Gene info: ID 9314

Gene: KLF4

GENE ID: 9314

Synonyms: EZF|GKLF

Description: Kruppel like factor 4

Gene type: protein-coding

Location: 9q31.2

dbXrefs: Ensembl:ENSG00000136826 MIM:602253 Vega:OTTHUMG00000020449 UniprotKB:O43474

RefSeq: NC_000009.12

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND|AD

# Publications: 2

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 4.580e-1 (AD) 6.035e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
NR4A1	0.761
KLF2	0.756
DUSP1	0.754
BTG2	0.716
FOXF1	0.692
SIK1	0.674
SOX18	0.648
DUSP5	0.647
FOS	0.64
CYR61	0.627

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OPRK1	-0.246
KCNH6	-0.233
TDRD9	-0.229
DYDC2	-0.222
KLHL1	-0.213
NKX2-1	-0.21
MUM1L1	-0.209
MKX	-0.209
MAGEE2	-0.204
RSPO3	-0.202

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C051246	1-methylanthracene	[1-methylanthracene co-treated with fluoranthene] results in increased expression of KLF4 mRNA	28329830
C051246	1-methylanthracene	SB 203580 inhibits the reaction [[1-methylanthracene co-treated with fluoranthene] results in increased expression of KLF4 mRNA]	28329830
C111118	2',3,3',4',5-pentachloro-4-hydroxybiphenyl	"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of KLF4 mRNA"	19114083
C573693	2-(4-((4-(6-methoxy-3-pyridinyl)-5-(4-(trifluoromethoxy)phenyl)-2-thiazolyl)methoxy)-2-methylphenoxy)acetic acid	2-(4-((4-(6-methoxy-3-pyridinyl)-5-(4-(trifluoromethoxy)phenyl)-2-thiazolyl)methoxy)-2-methylphenoxy)acetic acid results in increased expression of KLF4 mRNA	22193206
C085911	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Gemfibrozil affects the localization of KLF4 protein]	22685291
C085911	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Estradiol results in increased expression of KLF4 protein]	21484412
C486184	4,4',4''-(4-propyl-((1)H)-pyrazole-1,3,5-triyl) tris-phenol	"4,4',4''-(4-propyl-((1)H)-pyrazole-1,3,5-triyl) tris-phenol results in increased expression of KLF4 protein"	21484412
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KLF4 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KLF4 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KLF4 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KLF4 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KLF4 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KLF4 mRNA"	27188386
C553817	7-(benzylamino)-1,3,4,8-tetrahydropyrrolo(4,3,2-de)quinolin-8(1H)-one	"7-(benzylamino)-1,3,4,8-tetrahydropyrrolo(4,3,2-de)quinolin-8(1H)-one results in increased expression of KLF4 mRNA"	19936915
D000082	Acetaminophen	Acetaminophen results in increased expression of KLF4 mRNA	29067470
D000082	Acetaminophen	Acetaminophen affects the expression of KLF4 mRNA	17562736
D000082	Acetaminophen	Acetaminophen results in increased expression of KLF4 mRNA	11264010
C487680	acetylbritannilatone	acetylbritannilatone analog results in increased expression of KLF4 protein	27262408
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of KLF4 mRNA	27153756
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of KLF4 mRNA	19770486
D000395	Air Pollutants, Occupational	"Air Pollutants, Occupational results in decreased expression of KLF4 mRNA"	26018793
D000395	Air Pollutants, Occupational	"Air Pollutants, Occupational results in increased methylation of KLF4 gene"	26018793
D000638	Amiodarone	Amiodarone results in increased expression of KLF4 mRNA	19774075
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of KLF4 mRNA	16483693
D018501	Antirheumatic Agents	Antirheumatic Agents results in decreased expression of KLF4 mRNA	24449571
D001151	Arsenic	Arsenic results in decreased expression of KLF4 mRNA	19654921
C006632	arsenic trioxide	KLF4 protein results in decreased susceptibility to arsenic trioxide	20707922
D017638	Asbestos, Crocidolite	"Asbestos, Crocidolite affects the expression of KLF4 mRNA"	25757056
D017638	Asbestos, Crocidolite	"Asbestos, Crocidolite results in increased expression of KLF4 mRNA"	18687144
D001554	Benzene	Benzene results in decreased expression of KLF4 mRNA	20036648
C006703	benzo(b)fluoranthene	benzo(b)fluoranthene results in increased expression of KLF4 mRNA	26377693
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of KLF4 mRNA	27195522
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of KLF4 mRNA	21569818
D015123	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of KLF4 mRNA"	19150397\|2038263
D004958	Estradiol	[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of KLF4 mRNA	19619570
D004958	Estradiol	Estradiol results in increased expression of KLF4 mRNA	19619570\|2118537
D004958	Estradiol	Progesterone promotes the reaction [Estradiol results in increased expression of KLF4 mRNA]	21795739
D004958	Estradiol	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Estradiol results in increased expression of KLF4 protein]	21484412
D004958	Estradiol	[bisphenol A co-treated with Estradiol] results in increased expression of KLF4 mRNA	26496021
D004958	Estradiol	[Estradiol binds to ESR1 protein] which affects the localization of KLF4 protein	21484412
D004958	Estradiol	[Estradiol binds to ESR1 protein] which results in increased expression of KLF4	21484412
D004958	Estradiol	Estradiol results in increased expression of KLF4 protein	21484412
D004958	Estradiol	fulvestrant inhibits the reaction [Estradiol results in increased expression of KLF4 protein]	21484412
D004958	Estradiol	KLF4 protein affects the reaction [Estradiol results in increased expression of SOD2]	21484412
D004958	Estradiol	KLF4 protein affects the susceptibility to Estradiol	21484412
D004958	Estradiol	wortmannin inhibits the reaction [Estradiol results in increased expression of KLF4 protein]	21484412
C483161	beta-hydroxy simvastatin acid	beta-hydroxy simvastatin acid results in increased expression of KLF4 mRNA	18192240
C006780	bisphenol A	bisphenol A affects the expression of KLF4 mRNA	20170705
C006780	bisphenol A	bisphenol A affects the methylation of KLF4 promoter	27334623
C006780	bisphenol A	[bisphenol A co-treated with Estradiol] results in increased expression of KLF4 mRNA	26496021
C006780	bisphenol A	bisphenol A results in increased expression of KLF4 mRNA	12075121\|2518105
D019328	Buthionine Sulfoximine	Buthionine Sulfoximine inhibits the reaction [KLF4 results in decreased susceptibility to Cisplatin]	21833590
C018475	butyraldehyde	butyraldehyde results in increased expression of KLF4 mRNA	26079696
C584509	C646 compound	C646 compound results in decreased expression of KLF4 mRNA	26191083
D002104	Cadmium	Cadmium results in decreased expression of KLF4 mRNA	16439709
