Gene: BCL7C

9274
-
BCL tumor suppressor 7C
protein-coding
16p11.2
Ensembl:ENSG00000099385 MIM:605847 Vega:OTTHUMG00000177719 UniprotKB:Q8WUZ0
NC_000016.10
PubMed
0   ANCO-SNPs
AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.760e-1 (AD)  6.154e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg07013258chr16:30905875BCL7C8.280e-8Maternal smoking in pregnancy27040690
cg07013258chr16:30905875BCL7C6.780e-9Maternal smoking in pregnancy27040690

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RPS190.817
RARRES20.812
ECI10.811
SERF20.806
TSC22D40.801
PPP1R14B0.793
RPS90.79
GTF3C60.788
RPL27A0.787
TMEM2190.787

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MCHR2-0.583
FMN1-0.572
SCN8A-0.569
FBXO40-0.568
PCDHA5-0.564
OR14I1-0.563
KCNH1-0.56
KCNH5-0.555
PCDHAC2-0.555
KSR2-0.553

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0264861,2,5,6-dibenzanthracene"1,2,5,6-dibenzanthracene results in decreased expression of BCL7C mRNA"26377693
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of BCL7C mRNA"28903501
C0352074-amino-2,6-dinitrotoluene"4-amino-2,6-dinitrotoluene affects the expression of BCL7C mRNA"21346803
D000082AcetaminophenAcetaminophen affects the expression of BCL7C mRNA17562736
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of BCL7C mRNA24449571
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of BCL7C mRNA19770486
D004958EstradiolEstradiol results in increased expression of BCL7C mRNA22467019
C006780bisphenol Abisphenol A affects the expression of BCL7C mRNA25181051
C584509C646 compoundC646 compound results in decreased expression of BCL7C mRNA26191083
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of BCL7C mRNA27339419
D002994ClofibrateClofibrate results in decreased expression of BCL7C mRNA17585979
D003471CuprizoneCuprizone results in increased expression of BCL7C mRNA26577399
D016572CyclosporineCyclosporine results in decreased expression of BCL7C mRNA25562108
D003976DiazinonDiazinon results in increased methylation of BCL7C gene22964155
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of BCL7C mRNA21266533
D002945CisplatinCisplatin results in increased expression of BCL7C mRNA27594783
C121718dicyclanildicyclanil results in decreased expression of BCL7C mRNA15664270
D004041Dietary FatsDietary Fats results in increased expression of BCL7C mRNA18042831
D005485FlutamideFlutamide results in increased expression of BCL7C mRNA24136188
D006861Hydrogen Peroxide[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of BCL7C protein18951874
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of BCL7C mRNA23086925
C410337K 7174K 7174 results in decreased expression of BCL7C mRNA24086573
C045463leflunomideleflunomide results in increased expression of BCL7C mRNA24136188
C406082monomethylarsonous acidmonomethylarsonous acid results in decreased expression of BCL7C protein24625837
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of BCL7C mRNA"25554681
C028007nickel monoxidenickel monoxide results in increased expression of BCL7C mRNA19167457
D000073878Palm OilPalm Oil results in increased expression of BCL7C mRNA18042831
C016030pantogabpantogab results in decreased expression of BCL7C mRNA17379144
D010634PhenobarbitalPhenobarbital affects the expression of BCL7C mRNA23091169
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of BCL7C mRNA19710929
C006253pirinixic acidpirinixic acid results in increased expression of BCL7C mRNA23811191
D011192Potassium DichromatePotassium Dichromate results in increased expression of BCL7C protein23718831
D012999SomanSoman results in increased expression of BCL7C mRNA19281266
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased methylation of BCL7C gene21212295
D013750TetrachloroethyleneTetrachloroethylene results in decreased expression of BCL7C mRNA28973375
D013806Theophylline[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of BCL7C protein18951874
D014050TolueneToluene results in decreased expression of BCL7C mRNA22967744
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of BCL7C mRNA"26179874
D014635Valproic AcidValproic Acid results in decreased expression of BCL7C mRNA29154799
D014635Valproic AcidValproic Acid results in increased methylation of BCL7C gene29154799
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of BCL7C gene25560391
C025643vinclozolinvinclozolin results in decreased expression of BCL7C mRNA23034163
D002762CholecalciferolCholecalciferol results in decreased expression of BCL7C mRNA16508948

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO:0006915apoptotic process-IEA-  
GO ID GO Term Qualifier Evidence PubMed
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28981154Variation in SWI/SNF Chromatin Remodeling Complex Proteins is Associated with Alcohol Dependence and Antisocial Behavior in Human Populations. (2017 Dec)Mathies LDAlcohol Clin Exp Res