Gene: GLYATL1

92292
GATF-C|GNAT
glycine-N-acyltransferase like 1
protein-coding
11q12.1
Ensembl:ENSG00000166840 MIM:614761 Vega:OTTHUMG00000167221 UniprotKB:Q969I3
NC_000011.10
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.556e-1 (AD)  3.957e-2 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs550864chr11:58926213 (GRCh38.p7)G>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CRYGD0.587
RET0.578
SLC17A60.573
PCSK10.565
EXTL20.561
TRHDE0.558
CADPS0.558
RPP400.556
TTC39A0.555
CADPS20.549

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
YES1-0.354
REST-0.345
CARHSP1-0.339
DOCK1-0.33
P2RY14-0.328
RAI14-0.328
CPM-0.319
FZD10-0.318
HIPK2-0.317
FYCO1-0.315

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00145GlycineSmall Molecule56-40-6Approved|NutraceuticalTarget
ID Drug Name Action PubMed
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GLYATL1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GLYATL1 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of GLYATL1 mRNA29067470
D016604Aflatoxin B1Aflatoxin B1 affects the expression of GLYATL1 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of GLYATL1 mRNA22100608|2715375
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of GLYATL1 gene27153756
D002220CarbamazepineCarbamazepine affects the expression of GLYATL1 mRNA25979313
D016572CyclosporineCyclosporine results in decreased expression of GLYATL1 mRNA20106945|2798913
D004726Endosulfan[Endosulfan co-treated with Tetrachlorodibenzodioxin] results in decreased expression of GLYATL1 mRNA26159488
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of GLYATL1 mRNA20044591
D008727MethotrexateMethotrexate results in increased expression of GLYATL1 mRNA17400583
D009532NickelNickel results in decreased expression of GLYATL1 mRNA25583101
C029938nickel sulfatenickel sulfate results in decreased expression of GLYATL1 mRNA22714537
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GLYATL1 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of GLYATL1 mRNA26272509
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of GLYATL1 mRNA23806026
D013749Tetrachlorodibenzodioxin[Endosulfan co-treated with Tetrachlorodibenzodioxin] results in decreased expression of GLYATL1 mRNA26159488
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of GLYATL1 mRNA22574217
D013853ThioacetamideThioacetamide results in decreased expression of GLYATL1 mRNA23411599
C012589trichostatin Atrichostatin A results in increased expression of GLYATL1 mRNA24935251
D014635Valproic AcidValproic Acid affects the expression of GLYATL1 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of GLYATL1 mRNA29154799
D014635Valproic AcidValproic Acid results in decreased methylation of GLYATL1 gene29154799
D014635Valproic AcidValproic Acid results in increased expression of GLYATL1 mRNA24383497|2493525
D024483Vitamin K 3Vitamin K 3 affects the expression of GLYATL1 mRNA20044591
C111237vorinostatvorinostat results in increased expression of GLYATL1 mRNA27188386

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0047946glutamine N-acyltransferase activity-IDA22475485  
GO:0047961glycine N-acyltransferase activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006541glutamine metabolic process-IDA22475485  
GO ID GO Term Qualifier Evidence PubMed
GO:0005739mitochondrion-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-156580Phase II - Conjugation of compoundsTAS
R-HSA-156587Amino Acid conjugationTAS
R-HSA-159424Conjugation of carboxylic acidsTAS
R-HSA-177128Conjugation of salicylate with glycineTAS
R-HSA-177135Conjugation of benzoate with glycineTAS
R-HSA-211859Biological oxidationsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal