Gene: BPIFB1

92747
C20orf114|LPLUNC1
BPI fold containing family B member 1
protein-coding
20q11.21
Ensembl:ENSG00000125999 Vega:OTTHUMG00000032252 UniprotKB:Q8TDL5
NC_000020.11
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.989e-1 (AD)  6.847e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR52Z10.584
NAPSA0.581
CXCL170.569
SFTPB0.555
GPR180.535
SFTPA10.529
SLC34A20.525
CLEC12A0.509
KRT70.506
OR51A40.5

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CRH-0.365
ABCD2-0.354
ADCYAP1-0.353
ACSL6-0.35
PPEF1-0.339
LIPT2-0.337
OSTN-0.337
TM7SF2-0.336
TMEM17-0.332
SPA17-0.33

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of BPIFB1 gene27153756
D001151ArsenicArsenic results in increased expression of BPIFB1 mRNA23221970
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of BPIFB1 mRNA21871943
D004958Estradiol[Estradiol binds to ESR2 protein] which results in increased expression of BPIFB1 mRNA20404318
C006780bisphenol Abisphenol A results in decreased methylation of BPIFB1 promoter27312807
C006780bisphenol Abisphenol A results in increased methylation of BPIFB1 promoter27312807
C006780bisphenol Abisphenol A affects the expression of BPIFB1 mRNA25181051
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of BPIFB1 mRNA25270620
D002737ChloropreneChloroprene results in increased expression of BPIFB1 mRNA23125180
D002994ClofibrateClofibrate results in increased expression of BPIFB1 mRNA17585979
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of BPIFB1 mRNA25613284
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of BPIFB1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of BPIFB1 mRNA"25554681
C572573N-nitroso-tris-chloroethylurea[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of BPIFB1 mRNA27935865
C572573N-nitroso-tris-chloroethylurea[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of BPIFB1 mRNA27935865
C060836pioglitazone[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of BPIFB1 mRNA27935865
D010936Plant ExtractsPlant Extracts results in decreased expression of BPIFB1 mRNA23557933
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of BPIFB1 mRNA25895662
D053260SootSoot results in decreased expression of BPIFB1 mRNA26551751
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of BPIFB1 mRNA25613284
C009495titanium dioxidetitanium dioxide results in decreased expression of BPIFB1 mRNA23557971
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of BPIFB1 mRNA20133372
C581157XL147[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of BPIFB1 mRNA27935865
D015032ZincZinc deficiency results in increased expression of BPIFB1 mRNA20857495

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003674molecular_function-ND-  
GO:0008289lipid binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0002227innate immune response in mucosa-IDA21900486  
GO:0019730antimicrobial humoral response-TAS-  
GO:0034144negative regulation of toll-like receptor 4 signaling pathway-IDA21900486  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-IDA20237794  
GO:0005576extracellular region-TAS-  
GO:0070062extracellular exosome-HDA19056867  19199708  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-6803157Antimicrobial peptidesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26306861Alterations in the sputum proteome and transcriptome in smokers and early-stage COPD subjects. (2015 Oct 14)Titz BJ Proteomics
25979078Elevated sputum BPIFB1 levels in smokers with chronic obstructive pulmonary disease: a longitudinal study. (2015 Jul 1)Gao JAm J Physiol Lung Cell Mol Physiol