Gene: VAMP3

9341
CEB
vesicle associated membrane protein 3
protein-coding
1p36.23
Ensembl:ENSG00000049245 MIM:603657 Vega:OTTHUMG00000001225 UniprotKB:Q15836
NC_000001.11
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.218e-1 (AD)  6.645e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
QKI0.912
C1orf1980.911
KDSR0.908
FGF10.888
SYPL10.881
EFHD10.88
MAPRE10.877
VEZF10.876
SEPT20.872
SEC11A0.871

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F29-0.529
OPRD1-0.516
FBLN7-0.494
GPR26-0.48
OR4F5-0.478
KCNH5-0.476
PRSS12-0.475
RTP1-0.475
CALHM1-0.473
OTUB2-0.47

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione results in decreased expression of VAMP3 mRNA"19162173
C0303702-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone"2-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone results in decreased expression of VAMP3 mRNA"20206263
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of VAMP3 mRNA"18648102
D000082AcetaminophenAcetaminophen affects the expression of VAMP3 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of VAMP3 mRNA27153756
D000643Ammonium ChlorideAmmonium Chloride affects the expression of VAMP3 mRNA16483693
D001151ArsenicArsenic affects the methylation of VAMP3 gene25304211
D001280AtrazineAtrazine results in increased expression of VAMP3 mRNA25929836
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of VAMP3 mRNA"20018196
C006780bisphenol Abisphenol A affects the expression of VAMP3 mRNA21786754
C006780bisphenol Abisphenol A affects the expression of VAMP3 mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of VAMP3 mRNA29097150
C006780bisphenol Abisphenol A results in increased expression of VAMP3 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of VAMP3 gene28505145
C096325botulinum toxin type Dbotulinum toxin type D results in increased cleavage of VAMP3 protein17666428
D004054DiethylstilbestrolDiethylstilbestrol results in decreased expression of VAMP3 mRNA17005392
D000431EthanolEthanol results in decreased expression of VAMP3 mRNA20655511
D000431EthanolEthanol results in increased expression of VAMP3 mRNA17920746
D005557FormaldehydeFormaldehyde results in increased expression of VAMP3 mRNA23649840
D005839GentamicinsGentamicins results in decreased expression of VAMP3 mRNA22061828
C492448ICG 001ICG 001 results in decreased expression of VAMP3 mRNA26191083
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of VAMP3 mRNA25613284
C008493methylselenic acidmethylselenic acid results in increased expression of VAMP3 mRNA18548127
D008777MethyltestosteroneMethyltestosterone results in increased expression of VAMP3 mRNA29191790
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of VAMP3 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of VAMP3 mRNA"25554681
C014707nitrosobenzylmethylaminenitrosobenzylmethylamine results in increased expression of VAMP3 mRNA17616710
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of VAMP3 mRNA19710929
D010936Plant ExtractsPlant Extracts results in increased expression of VAMP3 mRNA23557933
C010313pseudocumenepseudocumene results in decreased expression of VAMP3 protein17337753
C513428pyrachlostrobinpyrachlostrobin results in increased expression of VAMP3 mRNA27029645
C096323rimabotulinumtoxinBrimabotulinumtoxinB results in increased cleavage of VAMP3 protein17666428
D012524SarinSarin results in decreased expression of VAMP3 protein25842371
D012524SarinSarin results in decreased expression of VAMP3 mRNA19522546
D012715Sesame OilSesame Oil results in decreased expression of VAMP3 mRNA29191790
C020806tetrabromobisphenol Atetrabromobisphenol A affects the expression of VAMP3 mRNA18976794
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of VAMP3 mRNA21570461|2468072
D014635Valproic AcidValproic Acid affects the expression of VAMP3 mRNA25979313
C088658zoledronic acidzoledronic acid results in increased expression of VAMP3 mRNA20977926

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI12130530  16189514  19478182  22118466  24373201  25416956  
26359495  27107012  28626000  
GO:0017075syntaxin-1 binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001921positive regulation of receptor recycling-ISS-  
GO:0002479antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent-TAS-  
GO:0006887exocytosis-TAS9885218  
GO:0006904vesicle docking involved in exocytosis-TAS9885218  
GO:0016192vesicle-mediated transport-ISS-  
GO:0017156calcium ion regulated exocytosis-IEA-  
GO:0034446substrate adhesion-dependent cell spreading-ISS-  
GO:0035493SNARE complex assembly-IEA-  
GO:0042147retrograde transport, endosome to Golgi-IDA18195106  
GO:0043001Golgi to plasma membrane protein transport-IEA-  
GO:0051024positive regulation of immunoglobulin secretionNOTIMP24055037  
GO:0061024membrane organization-TAS-  
GO:0061025membrane fusion-TAS9885218  
GO:0065003protein-containing complex assembly-TAS9885218  
GO:0070254mucus secretionNOTIMP22144578  
GO:0071346cellular response to interferon-gamma-IEA-  
GO:1903531negative regulation of secretion by cell-IDA12130530  
GO:1903593regulation of histamine secretion by mast cellNOTIMP18253931  
GO ID GO Term Qualifier Evidence PubMed
GO:0005622intracellular-IDA24055037  
GO:0005829cytosol-IDA22589474  
GO:0005886plasma membrane-ISS-  
GO:0005886plasma membrane-TAS-  
GO:0009986cell surface-IEA-  
GO:0016021integral component of membrane-IEA-  
GO:0016324apical plasma membrane-IEA-  
GO:0030054cell junction-IEA-  
GO:0030133transport vesicle-TAS-  
GO:0030136clathrin-coated vesicle-IDA19478182  
GO:0030141secretory granule-IEA-  
GO:0030665clathrin-coated vesicle membrane-TAS-  
GO:0030670phagocytic vesicle membrane-TAS-  
GO:0031201SNARE complex-IDA12130530  
GO:0032588trans-Golgi network membrane-TAS-  
GO:0043005neuron projection-IEA-  
GO:0043231intracellular membrane-bounded organelle-IDA18253931  
GO:0045202synapse-IEA-  
GO:0048471perinuclear region of cytoplasm-IEA-  
GO:0055037recycling endosome-IDA19061864  
GO:0055038recycling endosome membrane-TAS-  
KEGG ID KEGG Term
hsa04130SNARE interactions in vesicular transport
hsa04145Phagosome
Reactome ID Reactome Term Evidence
R-HSA-1236974ER-Phagosome pathwayTAS
R-HSA-1236975Antigen processing-Cross presentationTAS
R-HSA-1280218Adaptive Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-199991Membrane TraffickingTAS
R-HSA-5653656Vesicle-mediated transportTAS
R-HSA-6811440Retrograde transport at the Trans-Golgi-NetworkTAS
R-HSA-6811442Intra-Golgi and retrograde Golgi-to-ER trafficTAS
R-HSA-8856825Cargo recognition for clathrin-mediated endocytosisTAS
R-HSA-8856828Clathrin-mediated endocytosisTAS
R-HSA-983169Class I MHC mediated antigen processing & presentationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25466412Genetic evidence for PLASMINOGEN as a shared genetic risk factor of coronary artery disease and periodontitis. (2015 Feb)Schaefer ASCirc Cardiovasc Genet