Gene: BCL7B

9275
-
BCL tumor suppressor 7B
protein-coding
7q11.23
Ensembl:ENSG00000106635 MIM:605846 Vega:OTTHUMG00000023412 UniprotKB:Q9BQE9
NG_027959.1
PubMed
0   ANCO-SNPs
AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.429e-1 (AD)  4.653e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MLF20.97
ARF10.959
CLTB0.957
ARPC40.954
ARPC1A0.951
FAM32A0.95
PEF10.95
ATP6V1F0.949
RHBDD20.949
STOML20.948

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.806
OR4F29-0.765
IL18RAP-0.282
CXCR2-0.275
KLRB1-0.273
FCGR3B-0.272
C9orf153-0.271
VNN2-0.269
KCNJ15-0.267
TFPI2-0.266

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000082AcetaminophenAcetaminophen results in increased expression of BCL7B mRNA22230336
D001151ArsenicArsenic affects the methylation of BCL7B gene25304211
C030935benz(a)anthracene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of BCL7B mRNA27858113
C006703benzo(b)fluoranthene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of BCL7B mRNA27858113
C022921benzo(k)fluoranthenebenzo(k)fluoranthene results in increased expression of BCL7B mRNA26377693
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of BCL7B mRNA27858113
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of BCL7B mRNA28628672
C006780bisphenol Abisphenol A results in increased expression of BCL7B mRNA25181051
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of BCL7B mRNA28628672
C031180chrysene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of BCL7B mRNA27858113
D003033Coal TarCoal Tar results in decreased expression of BCL7B mRNA27858113
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of BCL7B mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of BCL7B mRNA28628672
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of BCL7B mRNA17555576
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of BCL7B mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of BCL7B mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of BCL7B mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of BCL7B mRNA28628672
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of BCL7B mRNA"25554681
C513635S-2-pentyl-4-pentynoic hydroxamic acidS-2-pentyl-4-pentynoic hydroxamic acid results in decreased expression of BCL7B mRNA21427059
D012643SeleniumSelenium results in increased expression of BCL7B mRNA19244175
D013629TamoxifenTamoxifen affects the expression of BCL7B mRNA17555576
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of BCL7B mRNA21570461|2468072
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of BCL7B mRNA21215274
D013893ThiramThiram results in increased expression of BCL7B mRNA20530235
D014520UrethaneUrethane results in increased expression of BCL7B mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of BCL7B mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of BCL7B mRNA21427059
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of BCL7B gene25560391
C025643vinclozolinvinclozolin results in increased expression of BCL7B mRNA23034163

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003779actin binding-NAS8605326  
GO:0005515protein binding-IPI21044950  25416956  
GO ID GO Term Qualifier Evidence PubMed
GO:0006915apoptotic process-IEA-  
GO:0008150biological_process-ND-  
GO:0016055Wnt signaling pathway-IEA-  
GO:0030154cell differentiation-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005575cellular_component-ND-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28981154Variation in SWI/SNF Chromatin Remodeling Complex Proteins is Associated with Alcohol Dependence and Antisocial Behavior in Human Populations. (2017 Dec)Mathies LDAlcohol Clin Exp Res