Gene: DTD1

92675
C20orf88|DTD|DUE-B|DUEB|HARS2|pqn-68
D-tyrosyl-tRNA deacylase 1
protein-coding
20p11.23
Ensembl:ENSG00000125821 MIM:610996 Vega:OTTHUMG00000031980 UniprotKB:Q8TEA8
NC_000020.11
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.456e-1 (AD)  3.003e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NFU10.919
WDR610.919
MRPS230.918
DCTN20.916
ATXN100.916
EBNA1BP20.913
ACBD60.913
HINT10.912
MAGEF10.911
UQCRFS10.911

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.637
OR4F29-0.598
MTRNR2L6-0.43
MTRNR2L9-0.407
PPBP-0.382
P2RY14-0.364
MTRNR2L10-0.36
EVC2-0.352
TNFRSF10D-0.349
CLEC2B-0.339

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione results in increased expression of DTD1 mRNA"19162173
D000082AcetaminophenAcetaminophen results in decreased expression of DTD1 mRNA25704631
D000082AcetaminophenAcetaminophen affects the expression of DTD1 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of DTD1 mRNA21641981
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of DTD1 mRNA21632981
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of DTD1 mRNA21715664
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of DTD1 mRNA22228805
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of DTD1 mRNA"20382639
C006780bisphenol Abisphenol A results in decreased expression of DTD1 mRNA26063408
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of DTD1 gene20938992
D016572CyclosporineCyclosporine results in increased expression of DTD1 mRNA20106945|2556210
D002945CisplatinCisplatin results in decreased expression of DTD1 mRNA27594783
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of DTD1 mRNA23649840
D005485FlutamideFlutamide results in decreased expression of DTD1 mRNA24793618
D005485FlutamideFlutamide results in increased expression of DTD1 mRNA24136188
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of DTD1 gene20938992
D005557FormaldehydeFormaldehyde results in decreased expression of DTD1 mRNA23649840
C492448ICG 001ICG 001 results in increased expression of DTD1 mRNA26191083
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of DTD1 mRNA25613284
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of DTD1 mRNA23086925
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of DTD1 gene20938992
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of DTD1 mRNA26011545
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of DTD1 mRNA23649840
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of DTD1 mRNA"25554681
C051752nefazodonenefazodone results in increased expression of DTD1 mRNA24136188
C029938nickel sulfatenickel sulfate results in decreased expression of DTD1 mRNA22714537
C012655nimesulidenimesulide results in increased expression of DTD1 mRNA24136188
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of DTD1 mRNA25729387
C006253pirinixic acidpirinixic acid results in increased expression of DTD1 mRNA19162173
D012715Sesame OilSesame Oil results in increased expression of DTD1 mRNA29191790
C017947sodium arsenitesodium arsenite results in decreased expression of DTD1 mRNA22714537
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of DTD1 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of DTD1 mRNA22298810
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of DTD1 mRNA25613284
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of DTD1 mRNA25729387
D014635Valproic AcidValproic Acid affects the expression of DTD1 mRNA25979313
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of DTD1 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000049tRNA binding-IEA-  
GO:0002161aminoacyl-tRNA editing activity-IBA21873635  
GO:0003677DNA binding-IEA-  
GO:0046872metal ion binding-IEA-  
GO:0051500D-tyrosyl-tRNA(Tyr) deacylase activity-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0006260DNA replication-IEA-  
GO:0006399tRNA metabolic process-IBA21873635  
GO:0106074aminoacyl-tRNA metabolism involved in translational fidelity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005730nucleolus-IDA-  
GO:0005737cytoplasm-IBA21873635  
GO:0005829cytosol-IDA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
21479357Association analysis of DTD1 gene variations with aspirin-intolerance in asthmatics. (2011 Jul)Pasaje CFInt J Mol Med