Gene: FAM114A1

92689
Noxp20
family with sequence similarity 114 member A1
protein-coding
4p14
Ensembl:ENSG00000197712 Vega:OTTHUMG00000128583 UniprotKB:Q8IWE2
NG_053162.1
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.078e-2 (AD)  6.859e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs11943027chr4:38880267 (GRCh38.p7)G>Calcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SFT2D20.875
PARP40.867
LITAF0.867
SEPT100.863
SLC35D20.863
SPATA130.857
REST0.857
CLIC40.853
ACTL6A0.851
BAZ1A0.849

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
FBLN7-0.626
CDH22-0.619
MARCH4-0.618
ABCC12-0.61
KCNB2-0.61
ST6GALNAC5-0.606
ADRA1D-0.597
LRTM2-0.595
KCNQ4-0.594
TCERG1L-0.594

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of FAM114A1 mRNA"28903501
C5724913-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol3-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol results in increased expression of FAM114A1 protein26194647
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of FAM114A1 mRNA"28973690
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FAM114A1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FAM114A1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FAM114A1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FAM114A1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FAM114A1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FAM114A1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FAM114A1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FAM114A1 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of FAM114A1 mRNA21420995
D000082AcetaminophenAcetaminophen affects the expression of FAM114A1 mRNA17562736
D000111Acetylcysteine[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of FAM114A1 mRNA22129741
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of FAM114A1 gene27153756
C006780bisphenol Abisphenol A affects the expression of FAM114A1 mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of FAM114A1 mRNA25181051
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of FAM114A1 mRNA17484886
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of FAM114A1 mRNA28472532
D002994ClofibrateClofibrate results in decreased expression of FAM114A1 mRNA23811191
D019327Copper SulfateCopper Sulfate results in decreased expression of FAM114A1 mRNA19549813
D016572CyclosporineCyclosporine results in increased expression of FAM114A1 mRNA20106945
C093628cyproconazolecyproconazole results in increased expression of FAM114A1 mRNA22334560
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of FAM114A1 mRNA]27941970
D003907DexamethasoneDexamethasone results in decreased expression of FAM114A1 mRNA22733784
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of FAM114A1 mRNA21266533
D004052Diethylnitrosamine[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of FAM114A1 mRNA22129741
D004237DiuronDiuron results in decreased expression of FAM114A1 mRNA25152437
C118739entinostatentinostat results in increased expression of FAM114A1 mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FAM114A1 mRNA"27188386
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of FAM114A1 mRNA22079256
C109476epoxiconazoleepoxiconazole results in increased expression of FAM114A1 mRNA22334560
D018120FinasterideFinasteride results in increased expression of FAM114A1 mRNA24136188
D005472FluorouracilFluorouracil affects the expression of FAM114A1 mRNA16584549
D005485FlutamideFlutamide results in decreased expression of FAM114A1 mRNA24793618
D005485FlutamideFlutamide results in increased expression of FAM114A1 mRNA24136188
D005897GlafenineGlafenine results in increased expression of FAM114A1 mRNA24136188
D017313FenretinideFenretinide results in decreased expression of FAM114A1 mRNA28973697
C016517indole-3-carbinol[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of FAM114A1 mRNA22129741
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of FAM114A1 mRNA26752646
C410337K 7174K 7174 results in increased expression of FAM114A1 mRNA24086573
D037742Nanotubes, Carbon"Nanotubes, Carbon affects the expression of FAM114A1 mRNA"25554681
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of FAM114A1 mRNA25729387
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FAM114A1 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of FAM114A1 mRNA26272509
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of FAM114A1 mRNA19710929
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of FAM114A1 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of FAM114A1 mRNA22079256
C045950propiconazolepropiconazole results in increased expression of FAM114A1 mRNA21278054|2233456
C513428pyrachlostrobinpyrachlostrobin results in increased expression of FAM114A1 mRNA27029645
D011794QuercetinQuercetin results in increased expression of FAM114A1 mRNA21632981
C017947sodium arsenitesodium arsenite affects the expression of FAM114A1 mRNA29319823
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of FAM114A1 mRNA25729387
D019772TopotecanTopotecan results in increased expression of FAM114A1 mRNA25729387
C483909torcetrapibtorcetrapib results in increased expression of FAM114A1 mRNA23228038
C012589trichostatin Atrichostatin A results in increased expression of FAM114A1 mRNA24935251
D014520UrethaneUrethane results in decreased expression of FAM114A1 mRNA28818685
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FAM114A1 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of FAM114A1 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of FAM114A1 mRNA19101580|2317975
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of FAM114A1 gene25560391
C111237vorinostat"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FAM114A1 mRNA"27188386
C111237vorinostatvorinostat results in increased expression of FAM114A1 mRNA26272509

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI25416956  
GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA-  
GO:0005654nucleoplasm-IDA-  
GO:0005794Golgi apparatus-IDA-  
GO:0005829cytosol-IDA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal