Gene: SLIT2

9353
SLIL3|Slit-2
slit guidance ligand 2
protein-coding
4p15.31
Ensembl:ENSG00000145147 MIM:603746 Vega:OTTHUMG00000128551 UniprotKB:O94813
NG_047105.1
PubMed
0   ANCO-SNPs
ND
4   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.650e-1 (AD)  1.556e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ATP8A20.953
UNC800.945
CNTNAP20.945
PARM10.943
ADAM220.942
TBC1D300.941
NRXN30.941
GPRASP10.94
NEGR10.94
STXBP5L0.94

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RAB13-0.571
HEY2-0.564
ROM1-0.553
REST-0.552
TGIF1-0.546
YES1-0.543
CSAG1-0.534
MYL3-0.532
WWTR1-0.532
AGTRAP-0.53

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0235142,6-dinitrotoluene"2,6-dinitrotoluene results in decreased expression of SLIT2 mRNA"20406850
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLIT2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLIT2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLIT2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLIT2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLIT2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLIT2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLIT2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLIT2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLIT2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLIT2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLIT2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLIT2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLIT2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLIT2 mRNA"27188386
D000079AcetaldehydeAcetaldehyde affects the expression of SLIT2 mRNA22634333
D000082AcetaminophenAcetaminophen affects the expression of SLIT2 mRNA25458485
D000082AcetaminophenAcetaminophen results in increased expression of SLIT2 mRNA29067470
D020106AcrylamideAcrylamide results in decreased expression of SLIT2 mRNA28959563
C016601afimoxifeneafimoxifene inhibits the reaction [Estrogens results in decreased expression of SLIT2 mRNA]21233418
D016604Aflatoxin B1Aflatoxin B1 affects the expression of SLIT2 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of SLIT2 gene27153756
D000643Ammonium ChlorideAmmonium Chloride affects the expression of SLIT2 mRNA16483693
D017638Asbestos, Crocidolite"Asbestos, Crocidolite affects the expression of SLIT2 mRNA"17331233
D001280AtrazineAtrazine results in decreased expression of SLIT2 mRNA22378314
C487081belinostatbelinostat results in increased expression of SLIT2 mRNA26272509
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of SLIT2 mRNA21871943
D001564Benzo(a)pyreneBenzo(a)pyrene affects the reaction [AHR protein binds to SLIT2 promoter]19654925
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of SLIT2 mRNA"19150397|2001819
D004958EstradiolEstradiol results in increased expression of SLIT2 mRNA19484750
D004958EstradiolEstradiol results in increased expression of SLIT2 mRNA19484750
C044887beta-methylcholinebeta-methylcholine affects the expression of SLIT2 mRNA21179406
C006780bisphenol Abisphenol A results in decreased expression of SLIT2 mRNA22576693
C006780bisphenol Abisphenol A results in increased expression of SLIT2 mRNA25594700
C006780bisphenol Abisphenol A affects the expression of SLIT2 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of SLIT2 gene28505145
D002220CarbamazepineCarbamazepine affects the expression of SLIT2 mRNA25979313
D020245p-Chloromercuribenzoic Acid"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLIT2 mRNA"27188386
D020245p-Chloromercuribenzoic Acidp-Chloromercuribenzoic Acid results in increased expression of SLIT2 mRNA26272509
D004390ChlorpyrifosChlorpyrifos results in increased expression of SLIT2 mRNA21356183
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of SLIT2 mRNA20938992
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of SLIT2 mRNA28472532
D003300CopperCopper results in decreased expression of SLIT2 mRNA26293553
D003300Copper[Copper co-treated with Dietary Sucrose] results in increased expression of SLIT2 mRNA26033743
D003300CopperCopper deficiency results in increased expression of SLIT2 mRNA26033743
D003471CuprizoneCuprizone results in decreased expression of SLIT2 mRNA26577399
