Gene info: ID 9332

Gene: CD163

GENE ID: 9332

Synonyms: M130|MM130|SCARI1

Description: CD163 molecule

Gene type: protein-coding

Location: 12p13.31

dbXrefs: Ensembl:ENSG00000177575 MIM:605545 Vega:OTTHUMG00000168353 UniprotKB:Q86VB7

RefSeq: NG_029826.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: OD|ND

# Publications: 19

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 4.878e-1 (AD) 3.623e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
MS4A4A	0.9
SLA	0.883
SIGLEC9	0.883
MSR1	0.881
RBM47	0.873
SERPINA1	0.871
LAIR1	0.868
SLC11A1	0.868
SLC7A7	0.866
VSIG4	0.866

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
ATP2C2	-0.504
KCNIP3	-0.49
CPLX3	-0.485
KIT	-0.447
WNT7A	-0.442
NEUROD6	-0.442
ZSCAN1	-0.432
FRMPD1	-0.429
MARCH4	-0.425
EXTL1	-0.422

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB05389	WF10	Small Molecule	-	Approved\|Investigational	Target

ID	Drug Name	Action	PubMed
C009505	4,4'-diaminodiphenylmethane	"4,4'-diaminodiphenylmethane results in increased expression of CD163 mRNA"	25380136
D000082	Acetaminophen	Acetaminophen affects the expression of CD163 mRNA	17562736
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased expression of CD163 mRNA	23630614
D000535	Aluminum	[APP protein modified form binds to Aluminum] which results in decreased expression of CD163 mRNA	21298039
D018501	Antirheumatic Agents	Antirheumatic Agents results in decreased expression of CD163 mRNA	24449571
C015001	arsenite	arsenite results in increased methylation of CD163 promoter	23974009
C547126	AZM551248	AZM551248 results in increased expression of CD163 mRNA	22323515
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of CD163 mRNA	20064835
D001564	Benzo(a)pyrene	AHR protein affects the reaction [Benzo(a)pyrene affects the expression of CD163 mRNA]	22228805
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of CD163 mRNA	19770486\|2222880
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of CD163 mRNA	22228805\|2719552
D004958	Estradiol	Estradiol results in increased expression of CD163 mRNA	19484750
C006780	bisphenol A	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of CD163 mRNA	28628672
C006780	bisphenol A	bisphenol A results in decreased methylation of CD163 promoter	27312807
C006780	bisphenol A	bisphenol A results in decreased expression of CD163 mRNA	25181051
C000611646	bisphenol F	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of CD163 mRNA	28628672
D019328	Buthionine Sulfoximine	[Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased expression of CD163 mRNA	26177832
D019328	Buthionine Sulfoximine	gadolinium chloride inhibits the reaction [[Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased expression of CD163 mRNA]	26177832
D019256	Cadmium Chloride	Cadmium Chloride results in decreased expression of CD163 mRNA	25993096
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of CD163 mRNA	27339419
D002737	Chloroprene	Chloroprene results in increased expression of CD163 mRNA	23125180
D002737	Chloroprene	Chloroprene results in increased expression of CD163 mRNA	23125180
D002794	Choline	Choline affects the expression of CD163 mRNA	17616785
D003300	Copper	[gadolinium chloride co-treated with Fructose co-treated with Copper deficiency] results in decreased expression of CD163 mRNA	25813056
D016572	Cyclosporine	Cyclosporine results in decreased expression of CD163 mRNA	27989131
C107676	deguelin	[deguelin co-treated with Oxygen deficiency] results in increased expression of CD163 mRNA	22745725
D003907	Dexamethasone	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of CD163 mRNA	28628672
D003907	Dexamethasone	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of CD163 mRNA	28628672
D003907	Dexamethasone	Dexamethasone results in increased expression of CD163 protein	17410599
D004008	Diclofenac	Diclofenac results in increased expression of CD163 mRNA	26934552
D004041	Dietary Fats	Dietary Fats results in decreased expression of CD163 mRNA	18042831\|2260994
D004041	Dietary Fats	Dietary Fats results in decreased expression of CD163 mRNA	21852083
D004052	Diethylnitrosamine	[Diethylnitrosamine co-treated with Phenobarbital] results in decreased expression of CD163 mRNA	24535843
D004052	Diethylnitrosamine	Diethylnitrosamine results in decreased expression of CD163 mRNA	24535843
D002117	Calcitriol	Calcitriol results in decreased expression of CD163 mRNA	26485663
D004237	Diuron	Diuron results in decreased expression of CD163 mRNA	25152437
C007630	estradiol 17 beta-cypionate	estradiol 17 beta-cypionate results in increased expression of CD163 mRNA	22497863
D000431	Ethanol	Ethanol results in increased expression of CD163 mRNA	23832548\|2685800
D000431	Ethanol	[Fructose co-treated with Ethanol] results in increased expression of CD163 mRNA	26858005
D005485	Flutamide	Flutamide results in decreased expression of CD163 mRNA	24136188
D005632	Fructose	[Fructose co-treated with Ethanol] results in increased expression of CD163 mRNA	26858005
D005632	Fructose	[gadolinium chloride co-treated with Fructose co-treated with Copper deficiency] results in decreased expression of CD163 mRNA	25813056
C038958	gadolinium chloride	[gadolinium chloride co-treated with Fructose co-treated with Copper deficiency] results in decreased expression of CD163 mRNA	25813056
C038958	gadolinium chloride	gadolinium chloride inhibits the reaction [[Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased expression of CD163 mRNA]	26177832
D017313	Fenretinide	Fenretinide results in decreased expression of CD163 mRNA	28973697
D007213	Indomethacin	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of CD163 mRNA	28628672
D007213	Indomethacin	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of CD163 mRNA	28628672
C051890	irinotecan	irinotecan results in increased expression of CD163 mRNA	20097248
D015056	1-Methyl-3-isobutylxanthine	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of CD163 mRNA	28628672
D015056	1-Methyl-3-isobutylxanthine	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of CD163 mRNA	28628672
D007545	Isoproterenol	Isoproterenol results in increased expression of CD163 mRNA	20003209
C008261	lead acetate	lead acetate results in increased expression of CD163 mRNA	22641619
C482199	lipopolysaccharide, E coli O55-B5	"lipopolysaccharide, E coli O55-B5 results in increased expression of CD163 mRNA"	24972896
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of CD163 mRNA	26918785
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of CD163 protein	26918785
D008070	Lipopolysaccharides	"methyl 2-cyano-3,12-dioxoolean-1,9-dien-28-oate inhibits the reaction [Lipopolysaccharides results in increased expression of CD163 mRNA]"	26918785
D008070	Lipopolysaccharides	"methyl 2-cyano-3,12-dioxoolean-1,9-dien-28-oate inhibits the reaction [Lipopolysaccharides results in increased expression of CD163 protein]"	26918785
D008466	Mechlorethamine	Mechlorethamine results in increased expression of CD163 protein	26273949
D017258	Medroxyprogesterone Acetate	Medroxyprogesterone Acetate results in increased expression of CD163 mRNA	20843944
D008713	Methimazole	[Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased expression of CD163 mRNA	26177832
D008713	Methimazole	gadolinium chloride inhibits the reaction [[Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased expression of CD163 mRNA]	26177832
C445068	methyl 2-cyano-3,12-dioxoolean-1,9-dien-28-oate	"methyl 2-cyano-3,12-dioxoolean-1,9-dien-28-oate inhibits the reaction [Lipopolysaccharides results in increased expression of CD163 mRNA]"	26918785
C445068	methyl 2-cyano-3,12-dioxoolean-1,9-dien-28-oate	"methyl 2-cyano-3,12-dioxoolean-1,9-dien-28-oate inhibits the reaction [Lipopolysaccharides results in increased expression of CD163 protein]"	26918785
C016599	mono-(2-ethylhexyl)phthalate	mono-(2-ethylhexyl)phthalate results in increased expression of CD163 protein	22143055
D015058	1-Naphthylisothiocyanate	1-Naphthylisothiocyanate results in increased expression of CD163 mRNA	25380136
C017096	n-butoxyethanol	n-butoxyethanol results in increased expression of CD163 mRNA	19812364
D009532	Nickel	Nickel results in increased expression of CD163 mRNA	24768652\|2558310
D010100	Oxygen	[deguelin co-treated with Oxygen deficiency] results in increased expression of CD163 mRNA	22745725
D010126	Ozone	Ozone results in increased expression of CD163 mRNA	17095637
D017239	Paclitaxel	Paclitaxel results in increased expression of CD163 mRNA	18754875
D000073878	Palm Oil	Palm Oil results in decreased expression of CD163 mRNA	18042831
C016030	pantogab	pantogab results in increased expression of CD163 mRNA	17379144
D010396	Penicillamine	Penicillamine results in decreased expression of CD163 mRNA	19575532
D010396	Penicillamine	Penicillamine results in increased expression of CD163 mRNA	19575532
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in increased expression of CD163 mRNA	17560707
D010634	Phenobarbital	[Diethylnitrosamine co-treated with Phenobarbital] results in decreased expression of CD163 mRNA	24535843
D010634	Phenobarbital	NR1I3 protein affects the reaction [Phenobarbital results in decreased expression of CD163 mRNA]	19482888
D010634	Phenobarbital	Phenobarbital affects the expression of CD163 mRNA	23091169
D010634	Phenobarbital	Phenobarbital results in decreased expression of CD163 mRNA	19482888
C006253	pirinixic acid	[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of CD163 mRNA	19710929
D011374	Progesterone	Progesterone results in increased expression of CD163 mRNA	19690047
C059514	resveratrol	[resveratrol co-treated with Streptozocin] results in increased expression of CD163 mRNA	25905778
D012822	Silicon Dioxide	Silicon Dioxide results in decreased expression of CD163 mRNA	23221170
C009277	sodium arsenate	sodium arsenate results in increased expression of CD163 mRNA	21795629
C016104	sodium bichromate	sodium bichromate results in decreased expression of CD163 mRNA	17685462
D012969	Sodium Fluoride	Sodium Fluoride results in increased expression of CD163 protein	28918527
D013311	Streptozocin	[resveratrol co-treated with Streptozocin] results in increased expression of CD163 mRNA	25905778
D013629	Tamoxifen	Tamoxifen affects the expression of CD163 mRNA	20937368
D019772	Topotecan	Topotecan results in increased expression of CD163 mRNA	25729387
D014635	Valproic Acid	Valproic Acid results in decreased expression of CD163 mRNA	29154799
D000068756	Valsartan	Valsartan results in decreased expression of CD163 mRNA	22768174
C025643	vinclozolin	vinclozolin results in increased expression of CD163 mRNA	23034163

