Gene: NUMBL

9253
CAG3A|CTG3a|NBL|NUMB-R|NUMBLIKE|NUMBR|TNRC23
NUMB like, endocytic adaptor protein
protein-coding
19q13.2
Ensembl:ENSG00000105245 MIM:604018 Vega:OTTHUMG00000182627 UniprotKB:Q9Y6R0
NC_000019.10
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.737e-2 (AD)  4.322e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
AP2A20.943
NOC2L0.934
DBN10.932
CARM10.931
PISD0.931
ZFYVE270.93
TIMM500.93
PI4K2A0.928
DHX300.928
FOXK20.928

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.615
OR4F29-0.556
RAI14-0.374
ASB4-0.371
CTNNA3-0.366
MBNL3-0.365
MTRNR2L6-0.345
MTRNR2L9-0.343
YES1-0.34
REST-0.339

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of NUMBL mRNA"28973690
D000082AcetaminophenAcetaminophen affects the expression of NUMBL mRNA17562736
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of NUMBL mRNA24449571
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased methylation of NUMBL promoter28329817
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of NUMBL mRNA14625279
D001564Benzo(a)pyrene[Potassium Dichromate co-treated with potassium chromate(VI)] inhibits the reaction [Benzo(a)pyrene results in increased expression of NUMBL mRNA]14625279
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of NUMBL mRNA"20018196
D004958EstradiolEstradiol results in increased expression of NUMBL mRNA19484750
C006780bisphenol Abisphenol A affects the expression of NUMBL mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of NUMBL gene28505145
D000069286BortezomibBortezomib results in increased expression of NUMBL mRNA20977926
D003024ClozapineClozapine results in decreased expression of NUMBL mRNA18797397
D004365Drugs, Chinese Herbal"Drugs, Chinese Herbal results in increased expression of NUMBL mRNA"23811387
D006220HaloperidolHaloperidol results in decreased expression of NUMBL mRNA18797397
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of NUMBL mRNA"24972896
D008731MethoxychlorMethoxychlor results in increased methylation of NUMBL gene23303685
D009285NaphthoquinonesNaphthoquinones results in increased expression of NUMBL mRNA23811387
C076029olanzapineolanzapine results in decreased expression of NUMBL mRNA18797397
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of NUMBL mRNA19710929
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of NUMBL mRNA19710929
D010936Plant ExtractsPlant Extracts results in decreased expression of NUMBL mRNA23557933
C027373potassium chromate(VI)[Potassium Dichromate co-treated with potassium chromate(VI)] inhibits the reaction [Benzo(a)pyrene results in increased expression of NUMBL mRNA]14625279
D011192Potassium Dichromate[Potassium Dichromate co-treated with potassium chromate(VI)] inhibits the reaction [Benzo(a)pyrene results in increased expression of NUMBL mRNA]14625279
D011441PropylthiouracilPropylthiouracil results in increased expression of NUMBL mRNA24780913
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of NUMBL mRNA24680724
D014635Valproic AcidValproic Acid affects the expression of NUMBL mRNA25979313
D014635Valproic AcidValproic Acid results in increased methylation of NUMBL gene29154799

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI16713569  20079715  
GO ID GO Term Qualifier Evidence PubMed
GO:0007399nervous system development-TAS9303539  
GO:0007409axonogenesis-IEA-  
GO:0019221cytokine-mediated signaling pathway-IDA18299187  
GO:0019538protein metabolic process-IDA20079715  
GO:0021670lateral ventricle development-ISS-  
GO:0021849neuroblast division in subventricular zone-ISS-  
GO:0034332adherens junction organization-IEA-  
GO:0050769positive regulation of neurogenesis-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IEA-  
KEGG ID KEGG Term
hsa04330Notch signaling pathway
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
29092026COPD GWAS variant at 19q13.2 in relation with DNA methylation and gene expression. (2018 Jan 15)Nedeljkovic IHum Mol Genet
26407342A Genome-Wide Association Study of a Biomarker of Nicotine Metabolism. (2015)Loukola APLoS Genet