Gene: PTTG1

9232
EAP1|HPTTG|PTTG|TUTR1
pituitary tumor-transforming 1
protein-coding
5q33.3
Ensembl:ENSG00000164611 MIM:604147 Vega:OTTHUMG00000130328 UniprotKB:O95997
NC_000005.10
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.071e-1 (AD)  4.008e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CDK70.804
NANS0.788
NOP160.787
SMIM120.786
PTRH20.783
C9orf400.783
RNF113A0.779
TMEM700.778
H2AFZ0.777
MED310.772

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
P2RY14-0.467
ASB4-0.44
PARD3B-0.428
MYOM1-0.42
MBNL3-0.408
APCDD1-0.398
MYO10-0.39
DOCK1-0.39
C16orf96-0.385
OR4F5-0.381

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C44865917-(dimethylaminoethylamino)-17-demethoxygeldanamycin17-(dimethylaminoethylamino)-17-demethoxygeldanamycin promotes the reaction [arsenic trioxide results in increased expression of PTTG1 protein]19371599
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of PTTG1 mRNA"25510870
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of PTTG1 mRNA"19114083
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of PTTG1 mRNA"19167446
C0630022,3-dimethoxy-1,4-naphthoquinone"2,3-dimethoxy-1,4-naphthoquinone results in increased expression of PTTG1 mRNA"17547211
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of PTTG1 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of PTTG1 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of PTTG1 mRNA"25510870
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of PTTG1 mRNA"21346803
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of PTTG1 mRNA"25510870
C0194992-nitrofluorene2-nitrofluorene results in decreased expression of PTTG1 mRNA15890375
C0841792-phenyl-4-oxohydroquinoline2-phenyl-4-oxohydroquinoline analog affects the expression of PTTG1 protein27769712
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of PTTG1 mRNA"23196670
C4727913-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in decreased expression of PTTG1 mRNA16788091
C0179063-dinitrobenzene3-dinitrobenzene results in decreased expression of PTTG1 mRNA22841810
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PTTG1 mRNA"27188386
C0352074-amino-2,6-dinitrotoluene"4-amino-2,6-dinitrotoluene affects the expression of PTTG1 mRNA"21346803
C0165834-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in decreased expression of PTTG1 mRNA15890375
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PTTG1 mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of PTTG1 mRNA21420995|2223033
D000082AcetaminophenAcetaminophen affects the expression of PTTG1 mRNA17562736
D020106AcrylamideAcrylamide results in increased expression of PTTG1 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 affects the expression of PTTG1 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of PTTG1 gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of PTTG1 mRNA15890375|2363061
D000643Ammonium ChlorideAmmonium Chloride affects the expression of PTTG1 mRNA16483693
D000965AntimonyAntimony results in increased expression of PTTG1 mRNA17547211
D000966Antimony Potassium TartrateAntimony Potassium Tartrate results in increased expression of PTTG1 mRNA17547211
C006632arsenic trioxide17-(dimethylaminoethylamino)-17-demethoxygeldanamycin promotes the reaction [arsenic trioxide results in increased expression of PTTG1 protein]19371599
C006632arsenic trioxidearsenic trioxide results in increased expression of PTTG1 mRNA17547211
C006632arsenic trioxidearsenic trioxide results in increased expression of PTTG1 protein19371599
C006632arsenic trioxideKNK 437 promotes the reaction [arsenic trioxide results in increased expression of PTTG1 protein]19371599
D001280AtrazineAtrazine results in increased expression of PTTG1 mRNA22378314
C547126AZM551248AZM551248 results in increased expression of PTTG1 mRNA22323515
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in increased expression of PTTG1 mRNA26377693
D019324beta-Naphthoflavone[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of PTTG1 mRNA18164116
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of PTTG1 mRNA21715664
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of PTTG1 mRNA"20382639
D004958EstradiolEstradiol results in increased expression of PTTG1 mRNA18984771|1916744
C044887beta-methylcholinebeta-methylcholine affects the expression of PTTG1 mRNA21179406
C543008bis(4-hydroxyphenyl)sulfonebis(4-hydroxyphenyl)sulfone results in increased expression of PTTG1 mRNA27685785
