Gene: S1PR2

9294
AGR16|DFNB68|EDG-5|EDG5|Gpcr13|H218|LPB2|S1P2
sphingosine-1-phosphate receptor 2
protein-coding
19p13.2
Ensembl:ENSG00000267534 MIM:605111 Vega:OTTHUMG00000180399 UniprotKB:O95136
NG_046802.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.087e-1 (AD)  9.126e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CACNG50.587
EHD40.555
B3GNT70.511
LIMD10.506
EMILIN20.49
AKNA0.48
NTN10.472
ARID3A0.47
C15orf390.47
KDM6B0.467

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TMSB4Y-0.247
OMD-0.217
RPS4Y1-0.211
PRDM12-0.21
OR4F5-0.207
EIF1AY-0.205
ZNF705B-0.204
EDN3-0.2
INSL5-0.2
PLGLB1-0.197

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of S1PR2 mRNA"19114083
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of S1PR2 mRNA"18648102
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in increased expression of S1PR2 mRNA19191707
D000643Ammonium ChlorideAmmonium Chloride affects the expression of S1PR2 mRNA16483693
D047310ApigeninApigenin inhibits the reaction [Lipopolysaccharides results in increased expression of S1PR2 protein]25557508
D017638Asbestos, Crocidolite"Asbestos, Crocidolite affects the expression of S1PR2 mRNA"17331233
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of S1PR2 mRNA19770486
C495703bis(2-chloroethoxy)methanebis(2-chloroethoxy)methane results in decreased expression of S1PR2 mRNA16844662
C006780bisphenol Abisphenol A affects the expression of S1PR2 mRNA21786754
C006780bisphenol Abisphenol A affects the expression of S1PR2 mRNA25181051
C006780bisphenol Abisphenol A results in increased expression of S1PR2 mRNA18180321
C006780bisphenol Abisphenol A results in increased methylation of S1PR2 gene28505145
D002104CadmiumCadmium results in increased expression of S1PR2 mRNA24376830
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of S1PR2 mRNA17341687
D002251Carbon TetrachlorideS1PR2 protein affects the reaction [Carbon Tetrachloride results in increased expression of ACTA2 mRNA]17341687
D002251Carbon TetrachlorideS1PR2 protein affects the reaction [Carbon Tetrachloride results in increased expression of PDGFB mRNA]17341687
D002251Carbon TetrachlorideS1PR2 protein affects the reaction [Carbon Tetrachloride results in increased expression of TGFB1 mRNA]17341687
D002251Carbon TetrachlorideS1PR2 protein affects the reaction [Carbon Tetrachloride results in increased expression of TIMP1 mRNA]17341687
D002713ChlorineChlorine results in decreased expression of S1PR2 mRNA18636392
D002713Chlorine[Ozone co-treated with Chlorine] results in decreased expression of S1PR2 mRNA18636392
D002737ChloropreneChloroprene results in decreased expression of S1PR2 mRNA23125180
D003042CocaineCocaine results in decreased expression of S1PR2 mRNA17898221
C014347decitabine[decitabine co-treated with trichostatin A] affects the expression of S1PR2 mRNA17189669
D003976DiazinonDiazinon results in increased methylation of S1PR2 gene22964155
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of S1PR2 mRNA21266533
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of S1PR2 mRNA21266533
D004237DiuronDiuron results in decreased expression of S1PR2 mRNA25152437
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of S1PR2 mRNA17108234
D005419FlavonoidsFlavonoids results in decreased expression of S1PR2 mRNA18035473
D005485FlutamideFlutamide results in decreased expression of S1PR2 mRNA24793618
C039281furanfuran results in increased methylation of S1PR2 gene22079235
D005947GlucoseGlucose results in increased expression of S1PR2 mRNA22406263
D005947Glucose[JTE 013 binds to and results in decreased activity of S1PR2 protein] inhibits the reaction [[sphingosine 1-phosphate co-treated with Glucose] results in increased expression of FN1 protein]22406263
D005947Glucose[JTE 013 binds to and results in decreased activity of S1PR2 protein] results in decreased susceptibility to [sphingosine 1-phosphate co-treated with Glucose]22406263
D007213IndomethacinIndomethacin results in decreased expression of S1PR2 mRNA28201806
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of S1PR2 mRNA25613284
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of S1PR2 mRNA26752646
C471998JTE 013[JTE 013 binds to and results in decreased activity of S1PR2 protein] inhibits the reaction [[sphingosine 1-phosphate co-treated with Glucose] results in increased expression of FN1 protein]22406263
C471998JTE 013[JTE 013 binds to and results in decreased activity of S1PR2 protein] inhibits the reaction [sphingosine 1-phosphate results in increased expression of FN1 protein]22406263
C471998JTE 013[JTE 013 binds to and results in decreased activity of S1PR2 protein] results in decreased susceptibility to [sphingosine 1-phosphate co-treated with Glucose]22406263
C471998JTE 013[JTE 013 binds to and results in decreased activity of S1PR2 protein] which results in decreased susceptibility to sphingosine 1-phosphate22406263
C471998JTE 013JTE 013 binds to and results in decreased activity of S1PR2 protein22406263
D007649KetamineKetamine results in decreased expression of S1PR2 mRNA20080153
C045463leflunomideleflunomide results in increased expression of S1PR2 mRNA28988120
D008070LipopolysaccharidesApigenin inhibits the reaction [Lipopolysaccharides results in increased expression of S1PR2 protein]25557508
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of S1PR2 protein25557508
D008727MethotrexateMethotrexate results in increased expression of S1PR2 mRNA24449571
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of S1PR2 mRNA26011545
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of S1PR2 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of S1PR2 mRNA"25554681
D009532NickelNickel results in increased expression of S1PR2 mRNA25583101
C007350nitrofennitrofen results in decreased expression of S1PR2 mRNA20638522|2654302
C007350nitrofennitrofen results in decreased expression of S1PR2 protein26543024
D010126Ozone[Ozone co-treated with Chlorine] results in decreased expression of S1PR2 mRNA18636392
C006253pirinixic acidpirinixic acid results in increased expression of S1PR2 mRNA19162173
D010936Plant ExtractsPlant Extracts results in decreased expression of S1PR2 mRNA23557933
D011374ProgesteroneProgesterone results in decreased expression of S1PR2 mRNA23012394
C513428pyrachlostrobinpyrachlostrobin results in increased expression of S1PR2 mRNA27029645
C013672riddelliineriddelliine results in decreased expression of S1PR2 mRNA18047727
D012999SomanSoman results in increased expression of S1PR2 mRNA19281266
C060506sphingosine 1-phosphateS1PR2 mutant form inhibits the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 mRNA]18612546
C060506sphingosine 1-phosphatesphingosine 1-phosphate results in increased uptake of S1PR2 protein26518876
C060506sphingosine 1-phosphate[JTE 013 binds to and results in decreased activity of S1PR2 protein] inhibits the reaction [[sphingosine 1-phosphate co-treated with Glucose] results in increased expression of FN1 protein]22406263
C060506sphingosine 1-phosphate[JTE 013 binds to and results in decreased activity of S1PR2 protein] inhibits the reaction [sphingosine 1-phosphate results in increased expression of FN1 protein]22406263
C060506sphingosine 1-phosphate[JTE 013 binds to and results in decreased activity of S1PR2 protein] results in decreased susceptibility to [sphingosine 1-phosphate co-treated with Glucose]22406263
C060506sphingosine 1-phosphate[JTE 013 binds to and results in decreased activity of S1PR2 protein] which results in decreased susceptibility to sphingosine 1-phosphate22406263
C060506sphingosine 1-phosphatesphingosine 1-phosphate results in increased activity of S1PR2 protein22406263
C060506sphingosine 1-phosphate[sphingosine 1-phosphate results in increased activity of S1PR2 protein] which results in increased expression of FN122406263
D013311StreptozocinStreptozocin results in increased expression of S1PR2 mRNA22406263
D013656Taurocholic AcidS1PR2 mRNA promotes the reaction [Taurocholic Acid results in increased expression of PTGS2 protein]26518876
D013656Taurocholic AcidS1PR2 mRNA promotes the reaction [Taurocholic Acid results in increased phosphorylation of EGFR protein]26518876
D013656Taurocholic AcidTaurocholic Acid results in increased activity of and results in increased uptake of S1PR2 protein26518876
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of S1PR2 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of S1PR2 mRNA22298810
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of S1PR2 mRNA25613284
C012589trichostatin A[decitabine co-treated with trichostatin A] affects the expression of S1PR2 mRNA17189669
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of S1PR2 mRNA19042947
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of S1PR2 mRNA"26179874
D014635Valproic AcidValproic Acid results in increased methylation of S1PR2 gene29154799
C025643vinclozolinvinclozolin affects the expression of S1PR2 mRNA19015723

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0001664G-protein coupled receptor binding-IPI24851274  
GO:0004930G-protein coupled receptor activity-TAS8087418  
GO:0005178integrin binding-IPI24851274  
GO:0005515protein binding-IPI24453941  24851274  
GO:0008289lipid binding-TAS10617617  
GO:0038036sphingosine-1-phosphate receptor activity-IMP23106337  
GO ID GO Term Qualifier Evidence PubMed
GO:0000187activation of MAPK activity-TAS10617617  
GO:0003376sphingosine-1-phosphate signaling pathway-IMP23106337  
GO:0007186G-protein coupled receptor signaling pathway-TAS-  
GO:0008284positive regulation of cell proliferation-TAS10617617  
GO:0010800positive regulation of peptidyl-threonine phosphorylation-IMP23106337  
GO:0031532actin cytoskeleton reorganization-IMP23106337  
GO:0046847filopodium assembly-IMP23106337  
GO:1903142positive regulation of establishment of endothelial barrier-IMP24851274  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-IDA24851274  
GO:0005886plasma membrane-TAS-  
GO:0016021integral component of membrane-IEA-  
KEGG ID KEGG Term
hsa04080Neuroactive ligand-receptor interaction
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-372790Signaling by GPCRTAS
R-HSA-373076Class A/1 (Rhodopsin-like receptors)TAS
R-HSA-388396GPCR downstream signallingTAS
R-HSA-418594G alpha (i) signalling eventsTAS
R-HSA-419408Lysosphingolipid and LPA receptorsTAS
R-HSA-500792GPCR ligand bindingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26485657Potential Link between the Sphingosine-1-Phosphate (S1P) System and Defective Alveolar Macrophage Phagocytic Function in Chronic Obstructive Pulmonary Disease (COPD). (2015)Barnawi JPLoS One