Gene: DRC1

92749
C2orf39|CCDC164|CILD21
dynein regulatory complex subunit 1
protein-coding
2p23.3
Ensembl:ENSG00000157856 MIM:615288 Vega:OTTHUMG00000125531 UniprotKB:Q96MC2
NG_042824.1
SNP Mapped
1   ANCO-SNPs
AD
0   
3.284e-2 (AD)  8.431e-1 (ND)   (Frontal_Cortex)
1.818e-3 (AD)  8.542e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs2280515chr2:26454435 (GRCh38.p7)G>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ME30.761
WDR540.756
VPS33B0.752
DDX250.751
ZFR20.751
DSN10.745
ENDOV0.742
PRMT70.742
MAN1B10.74
STRIP10.735

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
YES1-0.438
RAI14-0.43
REST-0.424
HEY2-0.416
CNN2-0.412
CCDC102A-0.412
C1QTNF1-0.408
WWTR1-0.406
EVC2-0.389
TES-0.389

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0065512-amino-2-methyl-1-propanol2-amino-2-methyl-1-propanol results in decreased expression of DRC1 mRNA25088246
D000082AcetaminophenAcetaminophen results in decreased expression of DRC1 mRNA26690555
C006780bisphenol Abisphenol A results in decreased expression of DRC1 mRNA28079927
C006780bisphenol Abisphenol A results in decreased expression of DRC1 mRNA25181051
C018475butyraldehydebutyraldehyde results in increased expression of DRC1 mRNA26079696
D003471CuprizoneCuprizone results in increased expression of DRC1 mRNA26577399
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of DRC1 mRNA24535843
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of DRC1 mRNA29097150
C004312glycidolglycidol results in decreased expression of DRC1 mRNA24915197
D017313FenretinideFenretinide results in increased expression of DRC1 mRNA28973697
D008713MethimazoleMethimazole results in increased expression of DRC1 mRNA22504374
C583365N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in increased expression of DRC1 mRNA"29244179
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of DRC1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of DRC1 mRNA"25554681
C046012pentanalpentanal results in increased expression of DRC1 mRNA26079696
D011441PropylthiouracilPropylthiouracil results in increased expression of DRC1 mRNA22504374|2478091
C016104sodium bichromatesodium bichromate results in increased expression of DRC1 mRNA22155349
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to DRC1 promoter]19654925
C009495titanium dioxidetitanium dioxide results in decreased expression of DRC1 mRNA23557971
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of DRC1 mRNA"26179874

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO:0003352regulation of cilium movement-IBA21873635  
GO:0007368determination of left/right symmetry-IEA-  
GO:0007507heart development-IEA-  
GO:0060285cilium-dependent cell motility-IBA21873635  
GO:0060285cilium-dependent cell motility-IMP23354437  
GO:0070286axonemal dynein complex assembly-IBA21873635  
GO:0070286axonemal dynein complex assembly-IMP23354437  
GO ID GO Term Qualifier Evidence PubMed
GO:0005930axoneme-IBA21873635  
GO:0005930axoneme-ISS-  
GO:0031514motile cilium-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal