Gene: SCGB3A1

92304
HIN-1|HIN1|LU105|PnSP-2|UGRP2
secretoglobin family 3A member 1
protein-coding
5q35.3
Ensembl:ENSG00000161055 MIM:606500 Vega:OTTHUMG00000130936 UniprotKB:Q96QR1
NC_000005.10
PubMed
0   ANCO-SNPs
ND
3   
2.265e-1 (AD)  9.097e-1 (ND)   (Frontal_Cortex)
8.727e-1 (AD)  7.231e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PNMT0.541
PENK0.477
SCGN0.472
SFRP50.463
RND20.459
COX170.458
FAM207A0.458
C12orf450.457
C1orf500.457
TSTD10.456

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MMP9-0.292
SYNPO2L-0.265
KCNJ15-0.262
P2RY14-0.261
FUT7-0.261
TMEM105-0.26
XAGE3-0.255
GJC1-0.254
MTRNR2L4-0.252
GOLGA6B-0.249

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0264861,2,5,6-dibenzanthracene"1,2,5,6-dibenzanthracene results in decreased expression of SCGB3A1 mRNA"26377693
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of SCGB3A1 mRNA21641981
D001151ArsenicArsenic results in decreased methylation of SCGB3A1 gene27838757
D001151ArsenicArsenic results in increased expression of SCGB3A1 mRNA23221970
C022921benzo(k)fluoranthenebenzo(k)fluoranthene results in increased expression of SCGB3A1 mRNA26377693
D001564Benzo(a)pyreneAHR protein affects the reaction [Benzo(a)pyrene affects the expression of SCGB3A1 mRNA]22228805
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of SCGB3A1 mRNA22228805|2373587
D004958Estradiol[bisphenol A co-treated with Estradiol] results in increased expression of SCGB3A1 mRNA26496021
C006780bisphenol A[bisphenol A co-treated with Estradiol] results in increased expression of SCGB3A1 mRNA26496021
C006780bisphenol Abisphenol A results in decreased expression of SCGB3A1 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of SCGB3A1 gene28505145
D019256Cadmium ChlorideCadmium Chloride results in increased methylation of SCGB3A1 promoter22457795
D002509CephaloridineCephaloridine results in increased expression of SCGB3A1 mRNA18500788
D003471CuprizoneCuprizone results in increased expression of SCGB3A1 mRNA27523638
C014347decitabinedecitabine results in decreased methylation of SCGB3A1 promoter19442645
C014347decitabinedecitabine results in increased expression of SCGB3A1 mRNA19442645
D004051Diethylhexyl Phthalate[Diethylhexyl Phthalate co-treated with Genistein] results in increased expression of SCGB3A1 mRNA25031359
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in increased expression of SCGB3A1 mRNA25031359
D019833Genistein[Diethylhexyl Phthalate co-treated with Genistein] results in increased expression of SCGB3A1 mRNA25031359
D007545IsoproterenolIsoproterenol results in increased expression of SCGB3A1 mRNA20003209
D008767Methylmercury CompoundsMethylmercury Compounds results in increased expression of SCGB3A1 mRNA21628967|2428428
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of SCGB3A1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of SCGB3A1 mRNA"25554681
C031721naphthalenenaphthalene results in decreased expression of SCGB3A1 mRNA20522644
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in increased expression of SCGB3A1 mRNA22237054
C017947sodium arsenitesodium arsenite results in decreased expression of SCGB3A1 mRNA18812580
D053260SootSoot results in decreased expression of SCGB3A1 mRNA26551751
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SCGB3A1 mRNA22298810
C009495titanium dioxidetitanium dioxide results in decreased expression of SCGB3A1 mRNA23557971
D014028Tobacco Smoke PollutionNFE2L2 protein affects the reaction [Tobacco Smoke Pollution affects the expression of SCGB3A1 mRNA]20133372
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of SCGB3A1 mRNA20133372
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of SCGB3A1 mRNA18087596
D014635Valproic AcidValproic Acid results in increased methylation of SCGB3A1 gene29154799
C025643vinclozolinvinclozolin affects the expression of SCGB3A1 mRNA19015723

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005125cytokine activity-NAS11481438  
GO ID GO Term Qualifier Evidence PubMed
GO:0010469regulation of signaling receptor activity-IEA-  
GO:0030308negative regulation of cell growth-NAS11481438  
GO:0042127regulation of cell proliferation-NAS11481438  
GO:1901741positive regulation of myoblast fusion-IBA21873635  
GO:1901741positive regulation of myoblast fusion-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005615extracellular space-HDA16502470  
GO:0005615extracellular space-IBA21873635  
GO:0005615extracellular space-IDA11481438  
GO:0070062extracellular exosome-HDA19199708  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26937342NGS meta data analysis for identification of SNP and INDEL patterns in human airway transcriptome: A preliminary indicator for lung cancer. (2015 Mar)B SAppl Transl Genom
29197760Lifetime exposure to ambient air pollution and methylation of tumor suppressor genes in breast tumors. (2018 Feb)Callahan CLEnviron Res
19334046Current smoking-specific gene expression signature in normal bronchial epithelium is enhanced in squamous cell lung cancer. (2009 Jun)Boelens MCJ Pathol