Gene: CD9

928
BTCC-1|DRAP-27|MIC3|MRP-1|TSPAN-29|TSPAN29
CD9 molecule
protein-coding
12p13.31
Ensembl:ENSG00000010278 MIM:143030 Vega:OTTHUMG00000044400 UniprotKB:P21926
NG_055677.1
PubMed
ND
5   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.676e-3 (AD)  2.070e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RHOG0.89
SLC35D20.875
SYPL10.875
CDC42EP10.873
ELOVL10.868
REEP30.857
LITAF0.856
GLTP0.85
CERS20.845
GSN0.841

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F29-0.425
OR4F5-0.423
CUX2-0.389
CNGB1-0.388
SSTR4-0.386
OPRD1-0.385
KCNQ4-0.383
KCNG1-0.37
HNF1A-0.369
CDH22-0.361

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB05398C31GSmall Molecule-InvestigationalTarget
ID Drug Name Action PubMed
C0235142,6-dinitrotoluene"2,6-dinitrotoluene results in increased expression of CD9 mRNA"20406850
C0303702-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone"2-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone affects the expression of CD9 mRNA"20206263
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of CD9 mRNA"18648102
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CD9 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CD9 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CD9 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CD9 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CD9 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CD9 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CD9 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CD9 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CD9 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CD9 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CD9 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CD9 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CD9 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CD9 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CD9 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CD9 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CD9 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CD9 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of CD9 mRNA21420995
D000082AcetaminophenAcetaminophen affects the expression of CD9 mRNA17562736
D019342Acetic AcidAcetic Acid results in decreased expression of CD9 protein21296659
D016604Aflatoxin B1Aflatoxin B1 affects the expression of CD9 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of CD9 mRNA21632981
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in decreased expression of CD9 mRNA28522335
C011512alpha-naphthoflavonealpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in decreased expression of CD9 mRNA]29094188
D000643Ammonium ChlorideAmmonium Chloride affects the expression of CD9 mRNA16483693
C059765amphotericin B, deoxycholate drug combination"amphotericin B, deoxycholate drug combination results in increased expression of CD9 mRNA"22863853
D001151ArsenicArsenic affects the methylation of CD9 gene25304211
C006632arsenic trioxideCD9 protein results in decreased susceptibility to arsenic trioxide20707922
D001280AtrazineAtrazine results in increased expression of CD9 mRNA22378314
C487081belinostatbelinostat results in increased expression of CD9 mRNA26272509
C487081belinostat"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CD9 mRNA"27188386
D019324beta-Naphthoflavone[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of CD9 mRNA18164116
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of CD9 mRNA20106945|2163298
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of CD9 mRNA22228805
D004958EstradiolEstradiol results in decreased expression of CD9 mRNA23019147
D004958EstradiolEstradiol results in increased expression of CD9 mRNA19484750
C053541bicalutamidebicalutamide results in increased expression of CD9 mRNA15790403
C006780bisphenol Abisphenol A results in increased expression of CD9 mRNA27685785
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of CD9 mRNA28628672
C006780bisphenol Abisphenol A results in decreased methylation of CD9 promoter27312807
C006780bisphenol Abisphenol A results in increased expression of CD9 mRNA25181051
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of CD9 mRNA28628672
D000069286BortezomibBortezomib results in increased expression of CD9 mRNA20977926
D0151248-Bromo Cyclic Adenosine Monophosphate8-Bromo Cyclic Adenosine Monophosphate results in increased expression of CD9 mRNA22079614
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide affects the expression of CD9 mRNA23410634
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of CD9 mRNA15336504
D019256Cadmium Chloride[Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in increased expression of CD9 mRNA19840844
C059041calyculin Acalyculin A results in increased expression of CD9 mRNA25270620
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of CD9 mRNA17484886|2733941
D002392CatechinCatechin results in increased expression of CD9 mRNA15465739
D002713Chlorine[Ozone co-treated with Chlorine] results in decreased expression of CD9 mRNA18636392
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of CD9 mRNA23650126
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of CD9 mRNA20938992
C018021cobaltous chloridecobaltous chloride results in decreased expression of CD9 mRNA19320972|1937684
D003300Copper[Disulfiram binds to Copper] which results in increased expression of CD9 mRNA24690739
D003300Copper[ATP7A gene mutant form results in increased abundance of Copper] which results in decreased expression of CD9 mRNA15467011
D019327Copper SulfateCopper Sulfate results in decreased expression of CD9 mRNA19549813
D019327Copper SulfateCopper Sulfate results in increased expression of CD9 mRNA18579281
D003471CuprizoneCuprizone results in decreased expression of CD9 mRNA26577399|2752363
D016572CyclosporineCyclosporine results in increased expression of CD9 mRNA20106945|2556210
C014347decitabine[decitabine co-treated with vorinostat] affects the expression of CD9 mRNA17330099
D003687DehydroepiandrosteroneDehydroepiandrosterone results in increased expression of CD9 mRNA17823450
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of CD9 mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of CD9 mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in decreased expression of CD9 mRNA28628672
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of CD9 mRNA21266533
D002945CisplatinCisplatin results in increased expression of CD9 mRNA21151649|2527062
D004008DiclofenacDiclofenac results in increased expression of CD9 mRNA26934552
C000944dicrotophosdicrotophos results in decreased expression of CD9 mRNA28302478
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of CD9 mRNA26924002
D004041Dietary FatsDietary Fats results in increased expression of CD9 mRNA18042831|2260994
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in increased expression of CD9 mRNA19850644
D004051Diethylhexyl PhthalatePPARA protein promotes the reaction [Diethylhexyl Phthalate results in increased expression of CD9 mRNA]19850644
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of CD9 mRNA18164116
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of CD9 mRNA14648872
D004054DiethylstilbestrolDiethylstilbestrol results in decreased expression of CD9 mRNA21658437
C024629dimethyl phthalatedimethyl phthalate affects the expression of CD9 mRNA26924002
D004147DioxinsDioxins affects the expression of CD9 mRNA20463971
D004221Disulfiram[Disulfiram binds to Copper] which results in increased expression of CD9 mRNA24690739
D004237DiuronDiuron results in decreased expression of CD9 mRNA21551480
D052244Endocrine DisruptorsEndocrine Disruptors results in increased expression of CD9 mRNA25198161
C118739entinostatentinostat results in increased expression of CD9 mRNA26272509|2718838
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CD9 mRNA"27188386
C024565ethylene dichlorideethylene dichloride results in increased expression of CD9 mRNA28189721
D005472FluorouracilFluorouracil results in decreased expression of CD9 protein21296659
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of CD9 mRNA20938992
C056933fumonisin B1fumonisin B1 results in increased expression of CD9 mRNA16221962
C546771gardiquimodgardiquimod results in decreased expression of CD9 mRNA28003376
C546771gardiquimodProtein Kinase Inhibitors inhibits the reaction [gardiquimod results in decreased expression of CD9 mRNA]28003376
D019833GenisteinESR2 promotes the reaction [Genistein results in increased expression of CD9 protein]20884965
D019833GenisteinGenistein results in increased expression of CD9 protein20884965
D019833GenisteinGenistein results in increased expression of CD9 mRNA17341692
D005839GentamicinsGentamicins results in increased expression of CD9 mRNA22061828
D006581HexachlorobenzeneHexachlorobenzene results in increased expression of CD9 mRNA15159207
D017313FenretinideFenretinide results in increased expression of CD9 mRNA28973697
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of CD9 mRNA23410634
C016517indole-3-carbinolindole-3-carbinol affects the expression of CD9 mRNA21396975
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of CD9 mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of CD9 mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in decreased expression of CD9 mRNA28628672
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of CD9 mRNA25613284
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of CD9 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of CD9 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in decreased expression of CD9 mRNA28628672
C544151jinfukangjinfukang results in increased expression of CD9 mRNA27392435
D007657Ketone BodiesKetone Bodies results in increased expression of CD9 mRNA16807920
D007854LeadLead affects the expression of CD9 mRNA28903495
D007854LeadLead results in decreased expression of CD9 mRNA19921347
C045463leflunomideleflunomide results in increased expression of CD9 mRNA28988120
C042720mercuric bromidemercuric bromide results in increased expression of CD9 mRNA26272509
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CD9 mRNA"27188386
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of CD9 mRNA20938992
D008748Methylcholanthrenealpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in decreased expression of CD9 mRNA]29094188
D008748MethylcholanthreneMethylcholanthrene results in decreased expression of CD9 mRNA29094188
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of CD9 mRNA23179753|2627250
C004925methylmercuric chloride"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CD9 mRNA"27188386
D008769Methylnitronitrosoguanidine[Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in increased expression of CD9 mRNA19840844
D008769Methylnitronitrosoguanidine[Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in increased expression of CD9 mRNA19840844
D008769Methylnitronitrosoguanidine[Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in increased expression of CD9 mRNA19840844
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CD9 mRNA"20230807
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of CD9 mRNA"20230807
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CD9 mRNA]"20230807
D016685MitomycinCD9 protein affects the susceptibility to Mitomycin16217747
C091888monoisoamyl-2,3-dimercaptosuccinate"monoisoamyl-2,3-dimercaptosuccinate results in increased expression of CD9 mRNA"19615344
C517284monomethyl phthalatemonomethyl phthalate affects the expression of CD9 mRNA26924002
D009020MorphineMorphine results in increased expression of CD9 protein23056601
C500085muraglitazarmuraglitazar results in decreased expression of CD9 mRNA21515302
C028473N-acetyl-4-benzoquinoneimineCD9 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine21177773
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of CD9 mRNA"25511174
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of CD9 mRNA"25620056
D009538Nicotine"[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of CD9 mRNA"20230807
D009538Nicotine"Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CD9 mRNA]"20230807
D019319Okadaic Acid[Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in increased expression of CD9 mRNA19840844
D010126Ozone[Ozone co-treated with Chlorine] results in decreased expression of CD9 mRNA18636392
D000073878Palm OilPalm Oil results in increased expression of CD9 mRNA18042831
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CD9 mRNA"27188386
C496932panobinostatpanobinostat results in increased expression of CD9 mRNA26272509
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in increased expression of CD9 mRNA26705709
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of CD9 mRNA18692542
D010634PhenobarbitalPhenobarbital affects the expression of CD9 mRNA23091169
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CD9 mRNA"27188386
C006253pirinixic acidpirinixic acid results in decreased expression of CD9 mRNA17426115
C006253pirinixic acidpirinixic acid results in increased expression of CD9 mRNA18301758|2005976
C006253pirinixic acidPPARA protein promotes the reaction [pirinixic acid results in increased expression of CD9 mRNA]20059764
C006253pirinixic acidpirinixic acid results in decreased expression of CD9 mRNA19162173
D011192Potassium DichromatePotassium Dichromate results in increased expression of CD9 protein23718831
D011441PropylthiouracilPropylthiouracil results in decreased expression of CD9 mRNA24780913
D047428Protein Kinase InhibitorsProtein Kinase Inhibitors inhibits the reaction [gardiquimod results in decreased expression of CD9 mRNA]28003376
D011794QuercetinQuercetin results in increased expression of CD9 mRNA21632981
C089730rosiglitazonerosiglitazone results in decreased expression of CD9 mRNA21515302
D012402RotenoneRotenone results in increased expression of CD9 mRNA25682864
D012402RotenoneRotenone results in increased expression of CD9 protein25682864
D012524SarinSarin results in decreased expression of CD9 mRNA19522546
D012524SarinSarin results in decreased expression of CD9 protein19522546
C017947sodium arsenitesodium arsenite results in decreased expression of CD9 mRNA19615344
D012999SomanSoman results in increased expression of CD9 mRNA19281266
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CD9 mRNA22574217
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of CD9 mRNA19684285|2010694
D013749TetrachlorodibenzodioxinCD9 promotes the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]23997114
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CD9 mRNA21570461|2892240
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of CD9 mRNA19684285
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate results in increased expression of CD9 protein10910098
D013755Tetradecanoylphorbol Acetate[Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of CD9 mRNA16979875
D013755Tetradecanoylphorbol Acetate[Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in increased expression of CD9 mRNA19840844
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of CD9 mRNA25613284
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of CD9 mRNA28065790
D014212TretinoinTretinoin results in decreased expression of CD9 mRNA16168501|2193413
D014212TretinoinTretinoin results in increased expression of CD9 mRNA17218384
C032910triadimefontriadimefon results in decreased expression of CD9 mRNA26705709
D014241TrichloroethyleneTrichloroethylene results in decreased expression of CD9 mRNA19448997
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CD9 mRNA"27188386
C012589trichostatin Atrichostatin A results in increased expression of CD9 mRNA24935251|2627250
C057693troglitazonetroglitazone results in decreased expression of CD9 mRNA21515302
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CD9 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of CD9 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of CD9 mRNA19101580|2317975
D014635Valproic AcidValproic Acid results in increased methylation of CD9 gene29154799
D014640VancomycinVancomycin results in decreased expression of CD9 mRNA18930951
D001335Vehicle EmissionsVehicle Emissions affects the methylation of CD9 gene25560391
D024483Vitamin K 3Vitamin K 3 affects the expression of CD9 mRNA20044591|2341063
C111237vorinostat[decitabine co-treated with vorinostat] affects the expression of CD9 mRNA17330099
C111237vorinostat"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CD9 mRNA"27188386
C111237vorinostatvorinostat results in increased expression of CD9 mRNA26272509|2718838
D014874Water Pollutants, Chemical"Water Pollutants, Chemical results in increased expression of CD9 mRNA"25198161
D015032Zinc[Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of CD9 mRNA16979875
D015032ZincZinc results in increased expression of CD9 mRNA16870260
C016837zinc chloridezinc chloride results in increased expression of CD9 mRNA16870260

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005178integrin binding-IDA27993971  
GO:0005515protein binding-IPI11278880  11504738  18541721  23289620  
GO ID GO Term Qualifier Evidence PubMed
GO:0002576platelet degranulation-TAS-  
GO:0007155cell adhesion-IBA21873635  
GO:0007155cell adhesion-IDA7511626  
GO:0007166cell surface receptor signaling pathway-IBA21873635  
GO:0007342fusion of sperm to egg plasma membrane involved in single fertilization-IBA21873635  
GO:0007342fusion of sperm to egg plasma membrane involved in single fertilization-IDA14575715  
GO:0007342fusion of sperm to egg plasma membrane involved in single fertilization-TAS-  
GO:0007420brain development-IEA-  
GO:0008285negative regulation of cell proliferation-IEA-  
GO:0009414response to water deprivation-IEA-  
GO:0014003oligodendrocyte development-IEA-  
GO:0030168platelet activation-NAS2037603  
GO:0030913paranodal junction assembly-IBA21873635  
GO:0030913paranodal junction assembly-ISS-  
GO:0031623receptor internalization-ISS-  
GO:0051271negative regulation of cellular component movement-IDA8478605  
GO:0071404cellular response to low-density lipoprotein particle stimulus-ISS-  
GO:0090331negative regulation of platelet aggregation-IDA18541721  
GO ID GO Term Qualifier Evidence PubMed
GO:0005615extracellular space-HDA16502470  
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-IBA21873635  
GO:0005887integral component of plasma membrane-NAS2037603  
GO:0005925focal adhesion-HDA21423176  
GO:0009897external side of plasma membrane-IEA-  
GO:0016020membrane-ISS-  
GO:0016324apical plasma membrane-IEA-  
GO:0030666endocytic vesicle membrane-TAS-  
GO:0030669clathrin-coated endocytic vesicle membrane-TAS-  
GO:0031092platelet alpha granule membrane-TAS-  
GO:0070062extracellular exosome-HDA19056867  19199708  23533145  
GO:0070062extracellular exosome-IDA15326289  15908444  
GO:1903561extracellular vesicle-HDA24769233  
KEGG ID KEGG Term
hsa04640Hematopoietic cell lineage
Reactome ID Reactome Term Evidence
R-HSA-109582HemostasisTAS
R-HSA-114608Platelet degranulation TAS
R-HSA-1187000FertilizationTAS
R-HSA-1300652Sperm:Oocyte Membrane BindingTAS
R-HSA-1474165ReproductionTAS
R-HSA-1643685DiseaseTAS
R-HSA-5336415Uptake and function of diphtheria toxinTAS
R-HSA-5339562Uptake and actions of bacterial toxinsTAS
R-HSA-5663205Infectious diseaseTAS
R-HSA-76002Platelet activation, signaling and aggregationTAS
R-HSA-76005Response to elevated platelet cytosolic Ca2+TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23988617Cigarette smoke impairs phagocytosis of apoptotic neutrophils by alveolar macrophages via inhibition of the histone deacetylase/Rac/CD9 pathways. (2013 Nov)Noda NInt Immunol
24201754Tetraspanins CD9 and CD151, epidermal growth factor receptor and cyclooxygenase-2 expression predict malignant progression in oral epithelial dysplasia. (2013 Nov 26)Nankivell PBr J Cancer
18662991Double deficiency of tetraspanins CD9 and CD81 alters cell motility and protease production of macrophages and causes chronic obstructive pulmonary disease-like phenotype in mice. (2008 Sep 19)Takeda YJ Biol Chem
27143927Integrin and gene network analysis reveals that ITGA5 and ITGB1 are prognostic in non-small-cell lung cancer. (2016)Zheng WOnco Targets Ther
28476471Elevated levels of circulating exosome in COPD patients are associated with systemic inflammation. (2017 Nov)Tan DBARespir Med