern specification-ISS-  
GO:0032525somite rostral/caudal axis specification-ISS-  
GO:0045892negative regulation of transcription, DNA-templated-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-ISS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25253127Polymorphisms at PRSS1-PRSS2 and CLDN2-MORC4 loci associate with alcoholic and non-alcoholic chronic pancreatitis in a European replication study. (2015 Sep)Derikx MHGut