Gene: CD22

933
SIGLEC-2|SIGLEC2
CD22 molecule
protein-coding
19q13.12
Ensembl:ENSG00000012124 MIM:107266 Vega:OTTHUMG00000183298 UniprotKB:P20273
NC_000019.10
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.166e-1 (AD)  6.575e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MYRF0.923
SLC45A30.914
TMEM63A0.91
CAPN30.909
FA2H0.907
TJAP10.907
ERBB30.904
PLEKHH10.897
CERCAM0.896
SLC5A110.892

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NR2F2-0.4
PAX2-0.362
NDNF-0.358
CALB2-0.349
NPBWR1-0.345
THSD7A-0.326
CERKL-0.324
CHRNA6-0.321
NEUROD1-0.32
AVPR2-0.316

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB04958EpratuzumabBiotechDrug205923-57-5InvestigationalTarget
DB05889Inotuzumab ozogamicinBiotechDrug635715-01-4Approved|InvestigationalTarget
ID Drug Name Action PubMed
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of CD22 gene27153756
C006632arsenic trioxidearsenic trioxide results in increased expression of CD22 mRNA20458559
D001280AtrazineAtrazine affects the expression of CD22 mRNA25929836
D001507BeclomethasoneBeclomethasone results in increased expression of CD22 mRNA23656298
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of CD22 mRNA21569818
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of CD22 mRNA22228805
D004958Estradiol[Estradiol binds to ESR2 protein] which results in increased expression of CD22 mRNA20404318
C006780bisphenol Abisphenol A affects the expression of CD22 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of CD22 gene28505145
C046785bryostatin 1bryostatin 1 results in increased expression of CD22 protein10741703
C018475butyraldehydebutyraldehyde results in increased expression of CD22 mRNA26079696
D019256Cadmium ChlorideCadmium Chloride results in increased expression of CD22 mRNA18804290
D002737ChloropreneChloroprene results in decreased expression of CD22 mRNA23125180
D003471CuprizoneCuprizone results in increased expression of CD22 mRNA27523638
D003907DexamethasoneDexamethasone results in increased expression of CD22 mRNA21041162
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of CD22 mRNA27392435
C000944dicrotophosdicrotophos results in increased expression of CD22 mRNA28302478
D004041Dietary FatsDietary Fats results in increased expression of CD22 mRNA25016146
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CD22 mRNA17942748
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of CD22 mRNA23649840
D004397FonofosFonofos results in decreased methylation of CD22 promoter22847954
D005557FormaldehydeFormaldehyde results in decreased expression of CD22 mRNA23649840
D005620Freund's AdjuvantFreund's Adjuvant results in decreased expression of CD22 mRNA20846436
D017313FenretinideFenretinide results in decreased expression of CD22 mRNA28973697
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of CD22 mRNA25613284
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of CD22 mRNA27392435
C544151jinfukangjinfukang results in increased expression of CD22 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of CD22 mRNA24332044
C011890kojic acidkojic acid results in decreased expression of CD22 mRNA16595896
C045463leflunomideleflunomide results in increased expression of CD22 mRNA28988120
D008627Mercuric ChlorideMercuric Chloride inhibits the reaction [CD22 protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]17656488
D008627Mercuric ChlorideMercuric Chloride inhibits the reaction [CD22 protein results in increased phosphorylation of and results in increased activity of MAPK3 protein]17656488
D008627Mercuric ChlorideMercuric Chloride promotes the reaction [CD22 protein results in increased phosphorylation of SYK protein]17656488
D008748MethylcholanthreneMethylcholanthrene results in increased expression of CD22 mRNA18804290
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of CD22 mRNA23649840
D009151Mustard GasMustard Gas results in increased expression of CD22 mRNA15674843
C017096n-butoxyethanoln-butoxyethanol results in decreased expression of CD22 mRNA19812364
C025589ochratoxin Aochratoxin A results in increased acetylation of CD22 promoter29098329
C025589ochratoxin A[ochratoxin A results in increased acetylation of CD22 promoter] which results in increased expression of CD22 mRNA29098329|2909832
C025589ochratoxin Aochratoxin A results in increased expression of CD22 mRNA29098329
D010126OzoneOzone results in decreased expression of CD22 mRNA28623178
D010278ParathionParathion results in decreased methylation of CD22 promoter22847954
D052638Particulate MatterParticulate Matter results in decreased expression of CD22 mRNA17987463
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in decreased expression of CD22 mRNA28903501
C005556propionaldehydepropionaldehyde results in increased expression of CD22 mRNA26079696
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of CD22 mRNA25895662
D012906SmokeSmoke affects the expression of CD22 mRNA26109882
C061133tamibarotenetamibarotene affects the expression of CD22 mRNA15498508
C012568terbufosterbufos results in decreased methylation of CD22 promoter22847954
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CD22 mRNA26377647
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CD22 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of CD22 mRNA26232522
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of CD22 mRNA25613284
C009495titanium dioxidetitanium dioxide results in increased expression of CD22 mRNA23557971
D014212TretinoinTretinoin affects the expression of CD22 mRNA15498508
D014212TretinoinTretinoin results in increased expression of CD22 mRNA21934132|2383079
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of CD22 mRNA19042947
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of CD22 mRNA"26179874
C013320tris(2-butoxyethyl) phosphatetris(2-butoxyethyl) phosphate affects the expression of CD22 mRNA29024780
D014520UrethaneUrethane results in decreased expression of CD22 mRNA28818685
D014635Valproic AcidValproic Acid results in increased methylation of CD22 gene29154799
D001335Vehicle EmissionsVehicle Emissions results in decreased expression of CD22 mRNA17987463
D015032ZincZinc results in increased expression of CD22 mRNA15226459
D019287Zinc SulfateZinc Sulfate results in increased expression of CD22 mRNA15226459

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI8627166  8647200  
GO:0030246carbohydrate binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0007155cell adhesion-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-TAS-  
GO:0016021integral component of membrane-IEA-  
GO:0070062extracellular exosome-HDA20458337  
KEGG ID KEGG Term
hsa04514Cell adhesion molecules (CAMs)
hsa04640Hematopoietic cell lineage
hsa04662B cell receptor signaling pathway
Reactome ID Reactome Term Evidence
R-HSA-1280218Adaptive Immune SystemIEA
R-HSA-1280218Adaptive Immune SystemTAS
R-HSA-168256Immune SystemIEA
R-HSA-168256Immune SystemTAS
R-HSA-198933Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cellTAS
R-HSA-5690714CD22 mediated BCR regulationTAS
R-HSA-983695Antigen activates B Cell Receptor (BCR) leading to generation of second messengersIEA
R-HSA-983695Antigen activates B Cell Receptor (BCR) leading to generation of second messengersTAS
R-HSA-983705Signaling by the B Cell Receptor (BCR)IEA
R-HSA-983705Signaling by the B Cell Receptor (BCR)TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
9989877Lymphocytes and dendritic cells in the normal uterine cervix. An immunohistochemical study. (1998 Dec)Poppe WAEur J Obstet Gynecol Reprod Biol