Gene: CD8A

925
CD8|Leu2|MAL|p32
CD8a molecule
protein-coding
2p11.2
Ensembl:ENSG00000153563 MIM:186910 Vega:OTTHUMG00000130265 UniprotKB:P01732
NG_011608.2
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.376e-1 (AD)  1.294e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SLC1A60.83
RAB9B0.823
TUSC30.823
EFNB30.823
NETO20.821
SPTB0.821
P2RX50.818
ARHGEF330.816
TTC90.813
GLT1D10.808

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CPM-0.529
TGIF1-0.517
ROM1-0.49
MYL3-0.482
AGTRAP-0.48
OTOS-0.48
YES1-0.478
LATS2-0.476
COPZ2-0.472
RAB13-0.469

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of CD8A mRNA"25510870
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of CD8A mRNA"19114083
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of CD8A mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of CD8A mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of CD8A mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of CD8A mRNA"25510870
D000171AcroleinCD8A gene mutant form inhibits the reaction [Acrolein results in increased activity of MMP2 protein]17950725
D000171AcroleinCD8A gene mutant form inhibits the reaction [Acrolein results in increased activity of MMP9 protein]17950725
D000171AcroleinCD8A gene mutant form inhibits the reaction [Acrolein results in increased expression of CXCL10 mRNA]17950725
D000171AcroleinCD8A gene mutant form inhibits the reaction [Acrolein results in increased expression of IFNG mRNA]17950725
D000171AcroleinCD8A gene mutant form inhibits the reaction [Acrolein results in increased expression of IL12B mRNA]17950725
D000171AcroleinCD8A protein promotes the reaction [Acrolein results in increased activity of CASP3 protein]17950725
D000171AcroleinCD8A protein promotes the reaction [Acrolein results in increased expression of CCL2 mRNA]17950725
D000171AcroleinCD8A protein promotes the reaction [Acrolein results in increased expression of CCL5 mRNA]17950725
D020875Enkephalin, Ala(2)-MePhe(4)-Gly(5)-"Enkephalin, Ala(2)-MePhe(4)-Gly(5)- inhibits the reaction [Carbon Tetrachloride results in increased expression of CD8A mRNA]"17299060
D000447AldehydesAldehydes results in increased expression of CD8A mRNA25014914
D000643Ammonium ChlorideAmmonium Chloride affects the expression of CD8A mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of CD8A mRNA24449571
D001151ArsenicArsenic affects the methylation of CD8A gene25304211
D001241AspirinAspirin results in decreased expression of CD8A mRNA15928584
C547126AZM551248AZM551248 results in increased expression of CD8A mRNA22323515
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of CD8A mRNA21569818
D004958EstradiolEstradiol results in decreased expression of CD8A mRNA19484750
C006780bisphenol Abisphenol A affects the expression of CD8A mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of CD8A mRNA25181051
C018475butyraldehydebutyraldehyde results in increased expression of CD8A mRNA26079696
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of CD8A mRNA17299060
D002251Carbon Tetrachloride"Enkephalin, Ala(2)-MePhe(4)-Gly(5)- inhibits the reaction [Carbon Tetrachloride results in increased expression of CD8A mRNA]"17299060
D002737ChloropreneChloroprene results in decreased expression of CD8A mRNA23125180
D003471CuprizoneCuprizone results in increased expression of CD8A mRNA27523638
D003513Cycloheximide[Tetrachlorodibenzodioxin co-treated with Cycloheximide] results in increased expression of CD8A mRNA19684285
D003520CyclophosphamideCyclophosphamide results in decreased expression of CD8A mRNA21041162
D003561CytarabineCytarabine results in increased expression of CD8A mRNA19194470
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of CD8A mRNA23914054
D003907DexamethasoneDexamethasone results in decreased expression of CD8A mRNA21041162
D003999Dichloroacetic AcidDichloroacetic Acid results in increased expression of CD8A mRNA28962523
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of CD8A mRNA27392435
D002945CisplatinCisplatin results in decreased expression of CD8A mRNA27392435
D004041Dietary FatsDietary Fats results in increased expression of CD8A mRNA22010203
D004041Dietary FatsTestosterone inhibits the reaction [Dietary Fats results in increased expression of CD8A mRNA]22010203
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in increased expression of CD8A mRNA23830814
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Thioacetamide] results in increased expression of CD8A mRNA23830814
D004054DiethylstilbestrolDiethylstilbestrol results in decreased expression of CD8A mRNA21041162
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of CD8A mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of CD8A mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CD8A mRNA17942748
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of CD8A mRNA15576828
C004912ethylbenzeneethylbenzene results in increased expression of CD8A mRNA20955722
D005419FlavonoidsFlavonoids results in increased expression of CD8A mRNA18035473
D005472FluorouracilTP53 protein affects the reaction [Fluorouracil results in decreased expression of CD8A mRNA]15016801
D005473FluoxetineFluoxetine results in increased expression of CD8A protein21497159
D004397FonofosFonofos results in increased methylation of CD8A promoter22847954
D005839GentamicinsGentamicins results in increased expression of CD8A mRNA22061828
C004312glycidolglycidol results in decreased expression of CD8A mRNA24915197
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of CD8A mRNA27392435
D008713MethimazoleMethimazole results in increased expression of CD8A mRNA22504374
D008727MethotrexateMethotrexate results in decreased expression of CD8A protein15476228
D008752Methylene ChlorideMethylene Chloride results in increased expression of CD8A mRNA20955722
C047806monomethylpropionmonomethylpropion results in increased expression of CD8A mRNA22303338
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of CD8A mRNA"25554681
D009532NickelNickel results in increased expression of CD8A mRNA25583101
C029938nickel sulfatenickel sulfate results in increased expression of CD8A mRNA16780908
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of CD8A mRNA25729387
C030110oxaliplatinoxaliplatin results in increased expression of CD8A mRNA25729387
D010278ParathionParathion results in increased methylation of CD8A promoter22847954
D052638Particulate MatterParticulate Matter results in decreased expression of CD8A mRNA23638009
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of CD8A mRNA"25510870
C046012pentanalpentanal results in increased expression of CD8A mRNA26079696
D010615PhenacetinPhenacetin results in decreased expression of CD8A mRNA17698508
C030299phenylhydrazinephenylhydrazine results in decreased expression of CD8A mRNA17698508
C006253pirinixic acidpirinixic acid results in decreased expression of CD8A mRNA17426115
D011374ProgesteroneProgesterone results in decreased expression of CD8A mRNA23012394
D011374ProgesteroneProgesterone results in increased expression of CD8A mRNA19690047
C005556propionaldehydepropionaldehyde results in increased expression of CD8A mRNA26079696
D011441PropylthiouracilPropylthiouracil results in increased expression of CD8A mRNA22504374
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride affects the expression of CD8A mRNA16079270
C059514resveratrolresveratrol inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of CD8A protein]20715097
C017947sodium arsenitesodium arsenite affects the methylation of CD8A gene28589171
C017947sodium arsenitesodium arsenite results in decreased expression of CD8A protein16275621
D012999SomanSoman results in increased expression of CD8A mRNA19281266
C012568terbufosterbufos results in increased methylation of CD8A promoter22847954
D013739TestosteroneTestosterone inhibits the reaction [Dietary Fats results in increased expression of CD8A mRNA]22010203
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Cycloheximide] results in increased expression of CD8A mRNA19684285
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of CD8A mRNA19684285
D013749Tetrachlorodibenzodioxinresveratrol inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of CD8A protein]20715097
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CD8A mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of CD8A protein14718643|1597263
D013853Thioacetamide[Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in increased expression of CD8A mRNA23830814
D013853Thioacetamide[Diethylnitrosamine co-treated with Thioacetamide] results in increased expression of CD8A mRNA23830814
D008063Thioctic Acid[Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in increased expression of CD8A mRNA23830814
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of CD8A mRNA22363418
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of CD8A mRNA25729387
D019772TopotecanTopotecan results in increased expression of CD8A mRNA25729387
D014241TrichloroethyleneTrichloroethylene results in increased expression of CD8A mRNA20955722
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of CD8A mRNA"26179874
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of CD8A gene25560391
C025643vinclozolinvinclozolin results in increased expression of CD8A mRNA23034163

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI2470098  2493728  
GO:0015026coreceptor activity-NAS11131152  
GO:0019901protein kinase binding-IEA-  
GO:0042288MHC class I protein binding-NAS11131152  
GO ID GO Term Qualifier Evidence PubMed
GO:0002456T cell mediated immunity-IBA21873635  
GO:0006955immune response-NAS11131152  
GO:0007166cell surface receptor signaling pathway-IBA21873635  
GO:0007169transmembrane receptor protein tyrosine kinase signaling pathway-NAS9830036  
GO:0019882antigen processing and presentation-NAS2496167  
GO:0042110T cell activation-NAS9830036  
GO:0045065cytotoxic T cell differentiation-IBA21873635  
GO:0050776regulation of immune response-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-IEA-  
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-NAS2496167  
GO:0009897external side of plasma membrane-IBA21873635  
GO:0009897external side of plasma membrane-IDA17213291  
GO:0042101T cell receptor complex-NAS11131152  
GO:0044853plasma membrane raft-IDA17341584  
KEGG ID KEGG Term
hsa04514Cell adhesion molecules (CAMs)
hsa04612Antigen processing and presentation
hsa04640Hematopoietic cell lineage
hsa04660T cell receptor signaling pathway
hsa05340Primary immunodeficiency
Reactome ID Reactome Term Evidence
R-HSA-1280218Adaptive Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-198933Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cellTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24639246Clinical features of cytotoxic CD8+ T-lymphocyte deficiency in chronic rhinosinusitis patients: a demographic and functional study. (2014 Jun)Gabra NInt Forum Allergy Rhinol