Gene: GTF3C5

9328
TFIIIC63|TFIIICepsilon|TFiiiC2-63
general transcription factor IIIC subunit 5
protein-coding
9q34.13
Ensembl:ENSG00000148308 MIM:604890 Vega:OTTHUMG00000020856 UniprotKB:Q9Y5Q8
NC_000009.12
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.182e-1 (AD)  4.015e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs1541331chr9:133050630 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
LZTS20.918
GGA10.917
WDR590.915
CYTH10.912
PRKCSH0.906
FAM50A0.903
ARHGAP10.902
XAB20.902
ZBTB170.899
KIAA20130.898

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.708
OR4F29-0.684
MTRNR2L9-0.284
MTRNR2L6-0.281
MTRNR2L10-0.253
TTLL10-AS1-0.242
UNC45B-0.241
C10orf71-0.239
OR4F16-0.238
KRT73-0.236

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of GTF3C5 mRNA"21346803
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of GTF3C5 mRNA"18648102
D000082AcetaminophenAcetaminophen results in increased expression of GTF3C5 mRNA22230336
D000082AcetaminophenAcetaminophen affects the expression of GTF3C5 mRNA17562736
C103505AM 251AM 251 results in decreased expression of GTF3C5 mRNA16500647
C006780bisphenol Abisphenol A affects the expression of GTF3C5 mRNA21786754
C006780bisphenol Abisphenol A affects the expression of GTF3C5 mRNA25181051
D000068579CelecoxibCelecoxib results in increased expression of GTF3C5 mRNA28201806
C010902decabromobiphenyl etherdecabromobiphenyl ether results in decreased expression of GTF3C5 mRNA23640034
D002945CisplatinCisplatin results in increased expression of GTF3C5 mRNA27594783
D007213IndomethacinIndomethacin results in increased expression of GTF3C5 mRNA28201806
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of GTF3C5 mRNA26011545
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of GTF3C5 mRNA23649840
C017947sodium arsenitesodium arsenite results in decreased expression of GTF3C5 protein21925251
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of GTF3C5 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of GTF3C5 mRNA21215274
D014635Valproic AcidValproic Acid results in increased methylation of GTF3C5 gene29154799
D014635Valproic AcidValproic Acid affects the expression of GTF3C5 mRNA17292431|1796380
D014638VanadatesVanadates results in decreased expression of GTF3C5 mRNA22714537
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of GTF3C5 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000995RNA polymerase III general transcription initiation factor activityCONTRIBUTES_TOIBA21873635  
GO:0001002RNA polymerase III type 1 promoter sequence-specific DNA bindingCONTRIBUTES_TOIBA21873635  
GO:0001003RNA polymerase III type 2 promoter sequence-specific DNA bindingCONTRIBUTES_TOIBA21873635  
GO:0003677DNA bindingcontributes_toIC17409385  
GO:0005515protein binding-IPI17409385  25416956  
GO ID GO Term Qualifier Evidence PubMed
GO:0006351transcription, DNA-templated-IC17409385  
GO:0006383transcription by RNA polymerase III-IC17409385  
GO:0035914skeletal muscle cell differentiation-IEA-  
GO:00427915S class rRNA transcription by RNA polymerase III-IC17409385  
GO:0042797tRNA transcription by RNA polymerase III-IC17409385  
GO ID GO Term Qualifier Evidence PubMed
GO:0000127transcription factor TFIIIC complex-IBA21873635  
GO:0000127transcription factor TFIIIC complex-IDA17409385  
GO:0005654nucleoplasm-IDA-  
GO:0005654nucleoplasm-TAS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-74158RNA Polymerase III TranscriptionIEA
R-HSA-74158RNA Polymerase III TranscriptionTAS
R-HSA-74160Gene expression (Transcription)IEA
R-HSA-74160Gene expression (Transcription)TAS
R-HSA-749476RNA Polymerase III Abortive And Retractive InitiationIEA
R-HSA-76046RNA Polymerase III Transcription InitiationIEA
R-HSA-76046RNA Polymerase III Transcription InitiationTAS
R-HSA-76061RNA Polymerase III Transcription Initiation From Type 1 PromoterIEA
R-HSA-76061RNA Polymerase III Transcription Initiation From Type 1 PromoterTAS
R-HSA-76066RNA Polymerase III Transcription Initiation From Type 2 PromoterIEA
R-HSA-76066RNA Polymerase III Transcription Initiation From Type 2 PromoterTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal