Gene: PTER

9317
HPHRP|RPR-1
phosphotriesterase related
protein-coding
10p13
Ensembl:ENSG00000165983 MIM:604446 Vega:OTTHUMG00000017737 UniprotKB:Q96BW5
NC_000010.11
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.662e-1 (AD)  4.162e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ENC10.932
NDFIP20.928
NELL20.928
ELAVL40.925
SH3GL20.925
VSNL10.925
LRFN50.922
PDP10.922
SYT10.92
ZNF3650.92

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HEY2-0.484
CSAG1-0.48
CNN2-0.47
ARHGEF5-0.466
ACAP1-0.462
RAI14-0.448
RUNX3-0.446
OR4F5-0.445
SYDE1-0.444
AJUBA-0.44

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of PTER mRNA"25614096
C0291412,2,5,7,8-pentamethyl-1-hydroxychroman"2,2,5,7,8-pentamethyl-1-hydroxychroman results in increased expression of PTER mRNA"21920950
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of PTER mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of PTER mRNA"21346803
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of PTER mRNA"23196670
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of PTER mRNA"25380136
C0352074-amino-2,6-dinitrotoluene"4-amino-2,6-dinitrotoluene affects the expression of PTER mRNA"21346803
D000082AcetaminophenAcetaminophen results in increased expression of PTER mRNA26690555
D000082AcetaminophenAcetaminophen affects the expression of PTER mRNA17562736
D000517alpha-Chlorohydrinalpha-Chlorohydrin analog results in decreased expression of PTER protein26597043
D000643Ammonium ChlorideAmmonium Chloride affects the expression of PTER mRNA16483693
D001280AtrazineAtrazine results in increased expression of PTER mRNA25929836
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of PTER mRNA22228805
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of PTER mRNA21839799
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of PTER mRNA"20018196
C006780bisphenol Abisphenol A affects the expression of PTER mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of PTER mRNA25181051
C010063carbonyl sulfidecarbonyl sulfide results in increased expression of PTER mRNA19395590
C018021cobaltous chloridecobaltous chloride results in decreased expression of PTER mRNA24386269
D019327Copper SulfateCopper Sulfate results in decreased expression of PTER mRNA19549813
D016572CyclosporineCyclosporine results in decreased expression of PTER mRNA20106945
D016572CyclosporineCyclosporine results in increased expression of PTER mRNA27989131
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of PTER mRNA21266533
C000944dicrotophosdicrotophos results in decreased expression of PTER mRNA28302478
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in increased expression of PTER mRNA19850644
D004051Diethylhexyl PhthalatePPARA protein inhibits the reaction [Diethylhexyl Phthalate results in increased expression of PTER mRNA]19850644
D004128DimethylnitrosamineDimethylnitrosamine results in increased expression of PTER mRNA25380136
D004147DioxinsDioxins affects the expression of PTER mRNA20463971
D004221DisulfiramDisulfiram results in decreased expression of PTER mRNA20530235
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of PTER mRNA22079256
D000431EthanolEthanol results in increased expression of PTER mRNA24355176
D000431EthanolEthanol results in decreased expression of PTER mRNA15353170
D005473FluoxetineFluoxetine results in decreased expression of PTER mRNA17033635
D005485FlutamideFlutamide results in decreased expression of PTER mRNA24793618
D005839GentamicinsGentamicins results in increased expression of PTER protein22061828
C004312glycidolglycidol results in increased expression of PTER mRNA24915197
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of PTER mRNA25613284
D008748MethylcholanthreneMethylcholanthrene results in increased expression of PTER mRNA20713471
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of PTER mRNA23179753|2718838
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of PTER mRNA26011545
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of PTER mRNA23649840
D037742Nanotubes, Carbon"Nanotubes, Carbon analog affects the expression of PTER mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of PTER mRNA"25620056
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in increased expression of PTER mRNA25380136
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of PTER protein23427857
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of PTER mRNA19710929
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of PTER mRNA19710929
C006253pirinixic acidpirinixic acid results in decreased expression of PTER mRNA18445702|2381119
D010936Plant ExtractsPlant Extracts results in increased expression of PTER mRNA23557933
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of PTER mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of PTER mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in increased expression of PTER mRNA22714537
D011374ProgesteroneProgesterone results in decreased expression of PTER mRNA23012394
C015586propiverinepropiverine binds to PTER protein29273565
D011441PropylthiouracilPropylthiouracil results in increased expression of PTER mRNA24780913
C009277sodium arsenatesodium arsenate results in increased expression of PTER mRNA23922661
D013629TamoxifenTamoxifen results in decreased expression of PTER mRNA25123088
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PTER mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of PTER mRNA19770486
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of PTER mRNA25613284
D013853ThioacetamideThioacetamide results in increased expression of PTER mRNA23411599
D013893ThiramThiram results in decreased expression of PTER mRNA20530235
D014212TretinoinTretinoin results in increased expression of PTER mRNA20488242
D014241TrichloroethyleneTrichloroethylene results in increased methylation of PTER gene27618143
C012589trichostatin Atrichostatin A results in increased expression of PTER mRNA24935251
C057693troglitazonetroglitazone results in increased expression of PTER mRNA28973697
D014520UrethaneUrethane affects the expression of PTER mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of PTER mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of PTER mRNA24935251
D014635Valproic AcidValproic Acid affects the expression of PTER mRNA17963808
D014638VanadatesVanadates results in decreased expression of PTER mRNA22714537
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of PTER gene25560391
C029297vinylidene chloridevinylidene chloride results in decreased expression of PTER mRNA26682919
C111237vorinostatvorinostat results in increased expression of PTER mRNA27188386

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003674molecular_function-ND-  
GO:0008270zinc ion binding-IEA-  
GO:0016787hydrolase activity-IBA21873635  
GO:0016788hydrolase activity, acting on ester bonds-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0009056catabolic process-IEA-  
GO:0030855epithelial cell differentiation-IEP21492153  
GO ID GO Term Qualifier Evidence PubMed
GO:0070062extracellular exosome-HDA19056867  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
20712903Obesity and diabetes genes are associated with being born small for gestational age: results from the Auckland Birthweight Collaborative study. (2010 Aug 16)Morgan ARBMC Med Genet