C006780bisphenol Abisphenol A results in decreased expression of PTTG1 mRNA29275510
C006780bisphenol Abisphenol A affects the methylation of PTTG1 promoter27334623
C006780bisphenol Abisphenol A results in decreased expression of PTTG1 mRNA25181051|2608855
C006780bisphenol Abisphenol A results in increased expression of PTTG1 mRNA27830003
C006780bisphenol Abisphenol A results in increased expression of PTTG1 protein27830003
D002065BuspironeBuspirone results in decreased expression of PTTG1 mRNA24136188
C040918buteinbutein results in decreased expression of PTTG1 protein24931875
C040918buteinPTTG1 protein results in decreased susceptibility to butein24931875
D019328Buthionine SulfoximineButhionine Sulfoximine results in increased expression of PTTG1 mRNA15878706
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of PTTG1 mRNA15003993
D002104CadmiumCadmium results in decreased expression of PTTG1 mRNA21120746
D002104CadmiumCadmium results in increased expression of PTTG1 mRNA17547211|1903142
D019256Cadmium ChlorideCadmium Chloride results in increased expression of PTTG1 mRNA17547211
D019256Cadmium Chloride[Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in increased expression of PTTG1 mRNA19840844
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of PTTG1 mRNA25993096
D000074262Canola OilCanola Oil metabolite results in decreased expression of PTTG1 mRNA27363782
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of PTTG1 mRNA17484886
D002251Carbon TetrachloridePLG gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of PTTG1 mRNA]16006527
D002857ChromiumChromium results in increased expression of PTTG1 mRNA17547211
C018021cobaltous chloridecobaltous chloride results in decreased expression of PTTG1 mRNA19376846
C018021cobaltous chloridecobaltous chloride results in decreased expression of PTTG1 mRNA24386269
D003300Copper[NSC 689534 binds to Copper] which results in decreased expression of PTTG1 mRNA20971185
D003300CopperCopper results in increased expression of PTTG1 mRNA17205981
D019327Copper SulfateCopper Sulfate results in decreased expression of PTTG1 mRNA19549813
D003345CorticosteroneCorticosterone results in decreased expression of PTTG1 mRNA15755911
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of PTTG1 mRNA"19167446
D003375Coumestrol[Coumestrol co-treated with resveratrol] results in increased expression of PTTG1 mRNA19167446
D003375CoumestrolCoumestrol results in increased expression of PTTG1 mRNA19167446
C408982CPG-oligonucleotideCPG-oligonucleotide results in increased expression of PTTG1 mRNA21878529
C408982CPG-oligonucleotideCPG-oligonucleotide results in increased expression of PTTG1 mRNA21878529
C030973cupric oxidecupric oxide results in decreased expression of PTTG1 mRNA22077320
D003471CuprizoneCuprizone results in increased expression of PTTG1 mRNA26577399
D016572CyclosporineCyclosporine results in decreased expression of PTTG1 mRNA20106945|2163298
D000069439DasatinibDasatinib results in decreased expression of PTTG1 mRNA20579391
C014347decitabinedecitabine affects the expression of PTTG1 mRNA23300844
D015255IdarubicinDexrazoxane inhibits the reaction [Idarubicin results in decreased expression of PTTG1 protein]28973540
D015255IdarubicinIdarubicin results in decreased expression of PTTG1 protein28973540
D064730DexrazoxaneDexrazoxane inhibits the reaction [Idarubicin results in decreased expression of PTTG1 protein]28973540
D003976DiazinonDiazinon affects the expression of PTTG1 mRNA22546817
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of PTTG1 mRNA21266533
D002945CisplatinCisplatin affects the expression of PTTG1 mRNA23300844
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of PTTG1 mRNA27392435
D002945CisplatinCisplatin results in decreased expression of PTTG1 mRNA27594783
D002945CisplatinCisplatin results in increased expression of PTTG1 mRNA27392435
D002945CisplatinCisplatin results in increased expression of PTTG1 mRNA21151649
D004026DieldrinDieldrin affects the expression of PTTG1 mRNA22546817
D004026DieldrinDieldrin results in increased expression of PTTG1 mRNA23153324
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of PTTG1 mRNA24535843
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of PTTG1 mRNA18164116
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of PTTG1 mRNA15890375|1700539
D002117CalcitriolCalcitriol results in decreased expression of PTTG1 mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in decreased expression of PTTG1 mRNA21592394
D004128DimethylnitrosamineDimethylnitrosamine results in increased expression of PTTG1 mRNA17547211|1903142
D004128DimethylnitrosamineDimethylnitrosamine results in increased expression of PTTG1 mRNA15890375
D004317DoxorubicinDoxorubicin results in decreased expression of PTTG1 mRNA15205334
D004317DoxorubicinDoxorubicin results in decreased expression of PTTG1 mRNA27181935
D004317DoxorubicinFungal Polysaccharides inhibits the reaction [Doxorubicin results in decreased expression of PTTG1 mRNA]27181935
C074283estradiol 3-benzoateestradiol 3-benzoate results in increased expression of PTTG1 mRNA27830003
C074283estradiol 3-benzoateestradiol 3-benzoate results in increased expression of PTTG1 protein27830003
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of PTTG1 mRNA17555576
D005038EthylnitrosoureaEthylnitrosourea results in decreased expression of PTTG1 mRNA15954086
C540355fenamidonefenamidone results in increased expression of PTTG1 mRNA27029645
D0150732-Acetylaminofluorene2-Acetylaminofluorene results in increased expression of PTTG1 mRNA19167416
D005472FluorouracilFluorouracil results in decreased expression of PTTG1 mRNA15205334|1655759
D005472FluorouracilFluorouracil results in increased expression of PTTG1 protein15016801
D005472FluorouracilTP53 protein affects the reaction [Fluorouracil results in decreased expression of PTTG1 mRNA]15016801
D005472FluorouracilTP53 protein inhibits the reaction [Fluorouracil results in increased expression of PTTG1 protein]15016801
D005472FluorouracilFluorouracil results in decreased expression of PTTG1 mRNA19272435
D005557FormaldehydeFormaldehyde results in increased expression of PTTG1 mRNA23649840
C070081fulvestrant[fulvestrant co-treated with Sirolimus] results in decreased expression of PTTG1 mRNA19016759
C070081fulvestrantfulvestrant results in decreased expression of PTTG1 mRNA18984771|1901675
C070081fulvestrantfulvestrant results in decreased expression of PTTG1 protein18984771
D062610Fungal PolysaccharidesFungal Polysaccharides inhibits the reaction [Doxorubicin results in decreased expression of PTTG1 mRNA]27181935
C039281furanfuran results in increased expression of PTTG1 mRNA22079235|2553966
D005688GalactosaminePTTG1 mRNA affects the susceptibility to Galactosamine19800905
C419708gefitinibgefitinib results in decreased stability of and results in decreased expression of PTTG1 protein23523951
C419708gefitinibPTTG1 protein results in decreased susceptibility to gefitinib23523951
D005944GlucosamineGlucosamine results in decreased expression of PTTG1 mRNA17109745
D006533HeptachlorHeptachlor results in increased expression of PTTG1 mRNA23153324
D017313FenretinideFenretinide results in decreased expression of PTTG1 mRNA16671099
C492448ICG 001ICG 001 results in decreased expression of PTTG1 mRNA26191083
C016517indole-3-carbinolindole-3-carbinol affects the expression of PTTG1 mRNA21396975
C051890irinotecanirinotecan affects the expression of PTTG1 mRNA20097248
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of PTTG1 mRNA27392435
C410027KNK 437KNK 437 promotes the reaction [arsenic trioxide results in increased expression of PTTG1 protein]19371599
D007840LatexLatex analog results in increased expression of PTTG1 mRNA24768652
C045463leflunomideleflunomide results in decreased expression of PTTG1 mRNA28988120
C045463leflunomideleflunomide results in decreased expression of PTTG1 mRNA24136188
C038753leptomycin Bleptomycin B results in decreased expression of PTTG1 mRNA20803015
D064704LevofloxacinLevofloxacin results in decreased expression of PTTG1 mRNA24136188
C533894LG 100815LG 100815 results in decreased expression of PTTG1 mRNA16951191
D015122MercaptopurineMercaptopurine results in decreased expression of PTTG1 mRNA23358152
D008628MercuryMercury results in increased expression of PTTG1 mRNA17547211
D008701MethapyrileneMethapyrilene results in increased expression of PTTG1 mRNA15890375|2248451
D008748MethylcholanthreneMethylcholanthrene results in increased expression of PTTG1 mRNA20713471
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of PTTG1 mRNA26011545
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of PTTG1 mRNA23649840
D008769Methylnitronitrosoguanidine[Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in increased expression of PTTG1 mRNA19840844
D008769Methylnitronitrosoguanidine[Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in increased expression of PTTG1 mRNA19840844
D008769Methylnitronitrosoguanidine[Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in increased expression of PTTG1 mRNA19840844
D008917MirexMirex results in increased expression of PTTG1 mRNA23153324
C047806monomethylpropionmonomethylpropion results in increased expression of PTTG1 mRNA22303338
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of PTTG1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of PTTG1 mRNA"25554681
D009532NickelNickel results in increased expression of PTTG1 mRNA19031421|2558310
C022838nickel chloridenickel chloride results in increased expression of PTTG1 mRNA17547211
C022838nickel chloridenickel chloride affects the expression of PTTG1 mRNA22546817
C028007nickel monoxidenickel monoxide results in decreased expression of PTTG1 mRNA19167457
C012655nimesulidenimesulide results in decreased expression of PTTG1 mRNA24136188
D009569Nitric OxideNitric Oxide deficiency results in increased expression of PTTG1 mRNA15878706
C558013NSC 689534[NSC 689534 binds to Copper] which results in decreased expression of PTTG1 mRNA20971185
C025589ochratoxin Aochratoxin A results in increased expression of PTTG1 mRNA19237604
C062198octa-2,4,6-trienoic acid"octa-2,4,6-trienoic acid results in decreased expression of PTTG1 mRNA"16951191
D019319Okadaic AcidOkadaic Acid affects the expression of PTTG1 mRNA23561263
D019319Okadaic Acid[Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in increased expression of PTTG1 mRNA19840844
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of PTTG1 mRNA25729387
C030110oxaliplatinoxaliplatin results in decreased expression of PTTG1 mRNA25729387
D017239PaclitaxelPaclitaxel affects the expression of PTTG1 protein27769712
C500026palbociclibpalbociclib results in decreased expression of PTTG1 mRNA22869556
D052638Particulate MatterParticulate Matter results in decreased expression of PTTG1 mRNA24769257
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of PTTG1 mRNA"25510870
D010416PentachlorophenolPentachlorophenol results in increased expression of PTTG1 mRNA23892564
D010634Phenobarbital[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of PTTG1 mRNA24535843
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in increased expression of PTTG1 mRNA]19482888
D010634PhenobarbitalPhenobarbital results in increased expression of PTTG1 mRNA19482888
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PTTG1 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of PTTG1 mRNA26272509
D010882Piperonyl ButoxidePiperonyl Butoxide results in increased expression of PTTG1 mRNA15890375
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of PTTG1 mRNA19710929
C006253pirinixic acidpirinixic acid results in decreased expression of PTTG1 mRNA17426115
C006253pirinixic acidpirinixic acid results in increased expression of PTTG1 mRNA18301758
C006253pirinixic acidpirinixic acid results in increased expression of PTTG1 mRNA15890375|1916217
D011192Potassium DichromatePotassium Dichromate results in increased expression of PTTG1 mRNA17547211
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of PTTG1 mRNA19162173
D011374ProgesteroneProgesterone results in decreased expression of PTTG1 mRNA23012394|2301818
D011374ProgesteroneProgesterone results in decreased expression of PTTG1 mRNA20726854
C005556propionaldehydepropionaldehyde results in decreased expression of PTTG1 mRNA26079696
D011441PropylthiouracilPropylthiouracil results in increased expression of PTTG1 mRNA24780913
D011794QuercetinQuercetin results in decreased expression of PTTG1 mRNA21632981|2372791
C059514resveratrol[Coumestrol co-treated with resveratrol] results in increased expression of PTTG1 mRNA19167446
C059514resveratrolresveratrol results in increased expression of PTTG1 mRNA19167446
D012834SilverSilver results in decreased expression of PTTG1 mRNA27131904
D012835Silver NitrateSilver Nitrate analog affects the expression of PTTG1 mRNA22831968
D012835Silver NitrateSilver Nitrate results in increased expression of PTTG1 mRNA22831968
D020123Sirolimus[fulvestrant co-treated with Sirolimus] results in decreased expression of PTTG1 mRNA19016759
C017947sodium arsenitePTTG1 protein results in decreased susceptibility to sodium arsenite16338954
C017947sodium arsenitesodium arsenite results in decreased expression of PTTG1 protein16338954
C017947sodium arsenitesodium arsenite results in increased stability of PTTG1 protein18501396
C017947sodium arsenitesodium arsenite results in decreased expression of PTTG1 protein16338954
