Gene: CAPN13

92291
-
calpain 13
protein-coding
2p23.1
Ensembl:ENSG00000162949 MIM:610228 Vega:OTTHUMG00000152053 UniprotKB:Q6MZZ7
NC_000002.12
SNP Mapped
0   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.420e-1 (AD)  5.349e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NIPAL40.87
GPR620.866
DNAH170.856
CLCA40.856
GALNT60.84
HHIP0.84
C10orf900.839
TRIM590.837
TP53TG50.837
NINJ20.836

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CALB2-0.356
WTIP-0.355
CUX2-0.341
GPR153-0.329
CNGB1-0.311
NEUROD1-0.311
PCDH8-0.311
CHRNA2-0.307
DIO2-0.306
OLFM4-0.301

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of CAPN13 gene27153756
D004958EstradiolEstradiol results in decreased expression of CAPN13 mRNA25321415
D004958Estradiol[bisphenol A co-treated with Estradiol] results in increased expression of CAPN13 mRNA26496021
C006780bisphenol Abisphenol A results in increased expression of CAPN13 mRNA24465770
C006780bisphenol A[bisphenol A co-treated with Estradiol] results in increased expression of CAPN13 mRNA26496021
C006780bisphenol A[bisphenol A co-treated with Testosterone] results in decreased expression of CAPN13 mRNA26496021
C006780bisphenol Abisphenol A results in decreased expression of CAPN13 mRNA25181051
C039281furanfuran results in increased expression of CAPN13 mRNA27387713
C071834glycidamideglycidamide results in decreased expression of CAPN13 mRNA17822822
C031721naphthalenenaphthalene analog results in increased expression of CAPN13 mRNA24976557
D009532NickelNickel results in decreased expression of CAPN13 mRNA24768652|2558310
D011441PropylthiouracilPropylthiouracil results in decreased expression of CAPN13 mRNA24780913
D013739Testosterone[bisphenol A co-treated with Testosterone] results in decreased expression of CAPN13 mRNA26496021
C088658zoledronic acidzoledronic acid results in increased expression of CAPN13 mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004198calcium-dependent cysteine-type endopeptidase activity-IBA21873635  
GO:0005509calcium ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006508proteolysis-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IBA21873635  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1474228Degradation of the extracellular matrixTAS
R-HSA-1474244Extracellular matrix organizationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal