Gene: XPR1

9213
IBGC6|SLC53A1|SYG1|X3
xenotropic and polytropic retrovirus receptor 1
protein-coding
1q25.3
Ensembl:ENSG00000143324 MIM:605237 Vega:OTTHUMG00000035116 UniprotKB:Q9UBH6
NG_050964.1
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.866e-1 (AD)  2.111e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs3789373chr1:180804994 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NCKAP10.942
CAND10.941
DYRK1A0.941
CLTC0.94
PPP2R5E0.939
UBE2K0.936
MTMR90.932
METAP10.931
SFXN10.93
OPA10.929

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.565
OR4F29-0.511
CSAG1-0.422
CTNNA3-0.399
MYL3-0.392
RAI14-0.39
HEY2-0.386
ANXA13-0.381
TGFB3-0.372
SNHG18-0.358

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of XPR1 mRNA19933214
C0297902,2',3',4,4',5-hexachlorobiphenyl"2,2',3',4,4',5-hexachlorobiphenyl results in increased expression of XPR1 mRNA"23829299
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of XPR1 mRNA"18648102
D000082AcetaminophenAcetaminophen results in decreased expression of XPR1 mRNA26690555
D000082AcetaminophenAcetaminophen results in increased expression of XPR1 mRNA21420995
D000082Acetaminophen[Clofibrate co-treated with Acetaminophen] affects the expression of XPR1 mRNA17585979
D000082AcetaminophenPPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of XPR1 mRNA]17585979
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of XPR1 mRNA24449571
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of XPR1 mRNA26001963
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of XPR1 mRNA20064835
C006780bisphenol Abisphenol A results in increased expression of XPR1 mRNA29275510
C006780bisphenol Abisphenol A affects the expression of XPR1 mRNA25181051
C006780bisphenol Abisphenol A results in increased expression of XPR1 mRNA29097150
D002994Clofibrate[Clofibrate co-treated with Acetaminophen] affects the expression of XPR1 mRNA17585979
D002994ClofibratePPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of XPR1 mRNA]17585979
C029892cupric chloridecupric chloride results in decreased expression of XPR1 mRNA24650576
D003471CuprizoneCuprizone results in increased expression of XPR1 mRNA26577399
D002945CisplatinCisplatin results in decreased expression of XPR1 mRNA27594783
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of XPR1 mRNA26924002
D004041Dietary FatsDietary Fats results in decreased expression of XPR1 mRNA25016146
D004041Dietary FatsDietary Fats results in increased expression of XPR1 mRNA18042831
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of XPR1 mRNA22079256
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of XPR1 mRNA29097150
D018120FinasterideFinasteride results in increased expression of XPR1 mRNA24136188
C069837fullerene C60fullerene C60 results in decreased expression of XPR1 mRNA19167457
D017313FenretinideFenretinide results in decreased expression of XPR1 mRNA28973697
C016517indole-3-carbinolindole-3-carbinol affects the expression of XPR1 mRNA21396975
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of XPR1 mRNA24796395
D048628KetolidesKetolides analog results in increased expression of XPR1 mRNA24967691
C045463leflunomideleflunomide results in increased expression of XPR1 mRNA24136188
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of XPR1 mRNA"24972896
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of XPR1 mRNA28001369
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of XPR1 mRNA"20188158
C028007nickel monoxidenickel monoxide results in decreased expression of XPR1 mRNA19167457
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of XPR1 mRNA25729387
D000073878Palm OilPalm Oil results in increased expression of XPR1 mRNA18042831
C410127PCB 180PCB 180 results in increased expression of XPR1 mRNA23829299
D010656PhenylephrinePhenylephrine results in increased expression of XPR1 mRNA18158353
D010710PhosphatesXPR1 gene mutant form affects the export of Phosphates25938945
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of XPR1 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of XPR1 mRNA22079256
D011192Potassium DichromatePotassium Dichromate results in decreased expression of XPR1 mRNA23608068
D011441PropylthiouracilPropylthiouracil results in decreased expression of XPR1 mRNA24780913
C010327salinomycinsalinomycin results in decreased expression of XPR1 mRNA19682730
D012969Sodium FluorideSodium Fluoride results in decreased expression of XPR1 mRNA27862939
D013467SulindacSulindac results in increased expression of XPR1 mRNA24136188
D000952Antigens, Polyomavirus Transforming"Antigens, Polyomavirus Transforming results in increased expression of XPR1 mRNA"26680231
D013739TestosteroneTestosterone results in decreased expression of XPR1 mRNA20403060
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of XPR1 mRNA19933214
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of XPR1 mRNA22298810
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of XPR1 mRNA25729387
D014212TretinoinTretinoin results in increased expression of XPR1 mRNA23724009
C012589trichostatin Atrichostatin A affects the expression of XPR1 mRNA28542535
C012589trichostatin Atrichostatin A results in increased expression of XPR1 mRNA15901671
D014635Valproic AcidValproic Acid affects the expression of XPR1 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of XPR1 mRNA23179753|2718838
D014635Valproic AcidValproic Acid results in increased expression of XPR1 mRNA15901671

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000822inositol hexakisphosphate binding-IDA27080106  
GO:0001618virus receptor activity-IMP23791524  
GO:0004888transmembrane signaling receptor activity-TAS9927670  
GO:0004930G-protein coupled receptor activity-TAS9990033  
GO:0015114phosphate ion transmembrane transporter activity-IMP23791524  
GO:0015562efflux transmembrane transporter activity-IMP23791524  
GO:0038023signaling receptor activity-TAS9988277  
GO ID GO Term Qualifier Evidence PubMed
GO:0007186G-protein coupled receptor signaling pathway-TAS9990033  
GO:0009615response to virus-IEA-  
GO:0030643cellular phosphate ion homeostasis-IMP20068231  
GO:0035435phosphate ion transmembrane transport-IMP23791524  
GO:0046718viral entry into host cell-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005794Golgi apparatus-IBA21873635  
GO:0005886plasma membrane-IBA21873635  
GO:0016021integral component of membrane-IEA-  
GO:0031226intrinsic component of plasma membrane-IDA23791524  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal