Gene: DLGAP1

9229
DAP-1|DAP-1-ALPHA|DAP-1-BETA|DAP1|DLGAP1A|DLGAP1B|GKAP|SAPAP1
DLG associated protein 1
protein-coding
18p11.31
Ensembl:ENSG00000170579 MIM:605445 Vega:OTTHUMG00000131537 UniprotKB:O14490
NC_000018.10
SNP Mapped
2   ANCO-SNPs
ND|AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.276e-2 (AD)  6.852e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs1372631chr18:4026587 (GRCh38.p7)T>Gnicotine dependenceSNV(Single Nucleotide Variation)
rs3910707chr18:3873447 (GRCh38.p7)A>Calcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CREG20.984
GABRB20.98
PRKCE0.978
KIAA1549L0.977
GABRA10.976
ATRNL10.975
CNTNAP20.974
KCNQ50.973
RBFOX10.973
FRMPD40.973

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RAB13-0.585
HEY2-0.575
CSAG1-0.572
MYL3-0.571
RNF135-0.554
WWTR1-0.547
SNHG18-0.545
FLT3LG-0.544
ROM1-0.544
ACAP1-0.542

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of DLGAP1 mRNA"27291303
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of DLGAP1 mRNA"19114083
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DLGAP1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DLGAP1 mRNA"27188386
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of DLGAP1 mRNA22100608
D000643Ammonium ChlorideAmmonium Chloride affects the expression of DLGAP1 mRNA16483693
D001280AtrazineAtrazine results in decreased expression of DLGAP1 mRNA25929836
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased mutagenesis of DLGAP1 gene25435355
C006780bisphenol Abisphenol A affects the expression of DLGAP1 mRNA25181051
C006780bisphenol Abisphenol A results in decreased expression of DLGAP1 mRNA24820113
C006780bisphenol Abisphenol A results in decreased expression of DLGAP1 protein24820113
D002104CadmiumCadmium results in decreased expression of DLGAP1 mRNA21120746
D002509CephaloridineCephaloridine results in increased expression of DLGAP1 mRNA18500788
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of DLGAP1 mRNA21266533
D004041Dietary FatsDietary Fats results in increased expression of DLGAP1 mRNA25016146
D002117CalcitriolCalcitriol results in increased expression of DLGAP1 mRNA16002434
D004785Environmental PollutantsEnvironmental Pollutants results in decreased expression of DLGAP1 mRNA20064776
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of DLGAP1 mRNA23649840
D005557FormaldehydeFormaldehyde results in decreased expression of DLGAP1 mRNA23649840
D005839GentamicinsGentamicins results in increased expression of DLGAP1 mRNA22061828
D017313FenretinideFenretinide results in increased expression of DLGAP1 mRNA28973697
D006918HydroxyureaHydroxyurea results in increased mutagenesis of DLGAP1 gene16868089
D007854LeadLead affects the expression of DLGAP1 mRNA28903495
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of DLGAP1 mRNA23649840
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of DLGAP1 mRNA"20188158
D008770MethylnitrosoureaMethylnitrosourea results in increased mutagenesis of DLGAP1 gene16868089
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DLGAP1 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of DLGAP1 mRNA26272509
D011192Potassium DichromatePotassium Dichromate results in increased expression of DLGAP1 mRNA23608068
D017035PravastatinPravastatin results in increased expression of DLGAP1 mRNA27225895
D017035PravastatinPravastatin results in increased expression of DLGAP1 mRNA27225895
D011374ProgesteroneProgesterone results in decreased expression of DLGAP1 mRNA22238285
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of DLGAP1 mRNA23806026
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of DLGAP1 mRNA21296121
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of DLGAP1 mRNA26377647
C012589trichostatin Atrichostatin A results in decreased expression of DLGAP1 mRNA24935251
C012589trichostatin Atrichostatin A results in increased expression of DLGAP1 mRNA24935251
D014635Valproic AcidValproic Acid results in decreased expression of DLGAP1 mRNA24935251
D014635Valproic AcidValproic Acid results in decreased methylation of DLGAP1 gene29154799
C025643vinclozolinvinclozolin affects the expression of DLGAP1 mRNA19015723

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI17474147  20936779  22117215  
GO:0044877protein-containing complex binding-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0007268chemical synaptic transmission-NAS9286858  
GO ID GO Term Qualifier Evidence PubMed
GO:0005575cellular_component-ND-  
GO:0005886plasma membrane-TAS-  
GO:0014069postsynaptic density-IEA-  
GO:0030054cell junction-IEA-  
GO:0045211postsynaptic membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-112316Neuronal SystemIEA
R-HSA-112316Neuronal SystemTAS
R-HSA-6794361Neurexins and neuroliginsIEA
R-HSA-6794361Neurexins and neuroliginsTAS
R-HSA-6794362Protein-protein interactions at synapsesIEA
R-HSA-6794362Protein-protein interactions at synapsesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal