Gene: GPR55

9290
LPIR1
G protein-coupled receptor 55
protein-coding
2q37.1
Ensembl:ENSG00000135898 MIM:604107 Vega:OTTHUMG00000133224 UniprotKB:Q9Y2T6
NG_050956.1
PubMed|SNP Mapped
1   ANCO-SNPs
OD|ND|AD
4   
9.230e-1 (AD)  8.141e-1 (ND)   (Frontal_Cortex)
1.753e-1 (AD)  5.630e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs6747728chr2:230914061 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg19827923chr2:231790777GPR555.600e-10Smoking27651444
cg16382047chr2:231790037GPR551.500e-8Smoking27651444
cg19827923chr2:231790777GPR557.140e-8Alcohol consumption per day27843151
cg19827923chr2:231790777GPR555.770e-10Tobacco smoking28225026
cg16382047chr2:231790037GPR551.740e-8Smoking28686328

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RAD54L0.666
WIPF30.657
PASK0.656
BAIAP20.65
GAS2L20.646
TUBA80.645
DAGLB0.644
TRIM110.642
SLC9A50.642
TMEM63C0.642

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MBNL3-0.423
TSPAN12-0.421
RAI14-0.407
NEK7-0.381
LRRCC1-0.376
KLHL5-0.375
AIF1L-0.374
YES1-0.371
SEPT10-0.368
ZNF501-0.361

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB06155RimonabantSmall Molecule168273-06-1Approved|InvestigationalTarget
DB09061CannabidiolSmall Molecule13956-29-1Approved|InvestigationalTarget
ID Drug Name Action PubMed
C0546493-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol"3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of GPR55 protein"17876302
C0546493-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol"[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of GPR55 protein] affects the reaction [Guanosine 5'-O-(3-Thiotriphosphate) binds to GNA13 protein]"17876302
C5831264-(4-(3-hydroxyphenyl)-3-(4-methylphenyl)-6-oxo-1H,4H,5H,6H-pyrrolo(3,4-c)pyrazol-5-yl)benzoic acid"4-(4-(3-hydroxyphenyl)-3-(4-methylphenyl)-6-oxo-1H,4H,5H,6H-pyrrolo(3,4-c)pyrazol-5-yl)benzoic acid inhibits the reaction [AM 251 results in increased activity of GPR55 protein]"27423937
C5831264-(4-(3-hydroxyphenyl)-3-(4-methylphenyl)-6-oxo-1H,4H,5H,6H-pyrrolo(3,4-c)pyrazol-5-yl)benzoic acid"4-(4-(3-hydroxyphenyl)-3-(4-methylphenyl)-6-oxo-1H,4H,5H,6H-pyrrolo(3,4-c)pyrazol-5-yl)benzoic acid results in decreased activity of GPR55 protein"27423937
C0006035004'-methoxy-1-naphthylfenoterol4'-methoxy-1-naphthylfenoterol inhibits the reaction [AM 251 results in increased activity of GPR55 protein]27423937
C0006035004'-methoxy-1-naphthylfenoterol4'-methoxy-1-naphthylfenoterol results in decreased activity of GPR55 protein27423937
D000111AcetylcysteineAcetylcysteine inhibits the reaction [[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of GPR55 mRNA]22129741
D000111Acetylcysteine[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of GPR55 mRNA22129741
D000393Air Pollutants[Air Pollutants results in increased abundance of Nitrogen Dioxide] which results in decreased expression of GPR55 mRNA27448387
D000535Aluminum[APP protein modified form binds to Aluminum] which results in decreased expression of GPR55 mRNA21298039
C103505AM 251"4-(4-(3-hydroxyphenyl)-3-(4-methylphenyl)-6-oxo-1H,4H,5H,6H-pyrrolo(3,4-c)pyrazol-5-yl)benzoic acid inhibits the reaction [AM 251 results in increased activity of GPR55 protein]"27423937
C103505AM 2514'-methoxy-1-naphthylfenoterol inhibits the reaction [AM 251 results in increased activity of GPR55 protein]27423937
C103505AM 251AM 251 results in increased activity of GPR55 protein27423937
D000643Ammonium ChlorideAmmonium Chloride affects the expression of GPR55 mRNA16483693
D001104ArbutinArbutin results in decreased expression of GPR55 mRNA17103032
C547126AZM551248AZM551248 results in decreased expression of GPR55 mRNA22323515
C006780bisphenol Abisphenol A affects the expression of GPR55 mRNA25181051
D004052DiethylnitrosamineAcetylcysteine inhibits the reaction [[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of GPR55 mRNA]22129741
D004052Diethylnitrosamine[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of GPR55 mRNA22129741
D004052Diethylnitrosamine[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of GPR55 mRNA22129741
D004397FonofosFonofos results in increased methylation of GPR55 promoter22847954
D005557FormaldehydeFormaldehyde results in increased expression of GPR55 mRNA23649840
D016244Guanosine 5'-O-(3-Thiotriphosphate)"[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of GPR55 protein] affects the reaction [Guanosine 5'-O-(3-Thiotriphosphate) binds to GNA13 protein]"17876302
C016517indole-3-carbinolAcetylcysteine inhibits the reaction [[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of GPR55 mRNA]22129741
C016517indole-3-carbinol[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of GPR55 mRNA22129741
C016517indole-3-carbinol[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of GPR55 mRNA22129741
D008727MethotrexateMethotrexate results in decreased expression of GPR55 mRNA24449571
D009585Nitrogen Dioxide[Air Pollutants results in increased abundance of Nitrogen Dioxide] which results in decreased expression of GPR55 mRNA27448387
D009585Nitrogen Dioxide[Vehicle Emissions results in increased abundance of Nitrogen Dioxide] which results in decreased expression of GPR55 mRNA27448387
C568698O 1602GPR55 protein affects the susceptibility to O 160222759743
C568698O 1602O 1602 binds to and results in increased activity of GPR55 protein22759743
D010278ParathionParathion results in increased methylation of GPR55 promoter22847954
C089032rimonabantrimonabant binds to and results in increased activity of GPR55 protein17876302
C012568terbufosterbufos results in increased methylation of GPR55 promoter22847954
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of GPR55 mRNA26377647
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased methylation of GPR55 gene26756918
D001335Vehicle Emissions[Vehicle Emissions results in increased abundance of Nitrogen Dioxide] which results in decreased expression of GPR55 mRNA27448387
D014750VincristineVincristine results in increased expression of GPR55 mRNA23649840

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004930G-protein coupled receptor activity-IBA21873635  
GO:0004930G-protein coupled receptor activity-TAS9931487  
GO:0004949cannabinoid receptor activity-IBA21873635  
GO:0004949cannabinoid receptor activity-IDA19723626  
GO ID GO Term Qualifier Evidence PubMed
GO:0007186G-protein coupled receptor signaling pathway-TAS-  
GO:0007202activation of phospholipase C activity-IBA21873635  
GO:0007202activation of phospholipase C activity-IDA18757503  
GO:0035025positive regulation of Rho protein signal transduction-IBA21873635  
GO:0035025positive regulation of Rho protein signal transduction-IDA18757503  19805329  
GO:0038171cannabinoid signaling pathway-IEA-  
GO:0045453bone resorption-IDA19805329  
GO:0045671negative regulation of osteoclast differentiation-IDA19805329  
GO:0051482positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway-IBA21873635  
GO:0070374positive regulation of ERK1 and ERK2 cascade-IDA19805329  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-IBA21873635  
GO:0005887integral component of plasma membrane-IDA18757503  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-372790Signaling by GPCRTAS
R-HSA-373076Class A/1 (Rhodopsin-like receptors)TAS
R-HSA-388396GPCR downstream signallingTAS
R-HSA-418594G alpha (i) signalling eventsTAS
R-HSA-500792GPCR ligand bindingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
22141465Differential effects of single versus repeated alcohol withdrawal on the expression of endocannabinoid system-related genes in the rat amygdala. (2012 Jun)Serrano AAlcohol Clin Exp Res
26971034The effect of O-1602, an atypical cannabinoid, on morphine-induced conditioned place preference and physical dependence. (2016 Jun)Alavi MSPharmacol Rep
24467410Cannabinoids inhibit cholinergic contraction in human airways through prejunctional CB1 receptors. (2014 Jun)Grassin-Delyle SBr J Pharmacol
24060590Differential expression and functional role of cannabinoid genes in alcohol users. (2013 Dec 1)Agudelo MDrug Alcohol Depend