C057862cyanoginosin LRcyanoginosin LR affects the expression of SLIT2 mRNA20957730
D016572CyclosporineCyclosporine results in increased expression of SLIT2 mRNA20106945
C093628cyproconazolecyproconazole results in increased expression of SLIT2 mRNA22045034
D003561CytarabineCytarabine results in decreased expression of SLIT2 mRNA21198554
C017180decamethrindecamethrin results in decreased expression of SLIT2 mRNA19017407
C014347decitabinedecitabine results in increased expression of SLIT2 mRNA19100240
D003907DexamethasoneDexamethasone results in decreased expression of SLIT2 mRNA25047013
D003907DexamethasoneDexamethasone results in decreased expression of SLIT2 mRNA22733784
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of SLIT2 mRNA17361019|2126653
D002945Cisplatin[Piroxicam co-treated with Cisplatin] results in decreased expression of SLIT2 mRNA21858171
D019422Dietary Sucrose[Copper co-treated with Dietary Sucrose] results in increased expression of SLIT2 mRNA26033743
D019422Dietary SucroseDietary Sucrose results in increased expression of SLIT2 mRNA26033743
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in increased expression of SLIT2 mRNA"22485181
D004221DisulfiramDisulfiram results in decreased expression of SLIT2 mRNA20530235
D004317DoxorubicinDoxorubicin results in decreased expression of SLIT2 mRNA25896364
D004967Estrogensafimoxifene inhibits the reaction [Estrogens results in decreased expression of SLIT2 mRNA]21233418
D004967EstrogensEstrogens results in decreased expression of SLIT2 mRNA21233418
D000431EthanolEthanol results in decreased expression of SLIT2 mRNA29018328
D015025ZearalenoneZearalenone results in decreased expression of SLIT2 mRNA28965971
C061365flusilazoleflusilazole affects the expression of SLIT2 mRNA22634333
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of SLIT2 mRNA20938992
C039281furanfuran results in decreased expression of SLIT2 mRNA25539665
C039281furanfuran results in decreased methylation of SLIT2 gene27387713
C039281furanfuran results in increased expression of SLIT2 mRNA27387713
D005839GentamicinsGentamicins results in decreased expression of SLIT2 mRNA22061828
C409722hexaconazolehexaconazole results in increased expression of SLIT2 mRNA22045034
D017313FenretinideFenretinide results in decreased expression of SLIT2 mRNA28973697
D017313FenretinideFenretinide results in increased expression of SLIT2 mRNA28973697
C094023iodopravadolineiodopravadoline inhibits the reaction [JZL 184 results in increased expression of SLIT2 protein]25030704
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of SLIT2 mRNA24796395
C561695(+)-JQ1 compound[PD 0325901 co-treated with (+)-JQ1 compound] results in decreased expression of SLIT2 mRNA25119042
C534333JZL 184iodopravadoline inhibits the reaction [JZL 184 results in increased expression of SLIT2 protein]25030704
C534333JZL 184JZL 184 results in increased expression of and affects the localization of SLIT2 protein25030704
D008094LithiumLithium results in decreased expression of SLIT2 protein20153733
D008094LithiumLithium results in increased expression of SLIT2 protein20153733
C042720mercuric bromidemercuric bromide results in increased expression of SLIT2 mRNA26272509
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLIT2 mRNA"27188386
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of SLIT2 mRNA20938992
D008748MethylcholanthreneMethylcholanthrene results in decreased expression of SLIT2 mRNA20713471
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of SLIT2 mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of SLIT2 mRNA26011545
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of SLIT2 mRNA"20188158
D015735MifepristoneMifepristone results in decreased expression of SLIT2 mRNA25972201
C406082monomethylarsonous acidmonomethylarsonous acid affects the expression of SLIT2 mRNA20886546
C500085muraglitazarmuraglitazar results in decreased expression of SLIT2 mRNA21515302
C583365N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in increased expression of SLIT2 mRNA"29244179
C028473N-acetyl-4-benzoquinoneimineSLIT2 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine21177773
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of SLIT2 mRNA"25554681
C029938nickel sulfatenickel sulfate results in increased expression of SLIT2 mRNA22714537
C007350nitrofennitrofen results in increased expression of SLIT2 mRNA19944214
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of SLIT2 mRNA25729387
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLIT2 mRNA"27188386
C496932panobinostatpanobinostat results in increased expression of SLIT2 mRNA26272509
C506614PD 0325901[PD 0325901 co-treated with (+)-JQ1 compound] results in decreased expression of SLIT2 mRNA25119042
C506614PD 0325901PD 0325901 results in decreased expression of SLIT2 mRNA25119042
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLIT2 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of SLIT2 mRNA26272509
D010862PilocarpinePilocarpine results in decreased expression of SLIT2 protein20153733
D010862PilocarpinePilocarpine results in increased expression of SLIT2 protein20153733
C006253pirinixic acidpirinixic acid results in increased expression of SLIT2 mRNA17426115
D010894Piroxicam[Piroxicam co-treated with Cisplatin] results in decreased expression of SLIT2 mRNA21858171
D012643SeleniumSelenium results in decreased expression of SLIT2 mRNA19244175
D012834SilverSilver results in decreased expression of SLIT2 mRNA27131904
C017947sodium arsenitesodium arsenite results in increased expression of SLIT2 mRNA22714537
C501413tesaglitazartesaglitazar results in decreased expression of SLIT2 mRNA21515302
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of SLIT2 mRNA16443690
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of SLIT2 mRNA21296121
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the reaction [AHR protein binds to SLIT2 promoter]19654925
D019284ThapsigarginThapsigargin results in decreased expression of SLIT2 mRNA22378314
D013893ThiramThiram results in decreased expression of SLIT2 mRNA20530235
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of SLIT2 mRNA25729387
D019772TopotecanTopotecan results in increased expression of SLIT2 mRNA25729387
D014212TretinoinTretinoin results in increased expression of SLIT2 mRNA20530235
D014212TretinoinTretinoin results in increased expression of SLIT2 mRNA23724009
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLIT2 mRNA"27188386
C012589trichostatin Atrichostatin A results in increased expression of SLIT2 mRNA24935251|2627250
C057693troglitazonetroglitazone results in decreased expression of SLIT2 mRNA21515302
D014415TunicamycinTunicamycin results in decreased expression of SLIT2 mRNA22378314
D014520UrethaneUrethane results in increased expression of SLIT2 mRNA28818685
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLIT2 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of SLIT2 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of SLIT2 mRNA23179753|2438349
D014635Valproic AcidValproic Acid affects the expression of SLIT2 mRNA17292431|2204503
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of SLIT2 gene25560391
C029297vinylidene chloridevinylidene chloride results in decreased expression of SLIT2 mRNA26682919
C111237vorinostat"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLIT2 mRNA"27188386
C111237vorinostatvorinostat results in increased expression of SLIT2 mRNA26272509

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005095GTPase inhibitor activity-IDA16439689  19759280  
GO:0005509calcium ion binding-NAS9813312  
GO:0005515protein binding-IPI10102268  17848514  
GO:0008201heparin binding-IDA17062560  
GO:0042802identical protein binding-IPI19498462  
GO:0042803protein homodimerization activity-IDA19498462  
GO:0043237laminin-1 binding-IDA10102268  
GO:0043394proteoglycan binding-IPI11375980  
GO:0048495Roundabout binding-IPI10102268  15207848  17848514  
GO ID GO Term Qualifier Evidence PubMed
GO:0001657ureteric bud development-IMP15130495  
GO:0001933negative regulation of protein phosphorylation-IDA18345009  
GO:0002042cell migration involved in sprouting angiogenesis-IMP19351956  
GO:0002689negative regulation of leukocyte chemotaxis-IDA11309622  
GO:0003180aortic valve morphogenesis-ISS-  
GO:0003184pulmonary valve morphogenesis-ISS-  
GO:0007411axon guidance-IDA11748139  
GO:0007411axon guidance-TAS-  
GO:0008045motor neuron axon guidance-IDA10102268  
GO:0010593negative regulation of lamellipodium assembly-IDA16439689  
GO:0010596negative regulation of endothelial cell migration-IDA18345009  
GO:0014912negative regulation of smooth muscle cell migration-IDA16439689  
GO:0021834chemorepulsion involved in embryonic olfactory bulb interneuron precursor migrationNOTIDA11748139  
GO:0021836chemorepulsion involved in postnatal olfactory bulb interneuron migration-IDA15207848  
GO:0021952central nervous system projection neuron axonogenesis-IBA21873635  
GO:0021972corticospinal neuron axon guidance through spinal cord-IMP10975526  
GO:0030308negative regulation of cell growth-IBA21873635  
GO:0030308negative regulation of cell growth-IMP18829537  
GO:0030336negative regulation of cell migration-IDA19005219  
GO:0030336negative regulation of cell migration-IMP18566128  
GO:0030837negative regulation of actin filament polymerization-IDA19759280  
GO:0031290retinal ganglion cell axon guidance-IBA21873635  
GO:0031290retinal ganglion cell axon guidance-IDA10864954  19498462  
GO:0032870cellular response to hormone stimulus-IEP18566128  
GO:0034260negative regulation of GTPase activity-IEA-  
GO:0035385Roundabout signaling pathway-IC10102268  
GO:0035385Roundabout signaling pathway-IMP18829537  
GO:0043065positive regulation of apoptotic process-IMP18566128  
GO:0043116negative regulation of vascular permeability-IDA18345009  
GO:0048754branching morphogenesis of an epithelial tube-IDA18345009  
GO:0048754branching morphogenesis of an epithelial tube-IMP19005219  
GO:0048846axon extension involved in axon guidance-IDA16840550  
GO:0050772positive regulation of axonogenesis-TAS10197527  
GO:0050919negative chemotaxis-IDA11748139  
GO:0050919negative chemotaxis-IMP19005219  
GO:0050929induction of negative chemotaxis-IDA10197527  
GO:0051058negative regulation of small GTPase mediated signal transduction-IDA16439689  
GO:0051414response to cortisol-IEP18566128  
GO:0060412ventricular septum morphogenesis-ISS-  
GO:0061364apoptotic process involved in luteolysis-IEP18566128  
GO:0070100negative regulation of chemokine-mediated signaling pathway-IMP18829537  
GO:0071504cellular response to heparin-IDA17062560  
GO:0071672negative regulation of smooth muscle cell chemotaxis-IDA16439689  
GO:0071676negative regulation of mononuclear cell migration-IDA16439689  
GO:0090024negative regulation of neutrophil chemotaxis-IDA19759280  
GO:0090027negative regulation of monocyte chemotaxis-ISS-  
GO:0090260negative regulation of retinal ganglion cell axon guidance-IDA17062560  
GO:0090288negative regulation of cellular response to growth factor stimulus-IDA16439689  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005615extracellular space-IDA16439689  19005219  
GO:0005737cytoplasm-IDA18566128  
GO:0005886plasma membrane-TAS-  
GO:0016020membrane-NAS16439689  
GO:0070062extracellular exosome-HDA19056867  
KEGG ID KEGG Term
hsa04360Axon guidance
Reactome ID Reactome Term Evidence
R-HSA-1266738Developmental BiologyIEA
R-HSA-1266738Developmental BiologyTAS
R-HSA-373752Netrin-1 signalingIEA
R-HSA-376176Signaling by ROBO receptorsIEA
R-HSA-376176Signaling by ROBO receptorsTAS
R-HSA-422475Axon guidanceIEA
R-HSA-422475Axon guidanceTAS
R-HSA-428540Activation of RAC1IEA
R-HSA-428542Regulation of commissural axon pathfinding by SLIT and ROBOIEA
R-HSA-428543Inactivation of CDC42 and RAC1IEA
R-HSA-428890Role of ABL in ROBO-SLIT signalingIEA
R-HSA-428890Role of ABL in ROBO-SLIT signalingTAS
R-HSA-8985586SLIT2:ROBO1 increases RHOA activityTAS
R-HSA-9010553Regulation of expression of SLITs and ROBOsIEA
R-HSA-9010553Regulation of expression of SLITs and ROBOsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
15911247CpG island methylation and expression of tumour-associated genes in lung carcinoma. (2005 May)Dammann REur J Cancer
20838434MicroRNA-218 is deleted and downregulated in lung squamous cell carcinoma. (2010 Sep 3)Davidson MRPLoS One
20651036Expression of the repulsive SLIT/ROBO pathway in the human endometrium and Fallopian tube. (2010 Dec)Duncan WCMol Hum Reprod
22011669Genome-wide analysis of DNA methylation and the gene expression change in lung cancer. (2012 Jan)Kwon YJJ Thorac Oncol