D019256	Cadmium Chloride	Cadmium Chloride inhibits the reaction [SP1 protein binds to SP3 protein binds to KLF4 protein binds to E2F1 protein binds to NECTIN2 promoter]	25046863
D002110	Caffeine	"[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of KLF4 mRNA"	20230807
D002110	Caffeine	"Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of KLF4 mRNA]"	20230807
D002211	Capsaicin	Capsaicin results in increased expression of KLF4 mRNA	20349343
D002251	Carbon Tetrachloride	Carbon Tetrachloride affects the expression of KLF4 mRNA	17484886
C010063	carbonyl sulfide	carbonyl sulfide affects the expression of KLF4 mRNA	19395590
C026678	carboprostacyclin	carboprostacyclin results in increased expression of KLF4 mRNA	25339356
C026678	carboprostacyclin	carboprostacyclin results in increased expression of KLF4 protein	25339356
D002746	Chlorpromazine	[Chlorpromazine co-treated with Cholic Acids] affects the expression of KLF4 mRNA	27344345
D002793	Cholic Acids	[1-Naphthylisothiocyanate co-treated with Cholic Acids] affects the expression of KLF4 mRNA	27344345
D002793	Cholic Acids	[Chlorpromazine co-treated with Cholic Acids] affects the expression of KLF4 mRNA	27344345
D002793	Cholic Acids	[Cyclosporine co-treated with Cholic Acids] affects the expression of KLF4 mRNA	27344345
D002794	Choline	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of and results in increased expression of KLF4	20938992
D002794	Choline	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of KLF4 gene	20938992
D002794	Choline	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of KLF4 mRNA	20938992
C039671	ciglitazone	ciglitazone results in increased expression of KLF4 mRNA	22193206
C018021	cobaltous chloride	cobaltous chloride results in increased expression of KLF4 mRNA	24386269
D003042	Cocaine	Cocaine affects the expression of KLF4 mRNA	20187946
D003375	Coumestrol	Coumestrol results in decreased expression of KLF4 mRNA	19167446
D003520	Cyclophosphamide	KLF4 results in decreased susceptibility to Cyclophosphamide	21833590
D016572	Cyclosporine	[Cyclosporine co-treated with Cholic Acids] affects the expression of KLF4 mRNA	27344345
D016572	Cyclosporine	Cyclosporine results in increased expression of KLF4 mRNA	20106945\|2556210
D016572	Cyclosporine	Cyclosporine results in increased expression of KLF4 mRNA	19770486
C017180	decamethrin	decamethrin results in decreased expression of KLF4 mRNA	19017407
D003840	Deoxycholic Acid	Deoxycholic Acid results in increased expression of KLF4 mRNA	27151938
D003907	Dexamethasone	[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of KLF4 mRNA	25559859
D003907	Dexamethasone	[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of KLF4 mRNA	16054899
D003907	Dexamethasone	Dexamethasone results in increased expression of KLF4 mRNA	21041162
D003907	Dexamethasone	silybin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of KLF4 mRNA]	25559859
D003907	Dexamethasone	[Tetrachlorodibenzodioxin co-treated with EGF protein] inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of KLF4 mRNA]	16054899
D003907	Dexamethasone	Tetrachlorodibenzodioxin inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of KLF4 mRNA]	16054899
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in increased expression of KLF4 mRNA	17361019\|2126653
D002945	Cisplatin	Buthionine Sulfoximine inhibits the reaction [KLF4 results in decreased susceptibility to Cisplatin]	21833590
D002945	Cisplatin	[Cisplatin co-treated with jinfukang] results in decreased expression of KLF4 mRNA	27392435
D002945	Cisplatin	KLF4 results in decreased susceptibility to Cisplatin	21833590
D002945	Cisplatin	[Piroxicam co-treated with Cisplatin] results in increased expression of KLF4 mRNA	21858171
D002945	Cisplatin	Cisplatin results in increased expression of KLF4 mRNA	21151649
D019259	Lamivudine	[Zidovudine co-treated with Lamivudine] results in increased expression of KLF4 mRNA	15784690
D004040	Dietary Carbohydrates	Dietary Carbohydrates results in increased expression of KLF4 mRNA	17490981
D004052	Diethylnitrosamine	Diethylnitrosamine results in increased expression of KLF4 mRNA	24535843
D004054	Diethylstilbestrol	Diethylstilbestrol results in increased expression of KLF4 mRNA	25242112
D004054	Diethylstilbestrol	Diethylstilbestrol results in increased expression of KLF4 mRNA	15591538\|1663631
D002117	Calcitriol	Calcitriol results in increased expression of KLF4 mRNA	16002434
D015127	9,10-Dimethyl-1,2-benzanthracene	"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of KLF4 mRNA"	22485181
D004121	Dimethyl Sulfoxide	Dimethyl Sulfoxide results in increased expression of KLF4 mRNA	22193206
C051904	dinophysistoxin 1	dinophysistoxin 1 results in increased expression of KLF4 mRNA	28939011
D004237	Diuron	Diuron results in decreased expression of KLF4 mRNA	25152437
C017435	enilconazole	enilconazole affects the expression of KLF4 mRNA	29106682
C118739	entinostat	entinostat results in increased expression of KLF4 mRNA	26272509
C118739	entinostat	"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KLF4 mRNA"	27188386
C045651	epigallocatechin gallate	[potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of KLF4 mRNA	22079256
D004997	Ethinyl Estradiol	Ethinyl Estradiol affects the expression of KLF4 mRNA	20170705\|2686566
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of KLF4 mRNA	18936297
D004997	Ethinyl Estradiol	Ethinyl Estradiol affects the expression of KLF4 mRNA	20170705\|2686566
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of KLF4 mRNA	12075121\|1583489
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in decreased expression of KLF4 mRNA	23550701
C004912	ethylbenzene	[Toluene co-treated with ethylbenzene co-treated with Xylenes] results in decreased expression of KLF4 mRNA	26018793
C004912	ethylbenzene	[Toluene co-treated with ethylbenzene co-treated with Xylenes] results in increased methylation of KLF4 gene	26018793
C540355	fenamidone	fenamidone results in increased expression of KLF4 mRNA	27029645
C000499	ferric oxide	ferric oxide analog results in decreased expression of KLF4 mRNA	25086211
D005419	Flavonoids	Flavonoids results in increased expression of KLF4 mRNA	18035473
C007738	fluoranthene	[1-methylanthracene co-treated with fluoranthene] results in increased expression of KLF4 mRNA	28329830
C007738	fluoranthene	SB 203580 inhibits the reaction [[1-methylanthracene co-treated with fluoranthene] results in increased expression of KLF4 mRNA]	28329830
D005472	Fluorouracil	Fluorouracil results in increased expression of KLF4 mRNA	16557594\|1703926
D005472	Fluorouracil	KLF4 results in decreased susceptibility to Fluorouracil	21833590
D005492	Folic Acid	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of and results in increased expression of KLF4	20938992
D005492	Folic Acid	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of KLF4 gene	20938992
D005492	Folic Acid	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of KLF4 mRNA	20938992
D005557	Formaldehyde	Formaldehyde results in increased expression of KLF4 mRNA	20655997\|2341626
C070081	fulvestrant	fulvestrant inhibits the reaction [Estradiol results in increased expression of KLF4 protein]	21484412
C039281	furan	furan results in increased expression of KLF4 mRNA	27387713
D015248	Gemfibrozil	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Gemfibrozil affects the localization of KLF4 protein]	22685291
D015248	Gemfibrozil	Gemfibrozil affects the localization of KLF4 protein	22685291
D015248	Gemfibrozil	Gemfibrozil results in increased phosphorylation of KLF4 protein	22685291
D015248	Gemfibrozil	KLF4 mRNA affects the reaction [Gemfibrozil results in increased expression of SOCS3 mRNA]	22685291
D015248	Gemfibrozil	KLF4 mRNA affects the susceptibility to Gemfibrozil	22685291
D019833	Genistein	Genistein affects the expression of KLF4 mRNA	26865667
D019833	Genistein	Genistein results in increased expression of KLF4 mRNA	26865667
D019833	Genistein	Genistein results in increased expression of KLF4 mRNA	12075121
D005839	Gentamicins	Gentamicins results in increased expression of KLF4 mRNA	22061828
D005978	Glutathione	KLF4 results in increased abundance of Glutathione	21833590
D005978	Glutathione	[KLF4 results in increased expression of GCLC mRNA] which results in increased abundance of Glutathione	21833590
C004312	glycidol	glycidol results in decreased expression of KLF4 mRNA	24915197
D006493	Heparin	Heparin inhibits the reaction [[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of KLF4 mRNA]	16401727
D007213	Indomethacin	Indomethacin results in increased expression of KLF4 mRNA	16984733
D015759	Ionomycin	pyrrolidine dithiocarbamic acid inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of KLF4 mRNA]	15477007
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of KLF4 mRNA	15477007
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of KLF4 mRNA	25613284
C051890	irinotecan	irinotecan analog results in increased expression of KLF4 mRNA	18927307
D015056	1-Methyl-3-isobutylxanthine	[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of KLF4 mRNA	25559859
D015056	1-Methyl-3-isobutylxanthine	[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of KLF4 mRNA	16054899
D015056	1-Methyl-3-isobutylxanthine	silybin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of KLF4 mRNA]	25559859
D015056	1-Methyl-3-isobutylxanthine	[Tetrachlorodibenzodioxin co-treated with EGF protein] inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of KLF4 mRNA]	16054899
D015056	1-Methyl-3-isobutylxanthine	Tetrachlorodibenzodioxin inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of KLF4 mRNA]	16054899
C544151	jinfukang	[Cisplatin co-treated with jinfukang] results in decreased expression of KLF4 mRNA	27392435
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in decreased expression of KLF4 mRNA	26830473
D008070	Lipopolysaccharides	Heparin inhibits the reaction [[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of KLF4 mRNA]	16401727
D008070	Lipopolysaccharides	[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of KLF4 mRNA	16401727\|1641532
D058185	Magnetite Nanoparticles	[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of KLF4 mRNA	26378955
D058185	Magnetite Nanoparticles	[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of KLF4 mRNA	21641980
D058185	Magnetite Nanoparticles	[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of KLF4 mRNA	26378955
C569869	malondialdehyde-low density lipoprotein, human	"KLF4 protein promotes the reaction [Oxytocin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of SELE protein]]"	29104011
C569869	malondialdehyde-low density lipoprotein, human	"KLF4 protein promotes the reaction [Oxytocin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of VCAM1 protein]]"	29104011
C569869	malondialdehyde-low density lipoprotein, human	"malondialdehyde-low density lipoprotein, human results in decreased expression of KLF4 protein"	29104011
C569869	malondialdehyde-low density lipoprotein, human	"Oxytocin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in decreased expression of KLF4 protein]"	29104011
D008345	Manganese	Manganese results in increased expression of KLF4 mRNA	17175027
C025340	manganese chloride	manganese chloride results in increased expression of KLF4 mRNA	17175027
D017258	Medroxyprogesterone Acetate	Medroxyprogesterone Acetate results in increased expression of KLF4 mRNA	18497975
D008627	Mercuric Chloride	Mercuric Chloride affects the expression of KLF4 mRNA	20353558
D008715	Methionine	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of and results in increased expression of KLF4	20938992
D008715	Methionine	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of KLF4 gene	20938992
D008715	Methionine	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of KLF4 mRNA	20938992
C004925	methylmercuric chloride	methylmercuric chloride results in increased expression of KLF4 mRNA	28001369
D015632	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	"1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of KLF4 mRNA"	20230807
D015632	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	"[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of KLF4 mRNA"	20230807
D015632	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	"Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of KLF4 mRNA]"	20230807
D015632	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	"[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of KLF4 mRNA"	20230807
D015632	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	"Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of KLF4 mRNA]"	20230807
C008493	methylselenic acid	KLF4 protein affects the reaction [methylselenic acid results in decreased expression of CCND1 mRNA]	18314491
C008493	methylselenic acid	KLF4 protein affects the reaction [methylselenic acid results in increased expression of CDKN1A mRNA]	18314491
C008493	methylselenic acid	KLF4 protein affects the reaction [methylselenic acid results in increased expression of CDKN1B mRNA]	18314491
C008493	methylselenic acid	methylselenic acid affects the expression of KLF4 mRNA	14617803
C008493	methylselenic acid	methylselenic acid results in increased activity of KLF4 protein	18314491
C008493	methylselenic acid	methylselenic acid results in increased expression of KLF4 mRNA	18314491
D008777	Methyltestosterone	Methyltestosterone results in increased expression of KLF4 mRNA	29191790
C000621033	napabucasin	napabucasin results in decreased expression of KLF4 mRNA	26899963
C000621033	napabucasin	napabucasin results in decreased expression of KLF4 protein	25605917\|2689996
D015058	1-Naphthylisothiocyanate	[1-Naphthylisothiocyanate co-treated with Cholic Acids] affects the expression of KLF4 mRNA	27344345
C115174	netoglitazone	KLF4 mRNA affects the reaction [netoglitazone results in increased expression of GDF15 protein]	22750490
C115174	netoglitazone	KLF4 mRNA affects the susceptibility to netoglitazone	22750490
C115174	netoglitazone	netoglitazone results in increased expression of KLF4 protein	22750490
C022838	nickel chloride	nickel chloride results in increased expression of KLF4 protein	26962057
C029938	nickel sulfate	nickel sulfate results in decreased expression of KLF4 mRNA	16780908
D009538	Nicotine	"[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of KLF4 mRNA"	20230807
D009538	Nicotine	"Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of KLF4 mRNA]"	20230807
D009538	Nicotine	Nicotine results in increased expression of KLF4 mRNA	17456735
C012655	nimesulide	nimesulide inhibits the reaction [KLKB1 gene mutant form results in increased expression of KLF4 mRNA]	25339356
C570897	NSC668394	NSC668394 results in increased expression of KLF4 mRNA	27137931
D010100	Oxygen	Oxygen affects the reaction [AHR protein results in increased expression of KLF4 mRNA]	27103661
D010100	Oxygen	Oxygen deficiency results in increased expression of KLF4 mRNA	17175027
D010100	Oxygen	Oxygen results in increased expression of KLF4 mRNA	27103661
D010121	Oxytocin	"KLF4 protein promotes the reaction [Oxytocin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of SELE protein]]"	29104011
D010121	Oxytocin	"KLF4 protein promotes the reaction [Oxytocin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of VCAM1 protein]]"	29104011
D010121	Oxytocin	MAP2K5 protein promotes the reaction [Oxytocin results in increased expression of KLF4 mRNA]	29104011
D010121	Oxytocin	MAP2K5 protein promotes the reaction [Oxytocin results in increased expression of KLF4 protein]	29104011
D010121	Oxytocin	MEF2A protein promotes the reaction [Oxytocin results in increased expression of KLF4 mRNA]	29104011
D010121	Oxytocin	MEF2A protein promotes the reaction [Oxytocin results in increased expression of KLF4 protein]	29104011
D010121	Oxytocin	"Oxytocin inhibits the reaction [malondialdehyde-low density lipoprotein, human results in decreased expression of KLF4 protein]"	29104011
D010121	Oxytocin	Oxytocin results in increased expression of KLF4 mRNA	29104011
D010121	Oxytocin	Oxytocin results in increased expression of KLF4 protein	29104011
D010126	Ozone	Ozone results in increased expression of KLF4 mRNA	16716893
C496932	panobinostat	"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KLF4 mRNA"	27188386
D010269	Paraquat	Paraquat results in decreased expression of KLF4 protein	26813466
C568608	PCI 5002	[PCI 5002 co-treated with Zinc] results in increased expression of KLF4 mRNA	18593933
D010396	Penicillamine	Penicillamine results in increased expression of KLF4 mRNA	19575532
C086401	pentabromodiphenyl ether	pentabromodiphenyl ether results in increased expression of KLF4 mRNA	26705709
D010656	Phenylephrine	Phenylephrine inhibits the reaction [KLF4 protein binds to NPPA promoter]	19729022
D010656	Phenylephrine	Phenylephrine results in decreased expression of KLF4 mRNA	19729022
D010656	Phenylephrine	Phenylephrine results in decreased expression of KLF4 protein	19729022
D010656	Phenylephrine	SK-7041 inhibits the reaction [Phenylephrine inhibits the reaction [KLF4 protein binds to NPPA promoter]]	19729022
C006253	pirinixic acid	pirinixic acid results in increased expression of KLF4 mRNA	18445702
D010894	Piroxicam	[Piroxicam co-treated with Cisplatin] results in increased expression of KLF4 mRNA	21858171
D010938	Plant Oils	Plant Oils results in increased expression of KLF4 mRNA	23370395
D011078	Polychlorinated Biphenyls	Polychlorinated Biphenyls affects the expression of KLF4 mRNA	21334430
D059808	Polyphenols	Polyphenols results in decreased expression of KLF4 mRNA	16293270
C027373	potassium chromate(VI)	[potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of KLF4 mRNA	22079256
C027373	potassium chromate(VI)	potassium chromate(VI) results in increased expression of KLF4 mRNA	22079256\|2271453
D011374	Progesterone	Progesterone promotes the reaction [Estradiol results in increased expression of KLF4 mRNA]	21795739
C513428	pyrachlostrobin	pyrachlostrobin results in increased expression of KLF4 mRNA	27029645
D011748	Pyrogallol	Pyrogallol results in increased expression of KLF4 mRNA	20362636
C020972	pyrrolidine dithiocarbamic acid	pyrrolidine dithiocarbamic acid inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of KLF4 mRNA]	15477007
D011794	Quercetin	Quercetin results in increased expression of KLF4 mRNA	21632981
D011899	Ranitidine	Heparin inhibits the reaction [[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of KLF4 mRNA]	16401727
D011899	Ranitidine	[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of KLF4 mRNA	16401727\|1641532
C059514	resveratrol	resveratrol promotes the reaction [[[EGR1 protein binds to KLF4 protein] which binds to ATF3 promoter] which results in increased expression of ATF3 mRNA]	21205742
C059514	resveratrol	resveratrol promotes the reaction [[KLF4 protein binds to ATF3 promoter] which results in increased expression of ATF3 mRNA]	21205742
C059514	resveratrol	resveratrol results in increased expression of KLF4 mRNA	21205742
C059514	resveratrol	resveratrol results in increased expression of KLF4 protein	21205742
C059514	resveratrol	[resveratrol co-treated with Streptozocin] results in increased expression of KLF4 mRNA	25905778
C089730	rosiglitazone	[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of KLF4 mRNA	16054899
C089730	rosiglitazone	[Tetrachlorodibenzodioxin co-treated with EGF protein] inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of KLF4 mRNA]	16054899
C089730	rosiglitazone	Tetrachlorodibenzodioxin inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of KLF4 mRNA]	16054899
C541923	sandostatinLAR	sandostatinLAR results in increased expression of KLF4 mRNA	17210224
C093642	SB 203580	SB 203580 inhibits the reaction [[1-methylanthracene co-treated with fluoranthene] results in increased expression of KLF4 mRNA]	28329830
D012601	Scopolamine Hydrobromide	Scopolamine Hydrobromide results in decreased expression of KLF4 mRNA	17540011
D012822	Silicon Dioxide	Silicon Dioxide analog results in increased expression of KLF4 mRNA	23806026
D012822	Silicon Dioxide	Silicon Dioxide results in decreased expression of KLF4 mRNA	19073995
D012834	Silver	Silver results in increased expression of KLF4 mRNA	26014281
C440975	silybin	silybin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of KLF4 mRNA]	25559859
C497103	SK-7041	KLF4 protein affects the reaction [SK-7041 affects the expression of NPPA mRNA]	19729022
C497103	SK-7041	SK-7041 inhibits the reaction [Phenylephrine inhibits the reaction [KLF4 protein binds to NPPA promoter]]	19729022
C497103	SK-7041	SK-7041 results in increased expression of KLF4 mRNA	19729022
C497103	SK-7041	SK-7041 results in increased expression of KLF4 protein	19729022
C017947	sodium arsenite	sodium arsenite results in decreased expression of KLF4 mRNA	12377979
C017947	sodium arsenite	sodium arsenite results in decreased expression of KLF4 protein	23562784
C017947	sodium arsenite	[OGG1 gene mutant form results in increased susceptibility to sodium arsenite] which affects the expression of KLF4 mRNA	26438402
C017947	sodium arsenite	sodium arsenite affects the expression of KLF4 mRNA	26438402
D012999	Soman	Soman results in increased expression of KLF4 mRNA	19281266
D053260	Soot	Soot results in increased expression of KLF4 mRNA	22461453\|2655175
D013311	Streptozocin	[resveratrol co-treated with Streptozocin] results in increased expression of KLF4 mRNA	25905778
D004113	Succimer	[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of KLF4 mRNA	26378955
D004113	Succimer	[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of KLF4 mRNA	21641980
D004113	Succimer	[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of KLF4 mRNA	26378955
D013656	Taurocholic Acid	Taurocholic Acid results in increased expression of KLF4 mRNA	27151938
D013749	Tetrachlorodibenzodioxin	[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of KLF4 mRNA	19619570
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of KLF4 mRNA	12377990\|1710120
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of KLF4 mRNA	23152189
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of KLF4 mRNA	21570461\|2637764
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with EGF protein] inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of KLF4 mRNA]	16054899
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with EGF protein] results in increased expression of KLF4 mRNA	16054899
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of KLF4 mRNA]	16054899
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of KLF4 mRNA	16054899\|1977048
D013755	Tetradecanoylphorbol Acetate	pyrrolidine dithiocarbamic acid inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of KLF4 mRNA]	15477007
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of KLF4 mRNA	15477007
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of KLF4 mRNA	25613284
D013849	Thimerosal	Thimerosal results in increased expression of KLF4 mRNA	16870260
C009495	titanium dioxide	titanium dioxide results in decreased expression of KLF4 mRNA	27760801
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in increased expression of KLF4 mRNA	28065790
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution affects the expression of KLF4 mRNA	20133372
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in decreased expression of KLF4 mRNA	28111298
D014028	Tobacco Smoke Pollution	KLF4 affects the susceptibility to Tobacco Smoke Pollution	23967268
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution promotes the reaction [KLF4 protein binds to ACTA2 promoter]	23967268
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution promotes the reaction [KLF4 protein binds to MYH11 promoter]	23967268
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution promotes the reaction [KLF4 protein binds to MYOCD promoter]	23967268
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in increased expression of KLF4 mRNA	23967268
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in increased expression of KLF4 protein	23967268
D014050	Toluene	[Toluene co-treated with ethylbenzene co-treated with Xylenes] results in decreased expression of KLF4 mRNA	26018793
D014050	Toluene	[Toluene co-treated with ethylbenzene co-treated with Xylenes] results in increased methylation of KLF4 gene	26018793
C496197	trans-10,cis-12-conjugated linoleic acid	"trans-10,cis-12-conjugated linoleic acid results in increased expression of KLF4 mRNA"	17951470
D014212	Tretinoin	Tretinoin results in increased expression of KLF4 mRNA	16249480\|2193413
C012589	trichostatin A	trichostatin A results in increased expression of KLF4 mRNA	19729022
C012589	trichostatin A	trichostatin A results in increased expression of KLF4 mRNA	15901671
C016805	tris(1,3-dichloro-2-propyl)phosphate	"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of KLF4 mRNA"	26179874
C013320	tris(2-butoxyethyl) phosphate	tris(2-butoxyethyl) phosphate affects the expression of KLF4 mRNA	29024780
D014520	Urethane	Urethane results in increased expression of KLF4 mRNA	28818685
D014635	Valproic Acid	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KLF4 mRNA"	27188386
D014635	Valproic Acid	Valproic Acid results in increased expression of KLF4 mRNA	23179753\|2438349
D014635	Valproic Acid	Valproic Acid results in increased methylation of KLF4 gene	28853863
D014635	Valproic Acid	Valproic Acid results in increased expression of KLF4 mRNA	19136453
D014635	Valproic Acid	Valproic Acid results in increased expression of KLF4 mRNA	15901671
D001335	Vehicle Emissions	Vehicle Emissions results in increased expression of KLF4 mRNA	19465080
C025643	vinclozolin	vinclozolin affects the expression of KLF4 mRNA	19015723
C025643	vinclozolin	vinclozolin results in increased expression of KLF4 mRNA	23034163\|2355583
C029297	vinylidene chloride	vinylidene chloride results in increased expression of KLF4 mRNA	26682919
C009687	wortmannin	wortmannin inhibits the reaction [Estradiol results in increased expression of KLF4 protein]	21484412
D014992	Xylenes	[Toluene co-treated with ethylbenzene co-treated with Xylenes] results in decreased expression of KLF4 mRNA	26018793
D014992	Xylenes	[Toluene co-treated with ethylbenzene co-treated with Xylenes] results in increased methylation of KLF4 gene	26018793
D015215	Zidovudine	[Zidovudine co-treated with Lamivudine] results in increased expression of KLF4 mRNA	15784690
D015032	Zinc	[PCI 5002 co-treated with Zinc] results in increased expression of KLF4 mRNA	18593933