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005044	scavenger receptor activity	-	NAS	8370408
GO:0005515	protein binding	-	IPI	15479433

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0006898	receptor-mediated endocytosis	-	TAS	-
GO:0006953	acute-phase response	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005576	extracellular region	-	IEA	-
GO:0005886	plasma membrane	-	IDA	-
GO:0005886	plasma membrane	-	TAS	-
GO:0005887	integral component of plasma membrane	-	TAS	8370408
GO:0009897	external side of plasma membrane	-	IBA	21873635
GO:0009897	external side of plasma membrane	-	IDA	24942581
GO:0030666	endocytic vesicle membrane	-	TAS	-

KEGG ID	KEGG Term

Reactome ID	Reactome Term	Evidence
R-HSA-2168880	Scavenging of heme from plasma	TAS
R-HSA-2173782	Binding and Uptake of Ligands by Scavenger Receptors	TAS
R-HSA-5653656	Vesicle-mediated transport	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
27541014	Soluble CD163, adiponectin, C-reactive protein and progression of dysglycaemia in individuals at high risk of type 2 diabetes mellitus: the ADDITION-PRO cohort. (2016 Nov)	Deichgraeber P	Diabetologia
26253658	M2 polarized macrophages induced by CSE promote proliferation, migration, and invasion of alveolar basal epithelial cells. (2015 Sep)	Fu X	Int Immunopharmacol
22797933	Impact of opiate addiction on neuroinflammation in HIV. (2012 Oct)	Byrd D	J Neurovirol
21426578	Smoking status and anti-inflammatory macrophages in bronchoalveolar lavage and induced sputum in COPD. (2011 Mar 22)	Kunz LI	Respir Res
22591690	Mucin5B expression by lung alveolar macrophages is increased in long-term smokers. (2012 Aug)	Sepper R	J Leukoc Biol
27488495	Adiposity influences airway wall thickness and the asthma phenotype of HIV-associated obstructive lung disease: a cross-sectional study. (2016 Aug 4)	Barton JH	BMC Pulm Med
15979079	The monocytic lineage specific soluble CD163 is a plasma marker of coronary atherosclerosis. (2006 Feb)	Aristoteli LP	Atherosclerosis
22178353	Genetic contribution to C-reactive protein levels in severe obesity. (2012 Mar)	Faucher G	Mol Genet Metab
25198511	Induction of murine macrophage M2 polarization by cigarette smoke extract via the JAK2/STAT3 pathway. (2014)	Yuan F	PLoS One
24598169	Increased pro-angiogenic factors, infiltrating neutrophils and CD163(+) macrophages in bronchoalveolar lavage fluid from lung cancer patients. (2014 May)	Chen L	Int Immunopharmacol
24651679	Macrophage inflammatory markers are associated with subclinical carotid artery disease in women with human immunodeficiency virus or hepatitis C virus infection. (2014 May)	Shaked I	Arterioscler Thromb Vasc Biol
26544583	Obesity is associated with greater inflammation and monocyte activation among HIV-infected adults receiving antiretroviral therapy. (2015 Oct 23)	Conley LJ	AIDS
28559931	Soluble plasma proteins ST2 and CD163 as early biomarkers of nephropathy in Swedish patients with diabetes, 15-34 years of age: a prospective cohort study. (2017)	Samuelsson M	Diabetol Metab Syndr
22820791	Arterial inflammation in patients with HIV. (2012 Jul 25)	Subramanian S	JAMA
23692821	Soluble CD163 does not predict first-time myocardial infarction in patients infected with human immunodeficiency virus: a nested case-control study. (2013 May 21)	Knudsen A	BMC Infect Dis
24111704	Analysis of the plasma proteome in COPD: Novel low abundance proteins reflect the severity of lung remodeling. (2014 Apr)	Merali S	COPD
28950145	Determination of poor prognostic immune features of tumour microenvironment in non-smoking patients with lung adenocarcinoma. (2017 Nov)	Kinoshita T	Eur J Cancer
26433887	The association of high sCD163/sTWEAK ratio with cardiovascular disease in hemodialysis patients. (2015 Dec)	Rusu CC	Int Urol Nephrol
24824543	Association between M1 and M2 macrophages in bronchoalveolar lavage fluid and tobacco smoking in patients with sarcoidosis. (2014)	Osinska I	Pol Arch Med Wewn