| Gene Symbol | Pearson Correlation Coefficient |
|---|---|
| GADL1 | 0.798 |
| DPPA4 | 0.744 |
| IL2RB | 0.728 |
| FCRL3 | 0.727 |
| C16orf54 | 0.727 |
| SLAMF6 | 0.727 |
| ASB9 | 0.723 |
| FMO1 | 0.714 |
| TRIM6 | 0.713 |
| MROH5 | 0.712 |
| Gene Symbol | Pearson Correlation Coefficient |
|---|---|
| FUT9 | -0.427 |
| LGI1 | -0.417 |
| B3GALT1 | -0.416 |
| GREB1 | -0.413 |
| SLC1A4 | -0.409 |
| CYP46A1 | -0.408 |
| BDH1 | -0.397 |
| ADCY2 | -0.394 |
| ZNF835 | -0.383 |
| KIAA0319 | -0.383 |
| ID | Drug Name | Drug Type | CAS Num | Status | Role |
|---|---|---|---|---|---|
| DB06342 | Coltuximab ravtansine | BiotechDrug | 1269764-99-9 | Investigational | Target |
| DB09052 | Blinatumomab | BiotechDrug | 853426-35-4 | Approved|Investigational | Target |
| DB13881 | Tisagenlecleucel | BiotechDrug | 1823078-37-0 | Approved|Investigational | Target |
| DB13915 | Axicabtagene ciloleucel | BiotechDrug | Approved | Target |
| ID | Drug Name | Action | PubMed |
|---|---|---|---|
| C459179 | 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide | "[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CD19 mRNA" | 27188386 |
| C516138 | (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine | "[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CD19 mRNA" | 27188386 |
| C030935 | benz(a)anthracene | benz(a)anthracene results in increased expression of CD19 mRNA | 26377693 |
| C006703 | benzo(b)fluoranthene | benzo(b)fluoranthene results in increased expression of CD19 mRNA | 26377693 |
| D001564 | Benzo(a)pyrene | Benzo(a)pyrene results in decreased expression of CD19 mRNA | 21569818 |
| C023888 | beta-hexachlorocyclohexane | beta-hexachlorocyclohexane results in increased expression of CD19 mRNA | 25270620 |
| C006780 | bisphenol A | bisphenol A affects the expression of CD19 mRNA | 25181051 |
| C006780 | bisphenol A | bisphenol A results in increased methylation of CD19 gene | 28505145 |
| D002084 | Butylated Hydroxytoluene | Butylated Hydroxytoluene results in decreased expression of CD19 mRNA | 19925653 |
| D002392 | Catechin | [Catechin co-treated with Grape Seed Proanthocyanidins] results in increased expression of CD19 mRNA | 24763279 |
| D002392 | Catechin | Catechin results in increased expression of CD19 mRNA | 15465739 |
| D002737 | Chloroprene | Chloroprene results in decreased expression of CD19 mRNA | 23125180 |
| D016264 | Dextran Sulfate | Dextran Sulfate results in increased expression of CD19 mRNA | 23894361 |
| D004041 | Dietary Fats | Dietary Fats results in increased expression of CD19 mRNA | 25016146 |
| D004051 | Diethylhexyl Phthalate | Diethylhexyl Phthalate results in decreased expression of CD19 mRNA | 28412506 |
| D019813 | 1,2-Dimethylhydrazine | "[APC protein affects the susceptibility to 1,2-Dimethylhydrazine] which results in increased expression of CD19 mRNA" | 27840820 |
| C118739 | entinostat | entinostat results in increased expression of CD19 mRNA | 26272509 |
| C118739 | entinostat | "[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CD19 mRNA" | 27188386 |
| C442659 | ethinyl estradiol-desogestrel combination | ethinyl estradiol-desogestrel combination results in increased expression of CD19 protein | 10813102 |
| C069837 | fullerene C60 | fullerene C60 results in increased expression of CD19 mRNA | 19167457 |
| C511402 | Grape Seed Proanthocyanidins | [Catechin co-treated with Grape Seed Proanthocyanidins] results in increased expression of CD19 mRNA | 24763279 |
| D015759 | Ionomycin | [Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of CD19 mRNA | 25613284 |
| D015122 | Mercaptopurine | Mercaptopurine results in decreased expression of CD19 mRNA | 23358152 |
| D008727 | Methotrexate | Methotrexate results in decreased expression of CD19 mRNA | 17400583 |
| D008741 | Methyl Methanesulfonate | Methyl Methanesulfonate results in decreased expression of CD19 mRNA | 23649840 |
| D037742 | Nanotubes, Carbon | "Nanotubes, Carbon affects the expression of CD19 mRNA" | 25554681 |
| D037742 | Nanotubes, Carbon | "Nanotubes, Carbon analog results in decreased expression of CD19 mRNA" | 25554681 |
| C017096 | n-butoxyethanol | n-butoxyethanol results in decreased expression of CD19 mRNA | 19812364 |
| C028007 | nickel monoxide | nickel monoxide results in increased expression of CD19 mRNA | 19167457 |
| D010126 | Ozone | TTPA protein affects the reaction [Ozone results in decreased expression of CD19 mRNA] | 19555225 |
| D010126 | Ozone | Ozone results in decreased expression of CD19 mRNA | 28623178 |
| D052638 | Particulate Matter | Particulate Matter results in decreased expression of CD19 mRNA | 23638009 |
| C006253 | pirinixic acid | pirinixic acid results in decreased expression of CD19 mRNA | 17426115 |
| D011285 | Pregnenolone Carbonitrile | Pregnenolone Carbonitrile results in decreased expression of CD19 mRNA | 28903501 |
| D012822 | Silicon Dioxide | Silicon Dioxide analog results in decreased expression of CD19 mRNA | 25895662 |
| D053260 | Soot | Soot results in decreased expression of CD19 mRNA | 26551751 |
| D013749 | Tetrachlorodibenzodioxin | Tetrachlorodibenzodioxin affects the expression of CD19 mRNA | 21570461 |
| D013755 | Tetradecanoylphorbol Acetate | [Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of CD19 mRNA | 25613284 |
| C009495 | titanium dioxide | titanium dioxide results in increased expression of CD19 mRNA | 23557971 |
| D014028 | Tobacco Smoke Pollution | Tobacco Smoke Pollution affects the expression of CD19 mRNA | 20133372 |
| C016805 | tris(1,3-dichloro-2-propyl)phosphate | "tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of CD19 mRNA" | 26179874 |
| D014520 | Urethane | Urethane results in decreased expression of CD19 mRNA | 28818685 |
| D014635 | Valproic Acid | Valproic Acid affects the expression of CD19 mRNA | 25979313 |
| D014635 | Valproic Acid | Valproic Acid results in increased methylation of CD19 gene | 29154799 |
| GO ID | GO Term | Qualifier | Evidence | PubMed |
|---|---|---|---|---|
| GO:0005515 | protein binding | - | IPI | 19214191 24963139 |
| GO:0046934 | phosphatidylinositol-4,5-bisphosphate 3-kinase activity | - | TAS | - |
| GO ID | GO Term | Qualifier | Evidence | PubMed |
|---|---|---|---|---|
| GO:0006968 | cellular defense response | - | TAS | 1373518 |
| GO:0007166 | cell surface receptor signaling pathway | - | TAS | 1714482 |
| GO:0030449 | regulation of complement activation | - | TAS | - |
| GO:0046854 | phosphatidylinositol phosphorylation | - | IEA | - |
| GO:0050776 | regulation of immune response | - | TAS | - |
| GO:0050853 | B cell receptor signaling pathway | - | IBA | 21873635 |
| GO:0051281 | positive regulation of release of sequestered calcium ion into cytosol | - | IEA | - |
| GO:0051897 | positive regulation of protein kinase B signaling | - | TAS | - |
| GO ID | GO Term | Qualifier | Evidence | PubMed |
|---|---|---|---|---|
| GO:0005886 | plasma membrane | - | TAS | - |
| GO:0005887 | integral component of plasma membrane | - | TAS | 2472450 |
| GO:0009897 | external side of plasma membrane | - | IBA | 21873635 |
| GO:0009897 | external side of plasma membrane | - | IDA | 17213291 20660734 |
| GO:0032991 | protein-containing complex | - | IDA | 23071339 |
| GO:0070062 | extracellular exosome | - | HDA | 20458337 |
| KEGG ID | KEGG Term |
|---|---|
| hsa04640 | Hematopoietic cell lineage |
| hsa04662 | B cell receptor signaling pathway |
| hsa05340 | Primary immunodeficiency |
| Reactome ID | Reactome Term | Evidence |
|---|---|---|
| R-HSA-1257604 | PIP3 activates AKT signaling | TAS |
| R-HSA-1280218 | Adaptive Immune System | TAS |
| R-HSA-162582 | Signal Transduction | TAS |
| R-HSA-1643685 | Disease | TAS |
| R-HSA-166658 | Complement cascade | TAS |
| R-HSA-168249 | Innate Immune System | TAS |
| R-HSA-168256 | Immune System | TAS |
| R-HSA-198933 | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | TAS |
| R-HSA-199418 | Negative regulation of the PI3K/AKT network | TAS |
| R-HSA-2219528 | PI3K/AKT Signaling in Cancer | TAS |
| R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer | TAS |
| R-HSA-5663202 | Diseases of signal transduction | TAS |
| R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | TAS |
| R-HSA-9006925 | Intracellular signaling by second messengers | TAS |
| R-HSA-977606 | Regulation of Complement cascade | TAS |
| R-HSA-983695 | Antigen activates B Cell Receptor (BCR) leading to generation of second messengers | TAS |
| R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | TAS |
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