Gene: TMEM132C

92293
PPP1R152
transmembrane protein 132C
protein-coding
12q24.32-q24.33
Ensembl:ENSG00000181234 Vega:OTTHUMG00000163736 UniprotKB:Q8N3T6
NC_000012.12
SNP Mapped
5   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.965e-1 (AD)  6.997e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs6486717chr12:128683327 (GRCh38.p7)T>Galcohol dependenceSNV(Single Nucleotide Variation)
rs1489430chr12:128681600 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)
rs10773566chr12:128679103 (GRCh38.p7)G>Talcohol dependenceSNV(Single Nucleotide Variation)
rs11608979chr12:128677080 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs7960753chr12:128673822 (GRCh38.p7)A>Calcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ZBTB40.788
OSBPL20.774
COG40.769
AGPAT30.767
VPS520.767
EXOC70.763
SPECC1L0.763
LZTR10.762
FAM168A0.762
WWP20.762

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.618
OR4F29-0.589
SDR42E1-0.362
C9orf135-0.33
IL24-0.304
H3F3C-0.284
KRTAP1-1-0.271
EVA1A-0.265
TTR-0.265
ARHGEF35-0.262

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of TMEM132C gene27153756
D001151ArsenicArsenic affects the methylation of TMEM132C gene25304211
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of TMEM132C mRNA22316170
D004958Estradiol[Estradiol binds to ESR2 protein] which results in increased expression of TMEM132C mRNA20404318
D004958Estradiol[Estradiol co-treated with Progesterone] results in increased expression of TMEM132C mRNA20660070
C543008bis(4-hydroxyphenyl)sulfonebis(4-hydroxyphenyl)sulfone results in increased expression of TMEM132C mRNA27685785
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of TMEM132C mRNA28628672
C006780bisphenol Abisphenol A results in decreased expression of TMEM132C mRNA24586524
C006780bisphenol Abisphenol A results in decreased expression of TMEM132C mRNA25181051
D002737ChloropreneChloroprene results in decreased expression of TMEM132C mRNA23125180
D003300CopperCopper deficiency results in increased expression of TMEM132C mRNA26033743
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of TMEM132C mRNA28628672
D019422Dietary SucroseDietary Sucrose results in increased expression of TMEM132C mRNA26033743
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of TMEM132C mRNA"19480007
D0198131,2-Dimethylhydrazine"1,2-Dimethylhydrazine results in decreased expression of TMEM132C mRNA"27840820
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of TMEM132C mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of TMEM132C mRNA28628672
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of TMEM132C mRNA28001369
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of TMEM132C mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of TMEM132C mRNA"25554681
D009532NickelNickel results in decreased expression of TMEM132C mRNA25583101
C572573N-nitroso-tris-chloroethylurea[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of TMEM132C mRNA27935865
C572573N-nitroso-tris-chloroethylurea[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of TMEM132C mRNA27935865
C060836pioglitazone[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of TMEM132C mRNA27935865
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of TMEM132C mRNA19710929
D011374Progesterone[Estradiol co-treated with Progesterone] results in increased expression of TMEM132C mRNA20660070
C012589trichostatin Atrichostatin A results in decreased expression of TMEM132C mRNA24935251
C012589trichostatin Atrichostatin A results in increased expression of TMEM132C mRNA24935251
C015559trimellitic anhydridetrimellitic anhydride results in decreased expression of TMEM132C mRNA19042947
D014635Valproic AcidValproic Acid affects the expression of TMEM132C mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of TMEM132C mRNA23179753|2718838
C581157XL147[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of TMEM132C mRNA27935865

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003674molecular_function-ND-  
GO ID GO Term Qualifier Evidence PubMed
GO:0008150biological_process-ND-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005575cellular_component-ND-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal