Gene: DLG5

9231
LP-DLG|P-DLG5|PDLG
discs large MAGUK scaffold protein 5
protein-coding
10q22.3
Ensembl:ENSG00000151208 MIM:604090 Vega:OTTHUMG00000018548 UniprotKB:Q8TDM6
NG_011484.1
PubMed
0   ANCO-SNPs
ND
3   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.871e-1 (AD)  8.376e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg03110921chr10:79597461DLG5Gene body3.727e-4Alcohol use disorders26763658
cg02407266chr10:79637979DLG54.400e-11Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TSTD20.825
PTPRJ0.813
BCL9L0.813
DCAF50.812
GPATCH80.789
EP3000.786
NSD10.784
DDX60.783
CDK120.778
GALNT20.778

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.407
OR4F29-0.383
KLRC3-0.3
UGT2B11-0.283
APOA1-0.26
SPRR2D-0.254
C17orf112-0.251
OR7A17-0.249
KLRC2-0.248
KRTAP10-12-0.225

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000082AcetaminophenAcetaminophen results in increased expression of DLG5 mRNA21420995|2223033
D000082AcetaminophenAcetaminophen affects the expression of DLG5 mRNA17562736
D020106AcrylamideAcrylamide results in decreased expression of DLG5 mRNA28959563
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of DLG5 mRNA24449571
D001151ArsenicArsenic affects the methylation of DLG5 gene25304211
D001280AtrazineAtrazine results in increased expression of DLG5 mRNA22378314
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of DLG5 mRNA26001963
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of DLG5 mRNA19770486
D004958Estradiol[Estradiol co-treated with Progesterone] results in increased expression of DLG5 mRNA20660070
D004958EstradiolEstradiol results in increased expression of DLG5 mRNA23019147
C006780bisphenol Abisphenol A affects the expression of DLG5 mRNA21786754
C018475butyraldehydebutyraldehyde results in decreased expression of DLG5 mRNA26079696
D019256Cadmium ChlorideCadmium Chloride results in decreased methylation of DLG5 promoter22457795
C030973cupric oxidecupric oxide results in decreased expression of DLG5 mRNA22077320
D016572CyclosporineCyclosporine results in increased expression of DLG5 mRNA25562108
D016047Zalcitabine"[gp120 protein, Human immunodeficiency virus 1 co-treated with Zalcitabine] results in increased expression of DLG5 mRNA"18606552
D003976DiazinonDiazinon affects the expression of DLG5 mRNA22546817
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of DLG5 mRNA21266533
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of DLG5 mRNA21266533
D002945CisplatinCisplatin results in increased expression of DLG5 mRNA27594783
C000944dicrotophosdicrotophos results in increased expression of DLG5 mRNA28302478
D004026DieldrinDieldrin affects the expression of DLG5 mRNA22546817
D011397Promegestonemethoxyacetic acid promotes the reaction [Promegestone results in increased expression of DLG5 mRNA]15103026
D011397PromegestonePromegestone results in increased expression of DLG5 mRNA15103026
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of DLG5 mRNA23649840
D005557FormaldehydeFormaldehyde results in increased expression of DLG5 mRNA23649840
D019833GenisteinGenistein results in increased expression of DLG5 mRNA23019147
C514793gp120 protein, Human immunodeficiency virus 1"[gp120 protein, Human immunodeficiency virus 1 co-treated with Zalcitabine] results in increased expression of DLG5 mRNA"18606552
D017313FenretinideFenretinide results in increased expression of DLG5 mRNA28973697
D006861Hydrogen PeroxideHydrogen Peroxide results in increased expression of DLG5 mRNA18951874
C410337K 7174K 7174 results in increased expression of DLG5 mRNA24086573
C008261lead acetatelead acetate results in decreased expression of DLG5 mRNA21829687
C482199lipopolysaccharide, E coli O55-B5"[lipopolysaccharide, E coli O55-B5 co-treated with Particulate Matter] results in increased expression of DLG5 mRNA"15522845
C482199lipopolysaccharide, E coli O55-B5"[lipopolysaccharide, E coli O55-B5 co-treated with Vehicle Emissions] results in increased expression of DLG5 mRNA"15522845
D017258Medroxyprogesterone AcetateMedroxyprogesterone Acetate results in increased expression of DLG5 mRNA18497975|1914686
C013598methoxyacetic acidmethoxyacetic acid promotes the reaction [Promegestone results in increased expression of DLG5 mRNA]15103026
D008767Methylmercury CompoundsMethylmercury Compounds affects the expression of DLG5 mRNA21664453
D008767Methylmercury CompoundsMethylmercury Compounds affects the expression of DLG5 mRNA21664453
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of DLG5 mRNA23649840
D015741MetriboloneMetribolone results in increased expression of DLG5 mRNA17010196
C022838nickel chloridenickel chloride affects the expression of DLG5 mRNA22546817
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of DLG5 mRNA25729387
D052638Particulate Matter"[lipopolysaccharide, E coli O55-B5 co-treated with Particulate Matter] results in increased expression of DLG5 mRNA"15522845
D010416PentachlorophenolPentachlorophenol results in increased expression of DLG5 mRNA23892564
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of DLG5 mRNA19710929
D011374Progesterone[Estradiol co-treated with Progesterone] results in increased expression of DLG5 mRNA20660070
D011374ProgesteroneProgesterone results in increased expression of DLG5 mRNA18497975
D015474IsotretinoinIsotretinoin results in increased expression of DLG5 mRNA20436886
C513635S-2-pentyl-4-pentynoic hydroxamic acidS-2-pentyl-4-pentynoic hydroxamic acid results in decreased expression of DLG5 mRNA21427059
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of DLG5 mRNA19465110
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of DLG5 mRNA25729387
C012589trichostatin Atrichostatin A affects the expression of DLG5 mRNA28542535
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of DLG5 mRNA"26179874
D014635Valproic AcidValproic Acid affects the expression of DLG5 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased methylation of DLG5 gene29154799
D014635Valproic AcidValproic Acid results in decreased expression of DLG5 mRNA21427059
D014635Valproic AcidValproic Acid results in decreased palmitoylation of DLG5 protein26348896
D014635Valproic AcidValproic Acid results in increased expression of DLG5 mRNA21427059
D001335Vehicle Emissions"[lipopolysaccharide, E coli O55-B5 co-treated with Vehicle Emissions] results in increased expression of DLG5 mRNA"15522845

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI23624079  28087714  28169360  
GO:0008013beta-catenin binding-IDA12657639  
GO:0008092cytoskeletal protein binding-IDA12657639  
GO:0030159receptor signaling complex scaffold activity-NAS12353226  
GO ID GO Term Qualifier Evidence PubMed
GO:0001837epithelial to mesenchymal transition-IMP28169360  
GO:0007165signal transduction-TAS9738934  
GO:0008285negative regulation of cell proliferation-TAS9738934  
GO:0030011maintenance of cell polarity-IMP28169360  
GO:0030336negative regulation of cell migration-IMP28169360  
GO:0030859polarized epithelial cell differentiation-IEA-  
GO:0030901midbrain development-IEA-  
GO:0035331negative regulation of hippo signaling-IMP28087714  
GO:0035332positive regulation of hippo signaling-IMP28169360  
GO:0035556intracellular signal transduction-NAS12353226  
GO:0042130negative regulation of T cell proliferation-IMP28169360  
GO:0042981regulation of apoptotic process-IEA-  
GO:0045176apical protein localization-IEA-  
GO:0045186zonula adherens assembly-IEA-  
GO:0045197establishment or maintenance of epithelial cell apical/basal polarity-IEA-  
GO:0045880positive regulation of smoothened signaling pathway-ISS-  
GO:0051965positive regulation of synapse assembly-ISS-  
GO:0060441epithelial tube branching involved in lung morphogenesis-IEA-  
GO:0060999positive regulation of dendritic spine development-ISS-  
GO:0065003protein-containing complex assembly-IEA-  
GO:0071896protein localization to adherens junction-IEA-  
GO:0072205metanephric collecting duct development-IEA-  
GO:0098609cell-cell adhesion-NAS12353226  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IEA-  
GO:0005886plasma membrane-TAS9738934  
GO:0005913cell-cell adherens junction-IEA-  
GO:0014069postsynaptic density-ISS-  
GO:0030054cell junction-IDA28169360  
GO:0036064ciliary basal body-ISS-  
GO:0045211postsynaptic membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
19953089Differences in genetic background between active smokers, passive smokers, and non-smokers with Crohn's disease. (2010 May)van der Heide FAm J Gastroenterol
17544013Prospective study of interaction between alcohol, NSAID use and polymorphisms in genes involved in the inflammatory response in relation to risk of colorectal cancer. (2007 Nov 1)Vogel UMutat Res
16944184Investigation of association of the DLG5 gene with phenotypes of inflammatory bowel disease in the British population. (2007 Apr)Pearce AVInt J Colorectal Dis