C017947sodium arsenitesodium arsenite results in increased expression of PTTG1 mRNA16014739
D013629TamoxifenTamoxifen affects the expression of PTTG1 mRNA17555576
D013739Testosterone[Testosterone co-treated with Calcitriol] results in decreased expression of PTTG1 mRNA21592394
D013739TestosteroneTestosterone results in decreased expression of PTTG1 mRNA21592394
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PTTG1 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of PTTG1 mRNA18172886
D013750TetrachloroethyleneTetrachloroethylene results in increased expression of PTTG1 mRNA19031421
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate results in increased expression of PTTG1 mRNA19031421
D013755Tetradecanoylphorbol Acetate[Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in increased expression of PTTG1 mRNA19840844
D019284ThapsigarginThapsigargin results in decreased expression of PTTG1 mRNA22378314
D019284ThapsigarginThapsigargin results in decreased expression of PTTG1 protein24648495
C009495titanium dioxidetitanium dioxide affects the expression of PTTG1 mRNA17656681
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of PTTG1 mRNA20133372
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of PTTG1 mRNA25729387
D019772TopotecanTopotecan results in decreased expression of PTTG1 mRNA25729387
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of PTTG1 mRNA19042947
C001899triptolidetriptolide results in increased expression of PTTG1 mRNA23639586
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of PTTG1 mRNA"26179874
C057693troglitazonetroglitazone results in decreased expression of PTTG1 mRNA19140230
C080163trovafloxacintrovafloxacin results in decreased expression of PTTG1 mRNA24136188
D014415TunicamycinTunicamycin results in decreased expression of PTTG1 mRNA22378314
D014520UrethaneUrethane results in increased expression of PTTG1 mRNA28818685
C406224valdecoxibvaldecoxib results in decreased expression of PTTG1 mRNA24136188
D014635Valproic AcidValproic Acid results in decreased methylation of PTTG1 gene29154799
D014635Valproic AcidValproic Acid results in increased expression of PTTG1 mRNA29154799
D014640VancomycinVancomycin results in decreased expression of PTTG1 mRNA18930951
D001335Vehicle EmissionsVehicle Emissions affects the methylation of PTTG1 gene25560391
D014747VinblastinePTTG1 protein affects the susceptibility to Vinblastine16217747
D019287Zinc SulfateZinc Sulfate results in increased expression of PTTG1 mRNA27215404

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-IMP9811450  
GO:0003700DNA-binding transcription factor activity-TAS9811450  
GO:0004869cysteine-type endopeptidase inhibitor activity-NAS12194817  
GO:0005515protein binding-IPI12194817  
GO:0017124SH3 domain binding-IEA-  
GO:0030414peptidase inhibitor activity-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0006281DNA repair-IEA-  
GO:0006357regulation of transcription by RNA polymerase II-IEA-  
GO:0006366transcription by RNA polymerase II-IMP9811450  
GO:0007283spermatogenesis-TAS9915854  
GO:0010951negative regulation of endopeptidase activity-IEA-  
GO:0031145anaphase-promoting complex-dependent catabolic process-TAS-  
GO:0045143homologous chromosome segregation-IBA21873635  
GO:0051276chromosome organization-IEA-  
GO:0051301cell division-IEA-  
GO:2000816negative regulation of mitotic sister chromatid separation-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-IDA9811450  
GO:0005737cytoplasm-TAS9811450  
GO:0005829cytosol-IDA9811450  
GO:0005829cytosol-TAS-  
KEGG ID KEGG Term
hsa04110Cell cycle
hsa04114Oocyte meiosis
Reactome ID Reactome Term Evidence
R-HSA-1640170Cell CycleTAS
R-HSA-174143APC/C-mediated degradation of cell cycle proteinsTAS
R-HSA-174154APC/C:Cdc20 mediated degradation of SecurinTAS
R-HSA-174178APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1TAS
R-HSA-176409APC/C:Cdc20 mediated degradation of mitotic proteinsTAS
R-HSA-176814Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteinsTAS
R-HSA-2467813Separation of Sister ChromatidsTAS
R-HSA-2555396Mitotic Metaphase and AnaphaseTAS
R-HSA-453276Regulation of mitotic cell cycleTAS
R-HSA-68882Mitotic AnaphaseTAS
R-HSA-68886M PhaseTAS
R-HSA-69278Cell Cycle, MitoticTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23541940TNIP1/ANXA6 and CSMD1 variants interacting with cigarette smoking, alcohol intake affect risk of psoriasis. (2013 May)Yin XYJ Dermatol Sci