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	-	IEA	-
GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding	-	IBA	21873635
GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding	-	ISA	-
GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding	-	NAS	19274049
GO:0000987	proximal promoter sequence-specific DNA binding	-	IDA	21539536
GO:0001010	transcription factor activity, sequence-specific DNA-binding transcription factor recruiting	-	ISS	-
GO:0001077	transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding	-	IMP	21539536
GO:0001085	RNA polymerase II transcription factor binding	-	IPI	21539536
GO:0001085	RNA polymerase II transcription factor binding	-	ISS	-
GO:0001190	transcriptional activator activity, RNA polymerase II transcription factor binding	-	IDA	21539536
GO:0001221	transcription cofactor binding	-	IEA	-
GO:0003700	DNA-binding transcription factor activity	-	NAS	9422764
GO:0005515	protein binding	-	IPI	19751731 24048479
GO:0008013	beta-catenin binding	-	IEA	-
GO:0008270	zinc ion binding	-	NAS	9422764
GO:0035014	phosphatidylinositol 3-kinase regulator activity	-	IEA	-
GO:0042826	histone deacetylase binding	-	IEA	-
GO:0044212	transcription regulatory region DNA binding	-	ISS	-
GO:1990841	promoter-specific chromatin binding	-	IDA	27907090

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000122	negative regulation of transcription by RNA polymerase II	-	IDA	20551324
GO:0006357	regulation of transcription by RNA polymerase II	-	IBA	21873635
GO:0006366	transcription by RNA polymerase II	-	ISS	-
GO:0007500	mesodermal cell fate determination	-	TAS	8940147
GO:0008285	negative regulation of cell proliferation	-	TAS	8702718
GO:0009913	epidermal cell differentiation	-	IEA	-
GO:0010628	positive regulation of gene expression	-	IGI	22267480
GO:0010629	negative regulation of gene expression	-	IGI	22267480
GO:0014067	negative regulation of phosphatidylinositol 3-kinase signaling	-	IEA	-
GO:0014740	negative regulation of muscle hyperplasia	-	IEA	-
GO:0016525	negative regulation of angiogenesis	-	IDA	23867820
GO:0019827	stem cell population maintenance	-	ISS	-
GO:0031077	post-embryonic camera-type eye development	-	IEA	-
GO:0032088	negative regulation of NF-kappaB transcription factor activity	-	IDA	20551324
GO:0032270	positive regulation of cellular protein metabolic process	-	IMP	22430140
GO:0034115	negative regulation of heterotypic cell-cell adhesion	-	IDA	20551324
GO:0035019	somatic stem cell population maintenance	-	TAS	-
GO:0035166	post-embryonic hemopoiesis	-	IMP	21539536
GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	-	IDA	20551324
GO:0043551	regulation of phosphatidylinositol 3-kinase activity	-	IEA	-
GO:0045415	negative regulation of interleukin-8 biosynthetic process	-	IDA	20551324
GO:0045429	positive regulation of nitric oxide biosynthetic process	-	IMP	22430140
GO:0045444	fat cell differentiation	-	ISS	-
GO:0045595	regulation of cell differentiation	-	ISS	-
GO:0045892	negative regulation of transcription, DNA-templated	-	IDA	9422764
GO:0045893	positive regulation of transcription, DNA-templated	-	IDA	27431648
GO:0045893	positive regulation of transcription, DNA-templated	-	ISS	-
GO:0045893	positive regulation of transcription, DNA-templated	-	NAS	9422764
GO:0045944	positive regulation of transcription by RNA polymerase II	-	IGI	20551324
GO:0045944	positive regulation of transcription by RNA polymerase II	-	IMP	22430140 22723415 27907090
GO:0045944	positive regulation of transcription by RNA polymerase II	-	ISS	-
GO:0046985	positive regulation of hemoglobin biosynthetic process	-	IMP	21539536
GO:0048662	negative regulation of smooth muscle cell proliferation	-	IEA	-
GO:0048679	regulation of axon regeneration	-	IEA	-
GO:0048730	epidermis morphogenesis	-	IEA	-
GO:0050728	negative regulation of inflammatory response	-	TAS	20551324
GO:0051247	positive regulation of protein metabolic process	-	IGI	20551324
GO:0051898	negative regulation of protein kinase B signaling	-	IEA	-
GO:0051973	positive regulation of telomerase activity	-	IDA	20629177
GO:0060070	canonical Wnt signaling pathway	-	IEA	-
GO:0060761	negative regulation of response to cytokine stimulus	-	IDA	20551324
GO:0061614	pri-miRNA transcription by RNA polymerase II	-	IDA	23867820
GO:0070301	cellular response to hydrogen peroxide	-	IEA	-
GO:0070373	negative regulation of ERK1 and ERK2 cascade	-	IEA	-
GO:0071300	cellular response to retinoic acid	-	IEA	-
GO:0071363	cellular response to growth factor stimulus	-	IDA	20551324
GO:0071409	cellular response to cycloheximide	-	IEA	-
GO:0071499	cellular response to laminar fluid shear stress	-	IMP	22430140
GO:0090051	negative regulation of cell migration involved in sprouting angiogenesis	-	IDA	20551324
GO:1901653	cellular response to peptide	-	IEA	-
GO:1903672	positive regulation of sprouting angiogenesis	-	IGI	27431648
GO:1904798	positive regulation of core promoter binding	-	IEA	-
GO:1904998	negative regulation of leukocyte adhesion to arterial endothelial cell	-	IGI	22267480
GO:1990830	cellular response to leukemia inhibitory factor	-	IEA	-
GO:2000134	negative regulation of G1/S transition of mitotic cell cycle	-	IDA	23867820
GO:2000342	negative regulation of chemokine (C-X-C motif) ligand 2 production	-	IDA	20551324

