Gene: PIWIL1

9271
CT80.1|HIWI|MIWI|PIWI
piwi like RNA-mediated gene silencing 1
protein-coding
12q24.33
Ensembl:ENSG00000125207 MIM:605571 Vega:OTTHUMG00000168382 UniprotKB:Q96J94
NC_000012.12
PubMed
1   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.800e-2 (AD)  6.073e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs11060883chr12:130419855 (GRCh38.p7)A>Gnicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PRAMEF50.602
LPA0.521
TEX350.501
NCAPG0.482
CENPF0.453
UCHL1-AS10.434
CES30.43
CYP4F20.419
GPR780.417
ATOH70.417

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
AKAP3-0.269
AAMDC-0.259
MYOM1-0.256
HVCN1-0.238
AZGP1-0.236
ID3-0.235
AKR1C3-0.234
COPZ2-0.226
HIGD1B-0.224
MEIG1-0.224

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of PIWIL1 mRNA"28712647
C006780bisphenol Abisphenol A affects the expression of PIWIL1 mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of PIWIL1 mRNA25181051
D003300CopperCopper affects the expression of PIWIL1 mRNA23825565
D016572CyclosporineCyclosporine results in decreased methylation of PIWIL1 promoter27989131
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of PIWIL1 mRNA20227414
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PIWIL1 mRNA17942748
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of PIWIL1 mRNA26752646
C101814perfluoro-n-undecanoic acidperfluoro-n-undecanoic acid results in increased expression of PIWIL1 mRNA23602845
C005556propionaldehydepropionaldehyde results in increased expression of PIWIL1 mRNA26079696
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PIWIL1 mRNA17942748
C012589trichostatin Atrichostatin A results in increased expression of PIWIL1 mRNA15901671
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of PIWIL1 mRNA"26743178
D014415TunicamycinTunicamycin results in increased expression of PIWIL1 mRNA22378314
D014635Valproic AcidValproic Acid results in increased expression of PIWIL1 mRNA15901671
D014635Valproic AcidValproic Acid results in increased methylation of PIWIL1 gene29154799

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003727single-stranded RNA binding-IEA-  
GO:0003729mRNA binding-ISS-  
GO:0004521endoribonuclease activity-ISS-  
GO:0005515protein binding-IPI14749716  20937909  
GO:0019901protein kinase binding-IEA-  
GO:0034584piRNA binding-IDA28552346  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006417regulation of translation-IEA-  
GO:0007275multicellular organism development-IEA-  
GO:0007283spermatogenesis-ISS-  
GO:0007286spermatid development-IMP28552346  
GO:0007286spermatid development-ISS-  
GO:0010529negative regulation of transposition-ISS-  
GO:0031047gene silencing by RNA-ISS-  
GO:0034587piRNA metabolic process-ISS-  
GO:0035093spermatogenesis, exchange of chromosomal proteins-ISS-  
GO:0051321meiotic cell cycle-IEA-  
GO:0090502RNA phosphodiester bond hydrolysis, endonucleolytic-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IEA-  
GO:0005737cytoplasm-ISS-  
GO:0005844polysome-IEA-  
GO:0005845mRNA cap binding complex-IEA-  
GO:0033391chromatoid body-ISS-  
GO:0043186P granule-ISS-  
GO:0097433dense body-IEA-  
KEGG ID KEGG Term
hsa04320Dorso-ventral axis formation
Reactome ID Reactome Term Evidence
R-HSA-211000Gene Silencing by RNAIEA
R-HSA-5601884PIWI-interacting RNA (piRNA) biogenesisIEA
R-HSA-74160Gene expression (Transcription)IEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27539334[Association between genetic variants in microRNA biosynthesis genes and the risk of head and neck squamous cell carcinoma]. (2016 Aug 10)Yuan WWZhonghua Liu Xing Bing Xue Za Zhi
28109471Smoking status regulates a novel panel of PIWI-interacting RNAs in head and neck squamous cell carcinoma. (2017 Feb)Krishnan AROral Oncol