Gene: KCNB2

9312
KV2.2
potassium voltage-gated channel subfamily B member 2
protein-coding
8q21.11
Ensembl:ENSG00000182674 MIM:607738 Vega:OTTHUMG00000164498 UniprotKB:Q92953
NC_000008.11
PubMed|SNP Mapped
2   ANCO-SNPs
AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.789e-1 (AD)  8.738e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs13251382chr8:72922542 (GRCh38.p7)A>G / A>Talcohol dependenceSNV(Single Nucleotide Variation)
rs2128158chr8:72917865 (GRCh38.p7)G>A / G>C / G>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
KCNB10.924
SV2B0.923
PRICKLE10.92
KIAA1549L0.917
STXBP5L0.914
FBXL20.912
HCN10.911
ST6GALNAC50.91
DLG30.91
SCN3B0.91

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
YES1-0.691
WWTR1-0.678
REST-0.667
RAB13-0.659
RNF135-0.652
HEY2-0.652
CHST14-0.645
CARD8-0.644
RAI14-0.644
SLC43A3-0.634

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB06637DalfampridineSmall Molecule504-24-5ApprovedTarget
ID Drug Name Action PubMed
C0415944-nonylphenol[4-tert-octylphenol co-treated with 4-nonylphenol] results in increased expression of KCNB2 mRNA23626723
C1052604-tert-octylphenol[4-tert-octylphenol co-treated with 4-nonylphenol] results in increased expression of KCNB2 mRNA23626723
D020106AcrylamideAcrylamide affects the expression of KCNB2 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of KCNB2 gene27153756
D000535Aluminum[APP protein modified form binds to Aluminum] which results in increased expression of KCNB2 mRNA21298039
C006780bisphenol Abisphenol A results in decreased expression of KCNB2 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of KCNB2 gene28505145
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of KCNB2 mRNA15336504
D004026DieldrinDieldrin results in decreased expression of KCNB2 mRNA28385952
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of KCNB2 mRNA26011545
D010269ParaquatParaquat affects the expression of KCNB2 mRNA15206577
D011441PropylthiouracilPropylthiouracil results in increased expression of KCNB2 mRNA24780913
C017947sodium arsenitesodium arsenite affects the methylation of KCNB2 gene28589171
D013849ThimerosalThimerosal results in increased expression of KCNB2 mRNA24675092
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of KCNB2 mRNA"26743178
D019287Zinc SulfateZinc Sulfate results in increased expression of KCNB2 mRNA27504894

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005249voltage-gated potassium channel activity-IBA21873635  
GO:0005251delayed rectifier potassium channel activity-IBA21873635  
GO:0005251delayed rectifier potassium channel activity-ISS-  
GO:0046982protein heterodimerization activity-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006813potassium ion transport-ISS-  
GO:0006940regulation of smooth muscle contraction-TAS9612272  
GO:0034765regulation of ion transmembrane transport-IEA-  
GO:0051260protein homooligomerization-IEA-  
GO:0071805potassium ion transmembrane transport-IBA21873635  
GO:0071805potassium ion transmembrane transport-ISS-  
GO:0072659protein localization to plasma membrane-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-ISS-  
GO:0005886plasma membrane-TAS-  
GO:0008076voltage-gated potassium channel complex-IBA21873635  
GO:0008076voltage-gated potassium channel complex-ISS-  
GO:0016021integral component of membrane-IBA21873635  
GO:0030425dendrite-IBA21873635  
GO:0030425dendrite-ISS-  
GO:0032809neuronal cell body membrane-ISS-  
GO:0043025neuronal cell body-IBA21873635  
GO:0043204perikaryon-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-112316Neuronal SystemTAS
R-HSA-1296071Potassium ChannelsTAS
R-HSA-1296072Voltage gated Potassium channelsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23953852Genome-wide association studies of maximum number of drinks. (2013 Nov)Pan YJ Psychiatr Res