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000790	nuclear chromatin	-	IDA	21539536
GO:0005634	nucleus	-	IBA	21873635
GO:0005654	nucleoplasm	-	IDA	-
GO:0005654	nucleoplasm	-	TAS	-
GO:0005719	nuclear euchromatin	-	IEA	-
GO:0005737	cytoplasm	-	IEA	-
GO:0044798	nuclear transcription factor complex	-	IEA	-

KEGG ID	KEGG Term

Reactome ID	Reactome Term	Evidence
R-HSA-1266738	Developmental Biology	TAS
R-HSA-1266738	Developmental Biology	IEA
R-HSA-2980736	Peptide hormone metabolism	TAS
R-HSA-381340	Transcriptional regulation of white adipocyte differentiation	IEA
R-HSA-392499	Metabolism of proteins	TAS
R-HSA-422085	Synthesis, secretion, and deacylation of Ghrelin	TAS
R-HSA-452723	Transcriptional regulation of pluripotent stem cells	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
27497606	Ethanol-induced changes in poly (ADP ribose) polymerase and neuronal developmental gene expression. (2016 Nov)	Gavin DP	Neuropharmacology
29511453	Role of Kruppel-like factor 4 in cigarette smoke-induced pulmonary vascular remodeling. (2018)	Sun D	Am J Transl Res