Gene: MSC

9242
ABF-1|ABF1|MYOR|bHLHa22
musculin
protein-coding
8q13.3
Ensembl:ENSG00000178860 MIM:603628 Vega:OTTHUMG00000164489 UniprotKB:O60682
NC_000008.11
PubMed
0   ANCO-SNPs
CD|OD|ND|AD
8   
6.358e-1 (AD)  4.585e-1 (ND)   (Frontal_Cortex)
7.475e-1 (AD)  9.372e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ADTRP0.647
KREMEN20.644
IFITM100.642
FEZF20.641
SYT120.634
ARL4D0.629
NKD20.626
GALNT140.618
CPNE70.616
CHRNA40.614

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PHEX-0.486
SYTL4-0.436
PARD3B-0.435
PON3-0.434
ASB4-0.432
C1orf87-0.432
SULT1C4-0.431
PRKD3-0.43
GNG12-0.42
FAM89A-0.42

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5768821-(2-trifluoromethoxyphenyl)-2-nitroethanone1-(2-trifluoromethoxyphenyl)-2-nitroethanone results in decreased expression of MSC mRNA25596134
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of MSC mRNA"23146750
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of MSC mRNA"19114083
C517041(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II)"(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II) results in increased expression of MSC mRNA"19561079
D000082AcetaminophenAcetaminophen results in increased expression of MSC mRNA29067470
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of MSC gene27153756
C006632arsenic trioxidearsenic trioxide results in decreased expression of MSC mRNA15761015
C015001arsenitearsenite results in increased methylation of MSC promoter23974009
D017638Asbestos, Crocidolite"Asbestos, Crocidolite affects the expression of MSC mRNA"25757056
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of MSC mRNA22316170
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of MSC mRNA20064835
D004958EstradiolEstradiol results in decreased expression of MSC mRNA25210133
C006780bisphenol Abisphenol A results in increased expression of MSC mRNA29275510
C006780bisphenol Abisphenol A affects the methylation of MSC promoter27334623
C006780bisphenol Abisphenol A results in decreased expression of MSC mRNA25270620
C006780bisphenol Abisphenol A results in increased expression of MSC mRNA25181051
C018475butyraldehydebutyraldehyde results in decreased expression of MSC mRNA26079696
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of MSC mRNA17484886
D002746ChlorpromazineChlorpromazine results in decreased expression of MSC mRNA25596134
D016572CyclosporineCyclosporine results in increased expression of MSC mRNA20106945
D002945CisplatinCisplatin results in decreased expression of MSC mRNA27392435
C121718dicyclanildicyclanil results in increased expression of MSC mRNA15664270
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of MSC mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of MSC mRNA17942748
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of MSC mRNA23649840
D005047EtoposideEtoposide results in decreased expression of MSC mRNA25270620
D011345FenofibrateFenofibrate results in decreased expression of MSC mRNA25596134
D017313FenretinideFenretinide results in increased expression of MSC mRNA28973697
D008687MetforminMetformin results in decreased expression of MSC mRNA25596134
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of MSC mRNA23649840
D008770MethylnitrosoureaMethylnitrosourea results in decreased expression of MSC mRNA25270620
C047806monomethylpropionmonomethylpropion results in increased expression of MSC mRNA22303338
C029938nickel sulfatenickel sulfate results in increased expression of MSC mRNA22714537
C570897NSC668394NSC668394 results in increased expression of MSC mRNA27137931
C046012pentanalpentanal results in decreased expression of MSC mRNA26079696
D010634PhenobarbitalPhenobarbital affects the expression of MSC mRNA19159669
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of MSC mRNA22714537
C089730rosiglitazonerosiglitazone results in decreased expression of MSC mRNA25596134
C017947sodium arsenitesodium arsenite results in increased expression of MSC mRNA22714537
D018038Sodium SeleniteSodium Selenite results in increased expression of MSC mRNA24383545
C016766sulforafansulforafan results in increased expression of MSC mRNA26833863
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of MSC mRNA17942748
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of MSC mRNA22363418
D014212TretinoinTretinoin results in decreased expression of MSC mRNA16604517
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of MSC mRNA"26179874

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000980RNA polymerase II distal enhancer sequence-specific DNA binding-IEA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0001206transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding-IEA-  
GO:0003700DNA-binding transcription factor activity-TAS9584154  
GO:0003714transcription corepressor activity-TAS9584154  
GO:0046983protein dimerization activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-IEA-  
GO:0006366transcription by RNA polymerase II-TAS9584154  
GO:0014707branchiomeric skeletal muscle development-IEA-  
GO:0060021roof of mouth development-IEA-  
GO:0060539diaphragm development-IEA-  
GO:1990830cellular response to leukemia inhibitory factor-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-TAS9584154  
GO:0005654nucleoplasm-IDA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23665932Marijuana smoke condensate induces p53-mediated apoptosis in human lung epithelial cells. (2013)Kim HRJ Toxicol Sci
23030247Nicotine alters MicroRNA expression and hinders human adult stem cell regenerative potential. (2013 Mar 1)Ng TKStem Cells Dev
29079789Electronic Cigarette Smoke Impairs Normal Mesenchymal Stem Cell Differentiation. (2017 Oct 27)Shaito ASci Rep
29217402Inflammatory profile analysis reveals differences in cytokine expression between smokers, moist snuff users, and dual users compared to non-tobacco consumers. (2018 Jul)Sgambato JACytokine
22307909Mesenchymal stem cell-conditioned media recovers lung fibroblasts from cigarette smoke-induced damage. (2012 May 1)Kim SYAm J Physiol Lung Cell Mol Physiol
15603002Combining stepped-care approaches with behavioral reinforcement to motivate employment in opioid-dependent outpatients. (2004)Kidorf MSubst Use Misuse
25834280Biological effects and mechanisms of action of mesenchymal stem cell therapy in chronic obstructive pulmonary disease. (2015 Jun)Jin ZJ Int Med Res
28090901PG Cert, PGDip or MSc in health improvement and health promotion. (2009 Sep 9)-Nurs Stand