Gene: MTDH

92140
3D3|AEG-1|AEG1|LYRIC|LYRIC/3D3
metadherin
protein-coding
8q22.1
Ensembl:ENSG00000147649 MIM:610323 Vega:OTTHUMG00000164692 UniprotKB:Q86UE4
NC_000008.11
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.587e-1 (AD)  9.659e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SLC39A60.943
SEL1L0.934
CCDC470.932
USO10.932
CAPRIN10.929
YTHDF30.927
BFAR0.924
DHX150.924
ARCN10.923
IPO70.921

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.639
OR4F29-0.608
MTRNR2L10-0.276
MTRNR2L6-0.272
MTRNR2L9-0.245
RSPO1-0.242
MTRNR2L3-0.233
OR4F16-0.227
C8orf74-0.216
PTGDR2-0.214

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of MTDH mRNA"19114083
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of MTDH mRNA"21346803
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MTDH mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MTDH mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MTDH mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MTDH mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MTDH mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MTDH mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of MTDH mRNA21420995
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of MTDH gene27153756
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of MTDH mRNA"19150397
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of MTDH mRNA"26238291
C044887beta-methylcholinebeta-methylcholine affects the expression of MTDH mRNA21179406
C006780bisphenol Abisphenol A affects the expression of MTDH mRNA25181051
C005961bis(tri-n-butyltin)oxidebis(tri-n-butyltin)oxide results in decreased phosphorylation of MTDH protein22174045
C584509C646 compoundC646 compound results in decreased expression of MTDH mRNA26191083
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of MTDH mRNA22041583
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of MTDH protein22041583
D002220CarbamazepineCarbamazepine affects the expression of MTDH mRNA25979313
D004390ChlorpyrifosChlorpyrifos results in decreased expression of MTDH mRNA18668222
C059262cidofovircidofovir results in decreased expression of MTDH mRNA25596134
D004002Clodronic AcidClodronic Acid results in decreased expression of MTDH mRNA25596134
D019327Copper SulfateCopper Sulfate results in decreased expression of MTDH mRNA19549813
D016572CyclosporineCyclosporine results in increased expression of MTDH mRNA20106945|2163298
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of MTDH mRNA21266533
D002945CisplatinCisplatin results in decreased expression of MTDH mRNA25596134
D004040Dietary CarbohydratesDietary Carbohydrates results in decreased expression of MTDH mRNA17490981
C015835dimethyl-4-toluidinedimethyl-4-toluidine results in decreased expression of MTDH mRNA27638505
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of MTDH mRNA23649840
D005485FlutamideFlutamide results in increased expression of MTDH mRNA24136188
D005557FormaldehydeFormaldehyde results in decreased expression of MTDH mRNA23649840
D005947Glucose[INS protein co-treated with Glucose] results in decreased expression of MTDH mRNA22634610
D005947Glucose[INS protein co-treated with Glucose] results in increased expression of MTDH mRNA22634610
D006997Hypochlorous AcidHypochlorous Acid results in increased expression of MTDH mRNA19376150
D007069IfosfamideIfosfamide results in decreased expression of MTDH mRNA25596134
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of MTDH mRNA25613284
D007854LeadLead affects the splicing of MTDH mRNA28903495
D007854LeadLead results in decreased expression of MTDH mRNA19921347
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of MTDH mRNA"24972896
D008687MetforminMetformin results in increased expression of MTDH mRNA25596134
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of MTDH mRNA23649840
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of MTDH mRNA"26251327
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in decreased expression of MTDH protein26558463
D010100OxygenOxygen deficiency results in increased expression of MTDH mRNA25596134
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of MTDH mRNA18804290
D010634PhenobarbitalPhenobarbital results in decreased expression of MTDH mRNA23091169
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MTDH mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of MTDH mRNA26272509
D010795Phthalic AcidsPhthalic Acids results in decreased expression of MTDH mRNA21061450
D011374ProgesteroneProgesterone results in increased expression of MTDH mRNA23012394
C045950propiconazolepropiconazole results in decreased expression of MTDH mRNA21278054
D012715Sesame OilSesame Oil results in increased expression of MTDH mRNA29191790
D012969Sodium FluorideSodium Fluoride results in increased expression of MTDH protein28918527
D012999SomanSoman results in increased expression of MTDH mRNA19281266
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of MTDH mRNA21570461|2468072
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased phosphorylation of MTDH protein23298284
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of MTDH mRNA25613284
D014241TrichloroethyleneTrichloroethylene affects the expression of MTDH mRNA21135412
D014241TrichloroethyleneTrichloroethylene results in increased expression of MTDH mRNA19448997
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MTDH mRNA"27188386
C012589trichostatin Atrichostatin A results in increased expression of MTDH mRNA24935251|2627250
C057693troglitazonetroglitazone results in decreased expression of MTDH mRNA28973697
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MTDH mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of MTDH mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of MTDH mRNA23179753|2627250

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0001085RNA polymerase II transcription factor binding-IBA21873635  
GO:0001085RNA polymerase II transcription factor binding-IPI18316612  
GO:0003712transcription coregulator activity-IBA21873635  
GO:0003713transcription coactivator activity-IMP18316612  
GO:0003723RNA binding-HDA22658674  22681889  
GO:0003725double-stranded RNA binding-IDA21266579  
GO:0005515protein binding-IPI18316612  18440304  19433866  19648967  24981741  
GO:0051059NF-kappaB binding-IBA21873635  
GO:0051059NF-kappaB binding-IPI16452207  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-IDA15927426  
GO:0006355regulation of transcription, DNA-templated-IBA21873635  
GO:0006357regulation of transcription by RNA polymerase II-IBA21873635  
GO:0007165signal transduction-IBA21873635  
GO:0010508positive regulation of autophagy-IDA21127263  
GO:0031663lipopolysaccharide-mediated signaling pathway-IMP19740331  
GO:0043066negative regulation of apoptotic process-IDA17704808  
GO:0043123positive regulation of I-kappaB kinase/NF-kappaB signaling-IDA16452207  18316612  
GO:0045766positive regulation of angiogenesis-IDA19940250  
GO:0051092positive regulation of NF-kappaB transcription factor activity-IDA16452207  18316612  
GO:0051897positive regulation of protein kinase B signaling-IDA17704808  
GO:0070830bicellular tight junction assembly-IEA-  
GO:1903508positive regulation of nucleic acid-templated transcription-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001650fibrillar center-IDA-  
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-IDA16452207  
GO:0005737cytoplasm-IDA19648967  
GO:0005783endoplasmic reticulum-IDA14980505  15927426  
GO:0005789endoplasmic reticulum membrane-IBA21873635  
GO:0005789endoplasmic reticulum membrane-ISS-  
GO:0005923bicellular tight junction-ISS-  
GO:0016021integral component of membrane-IEA-  
GO:0016324apical plasma membrane-ISS-  
GO:0016604nuclear body-IDA19648967  
GO:0031965nuclear membrane-IEA-  
GO:0046581intercellular canaliculus-ISS-  
GO:0048471perinuclear region of cytoplasm-IDA14980505  15927426  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27093812[Expression and clinical significance of MTDH, HIF-1alpha and TKTL1 in laryngeal carcinoma]. (2015 Dec)Jia XLin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi