Gene: MMP20

9313
AI2A2|MMP-20
matrix metallopeptidase 20
protein-coding
11q22.2
Ensembl:ENSG00000137674 MIM:604629 Vega:OTTHUMG00000168081 UniprotKB:O60882
NG_012151.1
PubMed
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.528e-1 (AD)  5.902e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CDY2A0.938
OR5F10.938
TSPY30.938
OR5M10.938
OR5T20.938
KRTAP6-20.938
OR4C120.938
KRTAP27-10.938
OR5W20.938
MAGEB50.938

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ADCY2-0.267
SLC1A4-0.261
TMEM221-0.245
FUT9-0.242
B3GALT1-0.241
CADM1-0.241
NTSR2-0.234
LGI1-0.234
CHST1-0.234
CORO2B-0.233

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00786MarimastatSmall Molecule154039-60-8Approved|InvestigationalTarget
DB08271N-ISOBUTYL-N-[4-METHOXYPHENYLSULFONYL]GLYCYL HYDROXAMIC ACIDSmall MoleculeExperimentalTarget
ID Drug Name Action PubMed
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of MMP20 gene27153756
D004958Estradiol[bisphenol A co-treated with Estradiol] results in increased expression of MMP20 mRNA26496021
D004958EstradiolEstradiol results in increased expression of MMP20 mRNA26945725
C006780bisphenol A[bisphenol A co-treated with Estradiol] results in increased expression of MMP20 mRNA26496021
C006780bisphenol Abisphenol A results in decreased expression of MMP20 mRNA25181051
D005473FluoxetineFluoxetine results in decreased expression of MMP20 mRNA21083617
D012701SerotoninSerotonin results in decreased expression of MMP20 mRNA21083617
D016226Phosphorus, Dietary"Phosphorus, Dietary affects the expression of MMP20 mRNA"17651324
D017632Asbestos, Serpentine"Asbestos, Serpentine results in increased expression of MMP20 mRNA"21514415
D012969Sodium FluorideSodium Fluoride results in decreased secretion of MMP20 protein21626649
D013853ThioacetamideThioacetamide results in increased expression of MMP20 mRNA23411599
D014635Valproic AcidValproic Acid results in increased expression of MMP20 mRNA28001369

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004222metalloendopeptidase activity-IDA9398237  
GO:0004252serine-type endopeptidase activity-TAS-  
GO:0005515protein binding-IPI18434575  
GO:0008270zinc ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006508proteolysis-IEA-  
GO:0022617extracellular matrix disassembly-IEA-  
GO:0030163protein catabolic process-IEA-  
GO:0030574collagen catabolic process-TAS-  
GO:0070173regulation of enamel mineralization-TAS18434575  
GO:0097186amelogenesis-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005615extracellular space-TAS9398237  
GO:0031012extracellular matrix-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1442490Collagen degradationTAS
R-HSA-1474228Degradation of the extracellular matrixIEA
R-HSA-1474228Degradation of the extracellular matrixTAS
R-HSA-1474244Extracellular matrix organizationIEA
R-HSA-1474244Extracellular matrix organizationTAS
R-HSA-1474290Collagen formationTAS
R-HSA-2022090Assembly of collagen fibrils and other multimeric structuresTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28266114Interaction of lifestyle, behaviour or systemic diseases with dental caries and periodontal diseases: consensus report of group 2 of the joint EFP/ORCA workshop on the boundaries between caries and periodontal diseases. (2017 Mar)Chapple ILJ Clin Periodontol